Retraction Note to: Compensatory role of the NBCn1 sodium/bicarbonate cotransporter on Ca2+-induced mitochondrial swelling in hypertrophic hearts.

abstract：:A model of vascular endothelial cell is proposed to describe the mechanisms by which cytosolic calcium (Cai) is modulated and endothelium-derived relaxing factor (EDRF) and prostacyclin (PGI2) are released when the cell is stimulated by agonist. The intracellular Ca2+ store of the model cell is comprised of a superfic...

journal_title：Basic research in cardiology

authors： Wong AY,Klassen GA

更新日期：1992-07-01 00:00:00

abstract：:The purpose of this study was to obtain more information about the role of the plasma membrane in cellular uptake of tracers used in myocardial scintigraphy (radioactive thallium chloride and palmitic acid). This knowledge is of importance for an adequate interpretation of the results obtained under clinical condition...

journal_title：Basic research in cardiology

authors： Rauch B,Kübler W

更新日期：1985-01-01 00:00:00

abstract：:Successive ischemic episodes are commonly seen in clinical and experimental cardiology. Although prolonged abnormalities of the canine myocardium have been described following a single ischemic episode, it is not known whether myocardial injury is cumulative following multiple ischemic episodes. Dogs were subjected to...

journal_title：Basic research in cardiology

authors： Lange R,Ingwall JS,Hale SL,Alker KJ,Kloner RA

更新日期：1984-07-01 00:00:00

abstract：:Enzymes involved in the metabolism nitric oxide (NO) and reactive oxygen species (ROS) may play a role for the decreased availability of NO in atherosclerosis. We, therefore, hypothesized that the pattern of gene expression of these enzymes is altered in atherosclerosis. Myocardial tissue from patients with coronary h...

journal_title：Basic research in cardiology

authors： Chen X,Niroomand F,Liu Z,Zankl A,Katus HA,Jahn L,Tiefenbacher CP

更新日期：2006-07-01 00:00:00

abstract：:Heat shock protein 70 (Hsp70) has been shown to have an anti-apoptotic function, but its mechanism is not clear in heart. In this study, we examined the effect of Hsp70 deletion on AIF-induced apoptosis during ischemia/reperfusion (I/R) in vivo. Although Hsp70 KO and WT mice demonstrated similar amounts of AIF release...

journal_title：Basic research in cardiology

authors： Choudhury S,Bae S,Ke Q,Lee JY,Kim J,Kang PM

更新日期：2011-05-01 00:00:00

abstract：:Both the severity and duration of postischemic myocardial dysfunction ("stunned" myocardium) are unpredictable and may vary considerably between subjects that underwent apparently similar ischemic insults. To explain this heterogeneous response of the heart to ischemia and reperfusion, we investigated the determinants...

journal_title：Basic research in cardiology

authors： Wouters PF,Van de Velde M,Van Aken H,Flameng W

更新日期：1996-03-01 00:00:00

abstract：:Exercise is an efficient strategy for myocardial protection against ischemia-reperfusion (IR) injury. Although endothelial nitric oxide synthase (eNOS) is phosphorylated and activated during exercise, its role in exercise-induced cardioprotection remains unknown. This study investigated whether modulation of eNOS acti...

journal_title：Basic research in cardiology

authors： Farah C,Kleindienst A,Bolea G,Meyer G,Gayrard S,Geny B,Obert P,Cazorla O,Tanguy S,Reboul C

更新日期：2013-11-01 00:00:00

abstract：:The mitochondrial electrochemical gradient (Δp), which comprises the pH gradient (ΔpH) and the membrane potential (ΔΨ), is crucial in controlling energy transduction. During myocardial ischemia and reperfusion (IR), mitochondrial dysfunction mediates superoxide (·O2-) and H2O2 overproduction leading to oxidative injur...

journal_title：Basic research in cardiology

authors： Kang PT,Chen CL,Lin P,Chilian WM,Chen YR

更新日期：2017-07-01 00:00:00

abstract：:Phospholamban is a regulatory phosphoprotein which modulates the active transport of Ca2+ by the cardiac sarcoplasmic reticular Ca(2+)-ATPase enzyme (SERCA2) into the lumen of the sarcoplasmic reticulum. Phospholamban, which is a reversible inhibitor of SERCA2, represses the enzyme's activity, and this inhibition is r...

journal_title：Basic research in cardiology

authors： Koss KL,Grupp IL,Kranias EG

更新日期：1997-01-01 00:00:00

abstract：:We have used x-ray microangiography to investigate the influence of EDRF and endothelin-1 on arterial diameters (70-800 microns) at bifurcations in the isolated rabbit ear and the "optimality" of its branching geometry. The median value of the junction exponent x (which is given by d0x = d1x + d2x, where d0, d1 and d2...

journal_title：Basic research in cardiology

authors： Griffith TM,Edwards DH,Randall MD

更新日期：1991-01-01 00:00:00

abstract：:Heart failure has been divided into several different forms depending on etiology, clinical course and pathophysiology of left ventricular (LV) dysfunction. Systolic and diastolic dysfunction are characterized by a reduced cardiac output with normal (= diastolic dysfunction) or depressed (= systolic dysfunction) LV pu...

journal_title：Basic research in cardiology

authors： Matter C,Nagel E,Stuber M,Boesiger P,Hess OM

更新日期：1996-01-01 00:00:00

abstract：:We investigated whether preconditioning could protect several cultured cell lines, to determine whether the protection is specific for cells derived from different myogenic and non-myogenic sources. Ischemia was simulated by centrifugation of cells into a pellet, and cell viability was determined by hypotonic trypan b...

journal_title：Basic research in cardiology

authors： Liu Y,Gao WD,O'Rourke B,Marban E

更新日期：1996-11-01 00:00:00

abstract：:In vivo studies have shown that sympathetic nerve stimulation improves the transmural distribution of myocardial perfusion by increasing the endocardial/epicardial flow ratio; however, the mechanism of this effect is unknown. During nerve stimulation both norepinephrine (NE) and neuropeptide Y (NPY) are released, eith...

journal_title：Basic research in cardiology

authors： Gutterman DD,Morgan DA

更新日期：1995-07-01 00:00:00

abstract：:Receptor binding studies usually show heterogenic characteristics of the binding isotherm. Scatchard transformation for graphical linearization of the data presentation affects the data inhomogeneously with respect to the experimental error. Thus a non-linear fitting procedure should be preferred for data analysis. Fu...

journal_title：Basic research in cardiology

authors： Wellstein A,Palm D

更新日期：1984-01-01 00:00:00

abstract：:The characterization of various ion transport systems has led to a better understanding of the effects, which seem to take part in the impairment of ischemic and reperfused cardiac tissue. This review discusses the role of the Na+/H+ exchange system in the pathophysiology of ischemia and reperfusion and the beneficial...

journal_title：Basic research in cardiology

authors： Scholz W,Albus U

更新日期：1993-09-01 00:00:00

abstract：:During long-term treatment with amiodarone, slowing of conduction through the atrioventricular node, a prolongation of the QT-interval, and a prolongation of the atrial and ventricular myocardial refractoriness always developed. During short-term treatment, these effects were not found, except for depression of the AV...

journal_title：Basic research in cardiology

authors： Stark G,Stark U,Windisch M,Vicenzi M,Eggenreich U,Nagl S,Kral K,Pilger E,Tritthart HA

更新日期：1991-03-01 00:00:00

abstract：:The role of the cardiac current Ik1 in arrhythmogenesis remains highly controversal. To gain further insights into the mechanisms of IK1 involvement in cardiac excitability, we studied the susceptibility of transgenic mice with altered IK1 to arrhythmia during various pharmacological and physiological challenges. Arrh...

journal_title：Basic research in cardiology

authors： Piao L,Li J,McLerie M,Lopatin AN

更新日期：2007-09-01 00:00:00

abstract：:We compared the effects of linagliptin (Lina, a DPP4 inhibitor) and GLP-1 receptor activation by exenatide followed by exendin-4 in an infusion pump (EX) on infarct size (IS), post-infarction activation of the inflammasome and remodeling in wild-type (WT) and db/db diabetic mice. Mice underwent 30 min ischemia followe...

journal_title：Basic research in cardiology

authors： Birnbaum Y,Tran D,Bajaj M,Ye Y

更新日期：2019-08-06 00:00:00

abstract：:Recent studies demonstrated that NADPH oxidase 2 (NOX2) expression in myocardium after ischemia-reperfusion (IR) is significantly upregulated. However, the underlying mechanisms remain unknown. This study aims to determine if nuclear cardiac myosin light chain 2 (MYL2), a well-known regulatory subunit of myosin, funct...

journal_title：Basic research in cardiology

authors： Zhang YS,Liu B,Luo XJ,Li TB,Zhang JJ,Peng JJ,Zhang XJ,Ma QL,Hu CP,Li YJ,Peng J,Li Q

更新日期：2015-01-01 00:00:00

abstract：:Intermittent, normobaric hypoxia confers robust cardioprotection against ischemia-induced myocardial infarction and lethal ventricular arrhythmias. δ-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) have been implicated in cardioprotective phenomena, but their roles in intermittent hypoxia are unknown...

journal_title：Basic research in cardiology

authors： Estrada JA,Williams AG Jr,Sun J,Gonzalez L,Downey HF,Caffrey JL,Mallet RT

更新日期：2016-03-01 00:00:00

abstract：:In the spontaneously hypertensive rat (SHR) with established hypertension left ventricular mass closely correlated with the proportion of ventricular myosin (VM)-3. A 60% VM-3 content was reached corresponding, under the present housing conditions, to an average age of 40 weeks without any significant change in total ...

journal_title：Basic research in cardiology

authors： Rupp H,Jacob R

更新日期：1986-01-01 00:00:00

abstract：:To understand the effect of transcription regulation in modulating cardiac aging, we sought to study the role of serum response factor (SRF), a key transcription factor in the heart that is normally increased with senescence and also in congestive heart failure. A Tet-Off gene expression system was used for cardiac-sp...

journal_title：Basic research in cardiology

authors： Azhar G,Zhang X,Wang S,Zhong Y,Quick CM,Wei JY

更新日期：2007-05-01 00:00:00

abstract：:In this paper, we review the hypothesis that activated tissue renin-angiotensin systems play a detrimental role in heart failure. The main arguments for this idea are discussed: a) tissue renin-angiotensin systems behave functionally distinct from the circulating renin-angiotensin system; b) tissue renin-angiotensin s...

journal_title：Basic research in cardiology

authors： Pinto YM,Buikema H,van Gilst WH,Lie KI

更新日期：1996-01-01 00:00:00

abstract：:Cardiac alpha- and beta-adrenoceptors and the positive inotropic effects of several adenylate cyclase dependent and independent agents have been measured in papillary muscle strips from patients without, as well as with moderate and severe heart failure. The number of beta-adrenoceptors was found to be decreased depen...

journal_title：Basic research in cardiology

authors： Erdmann E,Böhm M

更新日期：1989-01-01 00:00:00

abstract：:Reversibly injured myocardium after short periods of ischemia is characterized by a prolonged depression of contractile function which can, however, be enhanced by inotropic interventions. Thus, a lack of inotropic stimulation due to ischemic damage of cardiac sympathetic nerves has been suggested as a mechanism under...

journal_title：Basic research in cardiology

authors： Schulz R,Frehen D,Heusch G

更新日期：1990-01-01 00:00:00

abstract：:The cardiac renin angiotensin system (RAS) is the target for number of therapeutic interventions which proved successful in heart failure. Angiotensin converting enzyme (ACE) inhibitors belong to the most efficient strategies available and angiotensin receptor (ATR) antagonists may be comparably effective. The direct ...

journal_title：Basic research in cardiology

authors： Regitz-Zagrosek V,Fielitz J,Fleck E

更新日期：1998-01-01 00:00:00

abstract：:The aim of this study was to investigate the mechanism of beta-adrenergic preconditioning (BPC). The roles of adenosine and its receptor subtypes, the generation of oxygen free radicals (ROS) and activation of the K(ATP) channels as well as the phosphoinositide-3-kinase (PI(3)K)/PKB/Akt and extracellular signal-regula...

journal_title：Basic research in cardiology

authors： Salie R,Moolman JA,Lochner A

更新日期：2012-09-01 00:00:00

abstract：:To evaluate the hypothesis that maintenance of the integrity of myocardial membrane systems and prevention of Ca2+ influx into the cell are significant in the survival of ischaemic tissue, the effect of trifluoperazine and lysolecithin, were tested on the recovery of globally ischaemic rat hearts. Trifluoperazine incr...

journal_title：Basic research in cardiology

authors： Lochner A,van Niekerk I,Kotzé JC

更新日期：1985-07-01 00:00:00

abstract：:Thyroid hormone (TH) is critical for tissue differentiation at early stages of development, induces physiological hypertrophy and regulates the expression of important contractile proteins such as myosin heavy chain (MHC) isoform and calcium cycling proteins. Furthermore, TH seems to control the response to stress by ...

journal_title：Basic research in cardiology

authors： Pantos C,Mourouzis I,Markakis K,Tsagoulis N,Panagiotou M,Cokkinos DV

更新日期：2008-07-01 00:00:00

abstract：:We tested the hypothesis that in isolated cardiac myocytes, the negative functional effects of cyclic GMP would be blunted when the level of cyclic AMP was increased and that this interaction would be altered in renal hypertensive (One-Kidney-One-Clip, 1K1C) cardiac hypertrophic rabbits. Using isolated control and 1K1...

journal_title：Basic research in cardiology

authors： Patel KN,Yan L,Gandhi A,Scholz PM,Weiss HR

更新日期：2001-02-01 00:00:00