Clofilium in the isolated perfused rabbit heart: a new model to study proarrhythmia induced by class III antiarrhythmic drugs.

abstract：:Calcium transport functions of mitochondria and sarcoplasmic reticulum (SR) were studied without prior extraction using isolated rat heart myocytes permeabilized with saponin. Calcium uptake by SR was rapid and its affinity was high in comparison to calcium uptake by mitochondria, which had a higher capacity. The sens...

journal_title：Basic research in cardiology

authors： Kaminishi T,Kako KJ

更新日期：1989-05-01 00:00:00

abstract：:Increasing the frequency of steady state stimulation increases the rate of mechanical restitution in hypothermic (27 degrees C) guinea pig papillary muscles. In this paper we have investigated the influences of the calcium antagonist nifedipine and of reduced extracellular calcium concentration on this phenomenon. We ...

journal_title：Basic research in cardiology

authors： Spencer CI,Mörner SE,Noble MI,Seed WA

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVES:The impact of acute collagen disruption by the disulfide donor, 5,5'-dithio-2-nitrobenzoic acid (DTNB) on ventricular properties was tested in rat hearts. METHODS:Collagen was degraded acutely in 13 isolated, isovolumically contracting rat hearts by perfusion with 1 mM DTNB added to Krebs-Henseleit solution...

journal_title：Basic research in cardiology

authors： Todaka K,Jiang T,Chapman JT,Gu A,Zhu SM,Herzog E,Hochman JS,Steinberg SF,Burkhoff D

更新日期：1997-06-01 00:00:00

abstract：:Coronary vasomotion of normal, stenotic, and poststenotic vessel segments was studied in 18 patients with coronary artery disease at rest, during submaximal bicycle exercise, and 5 min after sublingual nitroglycerin or oral isosorbide-dinitrate (ISDN) spray. Patients were divided into two groups: group 1 consisted of ...

journal_title：Basic research in cardiology

authors： Gaglione A,Hess OM,Haemmerli C,Suter T,Kirkeeide RL,Osenberg HP,Muser M,Anliker M,Gould KL,Krayenbuehl HP

更新日期：1990-01-01 00:00:00

abstract：:The aim of the present study was to evaluate the expression of hedgehog (Hh) signaling molecules and the chemotactic activity of Sonic hedgehog (Shh) in monocytes from control (CTR) and diabetic patients with or without coronary artery disease (CAD). Previously several studies demonstrated that exogenous administratio...

journal_title：Basic research in cardiology

authors： Dunaeva M,Voo S,van Oosterhoud C,Waltenberger J

更新日期：2010-01-01 00:00:00

abstract：:The effect of isoproterenol perfusion on cAMP levels and phosphorylase activity was investigated in the spontaneously hypertensive rat (SHR) and Kyoto Wistar normotensive control rat (WKY) heart. The basal force of contraction in physiological salt solution perfused hearts was comparable between SHR and WKY. However, ...

journal_title：Basic research in cardiology

authors： Sharma RV,Gupta RC,Ramanadham M,Venema RC,Bhalla RC

更新日期：1983-11-01 00:00:00

abstract：:The cardiac organ manifestation of arterial hypertension comprises the myocardium itself with left-ventricular hypertrophy, the interstitium with perivascular and interstitial fibrosis, and the coronary circulation with disease of large and small coronary arteries. The consequences of the sum and interactions of these...

journal_title：Basic research in cardiology

authors： Vogt M,Motz W,Strauer BE

更新日期：1991-01-01 00:00:00

abstract：:The concept of metabolic coronary flow control provides a rationale for the close relationship of coronary flow and myocardial metabolic rate of oxygen. The concept is based on the presence of an oxygen (metabolic) sensor coupled functionally to effector mechanisms, which control vascular tone. Four modes of metabolic...

journal_title：Basic research in cardiology

authors： Deussen A,Brand M,Pexa A,Weichsel J

更新日期：2006-11-01 00:00:00

abstract：:The influence of changes in pre- and afterload, heart frequency and inotropic state on the difference between right ventricular dP/dtmax measured isovolumically and auxotonically has been investigated in canine heart-lung preparations. Isovolumic systoles were obtained by occluding the pulmonary artery during diastole...

journal_title：Basic research in cardiology

authors： Hoppe H,Schmidt HD,Seitz E

更新日期：1976-09-01 00:00:00

abstract：:In vivo studies have shown that sympathetic nerve stimulation improves the transmural distribution of myocardial perfusion by increasing the endocardial/epicardial flow ratio; however, the mechanism of this effect is unknown. During nerve stimulation both norepinephrine (NE) and neuropeptide Y (NPY) are released, eith...

journal_title：Basic research in cardiology

authors： Gutterman DD,Morgan DA

更新日期：1995-07-01 00:00:00

abstract：:Total cholesterol, phospholipids, and triglycerides in serum were studied during myocardial infarction in a patient group treated with glucose, insulin and potassium (GIK), and a conventionally treated group. There was no difference in the typical changes of cholesterol and phospholipids between the groups, but the GI...

journal_title：Basic research in cardiology

authors： Kirkeby OJ,Risöe C,Kirkeby K,Hjermann I

更新日期：1983-11-01 00:00:00

abstract：:The hypothesis was tested that vardenafil, a PDE5 inhibitor, specifically enhances coronary vasodilation during acidosis. In isolated constant pressure perfused guinea pig hearts, infusion of vardenafil (

journal_title：Basic research in cardiology

authors： Brand M,Deussen A

更新日期：2007-03-01 00:00:00

abstract：:Pentostatin (2-deoxycoformycin) is a potent inhibitor of adenosine deaminase and has been demonstrated to augment endogenous adenosine levels during regional and global myocardial ischemia. Based on the rationale that increasing endogenous adenosine during ischemia may be cardioprotective, the objective of this study ...

journal_title：Basic research in cardiology

authors： McClanahan TB,Ignasiak DP,Martin BJ,Mertz TE,Gallagher KP

更新日期：1995-03-01 00:00:00

abstract：:The authors have retracted this article [1] because of modifications in the control lanes of Figs. 2a and 8a of the COX1 blot obtained for 18-week-old rats (rotation, horizontal flipping and re-use of the control lanes for the 35-week-old rats blot). In light of the concerns raised, the conclusions drawn in this artic...

journal_title：Basic research in cardiology

authors： Vargas LA,Velasquez FC,Alvarez BV

更新日期：2018-04-18 00:00:00

abstract：:The hormone-sensitive adenylate cyclase is a multi-component system embedded in the lipid bilayer of the plasma membrane and serves as a signal transduction system for various membrane receptors. The complete system consists of various receptor molecules, which sensitize the external ligands, the effector enzyme adeny...

journal_title：Basic research in cardiology

authors： Jakobs KH,Minuth M,Bauer S,Grandt R,Greiner C,Zubin P

更新日期：1986-01-01 00:00:00

abstract：:Age-related changes in the myocardial energy metabolism were studied in spontaneously hypertensive (SHR) rats of 5-15 weeks of age. Systolic blood pressure increased rapidly during 5 to 10 weeks of age (developing phase) and attained a plateau level at 10 to 15 weeks (sustained phase). Even during the developing phase...

journal_title：Basic research in cardiology

authors： Shimamoto N,Goto N,Tanabe M,Imamoto T,Fujiwara S,Hirata M

更新日期：1982-07-01 00:00:00

abstract：:Rate or frequency-dependence is a characteristic property of antiarrhythmic drugs belonging to the Vaughan William classes I and III. The rate-dependence of class I drugs (i.e., increasing blockade of fast Na(+)-channels with faster rates) results from periodical drug binding to Na(+)-channel sites which are preferabl...

journal_title：Basic research in cardiology

authors： Weirich J,Antoni H

更新日期：1998-01-01 00:00:00

abstract：:Ventricular remodeling following nonfatal myocardial infarction includes an excentric hypertrophy of the surviving myocardium, associated with hemodynamic overload. Disseminated cardiomyocyte apoptosis and phenotype changes of the surviving myocardium, such as a labile calcium homeostasis of the hypertrophied cardiomy...

journal_title：Basic research in cardiology

authors： Holtz J

更新日期：1998-01-01 00:00:00

abstract：:Our understanding of what constitutes "normal" collagen organization in wound healing after myocardial injury and how such organization is achieved is still in its infancy. However, once this knowledge has been obtained, it may suggest methods of enhancing or even optimizing healing, and thus provide us with the possi...

journal_title：Basic research in cardiology

authors： Whittaker P

更新日期：1998-01-01 00:00:00

abstract：:In recent years research has shown that muscle is capable of reacting to mechanical stimuli by altering biochemical processes. Myocardium is probably the source of a biochemical factor, or factors which activate myocardial protein synthesis. In experimentally induced cardiac hypertrophy adaptive alterations have been ...

journal_title：Basic research in cardiology

authors： Kölbel F,Schreiber V

更新日期：1983-07-01 00:00:00

abstract：:Exercise training is a well-known non-pharmacological strategy for the prevention and treatment of cardiovascular diseases. Despite the established phenotypic knowledge, the molecular signature of exercise-induced cardiac remodeling remains poorly characterized. The great majority of studies dedicated to this topic us...

journal_title：Basic research in cardiology

authors： Ferreira R,Moreira-Gonçalves D,Azevedo AL,Duarte JA,Amado F,Vitorino R

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Single electrical field shocks are able to induce ventricular fibrillation (VF) if applied during the vulnerable period. During this period, a shock can either prolong the action potential duration or induce a new action potential. Whether the occurrence of different shock responses contributes to the induct...

journal_title：Basic research in cardiology

authors： Kirchhof PF,Fabritz CL,Behrens S,Franz MR

更新日期：1997-02-01 00:00:00

abstract：:Beta-blockers have been shown to reduce the risk of coronary events and reduce the mortality of patients with hypertension and in those who have had a myocardial infarction. Furthermore, the evidence for long-term benefits in these two patient groups are much more convincing for beta-blockers than for other therapeuti...

journal_title：Basic research in cardiology

authors： Kendall MJ

更新日期：2000-01-01 00:00:00

abstract：:The isolated working rabbit heart preparation was used to study whether the "contractile machinery" remains unchanged in globally stunned myocardium. The function of the heart has been measured in nonischemic and postischemic conditions. The effect of isoprenaline or calcium chloride administration in both conditions ...

journal_title：Basic research in cardiology

authors： Andres J,Moczarska A,Stepkowski D,Kakol I

更新日期：1991-05-01 00:00:00

abstract：:PDE3 cyclic nucleotide phosphodiesterase inhibitors raise cAMP and cGMP content in cardiac and vascular myocytes. Their administration to patients with dilated cardiomyopathy leads to improvements in hemodynamic parameters in the short term but reduces survival with chronic administration. The reasons for this 'biphas...

journal_title：Basic research in cardiology

authors： Movsesian MA

更新日期：2002-01-01 00:00:00

abstract：:The effects of 3 hours of ischemia and 1 hour of reperfusion on biochemical, physiological and ultrastructural parameters were studied in 12 dogs. In the ischemic subendocardium without reperfusion, mitochondrial losses of adenine (ATP + ADP + AMP) and pyridine (NAD + NADH) nucleotides far exceeded those observed in w...

journal_title：Basic research in cardiology

authors： Regitz V,Paulson DJ,Hodach RJ,Little SE,Schaper W,Shug AL

更新日期：1984-03-01 00:00:00

abstract：:We tested the hypothesis that isoproterenol would increase myocardial work and O2 consumption at reduced efficiency and that both left ventricular hypertrophy and chemical sympathectomy would lead to changes in this myocardial efficiency response. Left ventricular hypertrophy was produced by aortic valve plication in ...

journal_title：Basic research in cardiology

authors： Scholz PM,Kedem J,Cheinberg BV,Weiss HR

更新日期：1996-07-01 00:00:00

abstract：:We measured the amount of 1,2-diacylglycerol (DAG) and its fatty acid composition in hamster hearts of various ages because 1,2-DAG has been recognized to be one of the intracellular second messengers. The highest level in 1,2-DAG was detected in 30-day-old hamster hearts. The heart weight increased about 2.5 times be...

journal_title：Basic research in cardiology

authors： Okumura K,Yamada Y,Kondo J,Hashimoto H,Ito T,Ogawa K

更新日期：1990-03-01 00:00:00

abstract：:Pressure-overloaded cardiac hypertrophy was induced by abdominal aortic constriction in 10-week-old male Wistar rats. 24-26 weeks after aortic constriction, the hearts were excised and a myocardial mechanical study was performed using isolated left ventricular papillary muscles. There was no significant difference in ...

journal_title：Basic research in cardiology

authors： Takeda N,Ohkubo T,Nakamura I,Suzuki H,Nagano M

更新日期：1987-07-01 00:00:00

abstract：:Atrial fibrosis is important for the pathogenesis of atrial fibrillation (AF) but the underlying signal transduction is incompletely understood. We therefore studied the role of microRNA-21 (miR-21) and its downstream target Sprouty 1 (Spry1) during atrial fibrillation. Left atria (LA) from patients with AF showed a 2...

journal_title：Basic research in cardiology

authors： Adam O,Löhfelm B,Thum T,Gupta SK,Puhl SL,Schäfers HJ,Böhm M,Laufs U

更新日期：2012-09-01 00:00:00