Local photodynamic therapy reduces tissue hyperplasia after stenting in an experimental restenosis model.


:Local photodynamic therapy was used to prevent neointimal hyperplasia after stenting. Slotted tube stents were placed with 16 atmospheres in porcine femoral arteries with the external diameter to match the diameter at 10 atmospheres. Animals were randomly allocated to Group 1 (stenting only); or Group 2 with stenting, local drug delivery of a photosensitizer (5 mg Photofrin) and subsequent exposure to light (photodynamic therapy, 100 J). Fourteen days later, all vessels were excised, fixed and processed for histology. Tissue hyperplasia was observed after stenting in vessels from Group 1. In Group 2 with photodynamic therapy, the myoproliferative response was significantly reduced. Tissue hyperplasia after stenting was effectively suppressed by photodynamic therapy.


Basic Res Cardiol


Valassis G,Pragst I,Adolfs C,Paclik D,Wiens F,Vogel-Wiens C,Milz S,Gonschior P





Has Abstract


2002-03-01 00:00:00












  • Eicosanoids and myocardial ischaemia.

    abstract::The available data clearly suggest large alterations in myocardial eicosanoid generation during myocardial ischaemia and demonstrate important actions of eicosanoids on myocardial function during ischaemic conditions. These actions include direct effects on the injured myocardium as well as influences on other target ...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章,评审


    authors: Schrör K

    更新日期:1987-01-01 00:00:00

  • Theory of ligand-receptor interactions--evidence for more than one site.

    abstract::Receptor binding studies usually show heterogenic characteristics of the binding isotherm. Scatchard transformation for graphical linearization of the data presentation affects the data inhomogeneously with respect to the experimental error. Thus a non-linear fitting procedure should be preferred for data analysis. Fu...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Wellstein A,Palm D

    更新日期:1984-01-01 00:00:00

  • Transgenic upregulation of IK1 in the mouse heart is proarrhythmic.

    abstract::The role of the cardiac current Ik1 in arrhythmogenesis remains highly controversal. To gain further insights into the mechanisms of IK1 involvement in cardiac excitability, we studied the susceptibility of transgenic mice with altered IK1 to arrhythmia during various pharmacological and physiological challenges. Arrh...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Piao L,Li J,McLerie M,Lopatin AN

    更新日期:2007-09-01 00:00:00

  • Ischemia/reperfusion injury is increased and cardioprotection by a postconditioning protocol is lost as cardiac hypertrophy develops in nandrolone treated rats.

    abstract::We hypothesized that nandrolone (ND)-abuse induces cardiac hypertrophy, increases myocardial susceptibility to ischemia/reperfusion (I/R) injury, and reduces responsiveness to postconditioning (PostC) cardioprotection. Wistar-rats were ND treated for 2 weeks (short_ND) or 10 weeks (long_ND). Vehicle-treated rats serve...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Penna C,Tullio F,Perrelli MG,Moro F,Abbadessa G,Piccione F,Carriero V,Racca S,Pagliaro P

    更新日期:2011-05-01 00:00:00

  • Acetate-induced changes in cardiac energy metabolism and hemodynamics in the rat.

    abstract::The hemodynamic and metabolic effects of acetate were studied in rats in vivo and in the isolated perfused heart. Hemodynamic parameters, myocardial phosphagens, inorganic phosphate, and adenosine were measured in vivo. Acetate uptake, coronary flow, O2 consumption, parameters of the cellular energy state, and hypoxan...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Kiviluoma KT,Karhunen M,Lapinlampi T,Peuhkurinen KJ,Hassinen IE

    更新日期:1988-07-01 00:00:00

  • Reduced serine-16 and threonine-17 phospholamban phosphorylation in stunning of conscious dogs: no evidence for any involvement of protein kinase A or protein phosphatases.

    abstract:OBJECTIVE:Cardiac stunning is the consequence of a brief cardiac ischemia. The underlying mechanism is not completely understood. METHODS:Here we induced cardiac transient ischemia in conscious instrumented dogs by means of an occluder in the left anterior descending coronary artery (LAD). Contractile performance, mon...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Weber T,Neumann J,Meissner A,Grosse Hartlage M,Van Aken H,Hanske G,Schmitz W,Boknik P

    更新日期:2006-05-01 00:00:00

  • Kinetics of cellular uptake of tracers used in myocardial scintigraphy.

    abstract::The purpose of this study was to obtain more information about the role of the plasma membrane in cellular uptake of tracers used in myocardial scintigraphy (radioactive thallium chloride and palmitic acid). This knowledge is of importance for an adequate interpretation of the results obtained under clinical condition...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Rauch B,Kübler W

    更新日期:1985-01-01 00:00:00

  • Myocardial fibrosis: role of angiotensin II and aldosterone.

    abstract::In this report we review the replacement (i.e., scarring) and reactive (i.e., perivascular and interstitial fibrosis) fibrous tissue responses found in the myocardium in response to effector hormones of the renin-angiotensin-aldosterone system. Experimental data are presented to indicate: a) endogenous or exogenous el...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章,评审


    authors: Weber KT,Brilla CG,Campbell SE,Guarda E,Zhou G,Sriram K

    更新日期:1993-01-01 00:00:00

  • Voltage-dependent calcium release in guinea-pig cardiac ventricular muscle as antagonized by magnesium and calcium.

    abstract::An increase in extracellular potassium concentration from 4 to 16 mmol/l caused a decrease in membrane potential from -92 to -59 mV and selectively diminished the earlier of two contraction components of guinea-pig papillary muscles at 0.2 Hz stimulation frequency in the presence of noradrenaline. The influence on the...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Vierling W,Seibel K,Reiter M

    更新日期:1987-09-01 00:00:00

  • Impaired coronary flow and left ventricular dysfunction after mechanical recanalization in acute myocardial infarction: role of neurohumoral activation?

    abstract:BACKGROUND:Reopening of the infarct-related coronary artery is the treatment of choice in the clinical setting of acute myocardial infarction. Nevertheless the removal of the total occlusion obtained either by thrombolysis or by primary angioplasty is followed by the ischemia/reperfusion sequelae. One of many proposed ...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Schäfer U,Kurz T,Jain D,Hartmann F,Dendorfer A,Tölg R,Raasch W,Dominiak P,Katus H,Richardt G

    更新日期:2002-09-01 00:00:00

  • The influence of cardiac cholinergic activation on the induction and maintenance of ventricular fibrillation.

    abstract::The influence of cardiac cholinergic activation was studied in rats and cats on the induction and maintenance of ventricular fibrillation (VF). Acetylcholine (ACH 2-25 micrograms/kg), in doses which did not cause bradycardia or hypotension, induced appearance of spontaneous VF (duration 2-60 sec.) in 9/20 rats which h...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Amitzur G,Manoach M,Weinstock M

    更新日期:1984-11-01 00:00:00

  • Microembolization and myonecrosis during elective percutaneous coronary interventions in diabetic patients: an intracoronary Doppler ultrasound study with 2-year clinical follow-up.

    abstract::Elevation of cardiac troponin I (cTnI) is a well-known complication after percutaneous coronary interventions (PCI). The aims of this study were to quantify the extent of coronary microembolization during elective PCI, to identify predisposing anatomical and procedural factors, and to evaluate its impact on long-term ...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Otto S,Seeber M,Fujita B,Kretzschmar D,Ferrari M,Goebel B,Figulla HR,Poerner TC

    更新日期:2012-09-01 00:00:00

  • Nitric oxide synthase activity in rat cardiac mitochondria.

    abstract::Recent publications shown mitochondrial localization of the enzyme nitric oxide synthase (NOS) in a number of tissues. However, conflicting results about mitochondrial NOS (mtNOS) immunoreactivity and enzymatic activity are available to date in the literature. In this study we purified mitochondria from rat hearts and...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Zanella B,Giordano E,Muscari C,Zini M,Guarnieri C

    更新日期:2004-05-01 00:00:00

  • Inhibition of carnitine synthesis modulates protein contents of the cardiac sarcoplasmic reticulum Ca2+-ATPase and hexokinase type I in rat hearts with myocardial infarction.

    abstract::It was previously reported that inhibition of carnitine synthesis by 3-(2,2,2-trimethyl-hydrazinium) propionate (MET-88) restores left ventricular (LV) systolic and diastolic function in rats with myocardial infarction (MI). Preservation of the calcium uptake function of sarcoplasmic reticulum Ca2+-ATPase (SERCA2) is ...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Yonekura K,Eto Y,Yokoyama I,Matsumoto A,Sugiura S,Momomura S,Kirimoto T,Hayashi Y,Omata M,Aoyagi T

    更新日期:2000-10-01 00:00:00

  • DNA-PKcs promotes cardiac ischemia reperfusion injury through mitigating BI-1-governed mitochondrial homeostasis.

    abstract::DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel inducer to promote mitochondrial apoptosis and suppress tumor growth in a variety of cells although its role in cardiovascular diseases remains obscure. This study was designed to examine the role of DNA-PKcs in cardiac ischemia reperfusion (IR) inju...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Zhou H,Toan S,Zhu P,Wang J,Ren J,Zhang Y

    更新日期:2020-01-09 00:00:00

  • Serum lipids during treatment with glucose-insulin-potassium in myocardial infarction.

    abstract::Total cholesterol, phospholipids, and triglycerides in serum were studied during myocardial infarction in a patient group treated with glucose, insulin and potassium (GIK), and a conventionally treated group. There was no difference in the typical changes of cholesterol and phospholipids between the groups, but the GI...

    journal_title:Basic research in cardiology

    pub_type: 临床试验,杂志文章


    authors: Kirkeby OJ,Risöe C,Kirkeby K,Hjermann I

    更新日期:1983-11-01 00:00:00

  • Effects of recurrent ischemia on myocardial high energy phosphate content in canine hearts.

    abstract::Successive ischemic episodes are commonly seen in clinical and experimental cardiology. Although prolonged abnormalities of the canine myocardium have been described following a single ischemic episode, it is not known whether myocardial injury is cumulative following multiple ischemic episodes. Dogs were subjected to...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Lange R,Ingwall JS,Hale SL,Alker KJ,Kloner RA

    更新日期:1984-07-01 00:00:00

  • Comparison of acute electrophysiological effects of amiodarone and its metabolite desethylamiodarone in Langendorff perfused guinea pig hearts.

    abstract::During long-term treatment with amiodarone, slowing of conduction through the atrioventricular node, a prolongation of the QT-interval, and a prolongation of the atrial and ventricular myocardial refractoriness always developed. During short-term treatment, these effects were not found, except for depression of the AV...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Stark G,Stark U,Windisch M,Vicenzi M,Eggenreich U,Nagl S,Kral K,Pilger E,Tritthart HA

    更新日期:1991-03-01 00:00:00

  • Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction.

    abstract::Long QT syndrome is a potentially life-threatening disease characterized by delayed repolarization of cardiomyocytes, QT interval prolongation in the electrocardiogram, and a high risk for sudden cardiac death caused by ventricular arrhythmia. The genetic type 3 of this syndrome (LQT3) is caused by gain-of-function mu...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Malan D,Zhang M,Stallmeyer B,Müller J,Fleischmann BK,Schulze-Bahr E,Sasse P,Greber B

    更新日期:2016-03-01 00:00:00

  • Mouse models of atherosclerosis and their suitability for the study of myocardial infarction.

    abstract::Atherosclerotic plaques impair vascular function and can lead to arterial obstruction and tissue ischaemia. Rupture of an atherosclerotic plaque within a coronary artery can result in an acute myocardial infarction, which is responsible for significant morbidity and mortality worldwide. Prompt reperfusion can salvage ...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章,评审


    authors: Golforoush P,Yellon DM,Davidson SM

    更新日期:2020-11-30 00:00:00

  • Myofibroblasts in subepicardium after local cold injury.

    abstract::Rat hearts were exposed and injured locally by direct cryoapplication. The hearts were examined 2, 4, 20 and 48 hours, 7 and 12 days later. In the first 48 hours mast cell and polymorphonuclear (mainly eosinophilic) granulocyte infiltration was followed by proliferation of mononuclear phagocytic and fibroblastic cells...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Yarom R,Havivi Y,Heling I

    更新日期:1979-05-01 00:00:00

  • The effect of isolation on myocardial properties.

    abstract::Denervation deprives the heart of its normal adrenergic and cholinergic control via the sympathetic and parasympathetic pathways. In a heart which is blood supplied by a donor animal of the same species, normal contractility is maintained, probably by blood borne catecholamines or possibly by unknown inotropic agents ...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Reichel H

    更新日期:1976-01-01 00:00:00

  • Mitochondria to nucleus translocation of AIF in mice lacking Hsp70 during ischemia/reperfusion.

    abstract::Heat shock protein 70 (Hsp70) has been shown to have an anti-apoptotic function, but its mechanism is not clear in heart. In this study, we examined the effect of Hsp70 deletion on AIF-induced apoptosis during ischemia/reperfusion (I/R) in vivo. Although Hsp70 KO and WT mice demonstrated similar amounts of AIF release...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Choudhury S,Bae S,Ke Q,Lee JY,Kim J,Kang PM

    更新日期:2011-05-01 00:00:00

  • The relationship between ischemic contracture and no-reflow phenomenon in isolated rat heart.

    abstract::The relationship between ischemic contracture and no-reflow phenomenon was studied in 59 isolated rat hearts during global ischemia. The contracture was measured by a water-filled balloon catheter placed in the left ventricular lumen. The time of onset of contracture was changed by preischemic infusion with buffer con...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Lipasti JA,Nevalainen TJ,Alanen KA

    更新日期:1982-07-01 00:00:00

  • Ischemia-reperfusion injury activates early extracellular matrix processing and expression of endostatin in the heart with differential effects of temperature.

    abstract::Acute ischemia is a well-known inductor of extracellular matrix (ECM) remodeling, which leads to the development of congestive heart failure and is associated with left ventricular dilatation. Here we investigate the timecourse of ECM processing with release of endostatin (ES) and other low-molecular-weight fragments ...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Lauten A,Majos E,Mühlich A,Wahlers T,Weider S,Fischer JH,Figulla HR,Bloch W

    更新日期:2009-09-01 00:00:00

  • Transthoracic echocardiography in rats. Evalution of commonly used indices of left ventricular dimensions, contractile performance, and hypertrophy in a genetic model of hypertrophic heart failure (SHHF-Mcc-facp-Rats) in comparison with Wistar rats during

    abstract::Two-weekly echocardiographic examinations were conducted in nine SHHF-Mc-fa(cp) rats in comparison with eight age-matched Wistar rats. In the SHHF-rats, characterized by progressive LV-dilation and decreasing contractile function between 77-87 weeks of age, left ventricular (LV) hypertrophy was most sensitively demons...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Reffelmann T,Kloner RA

    更新日期:2003-09-01 00:00:00

  • Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation.

    abstract::Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia with a strong genetic component. Molecular pathways involving the homeodomain transcription factor Shox2 control the development and function of the cardiac conduction system in mouse and zebrafish. Here we report the analysis of human SHOX2 as a potent...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Hoffmann S,Clauss S,Berger IM,Weiß B,Montalbano A,Röth R,Bucher M,Klier I,Wakili R,Seitz H,Schulze-Bahr E,Katus HA,Flachsbart F,Nebel A,Guenther SP,Bagaev E,Rottbauer W,Kääb S,Just S,Rappold GA

    更新日期:2016-05-01 00:00:00

  • Inhibition of contractility during the early phase of total ischaemia in the working heart. Recovery during reperfusion.

    abstract::Total global ischaemia of the normothermic working rat heart caused an initial positive inotropic response characterized by vigorous contractions. After +/- 15 s this response reached a peak whereafter the isotonic contraction amplitude started to decline. After +/- 3.5 min the heart ceased to beat. The low level of h...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Steinmann CM,Lochner A,Niesler RA

    更新日期:1987-05-01 00:00:00

  • Myocardial function during acute hypoxia in the calf.

    abstract::Hemodynamics and myocardial contractility were evaluated in five unanesthetized calves during acute hypocapnic and isocapnic hypoxia and during acute hypocapnic hypoxia with beta-adrenergic blockade. Both hypocapnic and isocapnic hypoxia, with mean PaO2 levels of 33.1 and 39.1 mm Hg respectively, produced a decline in...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Buss DD,Bisgard GE

    更新日期:1976-09-01 00:00:00

  • Echographic method for the estimation of cardiac output from mitral-valve area, heart rate, and diastolic-filling period in conditions of mitral stenosis: correlation with cardiac catheterization.

    abstract::An orifice equation for the non-invasive measurement of mitral-valve area is demonstrated. It is shown that by combining this expression with the assumption of mitral-valve area invariance an orifice equation for the non-invasive assessment of cardiac output in conditions of mitral stenosis using simple echographicall...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Seitz WS,Spiel MS,Operschall J,Pachinger O,Klicpera M

    更新日期:1983-01-01 00:00:00