当前位置： SCI文献检索 > BASIC RESEARCH IN CARDIOLOGY期刊下所有文献 > Alcohol-induced congestive cardiomyopathy in adult turkeys: effects on myocardial antioxidant defence systems.

Alcohol-induced congestive cardiomyopathy in adult turkeys: effects on myocardial antioxidant defence systems.

Abstract：

:The effects of chronic intake of dietary alcohol upon left ventricular function, activities of myocardial antioxidant enzymes, reduced glutathione (GSH) content and lipoperoxidation (measured as the formation of diene conjugates and lipid-soluble fluorescence) were studied in adult domestic Nicholas turkeys. The non-invasive evaluation of left ventricular function by echocardiography revealed an impaired contractile function (the calculated fractional shortening values were 31.1 +/- 4.1% in the alcoholic group and 38.8 +/- 4.4% in the controls) and dilatation of the heart in the alcoholic birds. The changes in the non-invasive parameters of the left ventricle indicate that the adult Nicholas turkey developed congestive cardiomyopathy secondary to the ingestion of ethanol. In the hearts of normal adult turkeys, high GSH content (2.39 +/- 0.25 mumol/g wet weight) and superoxide dismutase activity were found, as compared to other animals, indicating the relatively higher development of antioxidant defence systems. Compared to the controls, significant increases were noted for all the antioxidant enzymes investigated (superoxide dismutase, catalase and glutathione peroxidase) and a moderately significant decrease in the GSH content was found in the left ventricle of alcoholic birds. The changes in GSH concentration and antioxidant enzyme activities might indirectly indicate some involvement of free radicals in the pathogenesis of ethanol-induced myocardial lesion. However, the levels of in vivo lipoperoxidation in the alcoholic birds did not significantly vary from those of control turkeys. Based on these findings, it appears that the reactive oxygen radicals may play a less important role in the pathogenesis of alcohol-induced cardiomyopathy in turkeys--probably due to the higher development of myocardial antioxidant defence systems.

journal_name

Basic Res Cardiol

journal_title

Basic research in cardiology

authors

Edes I,Piros G,Forster T,Csanady M

doi

10.1007/BF01907225

subject

Has Abstract

pub_date

1987-11-01 00:00:00

pages

551-6

issue

6

eissn

0300-8428

issn

1435-1803

journal_volume

82

pub_type

杂志文章

相关文献

BASIC RESEARCH IN CARDIOLOGY文献大全
  • Effects of vasoactive stimuli on coronary vascular resistance in isolated perfused rabbit hearts: no vasospastic response to ergonovine with or without atherogenic diet.

    abstract：:The mechanism of ergonovine-provoked coronary vasospasm is poorly understood. We tested the effect of ergonovine in perfused hearts from normal and cholesterol-fed (18 weeks, 2% cholesterol diet) rabbits in a constant-flow Langendorff perfusion. Aortic perfusion pressure was monitored to measure coronary vascular resi...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/BF02070165

    authors： von Arnim T,Crea F,Chierchia S,Thompson GR,Maseri A

    更新日期：1983-07-01 00:00:00

  • Coronary microembolization.

    abstract：:Atherosclerotic plaque rupture is the key event in the pathogenesis of acute coronary syndromes and it also occurs during coronary interventions. Atherosclerotic plaque rupture does not always result in complete thrombotic occlusion of the epicardial coronary artery with subsequent impending myocardial infarction, but...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章,评审

    doi：10.1007/s00395-006-0616-1

    authors： Skyschally A,Leineweber K,Gres P,Haude M,Erbel R,Heusch G

    更新日期：2006-09-01 00:00:00

  • Mechanical determinants of myocardial energy turnover.

    abstract：:Energy turnover of the left ventricle does not differ in isovolumic contractions and contractions where pressure is released from peak to zero. This experimental result corresponds to predictions from a time varying elastance model of the mechanical and energetic properties of the left ventricle. To assess the validit...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/978-3-662-11289-2_5

    authors： Elzinga G,Duwel CM,Mast F,Westerhof N

    更新日期：1987-01-01 00:00:00

  • Knock-out of nexilin in mice leads to dilated cardiomyopathy and endomyocardial fibroelastosis.

    abstract：:Cardiomyopathy is one of the most common causes of chronic heart failure worldwide. Mutations in the gene encoding nexilin (NEXN) occur in patients with both hypertrophic and dilated cardiomyopathy (DCM); however, little is known about the pathophysiological mechanisms and relevance of NEXN to these disorders. Here, w...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/s00395-015-0522-5

    authors： Aherrahrou Z,Schlossarek S,Stoelting S,Klinger M,Geertz B,Weinberger F,Kessler T,Aherrahrou R,Moreth K,Bekeredjian R,Hrabě de Angelis M,Just S,Rottbauer W,Eschenhagen T,Schunkert H,Carrier L,Erdmann J

    更新日期：2016-01-01 00:00:00

  • Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia-reperfusion injury.

    abstract：:Sprouty1 (Spry1) is a negative modulator of receptor tyrosine kinase signaling, but its role in cardiomyocyte survival has not been elucidated. The aim of this study was to investigate the potential role of cardiomyocyte Spry1 in cardiac ischemia-reperfusion (I/R) injury. Infarct areas of mouse hearts showed an increa...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/s00395-018-0713-y

    authors： Alakoski T,Ulvila J,Yrjölä R,Vainio L,Magga J,Szabo Z,Licht JD,Kerkelä R

    更新日期：2019-01-11 00:00:00

  • Reduced serine-16 and threonine-17 phospholamban phosphorylation in stunning of conscious dogs: no evidence for any involvement of protein kinase A or protein phosphatases.

    abstract：OBJECTIVE:Cardiac stunning is the consequence of a brief cardiac ischemia. The underlying mechanism is not completely understood. METHODS:Here we induced cardiac transient ischemia in conscious instrumented dogs by means of an occluder in the left anterior descending coronary artery (LAD). Contractile performance, mon...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/s00395-005-0577-9

    authors： Weber T,Neumann J,Meissner A,Grosse Hartlage M,Van Aken H,Hanske G,Schmitz W,Boknik P

    更新日期：2006-05-01 00:00:00

  • Role of ACE inhibition or AT1 blockade in the remodeling following myocardial infarction.

    abstract：:Ventricular remodeling following nonfatal myocardial infarction includes an excentric hypertrophy of the surviving myocardium, associated with hemodynamic overload. Disseminated cardiomyocyte apoptosis and phenotype changes of the surviving myocardium, such as a labile calcium homeostasis of the hypertrophied cardiomy...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章,评审

    doi：10.1007/s003950050228

    authors： Holtz J

    更新日期：1998-01-01 00:00:00

  • Regulatory T cells ameliorate cardiac remodeling after myocardial infarction.

    abstract：:Persistent inflammatory responses participate in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We hypothesized that regulatory T (Treg) cells modulate inflammatory responses, attenuate ventricular remodeling and subsequently improve cardiac function after MI. Acute MI was induced...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/s00395-011-0232-6

    authors： Tang TT,Yuan J,Zhu ZF,Zhang WC,Xiao H,Xia N,Yan XX,Nie SF,Liu J,Zhou SF,Li JJ,Yao R,Liao MY,Tu X,Liao YH,Cheng X

    更新日期：2012-01-01 00:00:00

  • Ginkgo biloba extract EGb 761 attenuates myocardial stunning in the pig heart.

    abstract：:Myocardial stunning, a transient contractile dysfunction that appears following a brief period of ischemia, is at least partly due to the production of oxygen-derived free radicals. The objective of the present study was to determine whether the Ginkgo biloba extract EGb761, which has antioxidant properties in vitro, ...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/s00395-003-0380-4

    authors： Rioufol G,Pietri S,Culcasi M,Loufoua J,Staat P,Pop C,Drieu K,Ovize M

    更新日期：2003-02-01 00:00:00

  • Long-term treatment in arterial hypertension for protecting hypertrophic myocardium.

    abstract：:The cardiac organ manifestation of arterial hypertension comprises the myocardium itself with left-ventricular hypertrophy, the interstitium with perivascular and interstitial fibrosis, and the coronary circulation with disease of large and small coronary arteries. The consequences of the sum and interactions of these...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章,评审

    doi：10.1007/978-3-662-30769-4_22

    authors： Vogt M,Motz W,Strauer BE

    更新日期：1991-01-01 00:00:00

  • Changes in calcium handling in atrophic heterotopically isotransplanted rat hearts.

    abstract：:Atrophy of the rat heart induced by hemodynamic unloading after heterotopic transplantation is associated with impaired relaxation while systolic function remains normal when compared to the heart of the recipient animal. To identify possible underlying mechanisms for the above, we studied some aspects of membrane cal...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/BF00788540

    authors： Kolár F,MacNaughton C,Papousek F,Korecky B,Rakusan K

    更新日期：1995-11-01 00:00:00

  • Stabilizing effect of antioxidants and inhibitors of prostaglandin synthesis on after-contractions in Ca2+-overloaded myocardium.

    abstract：:Ca2+ overload followed by after-contractions was induced by perfusion of mammalian papillary muscles with O-K0+, high Ca2+ solution. The effect of lipotrophic agents (dexamethasone, indomethacin) or free radical scavengers (alpha-tocopherol, reduced glutathione, synthetic antioxidant) was tested at different stages of...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/BF01908177

    authors： Saxon ME

    更新日期：1985-07-01 00:00:00

  • Effect of noise stress and ethanol intake on hearts of spontaneously hypertensive rats.

    abstract：:The pathogenesis and progression of hypertensive heart disease are unclear; however, both involve a genetic predisposition and environmental influences. To test the role of exogenous factors, we examined the hearts of spontaneously hypertensive rats (SHR) exposed to noise stress and ethanol intake. Twenty-two SHR and ...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/BF00794951

    authors： Herrmann HJ,Rohde HG,Schulze W,Eichhorn C,Luft FC

    更新日期：1994-11-01 00:00:00

  • Progressive heart failure after myocardial infarction in mice.

    abstract：:We tested the hypotheses that myocardial infarction in mice would lead to progressively worsening heart failure 12-18 weeks later and that exercise testing would provide a suitable means to evaluate left ventricular function sequentially. C57BL/6 mice (n = 69) underwent left coronary artery ligation (n = 50) or thorac...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/s003950200013

    authors： Bayat H,Swaney JS,Ander AN,Dalton N,Kennedy BP,Hammond HK,Roth DM

    更新日期：2002-05-01 00:00:00

  • Effects of different expression and posttranslational modifications of myosin light chains on contractility of skinned human cardiac fibers.

    abstract：:In the human ventricle two isoforms of the phosphorylatable myosin light chain (MPLC) are expressed. These two forms are designated with increasing acidity as LC-2 and LC-2*. In the normal human heart the relation between LC-2/LC-2*-expression is 70/30, suggesting the existence of three different myosin isoenzymes (MP...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/978-3-642-72474-9_11

    authors： Morano I

    更新日期：1992-01-01 00:00:00

  • Chronic cardiac pressure overload induces adrenal medulla hypertrophy and increased catecholamine synthesis.

    abstract：:Increased activity of the sympathetic system is an important feature contributing to the pathogenesis and progression of chronic heart failure. While the mechanisms and consequences of enhanced norepinephrine release from sympathetic nerves have been intensely studied, the role of the adrenal gland in the development ...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/s00395-011-0166-z

    authors： Schneider J,Lother A,Hein L,Gilsbach R

    更新日期：2011-06-01 00:00:00

  • PDE3 cyclic nucleotide phosphodiesterases and the compartmentation of cyclic nucleotide-mediated signalling in cardiac myocytes.

    abstract：:PDE3 cyclic nucleotide phosphodiesterase inhibitors raise cAMP and cGMP content in cardiac and vascular myocytes. Their administration to patients with dilated cardiomyopathy leads to improvements in hemodynamic parameters in the short term but reduces survival with chronic administration. The reasons for this 'biphas...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章,评审

    doi：10.1007/s003950200035

    authors： Movsesian MA

    更新日期：2002-01-01 00:00:00

  • High expression of the focal adhesion- and microfilament-associated protein VASP in vascular smooth muscle and endothelial cells of the intact human vessel wall.

    abstract：:The focal adhesion and microfilament-associated protein VASP is a major substrate of both cAMP- and cGMP-dependent protein kinase in intact human platelets. The recent elucidation of the primary VASP structure and identity of VASP binding proteins suggest that VASP is an important component of focal contacts which lin...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/BF00788712

    authors： Markert T,Krenn V,Leebmann J,Walter U

    更新日期：1996-09-01 00:00:00

  • Delayed attenuation of myocardial ischemia with repeated exercise in subjects with stable angina: a possible model for the second window of protection?

    abstract：AIMS:A delayed myocardial protection extends between 24 and 96 h after ischemic preconditioning in animals. To test for this phenomenon in humans, subjects with stable angina were subjected to exercise test-induced myocardial ischemia and the effect of this "preconditioning" ischemic insult on the exercise-induced myoc...

    journal_title：Basic research in cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s003950070042

    authors： Bilińska M,Rudnicki S,Beresewicz A

    更新日期：2000-10-01 00:00:00

  • Effects of beta-blockade on the incidence of ventricular tachyarrhythmias during acute myocardial ischemia: experimental findings and clinical implications.

    abstract：:Myocardial ischemia and infarction are the most common substrates for life-threatening ventricular tachyarrhythmias. Experimental and clinical evidence suggests that enhanced activity of the sympathetic nervous system plays an important role in the genesis of ischemia-related arrhythmias. In animal experiments, beta-b...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章,评审

    doi：10.1007/978-3-662-11038-6_24

    authors： Haverkamp W,Gülker H,Hindricks G,Breithardt G

    更新日期：1990-01-01 00:00:00

  • Myocardial angiotensin receptors in human hearts.

    abstract：:The cardiac renin angiotensin system (RAS) is the target for number of therapeutic interventions which proved successful in heart failure. Angiotensin converting enzyme (ACE) inhibitors belong to the most efficient strategies available and angiotensin receptor (ATR) antagonists may be comparably effective. The direct ...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章,评审

    doi：10.1007/s003950050207

    authors： Regitz-Zagrosek V,Fielitz J,Fleck E

    更新日期：1998-01-01 00:00:00

  • Alteration in 1,2-diacylglycerol level and its fatty acid composition in hearts during the growth of hamsters.

    abstract：:We measured the amount of 1,2-diacylglycerol (DAG) and its fatty acid composition in hamster hearts of various ages because 1,2-DAG has been recognized to be one of the intracellular second messengers. The highest level in 1,2-DAG was detected in 30-day-old hamster hearts. The heart weight increased about 2.5 times be...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/BF01906969

    authors： Okumura K,Yamada Y,Kondo J,Hashimoto H,Ito T,Ogawa K

    更新日期：1990-03-01 00:00:00

  • Mouse models of atherosclerosis and their suitability for the study of myocardial infarction.

    abstract：:Atherosclerotic plaques impair vascular function and can lead to arterial obstruction and tissue ischaemia. Rupture of an atherosclerotic plaque within a coronary artery can result in an acute myocardial infarction, which is responsible for significant morbidity and mortality worldwide. Prompt reperfusion can salvage ...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章,评审

    doi：10.1007/s00395-020-00829-5

    authors： Golforoush P,Yellon DM,Davidson SM

    更新日期：2020-11-30 00:00:00

  • The effects of autoantibodies against the second extracellular loop of alpha(1)-adrenoceptor on vasoconstriction.

    abstract：:Recent studies have demonstrated the presence of autoantibodies against alpha(1)-adrenoceptor (alpha(1)-AAB) in the serum of patients with primary hypertension, and that these autoantibodies exert adrenergic-agonist-like effects. However, their role in the development of hypertension remains unclear. The current study...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/s00395-009-0020-8

    authors： Yan L,Xu Y,Yao H,Xue W,Tian J,Ren H,Wu Y,Yang G,Ma XL,Liu H

    更新日期：2009-09-01 00:00:00

  • Sodium pump isoform expression in heart failure: implication for treatment.

    abstract：:In the human heart several isoforms of the sodium pump (Na,K-ATPase, the cardiac glycoside receptor) are expressed (alpha1beta1, alpha2beta1, and alpha3beta1). Their expression is regulated in a highly specific manner, so that there are region specific differences in the expression pattern. The isoform expression patt...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章,评审

    doi：10.1007/s003950200025

    authors： Müller-Ehmsen J,McDonough AA,Farley RA,Schwinger RH

    更新日期：2002-01-01 00:00:00

  • Cardiopulmonary vagal afferents in the monkey: a survey of receptor activity.

    abstract：:A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These cons...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/BF02023598

    authors： Zucker IH,Gilmore JP

    更新日期：1977-07-01 00:00:00

  • Inhibition of contractility during the early phase of total ischaemia in the working heart. Recovery during reperfusion.

    abstract：:Total global ischaemia of the normothermic working rat heart caused an initial positive inotropic response characterized by vigorous contractions. After +/- 15 s this response reached a peak whereafter the isotonic contraction amplitude started to decline. After +/- 3.5 min the heart ceased to beat. The low level of h...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/BF01906862

    authors： Steinmann CM,Lochner A,Niesler RA

    更新日期：1987-05-01 00:00:00

  • Serum lipids during treatment with glucose-insulin-potassium in myocardial infarction.

    abstract：:Total cholesterol, phospholipids, and triglycerides in serum were studied during myocardial infarction in a patient group treated with glucose, insulin and potassium (GIK), and a conventionally treated group. There was no difference in the typical changes of cholesterol and phospholipids between the groups, but the GI...

    journal_title：Basic research in cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF01907206

    authors： Kirkeby OJ,Risöe C,Kirkeby K,Hjermann I

    更新日期：1983-11-01 00:00:00

  • Developmental profiles of protective mechanisms of heart against peroxidative injury.

    abstract：:The developmental profiles of the protective mechanisms of heart against peroxidative injury during neonatal growth was examined in the pigs of three different age groups. Lipid peroxidation expressed in terms of malonaldehyde formation was considerably higher in the pig hearts of the 8-10 day age group compared to th...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/BF01907051

    authors： Das DK,Engelman RM,Flansaas D,Otani H,Rousou J,Breyer RH

    更新日期：1987-01-01 00:00:00

  • Sonic hedgehog is a potent chemoattractant for human monocytes: diabetes mellitus inhibits Sonic hedgehog-induced monocyte chemotaxis.

    abstract：:The aim of the present study was to evaluate the expression of hedgehog (Hh) signaling molecules and the chemotactic activity of Sonic hedgehog (Shh) in monocytes from control (CTR) and diabetic patients with or without coronary artery disease (CAD). Previously several studies demonstrated that exogenous administratio...

    journal_title：Basic research in cardiology

    pub_type： 杂志文章

    doi：10.1007/s00395-009-0047-x

    authors： Dunaeva M,Voo S,van Oosterhoud C,Waltenberger J

    更新日期：2010-01-01 00:00:00