Abstract：
:In this report we review the replacement (i.e., scarring) and reactive (i.e., perivascular and interstitial fibrosis) fibrous tissue responses found in the myocardium in response to effector hormones of the renin-angiotensin-aldosterone system. Experimental data are presented to indicate: a) endogenous or exogenous elevations in plasma angiotensin II are associated with acute cardiac myocyte necrosis and subsequent microscopic scarring; b) chronic elevations in plasma aldosterone (ALDO), relative to Na+ intake, are associated with a perivascular and interstitial fibrosis of the coronary and systemic circulations and are also seen in response to chronic administration of the mineralocorticoid hormone deoxycorticosterone (DOC); and c) chronic mineralocorticoid excess, due to ALDO or DOC, is associated with enhanced urinary K+ excretion, cardiac myocyte necrosis and scarring. Pharmacologic agents which interfere with these effector hormones (e.g., ACE inhibition and ALDO receptor antagonism) protect the myocardium against this pathologic structural remodeling created by the reactive and replacement (reparative) fibrosis. Evidence is also presented to indicate that chronic ACE inhibition is associated with a regression in reactive myocardial fibrosis. Based on these experimental findings we would suggest that clinical trials are indicated to address the prevention and regression of myocardial fibrosis--an important determinant of pathologic structural remodeling and abnormal myocardial stiffness.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Weber KT,Brilla CG,Campbell SE,Guarda E,Zhou G,Sriram Kdoi
10.1007/978-3-642-72497-8_8subject
Has Abstractpub_date
1993-01-01 00:00:00pages
107-24eissn
0300-8428issn
1435-1803journal_volume
88 Suppl 1pub_type
杂志文章,评审abstract：:There is no doubt that major advances have been made in cardiac electrophysiology using single heart cells. Accurate analysis of rapid inward sodium current and the second inward current carried by calcium has resulted in a major re-examination of the steps involved in excitation-contraction coupling in the heart. Fut...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11041-6_17
更新日期：1985-01-01 00:00:00
abstract：:Complete length-tension diagrams of myocardium were measured on isolated papillary muscles of cat right ventricle. These diagrams clearly demonstrate that irrespective of loading conditions there is no uniform maxima curve. As a function of preload the curves of afterloaded isotonic maxima obey totally separate nonlin...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907862
更新日期：1985-11-01 00:00:00
abstract：AIMS:Atrial fibrillation (AF) shortens the atrial action potential and the atrial refractory period. These changes promote persistence of AF. Pharmacological prolongation of atrial action potential duration (APD) may therefore help to prevent recurrent AF. In addition to prolonging APD, sodium channel blockers may prev...
journal_title：Basic research in cardiology
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00395-005-0513-4
更新日期：2005-03-01 00:00:00
abstract：:Receptor binding studies usually show heterogenic characteristics of the binding isotherm. Scatchard transformation for graphical linearization of the data presentation affects the data inhomogeneously with respect to the experimental error. Thus a non-linear fitting procedure should be preferred for data analysis. Fu...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-642-72376-6_2
更新日期：1984-01-01 00:00:00
abstract：:Previous studies indicated that the increase in protein kinase C (PKC)-mediated myofilament protein phosphorylation observed in failing myocardium might be detrimental for contractile function. This study was designed to reveal and compare the effects of PKCalpha- and PKCepsilon-mediated phosphorylation on myofilament...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-009-0053-z
更新日期：2010-03-01 00:00:00
abstract：:The influence of cardiac cholinergic activation was studied in rats and cats on the induction and maintenance of ventricular fibrillation (VF). Acetylcholine (ACH 2-25 micrograms/kg), in doses which did not cause bradycardia or hypotension, induced appearance of spontaneous VF (duration 2-60 sec.) in 9/20 rats which h...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908386
更新日期：1984-11-01 00:00:00
abstract：:A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These cons...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02023598
更新日期：1977-07-01 00:00:00
abstract：:Transient receptor potential melastatin-7 (TRPM7) channels have been recently reported in human atrial fibroblasts and are believed to mediate fibrogenesis in human atrial fibrillation. The present study investigates whether TRPM7 channels are expressed in human atrial myocytes using whole-cell patch voltage-clamp, RT...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-012-0282-4
更新日期：2012-09-01 00:00:00
abstract：:Coronary vasomotion of normal, stenotic, and poststenotic vessel segments was studied in 18 patients with coronary artery disease at rest, during submaximal bicycle exercise, and 5 min after sublingual nitroglycerin or oral isosorbide-dinitrate (ISDN) spray. Patients were divided into two groups: group 1 consisted of ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11038-6_28
更新日期：1990-01-01 00:00:00
abstract：:To evaluate the hypothesis that maintenance of the integrity of myocardial membrane systems and prevention of Ca2+ influx into the cell are significant in the survival of ischaemic tissue, the effect of trifluoperazine and lysolecithin, were tested on the recovery of globally ischaemic rat hearts. Trifluoperazine incr...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908180
更新日期：1985-07-01 00:00:00
abstract：BACKGROUND:Reopening of the infarct-related coronary artery is the treatment of choice in the clinical setting of acute myocardial infarction. Nevertheless the removal of the total occlusion obtained either by thrombolysis or by primary angioplasty is followed by the ischemia/reperfusion sequelae. One of many proposed ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950200049
更新日期：2002-09-01 00:00:00
abstract：:Parathyroid hormone-related peptide (PTHrP) was found to improve contractile function of stunned myocardium in pigs. The peptide is released from coronary endothelial cells during ischemia and significantly improves post-ischemic recovery. The present study was aimed to decide whether such an induction of contractile ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-005-0532-9
更新日期：2005-07-01 00:00:00
abstract：:A major limitation in long-term studies of quiescent adult cadiomyocytes in culture has been the decline in contractile properties of the cells over time. Regular contracting cardiomyocyte cultures may represent a more physiological model. The aim of the present study was to investigate the mechanical properties and c...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788941
更新日期：1997-10-01 00:00:00
abstract：:The effects of a c-myc antisense phosphorothioate DNA oligonucleotide were assessed on the proliferation rate of human arterial smooth muscle cells (HSMCs). Compared to a control oligonucleotide the antisense oligonucleotide suppressed the proliferation of HSMCs in a concentration-dependent manner without a major cyto...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788668
更新日期：1992-11-01 00:00:00
abstract：:The endothelin (ET) family of peptides have potent vascular, cardiac and renal actions which may be of pathophysiological importance in congestive heart failure (CHF). In vivo studies with selective and non-selective ET receptor antagonists are required to clarify the role of ET in the pathophysiology of CHF and deter...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/BF00810520
更新日期：1996-01-01 00:00:00
abstract：:The isolated working rabbit heart preparation was used to study whether the "contractile machinery" remains unchanged in globally stunned myocardium. The function of the heart has been measured in nonischemic and postischemic conditions. The effect of isoprenaline or calcium chloride administration in both conditions ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02190601
更新日期：1991-05-01 00:00:00
abstract：:Successive ischemic episodes are commonly seen in clinical and experimental cardiology. Although prolonged abnormalities of the canine myocardium have been described following a single ischemic episode, it is not known whether myocardial injury is cumulative following multiple ischemic episodes. Dogs were subjected to...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908148
更新日期：1984-07-01 00:00:00
abstract：:The effects of chronic intake of dietary alcohol upon left ventricular function, activities of myocardial antioxidant enzymes, reduced glutathione (GSH) content and lipoperoxidation (measured as the formation of diene conjugates and lipid-soluble fluorescence) were studied in adult domestic Nicholas turkeys. The non-i...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907225
更新日期：1987-11-01 00:00:00
abstract：:Recent studies have demonstrated the presence of autoantibodies against alpha(1)-adrenoceptor (alpha(1)-AAB) in the serum of patients with primary hypertension, and that these autoantibodies exert adrenergic-agonist-like effects. However, their role in the development of hypertension remains unclear. The current study...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-009-0020-8
更新日期：2009-09-01 00:00:00
abstract：:An increased occurrence of hypertension has been reported among leg-amputees. In order to investigate whether leg amputation is followed by an elevation of sympathetic tone, possibly enhanced by continuous mechanical irritation of the amputation stump by wearing a prosthesis, blood pressure (BP), pulse-rate (PR) and p...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907771
更新日期：1981-05-01 00:00:00
abstract：BACKGROUND:The phytosterol guggulsterone is a potent anti-inflammatory mediator with less side effects than classic steroids. This study assesses the impact of guggulsterone on tissue factor (TF) expression and thrombus formation. METHODS AND RESULTS:Guggulsterone inhibited TNF-alpha-induced endothelial TF protein exp...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-008-0757-5
更新日期：2009-05-01 00:00:00
abstract：:The behavior of Ca(2+)-activated K+ channels of large conductance (BKCa) in smooth muscle cells, which were obtained from atherosclerotic plaque material (SMCP) and from media segments (SMCM) of human coronary arteries, were compared using the patch-clamp technique. Voltage-clamp protocols in cell-attached patches rev...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788518
更新日期：1997-08-01 00:00:00
abstract：:We investigated whether preconditioning could protect several cultured cell lines, to determine whether the protection is specific for cells derived from different myogenic and non-myogenic sources. Ischemia was simulated by centrifugation of cells into a pellet, and cell viability was determined by hypotonic trypan b...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788726
更新日期：1996-11-01 00:00:00
abstract：:This study was designed to identify mechanisms responsible for coronary vasodilation in response to progressive decreases in hematocrit. Isovolemic hemodilution was produced in open-chest, anesthetized swine via concurrent removal of 500 ml of arterial blood and the addition of 500 ml of 37 °C saline or synthetic plas...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-017-0654-x
更新日期：2017-09-30 00:00:00
abstract：:In the chronically volume-overloaded canine heart due to AV-block evaluations of cardiac function were performed during the development of hypertrophy and at stable hypertrophy. In an early stage (1 and 2 weeks of AV-block) when no or only a slight increase of cardiac muscle occurred, contractility measured from dP/dt...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906357
更新日期：1977-03-01 00:00:00
abstract：:Recent publications shown mitochondrial localization of the enzyme nitric oxide synthase (NOS) in a number of tissues. However, conflicting results about mitochondrial NOS (mtNOS) immunoreactivity and enzymatic activity are available to date in the literature. In this study we purified mitochondria from rat hearts and...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-003-0454-3
更新日期：2004-05-01 00:00:00
abstract：:The concept of metabolic coronary flow control provides a rationale for the close relationship of coronary flow and myocardial metabolic rate of oxygen. The concept is based on the presence of an oxygen (metabolic) sensor coupled functionally to effector mechanisms, which control vascular tone. Four modes of metabolic...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-006-0621-4
更新日期：2006-11-01 00:00:00
abstract：:Pentostatin (2-deoxycoformycin) is a potent inhibitor of adenosine deaminase and has been demonstrated to augment endogenous adenosine levels during regional and global myocardial ischemia. Based on the rationale that increasing endogenous adenosine during ischemia may be cardioprotective, the objective of this study ...
journal_title：Basic research in cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00789447
更新日期：1995-03-01 00:00:00
abstract：:If everything happens strictly according to the natural laws, which meet extremum principles, in what way can the possibility for life be characterised, so that the optimization processes of evolution can take place? Is it legitimate to "enlarge" the natural laws by certain laws of conservation? The question then aris...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:The cardiac renin angiotensin system (RAS) is the target for number of therapeutic interventions which proved successful in heart failure. Angiotensin converting enzyme (ACE) inhibitors belong to the most efficient strategies available and angiotensin receptor (ATR) antagonists may be comparably effective. The direct ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950050207
更新日期：1998-01-01 00:00:00
