Abstract:
:Local photodynamic therapy was used to prevent neointimal hyperplasia after stenting. Slotted tube stents were placed with 16 atmospheres in porcine femoral arteries with the external diameter to match the diameter at 10 atmospheres. Animals were randomly allocated to Group 1 (stenting only); or Group 2 with stenting, local drug delivery of a photosensitizer (5 mg Photofrin) and subsequent exposure to light (photodynamic therapy, 100 J). Fourteen days later, all vessels were excised, fixed and processed for histology. Tissue hyperplasia was observed after stenting in vessels from Group 1. In Group 2 with photodynamic therapy, the myoproliferative response was significantly reduced. Tissue hyperplasia after stenting was effectively suppressed by photodynamic therapy.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Valassis G,Pragst I,Adolfs C,Paclik D,Wiens F,Vogel-Wiens C,Milz S,Gonschior Pdoi
10.1007/s003950200003keywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
132-6issue
2eissn
0300-8428issn
1435-1803journal_volume
97pub_type
杂志文章abstract::Heart failure has been divided into several different forms depending on etiology, clinical course and pathophysiology of left ventricular (LV) dysfunction. Systolic and diastolic dysfunction are characterized by a reduced cardiac output with normal (= diastolic dysfunction) or depressed (= systolic dysfunction) LV pu...
journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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doi:10.1007/BF01907132
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01935807
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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