Abstract：
:Myocardial stunning, a transient contractile dysfunction that appears following a brief period of ischemia, is at least partly due to the production of oxygen-derived free radicals. The objective of the present study was to determine whether the Ginkgo biloba extract EGb761, which has antioxidant properties in vitro, can attenuate myocardial stunning in vivo. Forty-seven anesthetized open-chest farm pigs underwent 10 min of occlusion of the left anterior descending coronary artery (LAD), followed by 3 hours of reperfusion. They were pretreated with either physiological saline, 100 mg or 300 mg of EGb 761 (Protocol I) or 3 mg or 9 mg of ginkgolide B (GkB) (Protocol II). Contractile function was assessed by sonomicrometry. Both doses of EGb 761 significantly improved recovery of contractile function in the reperfused myocardium with segment shortening averaging 23 +/- 5 % of baseline values at 3 hours post-reflow in controls versus 81 +/- 10 % and 57 +/- 12 % in the EGb100 and EGb300 groups, respectively (p < 0.05 vs control in both cases). In contrast, neither dose of GkB improved functional recovery during reperfusion. ESR experiments revealed that EGb761 resulted in a 59 % decrease in myocardial spin-adduct release during reperfusion (p < 0.05 versus control and GkB groups). A significant 28 % decrease (p < 0.05 vs control group) was also obtained in GkB-treated animals. These results indicate that EGb 761 can attenuate myocardial stunning following a brief ischemic insult in the in situ pig heart by an effect that involves a decrease in the formation of free radicals. As the effect of EGb 761 on functional recovery cannot be explained by the presence of GkB, the beneficial action of the extract on myocardial stunning likely involves complementary effects of both its non-ginkgolide and ginkgolide constituents.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Rioufol G,Pietri S,Culcasi M,Loufoua J,Staat P,Pop C,Drieu K,Ovize Mdoi
10.1007/s00395-003-0380-4keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
59-68issue
1eissn
0300-8428issn
1435-1803journal_volume
98pub_type
杂志文章abstract：:A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These cons...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02023598
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journal_title：Basic research in cardiology
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doi：10.1007/BF01923191
更新日期：1983-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 临床试验,杂志文章
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907422
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950050001
更新日期：2000-02-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-015-0494-5
更新日期：2015-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01909767
更新日期：1976-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788735
更新日期：1994-03-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906948
更新日期：1989-11-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788284
更新日期：1994-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907406
更新日期：1986-05-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-019-0743-0
更新日期：2019-08-06 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950070015
更新日期：2000-01-01 00:00:00
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journal_title：Basic research in cardiology
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更新日期：2018-02-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907029
更新日期：1987-07-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Ischemic heart disease is the main cause of death worldwide and is accelerated by increased levels of low-density lipoprotein cholesterol (LDL-C). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a potent circulating regulator of LDL-C through its ability to induce degradation of the LDL receptor (LDLR) in the...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
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journal_title：Basic research in cardiology
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doi：10.1007/BF00788668
更新日期：1992-11-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11289-2_25
更新日期：1987-01-01 00:00:00
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journal_title：Basic research in cardiology
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更新日期：2010-03-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906299
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-011-0218-4
更新日期：2011-11-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
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更新日期：1998-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908160
更新日期：1981-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907089
更新日期：1987-09-01 00:00:00
abstract：:The pathogenesis and progression of hypertensive heart disease are unclear; however, both involve a genetic predisposition and environmental influences. To test the role of exogenous factors, we examined the hearts of spontaneously hypertensive rats (SHR) exposed to noise stress and ethanol intake. Twenty-two SHR and ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00794951
更新日期：1994-11-01 00:00:00
