Abstract：
:Cardiac mass, cell size and capillary supply were studied in the hearts of spontaneously hypertensive rats (SHR) and compared to genetically similar non-hypertensive Wistar-Kyoto (WKY) of three adult ages: 5, 15 and 23 months. The left ventricular weight of SHR was not significantly greater than that of WKY at 5 months, but was by 15 months and became even more so by 23 months. This increase could be attributed to hypertrophy of the individual cardiac muscle cells and therefore, the estimated total number of myocytes per left ventricle was essentially the same in all experimental groups. Various indices of the myocardial capillary supply were also investigated. Cardiac hypertrophy in older hypertensive rats was characterized by greater and more variable intercapillary spacing, which may have importance in myocardial oxygen supply.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Rakusan K,Hrdina PW,Turek Z,Lakatta EG,Spurgeon HA,Wolford GDdoi
10.1007/BF01908138subject
Has Abstractpub_date
1984-07-01 00:00:00pages
389-95issue
4eissn
0300-8428issn
1435-1803journal_volume
79pub_type
杂志文章abstract：:Exercise training is a well-known non-pharmacological strategy for the prevention and treatment of cardiovascular diseases. Despite the established phenotypic knowledge, the molecular signature of exercise-induced cardiac remodeling remains poorly characterized. The great majority of studies dedicated to this topic us...
journal_title：Basic research in cardiology
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abstract：:To investigate the effect of nifedipine on hypercalcemic electrocardiographical alterations, steadily increasing hypercalcemia was induced in guinea-pigs by continuous calcium gluconate infusion until cardiac arrest occurred. During the experimental time the electrocardiograms were continuously recorded and compared i...
journal_title：Basic research in cardiology
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journal_title：Basic research in cardiology
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journal_title：Basic research in cardiology
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doi：10.1007/s00395-009-0035-1
更新日期：2009-11-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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更新日期：1987-11-01 00:00:00
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更新日期：2010-03-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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更新日期：1985-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907024
更新日期：1987-07-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02190601
更新日期：1991-05-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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更新日期：2001-02-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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更新日期：1994-05-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908204
更新日期：1989-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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更新日期：1979-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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journal_title：Basic research in cardiology
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journal_title：Basic research in cardiology
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更新日期：1988-05-01 00:00:00
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journal_title：Basic research in cardiology
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更新日期：2020-09-10 00:00:00
abstract：:The endothelin (ET) family of peptides have potent vascular, cardiac and renal actions which may be of pathophysiological importance in congestive heart failure (CHF). In vivo studies with selective and non-selective ET receptor antagonists are required to clarify the role of ET in the pathophysiology of CHF and deter...
journal_title：Basic research in cardiology
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更新日期：1996-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
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更新日期：1998-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11374-5_15
更新日期：1986-01-01 00:00:00
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journal_title：Basic research in cardiology
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更新日期：1984-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950050201
更新日期：1998-01-01 00:00:00
