Abstract:
:Energy turnover of the left ventricle does not differ in isovolumic contractions and contractions where pressure is released from peak to zero. This experimental result corresponds to predictions from a time varying elastance model of the mechanical and energetic properties of the left ventricle. To assess the validity of this model for cardiac muscle in general, experiments were designed to investigate whether mechanical and energetic behaviour of isolated cardiac muscle preparations could also be predicted from the time varying elastance model. The results obtained so far indicate, however, that not all experimental results can be accommodated by the model. This suggests that the value of the model may be limited.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Elzinga G,Duwel CM,Mast F,Westerhof Ndoi
10.1007/978-3-662-11289-2_5subject
Has Abstractpub_date
1987-01-01 00:00:00pages
51-9eissn
0300-8428issn
1435-1803journal_volume
82 Suppl 2pub_type
杂志文章abstract::Elevation of cardiac troponin I (cTnI) is a well-known complication after percutaneous coronary interventions (PCI). The aims of this study were to quantify the extent of coronary microembolization during elective PCI, to identify predisposing anatomical and procedural factors, and to evaluate its impact on long-term ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-012-0289-x
更新日期:2012-09-01 00:00:00
abstract::The stroke volume at rest of 81 test subjects with no evident cardiac or circulatory dysfunction was determined by impedance cardiography and the measurements were repeated after 11 weeks. In order to attain comparable and reproducible conditions, 44 test subjects were chosen who showed heart rates at rest not higher ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906800
更新日期:1978-11-01 00:00:00
abstract::The mechanism of ergonovine-provoked coronary vasospasm is poorly understood. We tested the effect of ergonovine in perfused hearts from normal and cholesterol-fed (18 weeks, 2% cholesterol diet) rabbits in a constant-flow Langendorff perfusion. Aortic perfusion pressure was monitored to measure coronary vascular resi...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02070165
更新日期:1983-07-01 00:00:00
abstract::Ultrasonic techniques for the measurement of ventricular dimensions are widely used in acute and chronic experiments. Implantation of ultrasonic crystals is associated with reversible and irreversible myocardial damage which might limit the interpretation of the obtained results, in particular during acute experiments...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907029
更新日期:1987-07-01 00:00:00
abstract::Hypertrophic cardiomyopathy (HCM) is a leading cause of heart failure and sudden death in adolescents and young adults. Recently, the role of the Hippo/YAP pathway has been investigated in the pathogenesis of HCM, although the detailed molecular mechanisms largely remain elusive. In this study, we demonstrated an up-r...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-014-0435-8
更新日期:2014-01-01 00:00:00
abstract::Local photodynamic therapy was used to prevent neointimal hyperplasia after stenting. Slotted tube stents were placed with 16 atmospheres in porcine femoral arteries with the external diameter to match the diameter at 10 atmospheres. Animals were randomly allocated to Group 1 (stenting only); or Group 2 with stenting,...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s003950200003
更新日期:2002-03-01 00:00:00
abstract::During myocardial ischemia, both the myocardial and serum TNFalpha concentrations are rapidly increased within the area at risk. With prolongation of ischemia and development of cardiomyocyte necrosis, the TNFalpha concentration increases also in the surrounding viable portions of the myocardium. Indeed, in the scenar...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-003-0431-x
更新日期:2004-01-01 00:00:00
abstract::Alcoholic heart muscle disease is characterized by structural changes which include chamber dilation, ventricular hypertrophy, and myocyte damage. These effects often lead to contractile dysfunction and ultimately to heart failure if alcohol consumption is not terminated. In rat models for heart failure in which heart...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s003950050164
更新日期:1999-12-01 00:00:00
abstract::The cardiac renin angiotensin system (RAS) is the target for number of therapeutic interventions which proved successful in heart failure. Angiotensin converting enzyme (ACE) inhibitors belong to the most efficient strategies available and angiotensin receptor (ATR) antagonists may be comparably effective. The direct ...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950050207
更新日期:1998-01-01 00:00:00
abstract::Ventricular remodeling following nonfatal myocardial infarction includes an excentric hypertrophy of the surviving myocardium, associated with hemodynamic overload. Disseminated cardiomyocyte apoptosis and phenotype changes of the surviving myocardium, such as a labile calcium homeostasis of the hypertrophied cardiomy...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950050228
更新日期:1998-01-01 00:00:00
abstract::The cardiac organ manifestation of arterial hypertension comprises the myocardium itself with left-ventricular hypertrophy, the interstitium with perivascular and interstitial fibrosis, and the coronary circulation with disease of large and small coronary arteries. The consequences of the sum and interactions of these...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/978-3-662-30769-4_22
更新日期:1991-01-01 00:00:00
abstract::Nitric oxide (NO) exerts several effects on myocardial contraction, including enhancement of relaxation and diastolic function, modulation of beta-adrenergic inotropic responses, and inotropic effects in the absence of agonist pre-stimulation. Different effects have been observed in different species and preparations,...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s003950050096
更新日期:1998-08-01 00:00:00
abstract::Persistent inflammatory responses participate in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We hypothesized that regulatory T (Treg) cells modulate inflammatory responses, attenuate ventricular remodeling and subsequently improve cardiac function after MI. Acute MI was induced...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-011-0232-6
更新日期:2012-01-01 00:00:00
abstract::Ischaemic preconditioning has not been demonstrated to reduce infarct size following global ischaemia in murine myocardium. Eighteen mouse hearts were isolated, perfused in the Langendorff mode, and randomised to control or preconditioning groups. Preconditioned hearts received four periods of five minutes global isch...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s003950050106
更新日期:1998-10-01 00:00:00
abstract::Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dep...
journal_title:Basic research in cardiology
pub_type: 社论
doi:10.1007/s00395-015-0510-9
更新日期:2015-09-01 00:00:00
abstract::The purpose of this study was to determine if decreased heart function after hypoxia followed by reoxygenation (H-R) is associated with increased degradation of cardiac myosin light chain 1 (MLC1) by matrix metalloproteinase-2 (MMP-2), and to investigate the effects of the increased level of peroxynitrite in the heart...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-009-0035-1
更新日期:2009-11-01 00:00:00
abstract::The endothelin (ET) family of peptides have potent vascular, cardiac and renal actions which may be of pathophysiological importance in congestive heart failure (CHF). In vivo studies with selective and non-selective ET receptor antagonists are required to clarify the role of ET in the pathophysiology of CHF and deter...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/BF00810520
更新日期:1996-01-01 00:00:00
abstract::For the quantitative evaluation of myocardial damage induced by isoprenaline (ISO) a method based on the uptake of 203Hg-labelled Mercurascan (MSC) in the heart was used. The increase of myocardial uptake of MSC in ISO-treated rats over control values was very rapid and might be directly proportional to the number of ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01910409
更新日期:1977-09-01 00:00:00
abstract:BACKGROUND:The phytosterol guggulsterone is a potent anti-inflammatory mediator with less side effects than classic steroids. This study assesses the impact of guggulsterone on tissue factor (TF) expression and thrombus formation. METHODS AND RESULTS:Guggulsterone inhibited TNF-alpha-induced endothelial TF protein exp...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-008-0757-5
更新日期:2009-05-01 00:00:00
abstract::There is a growing need for pharmacological agents to manage cardiovascular disease in the rapidly growing elderly population. Here, we determine if acetaminophen is efficacious in decreasing age-related increases in cardiac reactive oxygen species (ROS) and apoptosis in aging Fischer 344 X Brown Norway rats. Compared...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-010-0094-3
更新日期:2010-07-01 00:00:00
abstract::Cardiovascular cell therapy offers the first real potential to treat the underlying injuries associated with cardiac and vascular disease. By delivering appropriate exogenous cells to an injury site, the potential exists to mitigate injury or even to begin to reverse damage. Based on their inordinate pre-clinical prom...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-004-0558-z
更新日期:2005-11-01 00:00:00
abstract::Ex vivo multicellular preparations are essential tools to study tissue physiology. Among them, the recent methodological and technological developments in living myocardial slices (LMS) are attracting increasing interest by the cardiac research field. Despite this, this research model remains poorly perceived and util...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-020-00822-y
更新日期:2020-09-10 00:00:00
abstract::Impaired nitric oxide (NO)-soluble guanylate cyclase (sGC)-cGMP signaling is involved in the pathogenesis of ischemic heart diseases, yet the impact of long-term sGC activation on progressive cardiac remodeling and heart failure after myocardial infarction (MI) has not been explored. Moreover, it is unknown whether st...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-014-0421-1
更新日期:2014-07-01 00:00:00
abstract::Our understanding of what constitutes "normal" collagen organization in wound healing after myocardial injury and how such organization is achieved is still in its infancy. However, once this knowledge has been obtained, it may suggest methods of enhancing or even optimizing healing, and thus provide us with the possi...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950050201
更新日期:1998-01-01 00:00:00
abstract::Hypertension and resulting left ventricular hypertrophy was induced in young male Wistar rats (60 to 70 days old) by narrowing of one renal artery (Goldblatt II). 8 and 24 weeks after operation, myocardial oxygen consumption was measured on a modified in situ heart-lung preparation with nearly isovolumetric left ventr...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908041
更新日期:1982-05-01 00:00:00
abstract::Recent reports indicate that elevating DNA glycosylase/AP lyase repair enzyme activity offers marked cytoprotection in cultured cells and a variety of injury models. In this study, we measured the effect of EndoIII, a fusion protein construct that traffics Endonuclease III, a DNA glycosylase/AP lyase, to the mitochond...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-014-0459-0
更新日期:2015-03-01 00:00:00
abstract::The article describes a method for monitoring the total energy output and oxygen uptake of isolated perfused rat hearts with working left ventricles. Twenty-two unpaced hearts (rates 4-4.5 bs-1) were separately investigated inside a flow micro-calorimeter (one minute for 90% thermal response) at 37 degrees C. They pum...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907920
更新日期:1985-09-01 00:00:00
abstract::Epidemiological studies have repeatedly demonstrated a beneficial effect of moderate alcohol consumption on the incidence of coronary heart disease, myocardial infarction and overall mortality. The latter increases with excessive alcohol consumption. Although most epidemiological studies demonstrate a beneficial effec...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950170062
更新日期:2001-04-01 00:00:00
abstract::The aim of this study was to clarify the role of altered diabetic vascular reactivity in ischaemic heart disease. In diabetic condition, the necrotic area of myocardial infarction was significantly extended and myocardial oedema failed to develop after administration of norepinephrine 2 or 48 hours after ligation of t...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907942
更新日期:1982-09-01 00:00:00
abstract::Myocytes isolated from guinea pig ventricles were voltage-clamped using patch pipettes in the whole-cell configuration. For proper voltage control fast Na+ current was blocked by TTX or inactivated by an appropriate prepulse. Zero-load cell shortening was monitored by a photoelectric device. The mechanical response to...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907923
更新日期:1989-03-01 00:00:00