Abstract：
:The concept of metabolic coronary flow control provides a rationale for the close relationship of coronary flow and myocardial metabolic rate of oxygen. The concept is based on the presence of an oxygen (metabolic) sensor coupled functionally to effector mechanisms, which control vascular tone. Four modes of metabolic control models have been proposed. 1) An oxygen sensor located in the wall of coronary vessels coupling to smooth muscle tension. Endothelial prostaglandin production may support this concept. 2) An oxygen sensing mechanism located in the myocardium and changing metabolism in response to changes of local pO(2). Adenosine is a metabolite produced at an accelerated rate when the supply-to-demand relationship for oxygen falls. 3) Sensing of oxygen turnover may be achieved by carbon dioxide production and, potentially, by mitochondrial production of reactive oxygen species. 4) The red blood cell might serve as an oxygen sensor in response to changes of haemoglobin oxygenation. A potential link to vessel relaxation may be red cell ATP release. A large body of experimental evidence supports the notion that K(ATP) channels play a significant role causing smooth muscle hyper-polarization. However, additional yet unknown effector mechanisms must exist, because block of K(ATP) channels does not lead to deterioration of coronary flow control under conditions of exercise. Thus, although several lines of evidence show that metabolic flow regulation is effective during hypoxic conditions,mechanisms mediating normoxic metabolic flow control still await further clarification.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Deussen A,Brand M,Pexa A,Weichsel Jdoi
10.1007/s00395-006-0621-4subject
Has Abstractpub_date
2006-11-01 00:00:00pages
453-64issue
6eissn
0300-8428issn
1435-1803journal_volume
101pub_type
杂志文章,评审abstract：:Recent publications shown mitochondrial localization of the enzyme nitric oxide synthase (NOS) in a number of tissues. However, conflicting results about mitochondrial NOS (mtNOS) immunoreactivity and enzymatic activity are available to date in the literature. In this study we purified mitochondria from rat hearts and...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-003-0454-3
更新日期：2004-05-01 00:00:00
abstract：:Mesenchymal stromal cells (MSCs) exhibit antiapoptotic and proangiogenic functions in models of myocardial infarction which may be mediated by secreted small extracellular vesicles (sEVs). However, MSCs have frequently been harvested from aged or diseased patients, while the isolated sEVs often contain high levels of ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-020-0785-3
更新日期：2020-03-07 00:00:00
abstract：:Pentostatin (2-deoxycoformycin) is a potent inhibitor of adenosine deaminase and has been demonstrated to augment endogenous adenosine levels during regional and global myocardial ischemia. Based on the rationale that increasing endogenous adenosine during ischemia may be cardioprotective, the objective of this study ...
journal_title：Basic research in cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00789447
更新日期：1995-03-01 00:00:00
abstract：:We have recently gained evidence that segmental coronary microvascular diameters, and therefore resistances, are controlled by myogenic and endothelial responses to pressure and flow. Furthermore, intact heart studies are demonstrating that these mechanisms may interact importantly with the metabolic mechanisms primar...
journal_title：Basic research in cardiology
pub_type： 社论
doi：10.1007/BF00788525
更新日期：1993-01-01 00:00:00
abstract：:Two-weekly echocardiographic examinations were conducted in nine SHHF-Mc-fa(cp) rats in comparison with eight age-matched Wistar rats. In the SHHF-rats, characterized by progressive LV-dilation and decreasing contractile function between 77-87 weeks of age, left ventricular (LV) hypertrophy was most sensitively demons...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-003-0401-3
更新日期：2003-09-01 00:00:00
abstract：AIMS:A delayed myocardial protection extends between 24 and 96 h after ischemic preconditioning in animals. To test for this phenomenon in humans, subjects with stable angina were subjected to exercise test-induced myocardial ischemia and the effect of this "preconditioning" ischemic insult on the exercise-induced myoc...
journal_title：Basic research in cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s003950070042
更新日期：2000-10-01 00:00:00
abstract：:Both the severity and duration of postischemic myocardial dysfunction ("stunned" myocardium) are unpredictable and may vary considerably between subjects that underwent apparently similar ischemic insults. To explain this heterogeneous response of the heart to ischemia and reperfusion, we investigated the determinants...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00799686
更新日期：1996-03-01 00:00:00
abstract：:A new experimental in-vitro model is described, which was used for studying prostacyclin (PGI2)-thromboxane A2 (TXA2)-interactions. Langendorff hearts of guinea pigs are perfused at constant volume with Krebs-Henseleit buffer and washed human platelets (4 x 10(8)/min). PGI2 and TXA2 release are measured by bioassay. T...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908344
更新日期：1981-09-01 00:00:00
abstract：:Long QT syndrome is a potentially life-threatening disease characterized by delayed repolarization of cardiomyocytes, QT interval prolongation in the electrocardiogram, and a high risk for sudden cardiac death caused by ventricular arrhythmia. The genetic type 3 of this syndrome (LQT3) is caused by gain-of-function mu...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-016-0530-0
更新日期：2016-03-01 00:00:00
abstract：:The PKC hypothesis and its variants are attractive but unproved. The chief difficulty is the lack of an objective means to assess whether or not PKC has been activated in hearts preconditioned in vivo with ischemia or in hearts preconditioned by pharmacologic means. The strongest evidence is supporting the PKC hypothe...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00797206
更新日期：1997-01-01 00:00:00
abstract：:The present study was designed to test the hypothesis that in hypertrophied myocardium of patients with hypertrophic obstructive cardiomyopathy (HOCM) a reduced contractile reserve provided by frequency dependent potentiation of force of contraction contributes to the myocardial dysfunction. Myectomy was performed in ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950050134
更新日期：1999-04-01 00:00:00
abstract：:Complete length-tension diagrams of myocardium were measured on isolated papillary muscles of cat right ventricle. These diagrams clearly demonstrate that irrespective of loading conditions there is no uniform maxima curve. As a function of preload the curves of afterloaded isotonic maxima obey totally separate nonlin...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907862
更新日期：1985-11-01 00:00:00
abstract：:The influence of cardiac cholinergic activation was studied in rats and cats on the induction and maintenance of ventricular fibrillation (VF). Acetylcholine (ACH 2-25 micrograms/kg), in doses which did not cause bradycardia or hypotension, induced appearance of spontaneous VF (duration 2-60 sec.) in 9/20 rats which h...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908386
更新日期：1984-11-01 00:00:00
abstract：:Acute ischemia is a well-known inductor of extracellular matrix (ECM) remodeling, which leads to the development of congestive heart failure and is associated with left ventricular dilatation. Here we investigate the timecourse of ECM processing with release of endostatin (ES) and other low-molecular-weight fragments ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-009-0013-7
更新日期：2009-09-01 00:00:00
abstract：:1,2-Diacylglycerol (DAG) has been considered to play an important role as an activator of protein kinase C in the signal transduction of inositol phospholipid metabolism. To examine the relation of 1,2-DAG in heart tissues to cardiac hypertrophy associated with hypertension, we measured the amount of 1,2-DAG in sponta...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01931491
更新日期：1990-09-01 00:00:00
abstract：:The effect of 0.1 mg/kg Verapamil on the extent of the ischemic area following ligation of a branch of the left descending coronary artery was studied in anesthetized open chest dogs. The sum of the ST-segment elevation during the entire period of occlusion in the epicardial ECG was 15 mV in control infarction compare...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01905620
更新日期：1975-03-01 00:00:00
abstract：:Verapamil, at a dose of 1 mg/kg, was given intravenously to anesthetized cats one hour after coronary artery occlusion. Verapamil significantly reduced mean arterial blood pressure, but produced an increase in heart rate, partially offsetting the reduction in myocardial oxygen demand resulting from the reduction in pr...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907648
更新日期：1979-09-01 00:00:00
abstract：:The influence of perfusion pressure (5-8 kPa) on coronary flow and myocardial Ca2+-washout during Ca2+-free perfusion, and on the occurrence of calcium paradox after subsequent Ca2+-reperfusion, was studied in isolated, stimulated, rat heart ventricles. During the Ca2+-free perfusion period (3 min) the following chang...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907580
更新日期：1980-03-01 00:00:00
abstract：:Increase of Ca2+ concentration to 7.5 mM in the presence of 10 mM or 20 mM caffeine shifted length-tension relationships of 5 rat trabecular muscles and 5 cat papillary muscles to higher tensions. At 1max diastolic tension was enhanced from (formula: see text), for all measured points of stress-strain relationships af...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906525
更新日期：1978-09-01 00:00:00
abstract：:In open-chest pigs during severe myocardial ischemia [K+]e, [Ca2+]e and [H+]e increase, [Na+]e increases transiently reaching control values after 30 min. Extracellular osmolality of the ischemic area increases due to an H2O-shift from the ECS to the ICS. The increase of [Na+]e and [Ca2+]e must b explained by the shri...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908341
更新日期：1981-07-01 00:00:00
abstract：:An adult rat heart myocyte preparation was used to study the uptake and metabolism of the 1-14C-labelled fatty acids decanoate, laurate, myristate, and palmitate. Metabolism was saturable, but free fatty acid accumulation was not. Use of metabolic inhibitors indicated that metabolism and not uptake was rate limiting a...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:This study was designed to evaluate whether the decreased early survival rate of diabetic rats submitted to acute experimental myocardial infarction can be improved by pretreatment with lidocaine. Male Wistar rats (+/- 210 g) were rendered diabetic with i.v. injection of streptozotocin (50 mg/kg), and only those prese...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907132
更新日期：1990-07-01 00:00:00
abstract：:A rapid change in length of cat papillary muscle induces two reciprocal diastolic and systolic processes: stretching causes a viscoelastic relaxation of the muscle. The opposite behavior is observed after abrupt releases when - subsequent to an increase in resting tension - diastolic force attains its new equilibrium....
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01910780
更新日期：1976-07-01 00:00:00
abstract：:An orifice equation for the non-invasive measurement of mitral-valve area is demonstrated. It is shown that by combining this expression with the assumption of mitral-valve area invariance an orifice equation for the non-invasive assessment of cardiac output in conditions of mitral stenosis using simple echographicall...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01923191
更新日期：1983-01-01 00:00:00
abstract：:We tested the hypothesis that in isolated cardiac myocytes, the negative functional effects of cyclic GMP would be blunted when the level of cyclic AMP was increased and that this interaction would be altered in renal hypertensive (One-Kidney-One-Clip, 1K1C) cardiac hypertrophic rabbits. Using isolated control and 1K1...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950170075
更新日期：2001-02-01 00:00:00
abstract：:Elucidation of the subcellular mechanism of myocardial ischemic preconditioning should be facilitated by precise knowledge of the biology of the cardioprotective response. Any proposed molecular mechanism for preconditioning must be initiated during the required ischemic stress period. The studies reported in this pap...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00805571
更新日期：1997-04-01 00:00:00
abstract：:The developmental profiles of the protective mechanisms of heart against peroxidative injury during neonatal growth was examined in the pigs of three different age groups. Lipid peroxidation expressed in terms of malonaldehyde formation was considerably higher in the pig hearts of the 8-10 day age group compared to th...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907051
更新日期：1987-01-01 00:00:00
abstract：:A rat Langendorff heart preparation, perfused at constant pressure, was used to evaluate the role of K(ATP) channels in respiratory acidosis-induced coronary hyperemia. Prior administration of glibenclamide, an inhibitor of K(ATP) channels, reduced basal flow rates and eliminated the hyperemia associated with hypercap...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950050169
更新日期：2000-04-01 00:00:00
abstract：:Cardiac mass, cell size and capillary supply were studied in the hearts of spontaneously hypertensive rats (SHR) and compared to genetically similar non-hypertensive Wistar-Kyoto (WKY) of three adult ages: 5, 15 and 23 months. The left ventricular weight of SHR was not significantly greater than that of WKY at 5 month...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908138
更新日期：1984-07-01 00:00:00
abstract：:Alterations in myocardial membrane phospholipids may play an important role in the pathogenesis of ischaemic myocardial cell injury. Studies in canine myocardium, perfused rat heart, and cultured myocardial cells have demonstrated that the accumulation of free arachidonic acid correlates with the development of irreve...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-662-08390-1_15
更新日期：1987-01-01 00:00:00
