Electrophysiological properties of isolated ventricular myocytes.

abstract：:The present study was designed to test the hypothesis that in hypertrophied myocardium of patients with hypertrophic obstructive cardiomyopathy (HOCM) a reduced contractile reserve provided by frequency dependent potentiation of force of contraction contributes to the myocardial dysfunction. Myectomy was performed in ...

journal_title：Basic research in cardiology

authors： Schotten U,Voss S,Wiederin TB,Voss M,Schoendube F,Hanrath P,Schumacher C

更新日期：1999-04-01 00:00:00

abstract：:Recent publications shown mitochondrial localization of the enzyme nitric oxide synthase (NOS) in a number of tissues. However, conflicting results about mitochondrial NOS (mtNOS) immunoreactivity and enzymatic activity are available to date in the literature. In this study we purified mitochondria from rat hearts and...

journal_title：Basic research in cardiology

authors： Zanella B,Giordano E,Muscari C,Zini M,Guarnieri C

更新日期：2004-05-01 00:00:00

abstract：:Implicit in attempts to characterize and purify biologically active factors is the premise that the bioassay system employed will show a progressive increase in the response as the concentration of the responsible factor increases. We employed the hamster cheek pouch to assay the neovascularization potential of growth...

journal_title：Basic research in cardiology

authors： Orlandi C,Paskins-Hurlburt AJ,Hollenberg NK

更新日期：1986-05-01 00:00:00

abstract：:Enzymes involved in the metabolism nitric oxide (NO) and reactive oxygen species (ROS) may play a role for the decreased availability of NO in atherosclerosis. We, therefore, hypothesized that the pattern of gene expression of these enzymes is altered in atherosclerosis. Myocardial tissue from patients with coronary h...

journal_title：Basic research in cardiology

authors： Chen X,Niroomand F,Liu Z,Zankl A,Katus HA,Jahn L,Tiefenbacher CP

更新日期：2006-07-01 00:00:00

abstract：:Isolated cells obtained from adult myocardium are proving invaluable for a wide range of studies concerned with the mechanisms underlying many important cardiological processes. Although care must always be taken to ensure that the single myocyte is an appropriate model for the particular question to be researched, it...

journal_title：Basic research in cardiology

authors： Powell T

更新日期：1985-01-01 00:00:00

abstract：:In this report we review the replacement (i.e., scarring) and reactive (i.e., perivascular and interstitial fibrosis) fibrous tissue responses found in the myocardium in response to effector hormones of the renin-angiotensin-aldosterone system. Experimental data are presented to indicate: a) endogenous or exogenous el...

journal_title：Basic research in cardiology

authors： Weber KT,Brilla CG,Campbell SE,Guarda E,Zhou G,Sriram K

更新日期：1993-01-01 00:00:00

abstract：:Acute ischemia is a well-known inductor of extracellular matrix (ECM) remodeling, which leads to the development of congestive heart failure and is associated with left ventricular dilatation. Here we investigate the timecourse of ECM processing with release of endostatin (ES) and other low-molecular-weight fragments ...

journal_title：Basic research in cardiology

authors： Lauten A,Majos E,Mühlich A,Wahlers T,Weider S,Fischer JH,Figulla HR,Bloch W

更新日期：2009-09-01 00:00:00

abstract：:The pathogenesis and progression of hypertensive heart disease are unclear; however, both involve a genetic predisposition and environmental influences. To test the role of exogenous factors, we examined the hearts of spontaneously hypertensive rats (SHR) exposed to noise stress and ethanol intake. Twenty-two SHR and ...

journal_title：Basic research in cardiology

authors： Herrmann HJ,Rohde HG,Schulze W,Eichhorn C,Luft FC

更新日期：1994-11-01 00:00:00

abstract：:Hypoxia leads to an elevation of the pulmonary vascular resistance (pvR) in pigs. This alteration of the hemodynamic was accompanied by a slight increase of intraparenchymatous concentrations of cyclic GMP (cGMP), while cycle AMP (cAMP) levels were not different from values, measured during normoxia. beta-adrenergic a...

journal_title：Basic research in cardiology

authors： Kaukel E,Beier W,Lanser K,Sill V

更新日期：1977-09-01 00:00:00

abstract：OBJECTIVE:Chemokines control the migration of leukocytes to inflamed tissue, and in particular monocyte chemoattractant protein (MCP)-1 has been implicated in the pathogenesis of several cardiovascular disorders such as chronic heart failure (CHF) and myocarditis. We hypothesised that MCP-1 may directly contribute to a...

journal_title：Basic research in cardiology

authors： Damås JK,Aukrust P,Ueland T,Odegaard A,Eiken HG,Gullestad L,Sejersted OM,Christensen G

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:Ischemic or hypoxic preconditioning has been shown, in multicellular preparations, to reduce post-ischemic injury. In the present study, we attempted to develop a model of preconditioning in isolated rat myocytes in order to facilitate investigation into the mechanism of preconditioning. METHODS:The protecti...

journal_title：Basic research in cardiology

authors： Cave AC,Adrian S,Apstein CS,Silverman HS

更新日期：1996-05-01 00:00:00

abstract：:It has been investigated whether calcium- and verapamil-dependent sensitivities of carotis baroreceptors also exist in man. To answer this question, we pre- and postoperatively measured changes in heart rate during carotid sinus stimulation before and after intravenous administration of 5 mg verapamil in 23 patients w...

journal_title：Basic research in cardiology

authors： Behrmann C,Runge M,Ringe JD

更新日期：1992-09-01 00:00:00

abstract：:A study of substrate selection in the isolated heart was made using 13C NMR isotopomer analysis, a method that unequivocally identifies relative substrate utilization. This technique has several advantages over conventional approaches used to study this problem. It detects the labeling of metabolic end-products presen...

journal_title：Basic research in cardiology

authors： Jeffrey FM,Diczku V,Sherry AD,Malloy CR

更新日期：1995-09-01 00:00:00

abstract：:Elucidation of the subcellular mechanism of myocardial ischemic preconditioning should be facilitated by precise knowledge of the biology of the cardioprotective response. Any proposed molecular mechanism for preconditioning must be initiated during the required ischemic stress period. The studies reported in this pap...

journal_title：Basic research in cardiology

authors： Schwartz LM,Jennings RB,Reimer KA

更新日期：1997-04-01 00:00:00

abstract：:SIRT6, a member of the NAD(+)-dependent class III deacetylase sirtuin family, has been revealed to play important roles in promoting cellular resistance against oxidative stress. The formation of reactive oxygen species (ROS) and oxidative stress are the crucial mechanisms underlying cellular damage and dysfunction in...

journal_title：Basic research in cardiology

authors： Wang XX,Wang XL,Tong MM,Gan L,Chen H,Wu SS,Chen JX,Li RL,Wu Y,Zhang HY,Zhu Y,Li YX,He JH,Wang M,Jiang W

更新日期：2016-03-01 00:00:00

abstract：:A computer model is presented for simulation of the spread of activation and repolarization in ventricular myocardium. The program calculating the activation sequence is based on an algorithm similar to Huygen's principle of constructing wavefronts. Physiological parameters of the heart, such as areas of early activat...

journal_title：Basic research in cardiology

authors： Wach P,Killmann R,Dienstl F,Eichtinger C

更新日期：1989-07-01 00:00:00

abstract：:Increased activity of the sympathetic system is an important feature contributing to the pathogenesis and progression of chronic heart failure. While the mechanisms and consequences of enhanced norepinephrine release from sympathetic nerves have been intensely studied, the role of the adrenal gland in the development ...

journal_title：Basic research in cardiology

authors： Schneider J,Lother A,Hein L,Gilsbach R

更新日期：2011-06-01 00:00:00

abstract：:In situ hearts and isolated cardiomyocytes from heterozygous connexin 43-deficient (Cx43+/-) mice cannot be protected by ischemic preconditioning or diazoxide. We have now addressed the role of connexin 43 in ischemic postconditioning (PC). Wild type (WT) and Cx43+/- mice were subjected to 30 min coronary occlusion an...

journal_title：Basic research in cardiology

authors： Heusch G,Büchert A,Feldhaus S,Schulz R

更新日期：2006-07-01 00:00:00

abstract：:The renin angiotensin system and endothelium-derived vasoactive substances are both important regulators of vascular tone. Recent evidence suggests that the two systems may be tightly interconnected and drugs interfering with one system may also affect the other. Beside the circulating renin angiotensin system, a vasc...

journal_title：Basic research in cardiology

authors： Lüscher TF

更新日期：1993-01-01 00:00:00

abstract：:Ischaemic preconditioning has not been demonstrated to reduce infarct size following global ischaemia in murine myocardium. Eighteen mouse hearts were isolated, perfused in the Langendorff mode, and randomised to control or preconditioning groups. Preconditioned hearts received four periods of five minutes global isch...

journal_title：Basic research in cardiology

authors： Sumeray MS,Yellon DM

更新日期：1998-10-01 00:00:00

abstract：:Receptor binding studies usually show heterogenic characteristics of the binding isotherm. Scatchard transformation for graphical linearization of the data presentation affects the data inhomogeneously with respect to the experimental error. Thus a non-linear fitting procedure should be preferred for data analysis. Fu...

journal_title：Basic research in cardiology

authors： Wellstein A,Palm D

更新日期：1984-01-01 00:00:00

abstract：:The effects of the potassium channel openers (KCO), cromakalim or pinacidil, were evaluated in an anesthetized porcine model of pacing- and ischemia-induced ventricular fibrillation (VF). Hearts were paced at 180 bpm and the left anterior descending coronary artery was occluded until VF was induced. Reproducible times...

journal_title：Basic research in cardiology

authors： D'Alonzo AJ,Hess TA,Darbenzio RB,Sewter JC,Conder ML,McCullough JR

更新日期：1994-03-01 00:00:00

abstract：:Necrosis is a type of cell death characterized by a gain in cell volume, swelling of organelles, rupture of the plasma membrane and subsequent loss of intracellular contents. For a long time, the process has been considered as a merely accidental and uncontrolled form of cell death, but accumulating evidence suggests ...

journal_title：Basic research in cardiology

authors： Martinet W,Schrijvers DM,De Meyer GR

更新日期：2011-09-01 00:00:00

abstract：:We tested the hypothesis that isoproterenol would increase myocardial work and O2 consumption at reduced efficiency and that both left ventricular hypertrophy and chemical sympathectomy would lead to changes in this myocardial efficiency response. Left ventricular hypertrophy was produced by aortic valve plication in ...

journal_title：Basic research in cardiology

authors： Scholz PM,Kedem J,Cheinberg BV,Weiss HR

更新日期：1996-07-01 00:00:00

abstract：:During myocardial ischemia, both the myocardial and serum TNFalpha concentrations are rapidly increased within the area at risk. With prolongation of ischemia and development of cardiomyocyte necrosis, the TNFalpha concentration increases also in the surrounding viable portions of the myocardium. Indeed, in the scenar...

journal_title：Basic research in cardiology

authors： Schulz R,Aker S,Belosjorow S,Heusch G

更新日期：2004-01-01 00:00:00

abstract：:Verapamil, at a dose of 1 mg/kg, was given intravenously to anesthetized cats one hour after coronary artery occlusion. Verapamil significantly reduced mean arterial blood pressure, but produced an increase in heart rate, partially offsetting the reduction in myocardial oxygen demand resulting from the reduction in pr...

journal_title：Basic research in cardiology

authors： Lefer AM,Polansky EW,Bianchi CP,Narayan S

更新日期：1979-09-01 00:00:00

abstract：:To study the signaling mechanisms which mediate ventricular hypertrophy, we utilized the induction of the ANF gene as a marker of the hypertrophic response. The induction of the atrial natriuretic factor gene (ANF) is one of the most conserved features of ventricular hypertrophy, occurring in multiple species (mouse, ...

journal_title：Basic research in cardiology

authors： Chien R

更新日期：1992-01-01 00:00:00

abstract：:The aim of this study was to clarify the role of altered diabetic vascular reactivity in ischaemic heart disease. In diabetic condition, the necrotic area of myocardial infarction was significantly extended and myocardial oedema failed to develop after administration of norepinephrine 2 or 48 hours after ligation of t...

journal_title：Basic research in cardiology

authors： Palik I,Koltai MZ,Kolonics I,Wagner M,Pogátsa G

更新日期：1982-09-01 00:00:00

abstract：:Experiments were performed to determine the relative contributions of direct Ca(2+)-entry through the L-type Ca(2+)-current and of Ca(2+)-release from the sarcoplasmic reticulum (s.r.) to the intracellular [Ca2+]i-transient in isolated human atrial and ventricular myocytes from patients with severe heart failure and f...

journal_title：Basic research in cardiology

authors： Beuckelmann DJ

更新日期：1997-01-01 00:00:00

abstract：:The authors have retracted this article [1] because of modifications in the control lanes of Figs. 2a and 8a of the COX1 blot obtained for 18-week-old rats (rotation, horizontal flipping and re-use of the control lanes for the 35-week-old rats blot). In light of the concerns raised, the conclusions drawn in this artic...

journal_title：Basic research in cardiology

authors： Vargas LA,Velasquez FC,Alvarez BV

更新日期：2018-04-18 00:00:00