Exercise-induced cardioprotection: a role for eNOS uncoupling and NO metabolites.

abstract：:Apart from local heterogeneities of myocardial blood flow, the regulation of vascular tone is equally complex. Changes in vascular tone are essential for the adaptation of coronary blood flow to varying metabolic demands. The majority of coronary vascular resistance is found in the microcirculation, that is, in vessel...

journal_title：Basic research in cardiology

authors： Tiefenbacher CP,Chilian WM

更新日期：1998-12-01 00:00:00

abstract：:A reproducible tourniquet-shock has been produced in hind limbs of dogs by unilateral and bilateral extremity ischemia. The following parameters have been measured for analysing the function of the cardiovascular system: mean aortic pressure, heart rate, cardiac output, intraventricular pressure and left ventricular p...

journal_title：Basic research in cardiology

authors： Stock W,Geppert E,Haase W,Isselhard W

更新日期：1976-03-01 00:00:00

abstract：:In the control perfused working rat hearts subjected to 25 min global ischemia, reperfusion resulted in a 50% recovery of the hemodynamic functions. A concentration-dependent improvement of this recovery and a reduction of the postischemic lactate dehydrogenase (LDH) release was caused by calmidazolium (CMZ), trifluop...

journal_title：Basic research in cardiology

authors： Beresewicz A

更新日期：1989-11-01 00:00:00

abstract：:The effects of the dihydropyridine calcium antagonists, nifedipine, nitrendipine and FR 7534 on the transmural distribution of coronary blood flow (endo/epi) were compared to the structurally unrelated calcium antagonists, verapamil and diltiazem and to the non-calcium antagonist vasodilator drugs, chromonar and dipyr...

journal_title：Basic research in cardiology

authors： Warltier DC,Hardman HF,Brooks HL,Gross GJ

更新日期：1983-11-01 00:00:00

abstract：:Conflicting data on the inotropic effect of insulin are present in the literature suggesting a positive inotropic property or no inotropic effect or even a negative influence. To clarify the reason for these diverging findings, dose-response curves of insulin have been performed in isolated working rat and guinea pig ...

journal_title：Basic research in cardiology

authors： Schmidt HD,Koch M

更新日期：2002-07-01 00:00:00

abstract：:At 36 degrees C and 2 mM [Ca2+]o, single guinea-pig ventricular myocytes were voltage clamped with patch electrodes. When paired pulsing had potentiated the contraction to the maximum, the cells were shock-frozen for electron probe microanalysis (EPMA). Shock-freezing was timed at the end of diastole (-80 mV) or at di...

journal_title：Basic research in cardiology

authors： Wendt-Gallitelli MF,Isenberg G,Voigt T,Ross C

更新日期：1991-01-01 00:00:00

abstract：:Cardiac alpha- and beta-adrenoceptors and the positive inotropic effects of several adenylate cyclase dependent and independent agents have been measured in papillary muscle strips from patients without, as well as with moderate and severe heart failure. The number of beta-adrenoceptors was found to be decreased depen...

journal_title：Basic research in cardiology

authors： Erdmann E,Böhm M

更新日期：1989-01-01 00:00:00

abstract：:The developmental profiles of the protective mechanisms of heart against peroxidative injury during neonatal growth was examined in the pigs of three different age groups. Lipid peroxidation expressed in terms of malonaldehyde formation was considerably higher in the pig hearts of the 8-10 day age group compared to th...

journal_title：Basic research in cardiology

authors： Das DK,Engelman RM,Flansaas D,Otani H,Rousou J,Breyer RH

更新日期：1987-01-01 00:00:00

abstract：:Although epicardial blood flow can be restored by an early intervention in most cases, a lack of adequate reperfusion at the microvascular level is often a limiting prognostic factor of acute myocardial infarction (AMI). Our group has recently found that paracrine factors secreted from apoptotic peripheral blood monon...

journal_title：Basic research in cardiology

authors： Hoetzenecker K,Assinger A,Lichtenauer M,Mildner M,Schweiger T,Starlinger P,Jakab A,Berényi E,Pavo N,Zimmermann M,Gabriel C,Plass C,Gyöngyösi M,Volf I,Ankersmit HJ

更新日期：2012-09-01 00:00:00

abstract：:Successive ischemic episodes are commonly seen in clinical and experimental cardiology. Although prolonged abnormalities of the canine myocardium have been described following a single ischemic episode, it is not known whether myocardial injury is cumulative following multiple ischemic episodes. Dogs were subjected to...

journal_title：Basic research in cardiology

authors： Lange R,Ingwall JS,Hale SL,Alker KJ,Kloner RA

更新日期：1984-07-01 00:00:00

abstract：:The present study was designed to test the hypothesis that in hypertrophied myocardium of patients with hypertrophic obstructive cardiomyopathy (HOCM) a reduced contractile reserve provided by frequency dependent potentiation of force of contraction contributes to the myocardial dysfunction. Myectomy was performed in ...

journal_title：Basic research in cardiology

authors： Schotten U,Voss S,Wiederin TB,Voss M,Schoendube F,Hanrath P,Schumacher C

更新日期：1999-04-01 00:00:00

abstract：:Epidemiological studies have repeatedly demonstrated a beneficial effect of moderate alcohol consumption on the incidence of coronary heart disease, myocardial infarction and overall mortality. The latter increases with excessive alcohol consumption. Although most epidemiological studies demonstrate a beneficial effec...

journal_title：Basic research in cardiology

authors： Flesch M,Rosenkranz S,Erdmann E,Böhm M

更新日期：2001-04-01 00:00:00

abstract：:The aim of this study was to investigate the mechanism of beta-adrenergic preconditioning (BPC). The roles of adenosine and its receptor subtypes, the generation of oxygen free radicals (ROS) and activation of the K(ATP) channels as well as the phosphoinositide-3-kinase (PI(3)K)/PKB/Akt and extracellular signal-regula...

journal_title：Basic research in cardiology

authors： Salie R,Moolman JA,Lochner A

更新日期：2012-09-01 00:00:00

abstract：:It is generally believed that the increased contractility and tachycardia of the hyperthyroid heart are a result of thyroid hormone-induced alterations of the mechanical and electrical properties of the heart, respectively. We compared the contractility (dP/dtmax) and the spontaneous beating rate of hyperthyroid and e...

journal_title：Basic research in cardiology

authors： Wheatley AM,Butkow N,Marcus RH,Lippe IT,Rosendorff C

更新日期：1988-11-01 00:00:00

abstract：:SIRT6, a member of the NAD(+)-dependent class III deacetylase sirtuin family, has been revealed to play important roles in promoting cellular resistance against oxidative stress. The formation of reactive oxygen species (ROS) and oxidative stress are the crucial mechanisms underlying cellular damage and dysfunction in...

journal_title：Basic research in cardiology

authors： Wang XX,Wang XL,Tong MM,Gan L,Chen H,Wu SS,Chen JX,Li RL,Wu Y,Zhang HY,Zhu Y,Li YX,He JH,Wang M,Jiang W

更新日期：2016-03-01 00:00:00

abstract：:Coronary artery disease (CAD), also known as ischemic heart disease (IHD), is the leading cause of mortality in the western world, with developing countries showing a similar trend. With the increased understanding of the role of the immune system and inflammation in coronary artery disease, it was shown that macropha...

journal_title：Basic research in cardiology

authors： Jansen MF,Hollander MR,van Royen N,Horrevoets AJ,Lutgens E

更新日期：2016-07-01 00:00:00

abstract：:Recent publications shown mitochondrial localization of the enzyme nitric oxide synthase (NOS) in a number of tissues. However, conflicting results about mitochondrial NOS (mtNOS) immunoreactivity and enzymatic activity are available to date in the literature. In this study we purified mitochondria from rat hearts and...

journal_title：Basic research in cardiology

authors： Zanella B,Giordano E,Muscari C,Zini M,Guarnieri C

更新日期：2004-05-01 00:00:00

abstract：:The proximal segments of the left coronary artery are foreshortended in the usual projections. By additional cranio-caudal (half axial) projections the X-ray beam can be directed perpendicular to these segments. In some patients lesions especially of the left main coronary artery or the proximal LAD can be seen or acc...

journal_title：Basic research in cardiology

authors： Rentrop P

更新日期：1976-01-01 00:00:00

abstract：:The purpose of this study was to determine if decreased heart function after hypoxia followed by reoxygenation (H-R) is associated with increased degradation of cardiac myosin light chain 1 (MLC1) by matrix metalloproteinase-2 (MMP-2), and to investigate the effects of the increased level of peroxynitrite in the heart...

journal_title：Basic research in cardiology

authors： Doroszko A,Polewicz D,Sawicka J,Richardson JS,Cheung PY,Sawicki G

更新日期：2009-11-01 00:00:00

abstract：:Complete length-tension diagrams of myocardium were measured on isolated papillary muscles of cat right ventricle. These diagrams clearly demonstrate that irrespective of loading conditions there is no uniform maxima curve. As a function of preload the curves of afterloaded isotonic maxima obey totally separate nonlin...

journal_title：Basic research in cardiology

authors： Gülch RW

更新日期：1985-11-01 00:00:00

abstract：:Six dogs were subjected to an acute stenosis of the left anterior descending coronary artery. The mean aortic pressure was fixed with a windkessel and an occluder on four different levels. A significant decrease of coronary blood flow and poststenotic coronary pressure was closely related to the level of mean aortic ...

journal_title：Basic research in cardiology

authors： Dietze W,Mittmann U,Schmier J,Wirth RH

更新日期：1976-05-01 00:00:00

abstract：:Necrosis is a type of cell death characterized by a gain in cell volume, swelling of organelles, rupture of the plasma membrane and subsequent loss of intracellular contents. For a long time, the process has been considered as a merely accidental and uncontrolled form of cell death, but accumulating evidence suggests ...

journal_title：Basic research in cardiology

authors： Martinet W,Schrijvers DM,De Meyer GR

更新日期：2011-09-01 00:00:00

abstract：:Ischaemic preconditioning has not been demonstrated to reduce infarct size following global ischaemia in murine myocardium. Eighteen mouse hearts were isolated, perfused in the Langendorff mode, and randomised to control or preconditioning groups. Preconditioned hearts received four periods of five minutes global isch...

journal_title：Basic research in cardiology

authors： Sumeray MS,Yellon DM

更新日期：1998-10-01 00:00:00

abstract：:Ischaemic preconditioning is one of the most potent experimental modalities known to decrease infarct size after ischaemia and reperfusion. Much interest has been stimulated by the phenomenon of remote ischaemic conditioning (RIC), in which the preconditioning stimulus is applied to a limb remote from the heart to sti...

journal_title：Basic research in cardiology

authors： Davidson SM,Selvaraj P,He D,Boi-Doku C,Yellon RL,Vicencio JM,Yellon DM

更新日期：2013-09-01 00:00:00

abstract：:A previous study indicated that 5 mg/kg aspirin can reverse the cardioprotective effects of thromboxane A2 synthetase inhibitors. We determined in the present study if this dose of aspirin can also reverse the protective effects of the thromboxane A2/PGH2 receptor antagonist SQ 30,741 in the same model of coronary occ...

journal_title：Basic research in cardiology

authors： Grover GJ,Parham CS,Schumacher WA

更新日期：1991-03-01 00:00:00

abstract：:We have recently gained evidence that segmental coronary microvascular diameters, and therefore resistances, are controlled by myogenic and endothelial responses to pressure and flow. Furthermore, intact heart studies are demonstrating that these mechanisms may interact importantly with the metabolic mechanisms primar...

journal_title：Basic research in cardiology

authors： Jones CJ,Kuo L,Davis MJ,Chilian WM

更新日期：1993-01-01 00:00:00

abstract：:The concentration of fibroblast growth factor 23 (FGF23) rises progressively in renal failure (RF). High FGF23 concentrations have been consistently associated with adverse cardiovascular outcomes or death, in chronic kidney disease (CKD), heart failure or liver cirrhosis. We identified the mechanisms whereby high con...

journal_title：Basic research in cardiology

authors： Lindner M,Mehel H,David A,Leroy C,Burtin M,Friedlander G,Terzi F,Mika D,Fischmeister R,Prié D

更新日期：2020-07-22 00:00:00

abstract：:In the spontaneously hypertensive rat (SHR) with established hypertension left ventricular mass closely correlated with the proportion of ventricular myosin (VM)-3. A 60% VM-3 content was reached corresponding, under the present housing conditions, to an average age of 40 weeks without any significant change in total ...

journal_title：Basic research in cardiology

authors： Rupp H,Jacob R

更新日期：1986-01-01 00:00:00

abstract：:In this paper, we review the hypothesis that activated tissue renin-angiotensin systems play a detrimental role in heart failure. The main arguments for this idea are discussed: a) tissue renin-angiotensin systems behave functionally distinct from the circulating renin-angiotensin system; b) tissue renin-angiotensin s...

journal_title：Basic research in cardiology

authors： Pinto YM,Buikema H,van Gilst WH,Lie KI

更新日期：1996-01-01 00:00:00

abstract：:We investigated the force-frequency relationship (0.5-3 Hz) in non-failing human myocardium and in end-stage failing human myocardium due to dilated cardiomyopathy or subacute myocarditis. In non-failing myocardium, force of contraction increased with increasing stimulation frequency. In end-stage heart failure, the f...

journal_title：Basic research in cardiology

authors： Pieske B,Hasenfuss G,Holubarsch C,Schwinger R,Böhm M,Just H

更新日期：1992-01-01 00:00:00