Influence of verapamil on cellular integrity and electrolyte concentrations of ischemic myocardial tissue in the cat.

abstract：:The influence of perfusion pressure (5-8 kPa) on coronary flow and myocardial Ca2+-washout during Ca2+-free perfusion, and on the occurrence of calcium paradox after subsequent Ca2+-reperfusion, was studied in isolated, stimulated, rat heart ventricles. During the Ca2+-free perfusion period (3 min) the following chang...

journal_title：Basic research in cardiology

authors： Koomen JM,Jager LP,van Noordwijk J

更新日期：1980-03-01 00:00:00

abstract：:The genetic defect in the cardiomyopathic (CM) hamster is a mutation in the glycoprotein-sarcoglycan (a component of the dystrophin-glycoprotein complex). Apoptosis has been identified in skeletal muscle of dystrophin-deficient mice, and therefore the role of myocardial apoptosis in relation to oncosis in causing myoc...

journal_title：Basic research in cardiology

authors： Ryoke T,Gu Y,Ikeda Y,Martone ME,Oh SS,Jeon ES,Knowlton KU,Ross J Jr

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Reopening of the infarct-related coronary artery is the treatment of choice in the clinical setting of acute myocardial infarction. Nevertheless the removal of the total occlusion obtained either by thrombolysis or by primary angioplasty is followed by the ischemia/reperfusion sequelae. One of many proposed ...

journal_title：Basic research in cardiology

authors： Schäfer U,Kurz T,Jain D,Hartmann F,Dendorfer A,Tölg R,Raasch W,Dominiak P,Katus H,Richardt G

更新日期：2002-09-01 00:00:00

abstract：:X-ray microanalysis was used to compare chemically untreated cryosections of quick-frozen myocardial tissue in "caffeine contracture" with cryosections of normal muscle. Our goal was to find out if it is possible by means of this method to detect changes in the calcium compartmentalization of the myocardial cell occur...

journal_title：Basic research in cardiology

authors： Wendt-Gallitelli MF,Wolburg H,Schlote W,Schwegler M,Holubarsch C,Jacob R

更新日期：1980-01-01 00:00:00

abstract：:Beta-blockers have been shown to reduce the risk of coronary events and reduce the mortality of patients with hypertension and in those who have had a myocardial infarction. Furthermore, the evidence for long-term benefits in these two patient groups are much more convincing for beta-blockers than for other therapeuti...

journal_title：Basic research in cardiology

authors： Kendall MJ

更新日期：2000-01-01 00:00:00

abstract：:Parathyroid hormone-related peptide (PTHrP) was found to improve contractile function of stunned myocardium in pigs. The peptide is released from coronary endothelial cells during ischemia and significantly improves post-ischemic recovery. The present study was aimed to decide whether such an induction of contractile ...

journal_title：Basic research in cardiology

authors： Lütteke D,Ross G,Abdallah Y,Schäfer C,Piper HM,Schlüter KD

更新日期：2005-07-01 00:00:00

abstract：:We studied TTX-sensitive Na channels in dissociated single ventricular cells from neonatal rats using the patch clamp method for single channel and whole cell recording. In both cases, slowly inactivating or window currents were observed that decayed in a biexponential fashion. Customary models of Na current kinetics ...

journal_title：Basic research in cardiology

authors： Wilson DL,Lacerda AE,Kunze DL,Brown AM

更新日期：1985-01-01 00:00:00

abstract：:The characterization of various ion transport systems has led to a better understanding of the effects, which seem to take part in the impairment of ischemic and reperfused cardiac tissue. This review discusses the role of the Na+/H+ exchange system in the pathophysiology of ischemia and reperfusion and the beneficial...

journal_title：Basic research in cardiology

authors： Scholz W,Albus U

更新日期：1993-09-01 00:00:00

abstract：:We have recently gained evidence that segmental coronary microvascular diameters, and therefore resistances, are controlled by myogenic and endothelial responses to pressure and flow. Furthermore, intact heart studies are demonstrating that these mechanisms may interact importantly with the metabolic mechanisms primar...

journal_title：Basic research in cardiology

authors： Jones CJ,Kuo L,Davis MJ,Chilian WM

更新日期：1993-01-01 00:00:00

abstract：:Two-weekly echocardiographic examinations were conducted in nine SHHF-Mc-fa(cp) rats in comparison with eight age-matched Wistar rats. In the SHHF-rats, characterized by progressive LV-dilation and decreasing contractile function between 77-87 weeks of age, left ventricular (LV) hypertrophy was most sensitively demons...

journal_title：Basic research in cardiology

authors： Reffelmann T,Kloner RA

更新日期：2003-09-01 00:00:00

abstract：:We have characterized the aerobic blood-perfused isolated heart model evaluating the hemodynamics and metabolism of both the blood donor animal and the isolated organ. Anaesthesia of the blood donor with sodium pentobarbital (30 mg/kg) increases arterial concentration of non esterified fatty acids (NEFA) from 80 +/- 6...

journal_title：Basic research in cardiology

authors： Pasini E,Solfrini R,Bachetti T,Marino M,Bernocchi P,Visioli F,Ferrari R

更新日期：1999-06-01 00:00:00

abstract：:We have compared in open-chest dogs the evolution of adenine nucleotides and creatine phosphate to that of regional mechanical function during ischemia and reperfusion. Reperfusion restored normal value of creatine phosphate whereas adenine nucleotide level remained depressed. The percentage of systolic shortening, wh...

journal_title：Basic research in cardiology

authors： Vial C,Crozatier B,Goldschmidt D,Font B

更新日期：1982-11-01 00:00:00

abstract：:The influence of cardiac cholinergic activation was studied in rats and cats on the induction and maintenance of ventricular fibrillation (VF). Acetylcholine (ACH 2-25 micrograms/kg), in doses which did not cause bradycardia or hypotension, induced appearance of spontaneous VF (duration 2-60 sec.) in 9/20 rats which h...

journal_title：Basic research in cardiology

authors： Amitzur G,Manoach M,Weinstock M

更新日期：1984-11-01 00:00:00

abstract：:Carotid baroreceptor stimulation (CBS) has been shown to improve cardiac dysfunction and pathological structure remodelling. This study aimed to investigate the effects of CBS on the ventricular electrophysiological properties in canines with chronic heart failure (CHF). Thirty-eight beagles were randomized into contr...

journal_title：Basic research in cardiology

authors： Wang J,Dai M,Cao Q,Yu Q,Luo Q,Shu L,Zhang Y,Bao M

更新日期：2019-09-09 00:00:00

abstract：:Atrial fibrosis is important for the pathogenesis of atrial fibrillation (AF) but the underlying signal transduction is incompletely understood. We therefore studied the role of microRNA-21 (miR-21) and its downstream target Sprouty 1 (Spry1) during atrial fibrillation. Left atria (LA) from patients with AF showed a 2...

journal_title：Basic research in cardiology

authors： Adam O,Löhfelm B,Thum T,Gupta SK,Puhl SL,Schäfers HJ,Böhm M,Laufs U

更新日期：2012-09-01 00:00:00

abstract：:Although it has long been recognized that thyroid hormone is an effective positive inotrope, its efficacy in supporting hemodynamics in the acute setting of ischaemia and reperfusion (R) without worsening reperfusion injury remains largely unknown. Thus, we investigated the effects of triiodothyronine (T3) on reperfus...

journal_title：Basic research in cardiology

authors： Pantos C,Mourouzis I,Saranteas T,Clavé G,Ligeret H,Noack-Fraissignes P,Renard PY,Massonneau M,Perimenis P,Spanou D,Kostopanagiotou G,Cokkinos DV

更新日期：2009-01-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia with a strong genetic component. Molecular pathways involving the homeodomain transcription factor Shox2 control the development and function of the cardiac conduction system in mouse and zebrafish. Here we report the analysis of human SHOX2 as a potent...

journal_title：Basic research in cardiology

authors： Hoffmann S,Clauss S,Berger IM,Weiß B,Montalbano A,Röth R,Bucher M,Klier I,Wakili R,Seitz H,Schulze-Bahr E,Katus HA,Flachsbart F,Nebel A,Guenther SP,Bagaev E,Rottbauer W,Kääb S,Just S,Rappold GA

更新日期：2016-05-01 00:00:00

abstract：:We have used x-ray microangiography to investigate the influence of EDRF and endothelin-1 on arterial diameters (70-800 microns) at bifurcations in the isolated rabbit ear and the "optimality" of its branching geometry. The median value of the junction exponent x (which is given by d0x = d1x + d2x, where d0, d1 and d2...

journal_title：Basic research in cardiology

authors： Griffith TM,Edwards DH,Randall MD

更新日期：1991-01-01 00:00:00

abstract：:A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These cons...

journal_title：Basic research in cardiology

authors： Zucker IH,Gilmore JP

更新日期：1977-07-01 00:00:00

abstract：:Persistent inflammatory responses participate in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We hypothesized that regulatory T (Treg) cells modulate inflammatory responses, attenuate ventricular remodeling and subsequently improve cardiac function after MI. Acute MI was induced...

journal_title：Basic research in cardiology

authors： Tang TT,Yuan J,Zhu ZF,Zhang WC,Xiao H,Xia N,Yan XX,Nie SF,Liu J,Zhou SF,Li JJ,Yao R,Liao MY,Tu X,Liao YH,Cheng X

更新日期：2012-01-01 00:00:00

abstract：:Mitochondria in largely postmitotic cells (e.g. cardiomyocytes, neurons or skeletal muscle myotubes) have a limited life span of a few weeks. Their replacement during normal turnover requires an intergenomic coordination between the mitochondrial genome (mtDNA, encoding for 13 protein subunits of the respiratory chain...

journal_title：Basic research in cardiology

authors： Szibor M,Holtz J

更新日期：2003-07-01 00:00:00

abstract：:Atherosclerotic coronary arteries are more calcified in patients with than without chronic kidney disease (CKD). We addressed the potential for coronary microvascular obstruction in patients with and without CKD during stenting for saphenous vein aorto-coronary graft (SVG) stenosis under protection with a distal occlu...

journal_title：Basic research in cardiology

authors： Baars T,Kleinbongard P,Böse D,Konorza T,Möhlenkamp S,Hippler J,Erbel R,Heusch G

更新日期：2012-11-01 00:00:00

abstract：:An increase in extracellular potassium concentration from 4 to 16 mmol/l caused a decrease in membrane potential from -92 to -59 mV and selectively diminished the earlier of two contraction components of guinea-pig papillary muscles at 0.2 Hz stimulation frequency in the presence of noradrenaline. The influence on the...

journal_title：Basic research in cardiology

authors： Vierling W,Seibel K,Reiter M

更新日期：1987-09-01 00:00:00

abstract：:In the human heart several isoforms of the sodium pump (Na,K-ATPase, the cardiac glycoside receptor) are expressed (alpha1beta1, alpha2beta1, and alpha3beta1). Their expression is regulated in a highly specific manner, so that there are region specific differences in the expression pattern. The isoform expression patt...

journal_title：Basic research in cardiology

authors： Müller-Ehmsen J,McDonough AA,Farley RA,Schwinger RH

更新日期：2002-01-01 00:00:00

abstract：:Denervation deprives the heart of its normal adrenergic and cholinergic control via the sympathetic and parasympathetic pathways. In a heart which is blood supplied by a donor animal of the same species, normal contractility is maintained, probably by blood borne catecholamines or possibly by unknown inotropic agents ...

journal_title：Basic research in cardiology

authors： Reichel H

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVE:Two types of hemodynamic overload, pressure and volume overload, result in morphologically distinct types of cardiac remodeling. We explored the possibility that distinct hemodynamic overload may differentially activate the signal transduction pathway. METHODS:Pressure and volume overload were induced by tho...

journal_title：Basic research in cardiology

authors： Miyamoto T,Takeishi Y,Takahashi H,Shishido T,Arimoto T,Tomoike H,Kubota I

更新日期：2004-09-01 00:00:00

abstract：:The aim of this study was to examine the effect of ischemic preconditioning on the releases of cardiac troponin T (TnT) during reperfusion in isolated rat hearts. Experiments were done on 22 rat hearts, which were perfused according to the method of Langendorff and were divided into the control group (n = 14) and the ...

journal_title：Basic research in cardiology

authors： Yamahara Y,Asayama J,Kobara M,Ohta B,Matsumoto T,Miyazaki H,Tatsumi T,Ishibashi K,Inoue M,Inoue D

更新日期：1994-05-01 00:00:00

abstract：:There is no doubt that major advances have been made in cardiac electrophysiology using single heart cells. Accurate analysis of rapid inward sodium current and the second inward current carried by calcium has resulted in a major re-examination of the steps involved in excitation-contraction coupling in the heart. Fut...

journal_title：Basic research in cardiology

authors： Powell T

更新日期：1985-01-01 00:00:00

abstract：:During long-term treatment with amiodarone, slowing of conduction through the atrioventricular node, a prolongation of the QT-interval, and a prolongation of the atrial and ventricular myocardial refractoriness always developed. During short-term treatment, these effects were not found, except for depression of the AV...

journal_title：Basic research in cardiology

authors： Stark G,Stark U,Windisch M,Vicenzi M,Eggenreich U,Nagl S,Kral K,Pilger E,Tritthart HA

更新日期：1991-03-01 00:00:00

abstract：:Coronary vasomotion of normal, stenotic, and poststenotic vessel segments was studied in 18 patients with coronary artery disease at rest, during submaximal bicycle exercise, and 5 min after sublingual nitroglycerin or oral isosorbide-dinitrate (ISDN) spray. Patients were divided into two groups: group 1 consisted of ...

journal_title：Basic research in cardiology

authors： Gaglione A,Hess OM,Haemmerli C,Suter T,Kirkeeide RL,Osenberg HP,Muser M,Anliker M,Gould KL,Krayenbuehl HP

更新日期：1990-01-01 00:00:00