Abstract：
:In the isometrically contracting rat trabecular muscle strip preparation, contracture tension was induced either by 10 min of hypoxia (low contracture tension) or by 30 min of joint oxygen and glucose withdrawal (severe contracture tension) at optimum length. Using stepwise 0.1 mm releases, length-tension relationships were recorded under control and contracture conditions in both types of contracture. Stress-strain relationships were evaluated as well as the linear function of the tangent elastic modulus delta sigma/delta epsilon versus stress sigma. The slope of the delta sigma/delta epsilon = f (sigma) function was not significantly changed in low contracture compared to control conditions (n = 8; p less than 0.001). When reversibility tests were performed by reoxygenation after 10 min hypoxia and reperfusion with oxygen and glucose after 30 min of glucose and oxygen withdrawal, low contracture tension was completely abolished after 15 min, whereas 28% of severe contracture was maintained even after 60 min of reperfusion. Additional morphological studies revealed uniform sarcomere lengths in low contracture, and two populations of sarcomere lengths in the severe contracture. On the basis of the present and earlier results, a model of contracture tension generation is proposed in which cross-bridges between actin and myosin cycle at a very low rate and are attached in a force-generating position for a long time.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Holubarsch C,Jacob Rdoi
10.1007/BF01908059subject
Has Abstractpub_date
1981-11-01 00:00:00pages
690-703issue
6eissn
0300-8428issn
1435-1803journal_volume
76pub_type
杂志文章abstract：:The hemodynamic and metabolic effects of acetate were studied in rats in vivo and in the isolated perfused heart. Hemodynamic parameters, myocardial phosphagens, inorganic phosphate, and adenosine were measured in vivo. Acetate uptake, coronary flow, O2 consumption, parameters of the cellular energy state, and hypoxan...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02005829
更新日期：1988-07-01 00:00:00
abstract：:Myocardial lipoprotein lipase (LPL) activity during ischaemia has not been fully understood, although it plays an important role in regulating myocardial fatty acid metabolism. In this experiment, the effects of ischaemia (Experiment A) and anoxia (Experiment B) on two distinct fractions of LPL, i.e. functional and no...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-08390-1_6
更新日期：1987-01-01 00:00:00
abstract：:Age-related changes in the myocardial energy metabolism were studied in spontaneously hypertensive (SHR) rats of 5-15 weeks of age. Systolic blood pressure increased rapidly during 5 to 10 weeks of age (developing phase) and attained a plateau level at 10 to 15 weeks (sustained phase). Even during the developing phase...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02005337
更新日期：1982-07-01 00:00:00
abstract：:A method is theoretically described to test the accuracy of various lead system of the ecg. The priniciple of this method consists in the following procedure. The heart position is changed maximally in a proband by varying the position of the body and by deep inspiration and exspiration. If the lead field is parallel,...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:Guinea-pig left atria were loaded with 10 microCi 7-[3H]noradrenaline, and noradrenaline release from sympathetic nerve endings was then elicited by refractory period field stimulation. When one pulse of 0.2 ms duration was applied during each refractory period, the resulting transmitter release was halved by 3 x 10(-...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788873
更新日期：1993-11-01 00:00:00
abstract：:Coronary artery disease (CAD), also known as ischemic heart disease (IHD), is the leading cause of mortality in the western world, with developing countries showing a similar trend. With the increased understanding of the role of the immune system and inflammation in coronary artery disease, it was shown that macropha...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-016-0554-5
更新日期：2016-07-01 00:00:00
abstract：:Alterations in myocardial membrane phospholipids may play an important role in the pathogenesis of ischaemic myocardial cell injury. Studies in canine myocardium, perfused rat heart, and cultured myocardial cells have demonstrated that the accumulation of free arachidonic acid correlates with the development of irreve...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-662-08390-1_15
更新日期：1987-01-01 00:00:00
abstract：:Atherosclerotic plaques impair vascular function and can lead to arterial obstruction and tissue ischaemia. Rupture of an atherosclerotic plaque within a coronary artery can result in an acute myocardial infarction, which is responsible for significant morbidity and mortality worldwide. Prompt reperfusion can salvage ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-020-00829-5
更新日期：2020-11-30 00:00:00
abstract：:Recent studies demonstrated that NADPH oxidase 2 (NOX2) expression in myocardium after ischemia-reperfusion (IR) is significantly upregulated. However, the underlying mechanisms remain unknown. This study aims to determine if nuclear cardiac myosin light chain 2 (MYL2), a well-known regulatory subunit of myosin, funct...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-015-0494-5
更新日期：2015-01-01 00:00:00
abstract：:Myocardial ischemia-reperfusion (I/R) injury leads to intensive sympathetic nervous system (SNS) activation and inflammatory reactions. Whether renal sympathetic denervation (RDN) could be a new therapeutic strategy to modulate I/R inflammation and reduce infarct size after myocardial I/R injury needs to be explored. ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-020-0776-4
更新日期：2020-01-13 00:00:00
abstract：:Dietary intake of unsaturated fatty acid of eicosapentaenoic acid (EPA) is thought to reduce the size and incidence of myocardial infarction. These beneficial effects are postulated to be due to chronic antithrombotic properties of EPA itself. We studied the possible direct effects of EPA on vascular smooth muscle as ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907066
更新日期：1987-03-01 00:00:00
abstract：:The effects of the dihydropyridine calcium antagonists, nifedipine, nitrendipine and FR 7534 on the transmural distribution of coronary blood flow (endo/epi) were compared to the structurally unrelated calcium antagonists, verapamil and diltiazem and to the non-calcium antagonist vasodilator drugs, chromonar and dipyr...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907211
更新日期：1983-11-01 00:00:00
abstract：:The concept of metabolic coronary flow control provides a rationale for the close relationship of coronary flow and myocardial metabolic rate of oxygen. The concept is based on the presence of an oxygen (metabolic) sensor coupled functionally to effector mechanisms, which control vascular tone. Four modes of metabolic...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-006-0621-4
更新日期：2006-11-01 00:00:00
abstract：:The developmental profiles of the protective mechanisms of heart against peroxidative injury during neonatal growth was examined in the pigs of three different age groups. Lipid peroxidation expressed in terms of malonaldehyde formation was considerably higher in the pig hearts of the 8-10 day age group compared to th...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907051
更新日期：1987-01-01 00:00:00
abstract：:The cardiac renin angiotensin system (RAS) is the target for number of therapeutic interventions which proved successful in heart failure. Angiotensin converting enzyme (ACE) inhibitors belong to the most efficient strategies available and angiotensin receptor (ATR) antagonists may be comparably effective. The direct ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950050207
更新日期：1998-01-01 00:00:00
abstract：OBJECTIVE:The clinical usefulness of class III antiarrhythmic drugs for the treatment of tachyarrhythmias is limited by their potential proarrhythmic effects, mainly torsades-depointes (TdP). The goal of this experimental study was to develop an isolated whole-heart model exhibiting typical characteristics of class III...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950050073
更新日期：1998-04-01 00:00:00
abstract：:We studied TTX-sensitive Na channels in dissociated single ventricular cells from neonatal rats using the patch clamp method for single channel and whole cell recording. In both cases, slowly inactivating or window currents were observed that decayed in a biexponential fashion. Customary models of Na current kinetics ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Atherosclerotic coronary arteries are more calcified in patients with than without chronic kidney disease (CKD). We addressed the potential for coronary microvascular obstruction in patients with and without CKD during stenting for saphenous vein aorto-coronary graft (SVG) stenosis under protection with a distal occlu...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-012-0303-3
更新日期：2012-11-01 00:00:00
abstract：:A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These cons...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02023598
更新日期：1977-07-01 00:00:00
abstract：:Increasing the frequency of steady state stimulation increases the rate of mechanical restitution in hypothermic (27 degrees C) guinea pig papillary muscles. In this paper we have investigated the influences of the calcium antagonist nifedipine and of reduced extracellular calcium concentration on this phenomenon. We ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00798259
更新日期：1993-03-01 00:00:00
abstract：:Beta-blockers have been shown to reduce the risk of coronary events and reduce the mortality of patients with hypertension and in those who have had a myocardial infarction. Furthermore, the evidence for long-term benefits in these two patient groups are much more convincing for beta-blockers than for other therapeuti...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950070006
更新日期：2000-01-01 00:00:00
abstract：:Experiments were performed to determine the relative contributions of direct Ca(2+)-entry through the L-type Ca(2+)-current and of Ca(2+)-release from the sarcoplasmic reticulum (s.r.) to the intracellular [Ca2+]i-transient in isolated human atrial and ventricular myocytes from patients with severe heart failure and f...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00794074
更新日期：1997-01-01 00:00:00
abstract：:MicroRNAs (miRNAs) are important regulators of adaptive and maladaptive responses in cardiovascular diseases and hence are considered to be potential therapeutical targets. However, their role as novel biomarkers for the diagnosis of cardiovascular diseases still needs to be systematically evaluated. We assessed here ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-010-0123-2
更新日期：2011-01-01 00:00:00
abstract：:We describe diastolic properties of the myocardium in terms of stress-strain relations. In a mathematical analysis, the equation sigma = alpha(e beta.epsilon-1) of the stress-strain curve can be changed by an increase in the exponent beta or the multiplicative constant alpha. It can be experimentally shown that in hyp...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11289-2_26
更新日期：1987-01-01 00:00:00
abstract：:Pentostatin (2-deoxycoformycin) is a potent inhibitor of adenosine deaminase and has been demonstrated to augment endogenous adenosine levels during regional and global myocardial ischemia. Based on the rationale that increasing endogenous adenosine during ischemia may be cardioprotective, the objective of this study ...
journal_title：Basic research in cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00789447
更新日期：1995-03-01 00:00:00
abstract：:In the not so distant past, the idea of using beta-blockers as a primary therapy for congestive heart failure to improve symptoms and prognosis seemed paradoxical. The cardiac community reacted with skepticism when, in 1975, the pioneering report of Waagstein et al. appeared in the British Heart Journal. Since then nu...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950070015
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Reopening of the infarct-related coronary artery is the treatment of choice in the clinical setting of acute myocardial infarction. Nevertheless the removal of the total occlusion obtained either by thrombolysis or by primary angioplasty is followed by the ischemia/reperfusion sequelae. One of many proposed ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950200049
更新日期：2002-09-01 00:00:00
abstract：:Parathyroid hormone-related peptide (PTHrP) was found to improve contractile function of stunned myocardium in pigs. The peptide is released from coronary endothelial cells during ischemia and significantly improves post-ischemic recovery. The present study was aimed to decide whether such an induction of contractile ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-005-0532-9
更新日期：2005-07-01 00:00:00
abstract：:The purpose of this study was to obtain more information about the role of the plasma membrane in cellular uptake of tracers used in myocardial scintigraphy (radioactive thallium chloride and palmitic acid). This knowledge is of importance for an adequate interpretation of the results obtained under clinical condition...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11041-6_12
更新日期：1985-01-01 00:00:00
abstract：:The sympathetic and parasympathetic nervous system play a powerful role in controlling cardiac function by activating adrenergic and muscarinic receptors. In the human heart there exist alpha1-, beta1- and beta2-adrenoceptors and M2-muscarinic receptors and possibly also (prejunctional) alpha2-adrenoceptors. Beta1- an...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950170003
更新日期：2001-11-01 00:00:00
