Abstract:
:The cardiac renin angiotensin system (RAS) is the target for number of therapeutic interventions which proved successful in heart failure. Angiotensin converting enzyme (ACE) inhibitors belong to the most efficient strategies available and angiotensin receptor (ATR) antagonists may be comparably effective. The direct myocardial effects of both classes of substances depend on the cardiac ANG II receptors. Both subtypes, AT1 and AT2, are expressed in the human heart. AT1 is localized on myocytes, non-myocytes, vascular smooth muscle and endothelial cells, nerve endings, and conduction tissues. AT2 has so far been found in fibrous tissue and endothelial cells. AT1 mediates myocyte hypertrophy, fibroblast proliferation, collagen synthesis, smooth muscle cell growth, endothelial adhesion molecule expression, and catecholamine synthesis. AT1 is downregulated in cardiac failure as well as in the hypertrophied transplanted heart, indicating that a 50% loss of AT1 does not impede cardiac hypertrophy. In heart failure therapy, AT1 antagonists differ from ACE inhibitors by their inhibition of the degradation of bradykinin. Bradykinin has a number intrinsic effect including vasodilation, proinflammatory actions, and modulation of fibrous tissue synthesis. In addition to bradykinin, the functional role of AT2 seems crucial for the therapeutic differences of AT1 antagonists versus ACE inhibitors.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Regitz-Zagrosek V,Fielitz J,Fleck Edoi
10.1007/s003950050207subject
Has Abstractpub_date
1998-01-01 00:00:00pages
37-42eissn
0300-8428issn
1435-1803journal_volume
93 Suppl 2pub_type
杂志文章,评审abstract:OBJECTIVE:The clinical usefulness of class III antiarrhythmic drugs for the treatment of tachyarrhythmias is limited by their potential proarrhythmic effects, mainly torsades-depointes (TdP). The goal of this experimental study was to develop an isolated whole-heart model exhibiting typical characteristics of class III...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s003950050073
更新日期:1998-04-01 00:00:00
abstract::The role of miR-92a on vascular remodelling after injury is currently unknown. Thus, the aim of the present study was to evaluate the role of miR-92a on rat endothelial and vascular smooth muscle cells proliferation and migration in vitro as well as after balloon injury or arterial stenting in vivo. MiR-92a was highly...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-012-0296-y
更新日期:2012-09-01 00:00:00
abstract::The present study was designed to test the hypothesis that in hypertrophied myocardium of patients with hypertrophic obstructive cardiomyopathy (HOCM) a reduced contractile reserve provided by frequency dependent potentiation of force of contraction contributes to the myocardial dysfunction. Myectomy was performed in ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s003950050134
更新日期:1999-04-01 00:00:00
abstract::We investigated the force-frequency relationship (0.5-3 Hz) in non-failing human myocardium and in end-stage failing human myocardium due to dilated cardiomyopathy or subacute myocarditis. In non-failing myocardium, force of contraction increased with increasing stimulation frequency. In end-stage heart failure, the f...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/978-3-642-72474-9_17
更新日期:1992-01-01 00:00:00
abstract::The effects of increased perfusion pressure and epinephrine stimulation on the contractile parameters and glucose transport in the isolated perfused hearts of control and ketotic diabetic rats were studied. An increase in perfusion pressure from 60 mm Hg to 100 mm Hg resulted in increases in coronary flow and peak aor...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907437
更新日期:1983-05-01 00:00:00
abstract::The purpose of this study was to determine if decreased heart function after hypoxia followed by reoxygenation (H-R) is associated with increased degradation of cardiac myosin light chain 1 (MLC1) by matrix metalloproteinase-2 (MMP-2), and to investigate the effects of the increased level of peroxynitrite in the heart...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-009-0035-1
更新日期:2009-11-01 00:00:00
abstract::We compared the effects of linagliptin (Lina, a DPP4 inhibitor) and GLP-1 receptor activation by exenatide followed by exendin-4 in an infusion pump (EX) on infarct size (IS), post-infarction activation of the inflammasome and remodeling in wild-type (WT) and db/db diabetic mice. Mice underwent 30 min ischemia followe...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-019-0743-0
更新日期:2019-08-06 00:00:00
abstract::The hormone-sensitive adenylate cyclase is a multi-component system embedded in the lipid bilayer of the plasma membrane and serves as a signal transduction system for various membrane receptors. The complete system consists of various receptor molecules, which sensitize the external ligands, the effector enzyme adeny...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907422
更新日期:1986-01-01 00:00:00
abstract::Total cholesterol, phospholipids, and triglycerides in serum were studied during myocardial infarction in a patient group treated with glucose, insulin and potassium (GIK), and a conventionally treated group. There was no difference in the typical changes of cholesterol and phospholipids between the groups, but the GI...
journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章
doi:10.1007/BF01907206
更新日期:1983-11-01 00:00:00
abstract::Studies were carried out in 39 barbiturate-anesthetized dogs to determine whether the renin-angiotensin system is important in control of hemodynamics and coronary flow during myocardial ischemia. Plasma renin activity (PRA) was 2.2 +/- 0.4 ng x ml-l x hr-1 immediately before coronary artery occlusion (CAO) and increa...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906463
更新日期:1983-09-01 00:00:00
abstract::Sarcoplasmic reticulum (SR) from left ventricles of rats that developed spontaneous hypertension was studied in vitro. Similar increases of left ventricular mass were found when grouping the animals into mild and severe hypertensives (average systolic arterial pressure of 168 +/- 4 and 202 +/- 6 mmHg, respectively). T...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907362
更新日期:1988-05-01 00:00:00
abstract::This study aimed to analyze the role of endothelial progenitor cell (EPC)-derived angiogenic factors and chemokines in the multistep process driving angiogenesis with a focus on the recently discovered macrophage migration inhibitory factor (MIF)/chemokine receptor axis. Primary murine and murine embryonic EPCs (eEPCs...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-012-0310-4
更新日期:2013-01-01 00:00:00
abstract::The influence of cardiac cholinergic activation was studied in rats and cats on the induction and maintenance of ventricular fibrillation (VF). Acetylcholine (ACH 2-25 micrograms/kg), in doses which did not cause bradycardia or hypotension, induced appearance of spontaneous VF (duration 2-60 sec.) in 9/20 rats which h...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908386
更新日期:1984-11-01 00:00:00
abstract::Elucidation of the subcellular mechanism of myocardial ischemic preconditioning should be facilitated by precise knowledge of the biology of the cardioprotective response. Any proposed molecular mechanism for preconditioning must be initiated during the required ischemic stress period. The studies reported in this pap...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00805571
更新日期:1997-04-01 00:00:00
abstract::Both the severity and duration of postischemic myocardial dysfunction ("stunned" myocardium) are unpredictable and may vary considerably between subjects that underwent apparently similar ischemic insults. To explain this heterogeneous response of the heart to ischemia and reperfusion, we investigated the determinants...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00799686
更新日期:1996-03-01 00:00:00
abstract::Because of the close anatomical association between the ventricles, the volume of one ventricle can directly affect the volume and pressure within the other ventricle. To study the mechanical coupling between the ventricles, we modeled the right and left ventricles as a two-compartment model with right wall (Crw), sep...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907759
更新日期:1986-09-01 00:00:00
abstract::Recent studies demonstrated that NADPH oxidase 2 (NOX2) expression in myocardium after ischemia-reperfusion (IR) is significantly upregulated. However, the underlying mechanisms remain unknown. This study aims to determine if nuclear cardiac myosin light chain 2 (MYL2), a well-known regulatory subunit of myosin, funct...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-015-0494-5
更新日期:2015-01-01 00:00:00
abstract::The behavior of Ca(2+)-activated K+ channels of large conductance (BKCa) in smooth muscle cells, which were obtained from atherosclerotic plaque material (SMCP) and from media segments (SMCM) of human coronary arteries, were compared using the patch-clamp technique. Voltage-clamp protocols in cell-attached patches rev...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788518
更新日期:1997-08-01 00:00:00
abstract::During myocardial ischemia, both the myocardial and serum TNFalpha concentrations are rapidly increased within the area at risk. With prolongation of ischemia and development of cardiomyocyte necrosis, the TNFalpha concentration increases also in the surrounding viable portions of the myocardium. Indeed, in the scenar...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-003-0431-x
更新日期:2004-01-01 00:00:00
abstract::We describe diastolic properties of the myocardium in terms of stress-strain relations. In a mathematical analysis, the equation sigma = alpha(e beta.epsilon-1) of the stress-strain curve can be changed by an increase in the exponent beta or the multiplicative constant alpha. It can be experimentally shown that in hyp...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/978-3-662-11289-2_26
更新日期:1987-01-01 00:00:00
abstract::In open-chest pigs during severe myocardial ischemia [K+]e, [Ca2+]e and [H+]e increase, [Na+]e increases transiently reaching control values after 30 min. Extracellular osmolality of the ischemic area increases due to an H2O-shift from the ECS to the ICS. The increase of [Na+]e and [Ca2+]e must b explained by the shri...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908341
更新日期:1981-07-01 00:00:00
abstract::The quantitative predominance of free and total cholesterol over the amount of mural calcium is a most significant criterion of healthy human coronary arteries during the whole life span (0-90 years). However, this normal ratio increasingly changes as soon as arteriosclerotic alterations of the coronary walls set in. ...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-85660-0_15
更新日期:1994-01-01 00:00:00
abstract::Urapidil (URA) is used to treat acute hypertension in patients with coronary artery disease, but the effect of URA on the performance of ischemic myocardium has not yet been investigated. The present study was intended to assess the function of ischemic myocardium following URA administration. In eight anesthetized (p...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907115
更新日期:1990-05-01 00:00:00
abstract::Heat shock protein 70 (Hsp70) has been shown to have an anti-apoptotic function, but its mechanism is not clear in heart. In this study, we examined the effect of Hsp70 deletion on AIF-induced apoptosis during ischemia/reperfusion (I/R) in vivo. Although Hsp70 KO and WT mice demonstrated similar amounts of AIF release...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-011-0164-1
更新日期:2011-05-01 00:00:00
abstract::Regional glucose utilization of the developing fetal feline heart was assessed during three stages of gestation and compared with the maternal heart and non-pregnant controls. The specific aims were to determine: 1) if glucose utilization by the whole heart changes from early to late gestation; 2) if there are differe...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02191527
更新日期:1991-07-01 00:00:00
abstract::Ischaemic preconditioning is one of the most potent experimental modalities known to decrease infarct size after ischaemia and reperfusion. Much interest has been stimulated by the phenomenon of remote ischaemic conditioning (RIC), in which the preconditioning stimulus is applied to a limb remote from the heart to sti...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-013-0377-6
更新日期:2013-09-01 00:00:00
abstract::The role of the cardiac current Ik1 in arrhythmogenesis remains highly controversal. To gain further insights into the mechanisms of IK1 involvement in cardiac excitability, we studied the susceptibility of transgenic mice with altered IK1 to arrhythmia during various pharmacological and physiological challenges. Arrh...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-007-0659-y
更新日期:2007-09-01 00:00:00
abstract::Coronary artery disease causes an increase in glutamate uptake and alanine output by the heart. We assessed the effects of acute myocardial ischemia on alanine and glutamate exchange and ammonia production in 10 anesthetized open-chest domestic swine (46.9 +/- 0.7 kg). Coronary blood flow was controlled through an ext...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00801965
更新日期:1992-03-01 00:00:00
abstract::Sympathetic neural remodeling, which involves the inflammatory response, plays an important role in ventricular arrhythmias (VAs) after myocardial infarction (MI). Adrenergic receptors on macrophages potentially modulate the inflammatory response. We hypothesized that the increased level of catecholamines activates ma...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-020-0813-3
更新日期:2020-08-07 00:00:00
abstract::We measured the amount of 1,2-diacylglycerol (DAG) and its fatty acid composition in hamster hearts of various ages because 1,2-DAG has been recognized to be one of the intracellular second messengers. The highest level in 1,2-DAG was detected in 30-day-old hamster hearts. The heart weight increased about 2.5 times be...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906969
更新日期:1990-03-01 00:00:00