Local myocardial perfusion and epicardial NADH-fluorescence after coronary artery ligation in the isolated guinea pig heart.

abstract：:Dietary intake of unsaturated fatty acid of eicosapentaenoic acid (EPA) is thought to reduce the size and incidence of myocardial infarction. These beneficial effects are postulated to be due to chronic antithrombotic properties of EPA itself. We studied the possible direct effects of EPA on vascular smooth muscle as ...

journal_title：Basic research in cardiology

authors： Yanagisawa A,Lefer AM

更新日期：1987-03-01 00:00:00

abstract：:A study of substrate selection in the isolated heart was made using 13C NMR isotopomer analysis, a method that unequivocally identifies relative substrate utilization. This technique has several advantages over conventional approaches used to study this problem. It detects the labeling of metabolic end-products presen...

journal_title：Basic research in cardiology

authors： Jeffrey FM,Diczku V,Sherry AD,Malloy CR

更新日期：1995-09-01 00:00:00

abstract：:Receptor for advanced glycation end products (RAGE) is associated with inflammation and the progression of cardiovascular diseases. The current study tested the hypothesis that RAGE is involved in the pathogenesis of aortic valve (AV) calcification. Pioglitazone attenuated AV calcification in experimental hypercholest...

journal_title：Basic research in cardiology

authors： Li F,Cai Z,Chen F,Shi X,Zhang Q,Chen S,Shi J,Wang DW,Dong N

更新日期：2012-11-01 00:00:00

abstract：:Verapamil alleviates symptoms in patients with hypertrophic cardiomyopathy (HCM), but the underlying mechanism of improvement remains speculative. Baseline and dipyridamole myocardial blood flow (MBF) were measured in 15 HCM patients (14 men, 42 +/- 10 years), before and after 4 weeks of verapamil SR 480 mg daily, usi...

journal_title：Basic research in cardiology

authors： Choudhury L,Elliott P,Rimoldi O,Ryan M,Lammertsma AA,Boyd H,McKenna WJ,Camici PG

更新日期：1999-02-01 00:00:00

abstract：:Heat shock protein 70 (Hsp70) has been shown to have an anti-apoptotic function, but its mechanism is not clear in heart. In this study, we examined the effect of Hsp70 deletion on AIF-induced apoptosis during ischemia/reperfusion (I/R) in vivo. Although Hsp70 KO and WT mice demonstrated similar amounts of AIF release...

journal_title：Basic research in cardiology

authors： Choudhury S,Bae S,Ke Q,Lee JY,Kim J,Kang PM

更新日期：2011-05-01 00:00:00

abstract：:Diseases accompanied by severe cardiac impairment like sepsis and chronic uremia are frequently linked to an increase in cytokine release. In order to investigate possible toxic effects of the immune mediators on myocardial cells, we studied the contractility of cardiac myocytes and the de novo formation of stress pro...

journal_title：Basic research in cardiology

authors： Löw-Friedrich I,Weisensee D,Mitrou P,Schoeppe W

更新日期：1992-01-01 00:00:00

abstract：:Because of the close anatomical association between the ventricles, the volume of one ventricle can directly affect the volume and pressure within the other ventricle. To study the mechanical coupling between the ventricles, we modeled the right and left ventricles as a two-compartment model with right wall (Crw), sep...

journal_title：Basic research in cardiology

authors： Santamore WP,Shaffer T,Hughes D

更新日期：1986-09-01 00:00:00

abstract：:Ex vivo multicellular preparations are essential tools to study tissue physiology. Among them, the recent methodological and technological developments in living myocardial slices (LMS) are attracting increasing interest by the cardiac research field. Despite this, this research model remains poorly perceived and util...

journal_title：Basic research in cardiology

authors： Watson SA,Dendorfer A,Thum T,Perbellini F

更新日期：2020-09-10 00:00:00

abstract：:Recent studies demonstrated that NADPH oxidase 2 (NOX2) expression in myocardium after ischemia-reperfusion (IR) is significantly upregulated. However, the underlying mechanisms remain unknown. This study aims to determine if nuclear cardiac myosin light chain 2 (MYL2), a well-known regulatory subunit of myosin, funct...

journal_title：Basic research in cardiology

authors： Zhang YS,Liu B,Luo XJ,Li TB,Zhang JJ,Peng JJ,Zhang XJ,Ma QL,Hu CP,Li YJ,Peng J,Li Q

更新日期：2015-01-01 00:00:00

abstract：:Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dep...

journal_title：Basic research in cardiology

authors： Andreadou I,Iliodromitis EK,Szabo C,Papapetropoulos A

更新日期：2015-09-01 00:00:00

abstract：:A rapid change in length of cat papillary muscle induces two reciprocal diastolic and systolic processes: stretching causes a viscoelastic relaxation of the muscle. The opposite behavior is observed after abrupt releases when - subsequent to an increase in resting tension - diastolic force attains its new equilibrium....

journal_title：Basic research in cardiology

authors： Maisch B

更新日期：1976-07-01 00:00:00

abstract：:The sympathetic and parasympathetic nervous system play a powerful role in controlling cardiac function by activating adrenergic and muscarinic receptors. In the human heart there exist alpha1-, beta1- and beta2-adrenoceptors and M2-muscarinic receptors and possibly also (prejunctional) alpha2-adrenoceptors. Beta1- an...

journal_title：Basic research in cardiology

authors： Brodde OE,Bruck H,Leineweber K,Seyfarth T

更新日期：2001-11-01 00:00:00

abstract：:Denervation deprives the heart of its normal adrenergic and cholinergic control via the sympathetic and parasympathetic pathways. In a heart which is blood supplied by a donor animal of the same species, normal contractility is maintained, probably by blood borne catecholamines or possibly by unknown inotropic agents ...

journal_title：Basic research in cardiology

authors： Reichel H

更新日期：1976-01-01 00:00:00

abstract：:It has been investigated whether calcium- and verapamil-dependent sensitivities of carotis baroreceptors also exist in man. To answer this question, we pre- and postoperatively measured changes in heart rate during carotid sinus stimulation before and after intravenous administration of 5 mg verapamil in 23 patients w...

journal_title：Basic research in cardiology

authors： Behrmann C,Runge M,Ringe JD

更新日期：1992-09-01 00:00:00

abstract：:Experiments were performed to determine the relative contributions of direct Ca(2+)-entry through the L-type Ca(2+)-current and of Ca(2+)-release from the sarcoplasmic reticulum (s.r.) to the intracellular [Ca2+]i-transient in isolated human atrial and ventricular myocytes from patients with severe heart failure and f...

journal_title：Basic research in cardiology

authors： Beuckelmann DJ

更新日期：1997-01-01 00:00:00

abstract：:Calcium transport functions of mitochondria and sarcoplasmic reticulum (SR) were studied without prior extraction using isolated rat heart myocytes permeabilized with saponin. Calcium uptake by SR was rapid and its affinity was high in comparison to calcium uptake by mitochondria, which had a higher capacity. The sens...

journal_title：Basic research in cardiology

authors： Kaminishi T,Kako KJ

更新日期：1989-05-01 00:00:00

abstract：:The effects of 3 hours of ischemia and 1 hour of reperfusion on biochemical, physiological and ultrastructural parameters were studied in 12 dogs. In the ischemic subendocardium without reperfusion, mitochondrial losses of adenine (ATP + ADP + AMP) and pyridine (NAD + NADH) nucleotides far exceeded those observed in w...

journal_title：Basic research in cardiology

authors： Regitz V,Paulson DJ,Hodach RJ,Little SE,Schaper W,Shug AL

更新日期：1984-03-01 00:00:00

abstract：:Beta-blockers have been shown to reduce the risk of coronary events and reduce the mortality of patients with hypertension and in those who have had a myocardial infarction. Furthermore, the evidence for long-term benefits in these two patient groups are much more convincing for beta-blockers than for other therapeuti...

journal_title：Basic research in cardiology

authors： Kendall MJ

更新日期：2000-01-01 00:00:00

abstract：:The assessment of proarrhythmic risks of drugs remains challenging. To evaluate the suitability of rat engineered heart tissue (EHT) for detecting proarrhythmic effects. We monitored drug effects on spontaneous contractile activity and, in selected cases, on action potentials (sharp microelectrode) and Ca2+ transients...

journal_title：Basic research in cardiology

authors： Eder A,Hansen A,Uebeler J,Schulze T,Neuber C,Schaaf S,Yuan L,Christ T,Vos MA,Eschenhagen T

更新日期：2014-01-01 00:00:00

abstract：:A canine model for a standardized induction of collaterals is presented with a fixed external constrictor that is not designed to induce an occlusion of the coronary artery and at least over the timespan of 6 weeks does not impair perfusion under resting conditions in the myocardium-at-risk. The coronary constriction ...

journal_title：Basic research in cardiology

authors： Gottwik M,Wüsten B,Hofmann M,Puschmann S,Nienaber C,Schaper W

更新日期：1983-03-01 00:00:00

abstract：:A model of vascular endothelial cell is proposed to describe the mechanisms by which cytosolic calcium (Cai) is modulated and endothelium-derived relaxing factor (EDRF) and prostacyclin (PGI2) are released when the cell is stimulated by agonist. The intracellular Ca2+ store of the model cell is comprised of a superfic...

journal_title：Basic research in cardiology

authors： Wong AY,Klassen GA

更新日期：1992-07-01 00:00:00

abstract：:Mesenchymal stromal cells (MSCs) exhibit antiapoptotic and proangiogenic functions in models of myocardial infarction which may be mediated by secreted small extracellular vesicles (sEVs). However, MSCs have frequently been harvested from aged or diseased patients, while the isolated sEVs often contain high levels of ...

journal_title：Basic research in cardiology

authors： Takov K,He Z,Johnston HE,Timms JF,Guillot PV,Yellon DM,Davidson SM

更新日期：2020-03-07 00:00:00

abstract：:Sprouty1 (Spry1) is a negative modulator of receptor tyrosine kinase signaling, but its role in cardiomyocyte survival has not been elucidated. The aim of this study was to investigate the potential role of cardiomyocyte Spry1 in cardiac ischemia-reperfusion (I/R) injury. Infarct areas of mouse hearts showed an increa...

journal_title：Basic research in cardiology

authors： Alakoski T,Ulvila J,Yrjölä R,Vainio L,Magga J,Szabo Z,Licht JD,Kerkelä R

更新日期：2019-01-11 00:00:00

abstract：:An increase in extracellular potassium concentration from 4 to 16 mmol/l caused a decrease in membrane potential from -92 to -59 mV and selectively diminished the earlier of two contraction components of guinea-pig papillary muscles at 0.2 Hz stimulation frequency in the presence of noradrenaline. The influence on the...

journal_title：Basic research in cardiology

authors： Vierling W,Seibel K,Reiter M

更新日期：1987-09-01 00:00:00

abstract：:Our understanding of what constitutes "normal" collagen organization in wound healing after myocardial injury and how such organization is achieved is still in its infancy. However, once this knowledge has been obtained, it may suggest methods of enhancing or even optimizing healing, and thus provide us with the possi...

journal_title：Basic research in cardiology

authors： Whittaker P

更新日期：1998-01-01 00:00:00

abstract：:Cardiac glycosides like ouabain are used in the therapy of heart failure and atrial fibrillation. They exert a positive inotropic effect on cardiomyocytes by inhibiting the plasma membrane sodium pump (Na,K-ATPase), decreasing the Ca-extrusion by the sarcolemmal cardiac sodium/calcium exchanger (NCX) and increasing th...

journal_title：Basic research in cardiology

authors： Müller-Ehmsen J,Nickel J,Zobel C,Hirsch I,Bölck B,Brixius K,Schwinger RH

更新日期：2003-03-01 00:00:00

abstract：:A rat Langendorff heart preparation, perfused at constant pressure, was used to evaluate the role of K(ATP) channels in respiratory acidosis-induced coronary hyperemia. Prior administration of glibenclamide, an inhibitor of K(ATP) channels, reduced basal flow rates and eliminated the hyperemia associated with hypercap...

journal_title：Basic research in cardiology

authors： Phillis JW,Song D,O'Regan MH

更新日期：2000-04-01 00:00:00

abstract：:Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia with a strong genetic component. Molecular pathways involving the homeodomain transcription factor Shox2 control the development and function of the cardiac conduction system in mouse and zebrafish. Here we report the analysis of human SHOX2 as a potent...

journal_title：Basic research in cardiology

authors： Hoffmann S,Clauss S,Berger IM,Weiß B,Montalbano A,Röth R,Bucher M,Klier I,Wakili R,Seitz H,Schulze-Bahr E,Katus HA,Flachsbart F,Nebel A,Guenther SP,Bagaev E,Rottbauer W,Kääb S,Just S,Rappold GA

更新日期：2016-05-01 00:00:00

abstract：:In the isometrically contracting rat trabecular muscle strip preparation, contracture tension was induced either by 10 min of hypoxia (low contracture tension) or by 30 min of joint oxygen and glucose withdrawal (severe contracture tension) at optimum length. Using stepwise 0.1 mm releases, length-tension relationship...

journal_title：Basic research in cardiology

authors： Holubarsch C,Jacob R

更新日期：1981-11-01 00:00:00

abstract：:Reversibly injured myocardium after short periods of ischemia is characterized by a prolonged depression of contractile function which can, however, be enhanced by inotropic interventions. Thus, a lack of inotropic stimulation due to ischemic damage of cardiac sympathetic nerves has been suggested as a mechanism under...

journal_title：Basic research in cardiology

authors： Schulz R,Frehen D,Heusch G

更新日期：1990-01-01 00:00:00