Local photodynamic therapy reduces tissue hyperplasia after stenting in an experimental restenosis model.

Abstract:

:Local photodynamic therapy was used to prevent neointimal hyperplasia after stenting. Slotted tube stents were placed with 16 atmospheres in porcine femoral arteries with the external diameter to match the diameter at 10 atmospheres. Animals were randomly allocated to Group 1 (stenting only); or Group 2 with stenting, local drug delivery of a photosensitizer (5 mg Photofrin) and subsequent exposure to light (photodynamic therapy, 100 J). Fourteen days later, all vessels were excised, fixed and processed for histology. Tissue hyperplasia was observed after stenting in vessels from Group 1. In Group 2 with photodynamic therapy, the myoproliferative response was significantly reduced. Tissue hyperplasia after stenting was effectively suppressed by photodynamic therapy.

journal_name

Basic Res Cardiol

authors

Valassis G,Pragst I,Adolfs C,Paclik D,Wiens F,Vogel-Wiens C,Milz S,Gonschior P

doi

10.1007/s003950200003

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

132-6

issue

2

eissn

0300-8428

issn

1435-1803

journal_volume

97

pub_type

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