Cytokines induce stress protein formation in cultured cardiac myocytes.

abstract：:It is shown that hypertrophied rat myocardium exhibits marked prolongation of its action potential during non-essential changes both in the resting potential, as well as in the amplitude of the action potential, and during a moderate but nonsignificant reduction in the maximum upstroke velocity. When examining action ...

journal_title：Basic research in cardiology

authors： Gülch RW

更新日期：1980-01-01 00:00:00

abstract：:Necrosis is a type of cell death characterized by a gain in cell volume, swelling of organelles, rupture of the plasma membrane and subsequent loss of intracellular contents. For a long time, the process has been considered as a merely accidental and uncontrolled form of cell death, but accumulating evidence suggests ...

journal_title：Basic research in cardiology

authors： Martinet W,Schrijvers DM,De Meyer GR

更新日期：2011-09-01 00:00:00

abstract：:Atherosclerotic plaque rupture is the key event in the pathogenesis of acute coronary syndromes and it also occurs during coronary interventions. Atherosclerotic plaque rupture does not always result in complete thrombotic occlusion of the epicardial coronary artery with subsequent impending myocardial infarction, but...

journal_title：Basic research in cardiology

authors： Skyschally A,Leineweber K,Gres P,Haude M,Erbel R,Heusch G

更新日期：2006-09-01 00:00:00

abstract：:The purpose of this study was to determine if decreased heart function after hypoxia followed by reoxygenation (H-R) is associated with increased degradation of cardiac myosin light chain 1 (MLC1) by matrix metalloproteinase-2 (MMP-2), and to investigate the effects of the increased level of peroxynitrite in the heart...

journal_title：Basic research in cardiology

authors： Doroszko A,Polewicz D,Sawicka J,Richardson JS,Cheung PY,Sawicki G

更新日期：2009-11-01 00:00:00

abstract：:Parathyroid hormone-related peptide (PTHrP) was found to improve contractile function of stunned myocardium in pigs. The peptide is released from coronary endothelial cells during ischemia and significantly improves post-ischemic recovery. The present study was aimed to decide whether such an induction of contractile ...

journal_title：Basic research in cardiology

authors： Lütteke D,Ross G,Abdallah Y,Schäfer C,Piper HM,Schlüter KD

更新日期：2005-07-01 00:00:00

abstract：:The influence of norepinephrine on ventricular overdrive suppression and attendant potassium shifts has been studied in isolated perfused canine hearts with complete atrioventricular block. It was found that: 1) there is a potassium loss during the drive and a potassium uptake after the drive); 2) reducing the driving...

journal_title：Basic research in cardiology

authors： Pliam MB,Krellenstein DJ,Brooks CM,Vassalle M

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVES:Single electrical field shocks are able to induce ventricular fibrillation (VF) if applied during the vulnerable period. During this period, a shock can either prolong the action potential duration or induce a new action potential. Whether the occurrence of different shock responses contributes to the induct...

journal_title：Basic research in cardiology

authors： Kirchhof PF,Fabritz CL,Behrens S,Franz MR

更新日期：1997-02-01 00:00:00

abstract：:Since the discovery of a novel mechanism of cell death that differs from traditional necrosis, i.e., apoptosis, there have been numerous studies concluding that increased apoptosis augments myocardial infarction and heart failure and that limiting apoptosis protects the heart. Importantly, the vast majority of cells i...

journal_title：Basic research in cardiology

authors： Jose Corbalan J,Vatner DE,Vatner SF

更新日期：2016-05-01 00:00:00

abstract：:The influence of decapitation, ketamine and thiopental anesthesia on some properties of rat heart mitochondria was compared. Polarographic analysis were performed, oxygen consumption rates, respiratory control index, ADP : O ratio and oxidation of exogenous NADH were determined. Electronmicroscopic and gasometric exam...

journal_title：Basic research in cardiology

authors： Dutkiewicz T,Chelstowski K

更新日期：1981-03-01 00:00:00

abstract：:We tested the hypothesis that isoproterenol would increase myocardial work and O2 consumption at reduced efficiency and that both left ventricular hypertrophy and chemical sympathectomy would lead to changes in this myocardial efficiency response. Left ventricular hypertrophy was produced by aortic valve plication in ...

journal_title：Basic research in cardiology

authors： Scholz PM,Kedem J,Cheinberg BV,Weiss HR

更新日期：1996-07-01 00:00:00

abstract：:In an attempt to clarify the mechanism of sarcoplasmic reticulum (SR) dysfunction during the genesis of irreversible damage in the ischemic-reperfused myocardium, the changes in SR Ca2(+)-pumping ATPase (Ca2(+)-activated, Mg2(+)-dependent ATPase; Ca2(+)-ATPase) activity were studied during ischemia and subsequent repe...

journal_title：Basic research in cardiology

authors： Yoshida Y,Shiga T,Imai S

更新日期：1990-09-01 00:00:00

abstract：:To study the signaling mechanisms which mediate ventricular hypertrophy, we utilized the induction of the ANF gene as a marker of the hypertrophic response. The induction of the atrial natriuretic factor gene (ANF) is one of the most conserved features of ventricular hypertrophy, occurring in multiple species (mouse, ...

journal_title：Basic research in cardiology

authors： Chien R

更新日期：1992-01-01 00:00:00

abstract：:Protection from postconditioning has been documented in in situ animal models and it has been proposed that it is targeting circulating leukocytes. We therefore tested whether postconditioning can protect leukocyte-free, buffer-perfused rabbit hearts. Infarct size was measured with triphenyltetrazolium staining. In co...

journal_title：Basic research in cardiology

authors： Yang XM,Philipp S,Downey JM,Cohen MV

更新日期：2005-01-01 00:00:00

abstract：:In this paper, we review the hypothesis that activated tissue renin-angiotensin systems play a detrimental role in heart failure. The main arguments for this idea are discussed: a) tissue renin-angiotensin systems behave functionally distinct from the circulating renin-angiotensin system; b) tissue renin-angiotensin s...

journal_title：Basic research in cardiology

authors： Pinto YM,Buikema H,van Gilst WH,Lie KI

更新日期：1996-01-01 00:00:00

abstract：:Recent studies have demonstrated the presence of autoantibodies against alpha(1)-adrenoceptor (alpha(1)-AAB) in the serum of patients with primary hypertension, and that these autoantibodies exert adrenergic-agonist-like effects. However, their role in the development of hypertension remains unclear. The current study...

journal_title：Basic research in cardiology

authors： Yan L,Xu Y,Yao H,Xue W,Tian J,Ren H,Wu Y,Yang G,Ma XL,Liu H

更新日期：2009-09-01 00:00:00

abstract：:Hemodynamics and myocardial contractility were evaluated in five unanesthetized calves during acute hypocapnic and isocapnic hypoxia and during acute hypocapnic hypoxia with beta-adrenergic blockade. Both hypocapnic and isocapnic hypoxia, with mean PaO2 levels of 33.1 and 39.1 mm Hg respectively, produced a decline in...

journal_title：Basic research in cardiology

authors： Buss DD,Bisgard GE

更新日期：1976-09-01 00:00:00

abstract：:Delta-opioid receptors are known to participate in the protection found following ischemic preconditioning (IPC), but the role of kappa-receptors in IPC is currently controversial. Langendorff-perfused rat hearts received 35 min regional ischemia and 2 h reperfusion. PC (2 cycles 5 min global ischemia) substantially r...

journal_title：Basic research in cardiology

authors： Aitchison KA,Baxter GF,Awan MM,Smith RM,Yellon DM,Opie LH

更新日期：2000-02-01 00:00:00

abstract：:Receptor for advanced glycation end products (RAGE) is associated with inflammation and the progression of cardiovascular diseases. The current study tested the hypothesis that RAGE is involved in the pathogenesis of aortic valve (AV) calcification. Pioglitazone attenuated AV calcification in experimental hypercholest...

journal_title：Basic research in cardiology

authors： Li F,Cai Z,Chen F,Shi X,Zhang Q,Chen S,Shi J,Wang DW,Dong N

更新日期：2012-11-01 00:00:00

abstract：:A study of substrate selection in the isolated heart was made using 13C NMR isotopomer analysis, a method that unequivocally identifies relative substrate utilization. This technique has several advantages over conventional approaches used to study this problem. It detects the labeling of metabolic end-products presen...

journal_title：Basic research in cardiology

authors： Jeffrey FM,Diczku V,Sherry AD,Malloy CR

更新日期：1995-09-01 00:00:00

abstract：:We tested the hypothesis that in isolated cardiac myocytes, the negative functional effects of cyclic GMP would be blunted when the level of cyclic AMP was increased and that this interaction would be altered in renal hypertensive (One-Kidney-One-Clip, 1K1C) cardiac hypertrophic rabbits. Using isolated control and 1K1...

journal_title：Basic research in cardiology

authors： Patel KN,Yan L,Gandhi A,Scholz PM,Weiss HR

更新日期：2001-02-01 00:00:00

abstract：:A major limitation in long-term studies of quiescent adult cadiomyocytes in culture has been the decline in contractile properties of the cells over time. Regular contracting cardiomyocyte cultures may represent a more physiological model. The aim of the present study was to investigate the mechanical properties and c...

journal_title：Basic research in cardiology

authors： Holt E,Lunde PK,Sejersted OM,Christensen G

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:The clinical usefulness of class III antiarrhythmic drugs for the treatment of tachyarrhythmias is limited by their potential proarrhythmic effects, mainly torsades-depointes (TdP). The goal of this experimental study was to develop an isolated whole-heart model exhibiting typical characteristics of class III...

journal_title：Basic research in cardiology

authors： Johna R,Mertens H,Haverkamp W,Eckardt L,Niederbröker T,Borggrefe M,Breithardt G

更新日期：1998-04-01 00:00:00

abstract：:Pressure-overloaded cardiac hypertrophy was induced by abdominal aortic constriction in 10-week-old male Wistar rats. 24-26 weeks after aortic constriction, the hearts were excised and a myocardial mechanical study was performed using isolated left ventricular papillary muscles. There was no significant difference in ...

journal_title：Basic research in cardiology

authors： Takeda N,Ohkubo T,Nakamura I,Suzuki H,Nagano M

更新日期：1987-07-01 00:00:00

abstract：:The role of miR-92a on vascular remodelling after injury is currently unknown. Thus, the aim of the present study was to evaluate the role of miR-92a on rat endothelial and vascular smooth muscle cells proliferation and migration in vitro as well as after balloon injury or arterial stenting in vivo. MiR-92a was highly...

journal_title：Basic research in cardiology

authors： Iaconetti C,Polimeni A,Sorrentino S,Sabatino J,Pironti G,Esposito G,Curcio A,Indolfi C

更新日期：2012-09-01 00:00:00

abstract：:Total cholesterol, phospholipids, and triglycerides in serum were studied during myocardial infarction in a patient group treated with glucose, insulin and potassium (GIK), and a conventionally treated group. There was no difference in the typical changes of cholesterol and phospholipids between the groups, but the GI...

journal_title：Basic research in cardiology

authors： Kirkeby OJ,Risöe C,Kirkeby K,Hjermann I

更新日期：1983-11-01 00:00:00

abstract：:Vasoconstrictory and vasodilatory hormone systems may be important in the regulation of peripheral vascular resistance and renal hemodynamics in the early phase of heart failure. The activity of the renin-angiotensin-aldosterone system (RAAS), the sympathetic nervous activity, and, as possible counterregulating system...

journal_title：Basic research in cardiology

authors： Holmer SR,Riegger AJ,Notheis WF,Kromer EP,Kochsiek K

更新日期：1987-03-01 00:00:00

abstract：:Hearts preconditioned by brief ischemia are characterized by a reduced rate of cellular purine metabolite production during subsequent prolonged ischemia; the purpose of this study was to determine if transient exogenous adenosine pretreatment can mimic this phenomenon. The accumulation of interstitial fluid (ISF) pur...

journal_title：Basic research in cardiology

authors： Manthei SA,Van Wylen DG

更新日期：1997-12-01 00:00:00

abstract：:A reproducible tourniquet-shock has been produced in hind limbs of dogs by unilateral and bilateral extremity ischemia. The following parameters have been measured for analysing the function of the cardiovascular system: mean aortic pressure, heart rate, cardiac output, intraventricular pressure and left ventricular p...

journal_title：Basic research in cardiology

authors： Stock W,Geppert E,Haase W,Isselhard W

更新日期：1976-03-01 00:00:00

abstract：:The success of therapies targeting myocardial reperfusion injury is limited, while the cardioprotective impact of mitigating ischemia-related damage remains less explored. We have recently shown in a pig model that the intravenous administration of a modified atorvastatin preparation during ischemia attenuates the ris...

journal_title：Basic research in cardiology

authors： Mendieta G,Ben-Aicha S,Casani L,Badimon L,Sabate M,Vilahur G

更新日期：2019-11-28 00:00:00

abstract：:To investigate the effect of nifedipine on hypercalcemic electrocardiographical alterations, steadily increasing hypercalcemia was induced in guinea-pigs by continuous calcium gluconate infusion until cardiac arrest occurred. During the experimental time the electrocardiograms were continuously recorded and compared i...

journal_title：Basic research in cardiology

authors： Schäfer W,Schäfer A,Schäfer H

更新日期：1982-01-01 00:00:00