Abstract:
:Ischaemic preconditioning has not been demonstrated to reduce infarct size following global ischaemia in murine myocardium. Eighteen mouse hearts were isolated, perfused in the Langendorff mode, and randomised to control or preconditioning groups. Preconditioned hearts received four periods of five minutes global ischaemia with five minutes of intervening reperfusion. Control hearts were perfused normally during this period. Both groups were then subjected to 30 minutes global ischaemia followed by 30 minutes reperfusion. Infarct size, contractile recovery and LDH leakage were assessed. Mean infarct size was reduced from 57% of ventricular volume (controls) to 33% in preconditioned hearts (P = 0.003). A small improvement in contractile recovery was also observed (6.3% of baseline in controls, 15.5% in preconditioned hearts; P = 0.004). Release of LDH did not differ significantly between groups. This study confirms for the first time that ischaemic preconditioning can delay the onset of myocardial necrosis following global ischaemia in the isolated mouse heart.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Sumeray MS,Yellon DMdoi
10.1007/s003950050106subject
Has Abstractpub_date
1998-10-01 00:00:00pages
384-90issue
5eissn
0300-8428issn
1435-1803journal_volume
93pub_type
杂志文章abstract::The influence of norepinephrine on ventricular overdrive suppression and attendant potassium shifts has been studied in isolated perfused canine hearts with complete atrioventricular block. It was found that: 1) there is a potassium loss during the drive and a potassium uptake after the drive); 2) reducing the driving...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906299
更新日期:1977-01-01 00:00:00
abstract::The cardiac renin angiotensin system (RAS) is the target for number of therapeutic interventions which proved successful in heart failure. Angiotensin converting enzyme (ACE) inhibitors belong to the most efficient strategies available and angiotensin receptor (ATR) antagonists may be comparably effective. The direct ...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950050207
更新日期:1998-01-01 00:00:00
abstract::We have used x-ray microangiography to investigate the influence of EDRF and endothelin-1 on arterial diameters (70-800 microns) at bifurcations in the isolated rabbit ear and the "optimality" of its branching geometry. The median value of the junction exponent x (which is given by d0x = d1x + d2x, where d0, d1 and d2...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/978-3-642-72461-9_10
更新日期:1991-01-01 00:00:00
abstract::Local photodynamic therapy was used to prevent neointimal hyperplasia after stenting. Slotted tube stents were placed with 16 atmospheres in porcine femoral arteries with the external diameter to match the diameter at 10 atmospheres. Animals were randomly allocated to Group 1 (stenting only); or Group 2 with stenting,...
journal_title:Basic research in cardiology
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doi:10.1007/s003950200003
更新日期:2002-03-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788735
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abstract::A reproducible tourniquet-shock has been produced in hind limbs of dogs by unilateral and bilateral extremity ischemia. The following parameters have been measured for analysing the function of the cardiovascular system: mean aortic pressure, heart rate, cardiac output, intraventricular pressure and left ventricular p...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01927866
更新日期:1976-03-01 00:00:00
abstract::Experiments were performed to determine the relative contributions of direct Ca(2+)-entry through the L-type Ca(2+)-current and of Ca(2+)-release from the sarcoplasmic reticulum (s.r.) to the intracellular [Ca2+]i-transient in isolated human atrial and ventricular myocytes from patients with severe heart failure and f...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00794074
更新日期:1997-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-011-0218-4
更新日期:2011-11-01 00:00:00
abstract::1,2-Diacylglycerol (DAG) has been considered to play an important role as an activator of protein kinase C in the signal transduction of inositol phospholipid metabolism. To examine the relation of 1,2-DAG in heart tissues to cardiac hypertrophy associated with hypertension, we measured the amount of 1,2-DAG in sponta...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01931491
更新日期:1990-09-01 00:00:00
abstract::Elevation of cardiac troponin I (cTnI) is a well-known complication after percutaneous coronary interventions (PCI). The aims of this study were to quantify the extent of coronary microembolization during elective PCI, to identify predisposing anatomical and procedural factors, and to evaluate its impact on long-term ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-012-0289-x
更新日期:2012-09-01 00:00:00
abstract::The cardiac organ manifestation of arterial hypertension comprises the myocardium itself with left-ventricular hypertrophy, the interstitium with perivascular and interstitial fibrosis, and the coronary circulation with disease of large and small coronary arteries. The consequences of the sum and interactions of these...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/978-3-662-30769-4_22
更新日期:1991-01-01 00:00:00
abstract::Rate or frequency-dependence is a characteristic property of antiarrhythmic drugs belonging to the Vaughan William classes I and III. The rate-dependence of class I drugs (i.e., increasing blockade of fast Na(+)-channels with faster rates) results from periodical drug binding to Na(+)-channel sites which are preferabl...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950050236
更新日期:1998-01-01 00:00:00
abstract::In recent years research has shown that muscle is capable of reacting to mechanical stimuli by altering biochemical processes. Myocardium is probably the source of a biochemical factor, or factors which activate myocardial protein synthesis. In experimentally induced cardiac hypertrophy adaptive alterations have been ...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/BF02070160
更新日期:1983-07-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00789447
更新日期:1995-03-01 00:00:00
abstract::Therapeutic angiogenesis improves tissue ischemia by supplementing and supporting the intrinsic process of angiogenesis. Besides direct administration of angiogenic growth factor proteins, injection of naked DNA, non-viral vectors and viral vector constructs carrying angiogenic genes have been used. A novel approach i...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-004-0447-x
更新日期:2004-03-01 00:00:00
abstract::Cardiac mass, cell size and capillary supply were studied in the hearts of spontaneously hypertensive rats (SHR) and compared to genetically similar non-hypertensive Wistar-Kyoto (WKY) of three adult ages: 5, 15 and 23 months. The left ventricular weight of SHR was not significantly greater than that of WKY at 5 month...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908138
更新日期:1984-07-01 00:00:00
abstract::Autologous bone marrow mononuclear cell (BM-MNC) therapy for patients with ST-segment elevation myocardial infarction (STEMI) has produced inconsistent results, possibly due to BM-MNC product heterogeneity. Patient-specific cardiovascular risk factors (CRFs) may contribute to variations in BM-MNC composition. We sough...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0592-z
更新日期:2017-01-01 00:00:00
abstract::A previous study indicated that 5 mg/kg aspirin can reverse the cardioprotective effects of thromboxane A2 synthetase inhibitors. We determined in the present study if this dose of aspirin can also reverse the protective effects of the thromboxane A2/PGH2 receptor antagonist SQ 30,741 in the same model of coronary occ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02190542
更新日期:1991-03-01 00:00:00
abstract::A canine model for a standardized induction of collaterals is presented with a fixed external constrictor that is not designed to induce an occlusion of the coronary artery and at least over the timespan of 6 weeks does not impair perfusion under resting conditions in the myocardium-at-risk. The coronary constriction ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906671
更新日期:1983-03-01 00:00:00
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pub_type: 杂志文章
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationshi...
journal_title:Basic research in cardiology
pub_type: 社论
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更新日期:2020-04-09 00:00:00
abstract::Beta-blockers have been shown to reduce the risk of coronary events and reduce the mortality of patients with hypertension and in those who have had a myocardial infarction. Furthermore, the evidence for long-term benefits in these two patient groups are much more convincing for beta-blockers than for other therapeuti...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950070006
更新日期:2000-01-01 00:00:00
abstract::Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dep...
journal_title:Basic research in cardiology
pub_type: 社论
doi:10.1007/s00395-015-0510-9
更新日期:2015-09-01 00:00:00
abstract::Age-related changes in the myocardial energy metabolism were studied in spontaneously hypertensive (SHR) rats of 5-15 weeks of age. Systolic blood pressure increased rapidly during 5 to 10 weeks of age (developing phase) and attained a plateau level at 10 to 15 weeks (sustained phase). Even during the developing phase...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02005337
更新日期:1982-07-01 00:00:00
abstract::Myocardial stunning, a transient contractile dysfunction that appears following a brief period of ischemia, is at least partly due to the production of oxygen-derived free radicals. The objective of the present study was to determine whether the Ginkgo biloba extract EGb761, which has antioxidant properties in vitro, ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-003-0380-4
更新日期:2003-02-01 00:00:00
abstract::Increased activity of the sympathetic system is an important feature contributing to the pathogenesis and progression of chronic heart failure. While the mechanisms and consequences of enhanced norepinephrine release from sympathetic nerves have been intensely studied, the role of the adrenal gland in the development ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-011-0166-z
更新日期:2011-06-01 00:00:00
abstract::We studied TTX-sensitive Na channels in dissociated single ventricular cells from neonatal rats using the patch clamp method for single channel and whole cell recording. In both cases, slowly inactivating or window currents were observed that decayed in a biexponential fashion. Customary models of Na current kinetics ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:AIMS:There is a need for better identification of patients at high risk for malignant arrhythmias who would benefit from implantable cardioverter defibrillators (ICD). The purpose of this study was to assess whether the C825T polymorphism in the G-protein beta3 subunit gene, GNB3, might serve as a genetic marker for re...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-006-0600-9
更新日期:2006-09-01 00:00:00