Effects of perfusion pressure on coronary flow, myocardial Ca2+-washout, and the occurrence of calcium paradox in isolated perfused rat heart ventricles.

abstract：:Impaired nitric oxide (NO)-soluble guanylate cyclase (sGC)-cGMP signaling is involved in the pathogenesis of ischemic heart diseases, yet the impact of long-term sGC activation on progressive cardiac remodeling and heart failure after myocardial infarction (MI) has not been explored. Moreover, it is unknown whether st...

journal_title：Basic research in cardiology

authors： Fraccarollo D,Galuppo P,Motschenbacher S,Ruetten H,Schäfer A,Bauersachs J

更新日期：2014-07-01 00:00:00

abstract：:A canine model for a standardized induction of collaterals is presented with a fixed external constrictor that is not designed to induce an occlusion of the coronary artery and at least over the timespan of 6 weeks does not impair perfusion under resting conditions in the myocardium-at-risk. The coronary constriction ...

journal_title：Basic research in cardiology

authors： Gottwik M,Wüsten B,Hofmann M,Puschmann S,Nienaber C,Schaper W

更新日期：1983-03-01 00:00:00

abstract：:Phospholamban is a regulatory phosphoprotein which modulates the active transport of Ca2+ by the cardiac sarcoplasmic reticular Ca(2+)-ATPase enzyme (SERCA2) into the lumen of the sarcoplasmic reticulum. Phospholamban, which is a reversible inhibitor of SERCA2, represses the enzyme's activity, and this inhibition is r...

journal_title：Basic research in cardiology

authors： Koss KL,Grupp IL,Kranias EG

更新日期：1997-01-01 00:00:00

abstract：:Recent publications shown mitochondrial localization of the enzyme nitric oxide synthase (NOS) in a number of tissues. However, conflicting results about mitochondrial NOS (mtNOS) immunoreactivity and enzymatic activity are available to date in the literature. In this study we purified mitochondria from rat hearts and...

journal_title：Basic research in cardiology

authors： Zanella B,Giordano E,Muscari C,Zini M,Guarnieri C

更新日期：2004-05-01 00:00:00

abstract：:We compared the effects of linagliptin (Lina, a DPP4 inhibitor) and GLP-1 receptor activation by exenatide followed by exendin-4 in an infusion pump (EX) on infarct size (IS), post-infarction activation of the inflammasome and remodeling in wild-type (WT) and db/db diabetic mice. Mice underwent 30 min ischemia followe...

journal_title：Basic research in cardiology

authors： Birnbaum Y,Tran D,Bajaj M,Ye Y

更新日期：2019-08-06 00:00:00

abstract：:We have recently gained evidence that segmental coronary microvascular diameters, and therefore resistances, are controlled by myogenic and endothelial responses to pressure and flow. Furthermore, intact heart studies are demonstrating that these mechanisms may interact importantly with the metabolic mechanisms primar...

journal_title：Basic research in cardiology

authors： Jones CJ,Kuo L,Davis MJ,Chilian WM

更新日期：1993-01-01 00:00:00

abstract：:A computer model is presented for simulation of the spread of activation and repolarization in ventricular myocardium. The program calculating the activation sequence is based on an algorithm similar to Huygen's principle of constructing wavefronts. Physiological parameters of the heart, such as areas of early activat...

journal_title：Basic research in cardiology

authors： Wach P,Killmann R,Dienstl F,Eichtinger C

更新日期：1989-07-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) exhibit antiapoptotic and proangiogenic functions in models of myocardial infarction which may be mediated by secreted small extracellular vesicles (sEVs). However, MSCs have frequently been harvested from aged or diseased patients, while the isolated sEVs often contain high levels of ...

journal_title：Basic research in cardiology

authors： Takov K,He Z,Johnston HE,Timms JF,Guillot PV,Yellon DM,Davidson SM

更新日期：2020-03-07 00:00:00

abstract：:Hypoxia leads to an elevation of the pulmonary vascular resistance (pvR) in pigs. This alteration of the hemodynamic was accompanied by a slight increase of intraparenchymatous concentrations of cyclic GMP (cGMP), while cycle AMP (cAMP) levels were not different from values, measured during normoxia. beta-adrenergic a...

journal_title：Basic research in cardiology

authors： Kaukel E,Beier W,Lanser K,Sill V

更新日期：1977-09-01 00:00:00

abstract：:Total cholesterol, phospholipids, and triglycerides in serum were studied during myocardial infarction in a patient group treated with glucose, insulin and potassium (GIK), and a conventionally treated group. There was no difference in the typical changes of cholesterol and phospholipids between the groups, but the GI...

journal_title：Basic research in cardiology

authors： Kirkeby OJ,Risöe C,Kirkeby K,Hjermann I

更新日期：1983-11-01 00:00:00

abstract：:Transformation of structural, functional, metabolic and molecular characteristics is induced by stimulating fast-twitch muscles with the frequency pattern of a motoneuron normally innervating a slow-twitch muscle. These changes correspond to a transition of a "fast-white" into a "slow-red" muscle. Intermittent stimula...

journal_title：Basic research in cardiology

authors： Pette D,Heilmann C

更新日期：1977-03-01 00:00:00

abstract：:In Langendorff-perfused guinea pig hearts, local myocardial perfusion was evaluated by analysis of FITC-dextran-150 elution kinetics after bolus injection. Locally estimated half-times of the monoexponential elution curves showed good correlation with global undisturbed coronary flow. After ligation of the left anteri...

journal_title：Basic research in cardiology

authors： Rösen R,Marsen A,Klaus W

更新日期：1984-01-01 00:00:00

abstract：:Ceramide has been shown to be a key signaling molecule involved in the apoptotic effect of tumor necrosis factor alpha (TNF-alpha) and other cytokines. Given the importance of cytokines such as TNF-alpha in myocardial ischemia-reperfusion injury, we hypothesize that ceramide is increased during ischemia or reperfusion...

journal_title：Basic research in cardiology

authors： Zhang DX,Fryer RM,Hsu AK,Zou AP,Gross GJ,Campbell WB,Li PL

更新日期：2001-05-01 00:00:00

abstract：:The assessment of endothelium-mediated modulation of coronary vasomotor tone in the intact human circulation under physiologic conditions requires very precise determination of both epicardial artery diameters, reflecting effects within the conduit vessels, as well as coronary blood flow, reflecting effects within the...

journal_title：Basic research in cardiology

authors： Wollschläger H,Zeiher AM,Drexler H,Just H

更新日期：1991-01-01 00:00:00

abstract：:The influence of cardiac cholinergic activation was studied in rats and cats on the induction and maintenance of ventricular fibrillation (VF). Acetylcholine (ACH 2-25 micrograms/kg), in doses which did not cause bradycardia or hypotension, induced appearance of spontaneous VF (duration 2-60 sec.) in 9/20 rats which h...

journal_title：Basic research in cardiology

authors： Amitzur G,Manoach M,Weinstock M

更新日期：1984-11-01 00:00:00

abstract：:Intermittent, normobaric hypoxia confers robust cardioprotection against ischemia-induced myocardial infarction and lethal ventricular arrhythmias. δ-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) have been implicated in cardioprotective phenomena, but their roles in intermittent hypoxia are unknown...

journal_title：Basic research in cardiology

authors： Estrada JA,Williams AG Jr,Sun J,Gonzalez L,Downey HF,Caffrey JL,Mallet RT

更新日期：2016-03-01 00:00:00

abstract：:In situ hearts and isolated cardiomyocytes from heterozygous connexin 43-deficient (Cx43+/-) mice cannot be protected by ischemic preconditioning or diazoxide. We have now addressed the role of connexin 43 in ischemic postconditioning (PC). Wild type (WT) and Cx43+/- mice were subjected to 30 min coronary occlusion an...

journal_title：Basic research in cardiology

authors： Heusch G,Büchert A,Feldhaus S,Schulz R

更新日期：2006-07-01 00:00:00

abstract：:We tested the hypothesis that in isolated cardiac myocytes, the negative functional effects of cyclic GMP would be blunted when the level of cyclic AMP was increased and that this interaction would be altered in renal hypertensive (One-Kidney-One-Clip, 1K1C) cardiac hypertrophic rabbits. Using isolated control and 1K1...

journal_title：Basic research in cardiology

authors： Patel KN,Yan L,Gandhi A,Scholz PM,Weiss HR

更新日期：2001-02-01 00:00:00

abstract：:SIRT6, a member of the NAD(+)-dependent class III deacetylase sirtuin family, has been revealed to play important roles in promoting cellular resistance against oxidative stress. The formation of reactive oxygen species (ROS) and oxidative stress are the crucial mechanisms underlying cellular damage and dysfunction in...

journal_title：Basic research in cardiology

authors： Wang XX,Wang XL,Tong MM,Gan L,Chen H,Wu SS,Chen JX,Li RL,Wu Y,Zhang HY,Zhu Y,Li YX,He JH,Wang M,Jiang W

更新日期：2016-03-01 00:00:00

abstract：:The purpose of this study was to determine if decreased heart function after hypoxia followed by reoxygenation (H-R) is associated with increased degradation of cardiac myosin light chain 1 (MLC1) by matrix metalloproteinase-2 (MMP-2), and to investigate the effects of the increased level of peroxynitrite in the heart...

journal_title：Basic research in cardiology

authors： Doroszko A,Polewicz D,Sawicka J,Richardson JS,Cheung PY,Sawicki G

更新日期：2009-11-01 00:00:00

abstract：:Total global ischaemia of the normothermic working rat heart caused an initial positive inotropic response characterized by vigorous contractions. After +/- 15 s this response reached a peak whereafter the isotonic contraction amplitude started to decline. After +/- 3.5 min the heart ceased to beat. The low level of h...

journal_title：Basic research in cardiology

authors： Steinmann CM,Lochner A,Niesler RA

更新日期：1987-05-01 00:00:00

abstract：:Dietary intake of unsaturated fatty acid of eicosapentaenoic acid (EPA) is thought to reduce the size and incidence of myocardial infarction. These beneficial effects are postulated to be due to chronic antithrombotic properties of EPA itself. We studied the possible direct effects of EPA on vascular smooth muscle as ...

journal_title：Basic research in cardiology

authors： Yanagisawa A,Lefer AM

更新日期：1987-03-01 00:00:00

abstract：:Conflicting data on the inotropic effect of insulin are present in the literature suggesting a positive inotropic property or no inotropic effect or even a negative influence. To clarify the reason for these diverging findings, dose-response curves of insulin have been performed in isolated working rat and guinea pig ...

journal_title：Basic research in cardiology

authors： Schmidt HD,Koch M

更新日期：2002-07-01 00:00:00

abstract：:Sprouty1 (Spry1) is a negative modulator of receptor tyrosine kinase signaling, but its role in cardiomyocyte survival has not been elucidated. The aim of this study was to investigate the potential role of cardiomyocyte Spry1 in cardiac ischemia-reperfusion (I/R) injury. Infarct areas of mouse hearts showed an increa...

journal_title：Basic research in cardiology

authors： Alakoski T,Ulvila J,Yrjölä R,Vainio L,Magga J,Szabo Z,Licht JD,Kerkelä R

更新日期：2019-01-11 00:00:00

abstract：:An increase in extracellular potassium concentration from 4 to 16 mmol/l caused a decrease in membrane potential from -92 to -59 mV and selectively diminished the earlier of two contraction components of guinea-pig papillary muscles at 0.2 Hz stimulation frequency in the presence of noradrenaline. The influence on the...

journal_title：Basic research in cardiology

authors： Vierling W,Seibel K,Reiter M

更新日期：1987-09-01 00:00:00

abstract：:The cardiac renin angiotensin system (RAS) is the target for number of therapeutic interventions which proved successful in heart failure. Angiotensin converting enzyme (ACE) inhibitors belong to the most efficient strategies available and angiotensin receptor (ATR) antagonists may be comparably effective. The direct ...

journal_title：Basic research in cardiology

authors： Regitz-Zagrosek V,Fielitz J,Fleck E

更新日期：1998-01-01 00:00:00

abstract：:This paper reviews the recent data concerning the force-frequency relations in experimental animals with heart failure. After a brief overview of the nature of these relations, which are induced by 2 opposite phenomena, the potentiation of force of contraction by heart rate and the restitution process, the paper revie...

journal_title：Basic research in cardiology

authors： Crozatier B

更新日期：1998-01-01 00:00:00

abstract：:Sirtuin 3 (Sirt3) is an NAD(+)-dependent mitochondrial deacetylase associated with superoxide dismutase 2 (SOD2)-mediated protection from oxidative stress. We have reported accelerated weight gain and impaired metabolic flexibility in atherosclerotic Sirt3 (-/-) mice. Oxidative stress is a hallmark of endothelial dysf...

journal_title：Basic research in cardiology

authors： Winnik S,Gaul DS,Siciliani G,Lohmann C,Pasterk L,Calatayud N,Weber J,Eriksson U,Auwerx J,van Tits LJ,Lüscher TF,Matter CM

更新日期：2016-05-01 00:00:00

abstract：AIMS:We studied the capability of heart rate (HR) adjusted change in multichannel magnetocardiogram (MCG) to detect exercise-induced ischemia. METHODS AND RESULTS:The MCG and 12-lead ECG were recorded simultaneously during supine exercise testing in 17 healthy controls and 24 patients with single vessel coronary arter...

journal_title：Basic research in cardiology

authors： Takala P,Hänninen H,Montonen J,Korhonen P,Mäkijärvi M,Nenonen J,Oikarinen L,Toivonen L,Katila T

更新日期：2002-01-01 00:00:00

abstract：:Patients with insulin resistance and type 2 diabetes have poor cardiac outcomes following myocardial infarction (MI). The mitochondrial uncoupling protein 3 (UCP3) is down-regulated in the heart with insulin resistance. We hypothesized that decreased UCP3 levels contribute to poor cardiac recovery following ischemia/r...

journal_title：Basic research in cardiology

authors： Edwards KS,Ashraf S,Lomax TM,Wiseman JM,Hall ME,Gava FN,Hall JE,Hosler JP,Harmancey R

更新日期：2018-10-29 00:00:00