Comparison of acute electrophysiological effects of amiodarone and its metabolite desethylamiodarone in Langendorff perfused guinea pig hearts.

abstract：:Total cholesterol, phospholipids, and triglycerides in serum were studied during myocardial infarction in a patient group treated with glucose, insulin and potassium (GIK), and a conventionally treated group. There was no difference in the typical changes of cholesterol and phospholipids between the groups, but the GI...

journal_title：Basic research in cardiology

authors： Kirkeby OJ,Risöe C,Kirkeby K,Hjermann I

更新日期：1983-11-01 00:00:00

abstract：:The effects of chronic intake of dietary alcohol upon left ventricular function, activities of myocardial antioxidant enzymes, reduced glutathione (GSH) content and lipoperoxidation (measured as the formation of diene conjugates and lipid-soluble fluorescence) were studied in adult domestic Nicholas turkeys. The non-i...

journal_title：Basic research in cardiology

authors： Edes I,Piros G,Forster T,Csanady M

更新日期：1987-11-01 00:00:00

abstract：:Rat hearts were exposed and injured locally by direct cryoapplication. The hearts were examined 2, 4, 20 and 48 hours, 7 and 12 days later. In the first 48 hours mast cell and polymorphonuclear (mainly eosinophilic) granulocyte infiltration was followed by proliferation of mononuclear phagocytic and fibroblastic cells...

journal_title：Basic research in cardiology

authors： Yarom R,Havivi Y,Heling I

更新日期：1979-05-01 00:00:00

abstract：:The article describes a method for monitoring the total energy output and oxygen uptake of isolated perfused rat hearts with working left ventricles. Twenty-two unpaced hearts (rates 4-4.5 bs-1) were separately investigated inside a flow micro-calorimeter (one minute for 90% thermal response) at 37 degrees C. They pum...

journal_title：Basic research in cardiology

authors： Niesler RA,Fouche J,Peiser FE

更新日期：1985-09-01 00:00:00

abstract：:In this paper, we review the hypothesis that activated tissue renin-angiotensin systems play a detrimental role in heart failure. The main arguments for this idea are discussed: a) tissue renin-angiotensin systems behave functionally distinct from the circulating renin-angiotensin system; b) tissue renin-angiotensin s...

journal_title：Basic research in cardiology

authors： Pinto YM,Buikema H,van Gilst WH,Lie KI

更新日期：1996-01-01 00:00:00

abstract：:It is generally believed that the increased contractility and tachycardia of the hyperthyroid heart are a result of thyroid hormone-induced alterations of the mechanical and electrical properties of the heart, respectively. We compared the contractility (dP/dtmax) and the spontaneous beating rate of hyperthyroid and e...

journal_title：Basic research in cardiology

authors： Wheatley AM,Butkow N,Marcus RH,Lippe IT,Rosendorff C

更新日期：1988-11-01 00:00:00

abstract：:The authors have retracted this article [1] because of modifications in the control lanes of Figs. 2a and 8a of the COX1 blot obtained for 18-week-old rats (rotation, horizontal flipping and re-use of the control lanes for the 35-week-old rats blot). In light of the concerns raised, the conclusions drawn in this artic...

journal_title：Basic research in cardiology

authors： Vargas LA,Velasquez FC,Alvarez BV

更新日期：2018-04-18 00:00:00

abstract：:An increased occurrence of hypertension has been reported among leg-amputees. In order to investigate whether leg amputation is followed by an elevation of sympathetic tone, possibly enhanced by continuous mechanical irritation of the amputation stump by wearing a prosthesis, blood pressure (BP), pulse-rate (PR) and p...

journal_title：Basic research in cardiology

authors： Grubeck-Loebenstein B,Korn A,Waldhäusl W

更新日期：1981-05-01 00:00:00

abstract：:The purpose of this study was to determine the effects of bradykinin (BK), substance P (SP) and histamine on plasma exudation in the skin of conscious dogs with and without pacing-induced heart failure. We also determined the role tissue angiotensin I-converting enzyme (ACE) and neutral endopeptidase (NEP) play in mod...

journal_title：Basic research in cardiology

authors： Rubinstein I,Müns G,Zucker IH

更新日期：1994-09-01 00:00:00

abstract：:We have characterized the aerobic blood-perfused isolated heart model evaluating the hemodynamics and metabolism of both the blood donor animal and the isolated organ. Anaesthesia of the blood donor with sodium pentobarbital (30 mg/kg) increases arterial concentration of non esterified fatty acids (NEFA) from 80 +/- 6...

journal_title：Basic research in cardiology

authors： Pasini E,Solfrini R,Bachetti T,Marino M,Bernocchi P,Visioli F,Ferrari R

更新日期：1999-06-01 00:00:00

abstract：:Two-weekly echocardiographic examinations were conducted in nine SHHF-Mc-fa(cp) rats in comparison with eight age-matched Wistar rats. In the SHHF-rats, characterized by progressive LV-dilation and decreasing contractile function between 77-87 weeks of age, left ventricular (LV) hypertrophy was most sensitively demons...

journal_title：Basic research in cardiology

authors： Reffelmann T,Kloner RA

更新日期：2003-09-01 00:00:00

abstract：:The assessment of proarrhythmic risks of drugs remains challenging. To evaluate the suitability of rat engineered heart tissue (EHT) for detecting proarrhythmic effects. We monitored drug effects on spontaneous contractile activity and, in selected cases, on action potentials (sharp microelectrode) and Ca2+ transients...

journal_title：Basic research in cardiology

authors： Eder A,Hansen A,Uebeler J,Schulze T,Neuber C,Schaaf S,Yuan L,Christ T,Vos MA,Eschenhagen T

更新日期：2014-01-01 00:00:00

abstract：:Exercise is an efficient strategy for myocardial protection against ischemia-reperfusion (IR) injury. Although endothelial nitric oxide synthase (eNOS) is phosphorylated and activated during exercise, its role in exercise-induced cardioprotection remains unknown. This study investigated whether modulation of eNOS acti...

journal_title：Basic research in cardiology

authors： Farah C,Kleindienst A,Bolea G,Meyer G,Gayrard S,Geny B,Obert P,Cazorla O,Tanguy S,Reboul C

更新日期：2013-11-01 00:00:00

abstract：:Local photodynamic therapy was used to prevent neointimal hyperplasia after stenting. Slotted tube stents were placed with 16 atmospheres in porcine femoral arteries with the external diameter to match the diameter at 10 atmospheres. Animals were randomly allocated to Group 1 (stenting only); or Group 2 with stenting,...

journal_title：Basic research in cardiology

authors： Valassis G,Pragst I,Adolfs C,Paclik D,Wiens F,Vogel-Wiens C,Milz S,Gonschior P

更新日期：2002-03-01 00:00:00

abstract：:Successive ischemic episodes are commonly seen in clinical and experimental cardiology. Although prolonged abnormalities of the canine myocardium have been described following a single ischemic episode, it is not known whether myocardial injury is cumulative following multiple ischemic episodes. Dogs were subjected to...

journal_title：Basic research in cardiology

authors： Lange R,Ingwall JS,Hale SL,Alker KJ,Kloner RA

更新日期：1984-07-01 00:00:00

abstract：:The flow pattern and the paths of fluid particles in a saccular aneurysm located at the bifurcation of an intracranial arterial segment are investigated with a numerical method. A normal physiological flow pattern was assumed as input to the studied segment. The theoretical study is carried out for two different Reyno...

journal_title：Basic research in cardiology

authors： Perktold K,Kenner T,Hilbert D,Spork B,Florian H

更新日期：1988-01-01 00:00:00

abstract：:A previous study indicated that 5 mg/kg aspirin can reverse the cardioprotective effects of thromboxane A2 synthetase inhibitors. We determined in the present study if this dose of aspirin can also reverse the protective effects of the thromboxane A2/PGH2 receptor antagonist SQ 30,741 in the same model of coronary occ...

journal_title：Basic research in cardiology

authors： Grover GJ,Parham CS,Schumacher WA

更新日期：1991-03-01 00:00:00

abstract：:K201 has previously been shown to reduce diastolic contractions in vivo during β-adrenergic stimulation and elevated extracellular calcium concentration ([Ca(2+)](o)). The present study characterised the effect of K201 on electrically stimulated and spontaneous diastolic sarcoplasmic reticulum (SR)-mediated Ca(2+) rel...

journal_title：Basic research in cardiology

authors： Elliott EB,Hasumi H,Otani N,Matsuda T,Matsuda R,Kaneko N,Smith GL,Loughrey CM

更新日期：2011-11-01 00:00:00

abstract：:In the chronically volume-overloaded canine heart due to AV-block evaluations of cardiac function were performed during the development of hypertrophy and at stable hypertrophy. In an early stage (1 and 2 weeks of AV-block) when no or only a slight increase of cardiac muscle occurred, contractility measured from dP/dt...

journal_title：Basic research in cardiology

authors： Wüsten B,Flameng W,Schaper W

更新日期：1977-03-01 00:00:00

abstract：:In the human ventricle two isoforms of the phosphorylatable myosin light chain (MPLC) are expressed. These two forms are designated with increasing acidity as LC-2 and LC-2*. In the normal human heart the relation between LC-2/LC-2*-expression is 70/30, suggesting the existence of three different myosin isoenzymes (MP...

journal_title：Basic research in cardiology

authors： Morano I

更新日期：1992-01-01 00:00:00

abstract：:The role of miR-92a on vascular remodelling after injury is currently unknown. Thus, the aim of the present study was to evaluate the role of miR-92a on rat endothelial and vascular smooth muscle cells proliferation and migration in vitro as well as after balloon injury or arterial stenting in vivo. MiR-92a was highly...

journal_title：Basic research in cardiology

authors： Iaconetti C,Polimeni A,Sorrentino S,Sabatino J,Pironti G,Esposito G,Curcio A,Indolfi C

更新日期：2012-09-01 00:00:00

abstract：:The clinical use of positive inotropic agents has been associated with increased mortality, with proarrhythmia speculated to be a contributing factor. This study compares the arrhythmogenic potentials of six positive inotropic agents representing different mechanistic classes: the beta-adrenergic agonist dobutamine, t...

journal_title：Basic research in cardiology

authors： Stump GL,Wallace AA,Gilberto DB,Gehret JR,Lynch JJ Jr

更新日期：2000-06-01 00:00:00

abstract：:In open-chest pigs during severe myocardial ischemia [K+]e, [Ca2+]e and [H+]e increase, [Na+]e increases transiently reaching control values after 30 min. Extracellular osmolality of the ischemic area increases due to an H2O-shift from the ECS to the ICS. The increase of [Na+]e and [Ca2+]e must b explained by the shri...

journal_title：Basic research in cardiology

authors： Friedrich R,Hirche H,Kebbel U,Zylka V,Bissig R

更新日期：1981-07-01 00:00:00

abstract：:Reversibly injured myocardium after short periods of ischemia is characterized by a prolonged depression of contractile function which can, however, be enhanced by inotropic interventions. Thus, a lack of inotropic stimulation due to ischemic damage of cardiac sympathetic nerves has been suggested as a mechanism under...

journal_title：Basic research in cardiology

authors： Schulz R,Frehen D,Heusch G

更新日期：1990-01-01 00:00:00

abstract：:It is shown that hypertrophied rat myocardium exhibits marked prolongation of its action potential during non-essential changes both in the resting potential, as well as in the amplitude of the action potential, and during a moderate but nonsignificant reduction in the maximum upstroke velocity. When examining action ...

journal_title：Basic research in cardiology

authors： Gülch RW

更新日期：1980-01-01 00:00:00

abstract：:Hemodynamics and myocardial contractility were evaluated in five unanesthetized calves during acute hypocapnic and isocapnic hypoxia and during acute hypocapnic hypoxia with beta-adrenergic blockade. Both hypocapnic and isocapnic hypoxia, with mean PaO2 levels of 33.1 and 39.1 mm Hg respectively, produced a decline in...

journal_title：Basic research in cardiology

authors： Buss DD,Bisgard GE

更新日期：1976-09-01 00:00:00

abstract：:Age-related changes in the myocardial energy metabolism were studied in spontaneously hypertensive (SHR) rats of 5-15 weeks of age. Systolic blood pressure increased rapidly during 5 to 10 weeks of age (developing phase) and attained a plateau level at 10 to 15 weeks (sustained phase). Even during the developing phase...

journal_title：Basic research in cardiology

authors： Shimamoto N,Goto N,Tanabe M,Imamoto T,Fujiwara S,Hirata M

更新日期：1982-07-01 00:00:00

abstract：:Colloidal iron staining, calcium binding and enzyme activities were studied in the isolated rat heart sarcolemma. Colloidal iron staining of the sarcolemma revealed a high density of negatively charged sites associated with the cell surface. This membrane fraction was found to have calcium binding activity at both low...

journal_title：Basic research in cardiology

authors： Matsukubo MP,Singal PK,Dhalla NS

更新日期：1981-01-01 00:00:00

abstract：:We chronically implanted hygroscopic occluders around the left circumflex coronary artery in 49 anesthetized young male domestic pigs and we studied the development of a collateral circulation at 4, 8, 12, and 26 weeks after implantation. At these time intervals groups of animals were again anesthetized, the hearts we...

journal_title：Basic research in cardiology

authors： Görge G,Schmidt T,Ito BR,Pantely GA,Schaper W

更新日期：1989-09-01 00:00:00

abstract：:Disregarding the influence of thickness on elevated strength of isolated preparations inevitably leads to erroneous tension-frequency relations, especially in the range of high frequencies. Thus, much of the confusion in interpreting the atypical negative staircase phenomenon of the rat heart is due to this. In view o...

journal_title：Basic research in cardiology

authors： Gülch RW,Ebrecht G

更新日期：1987-01-01 00:00:00