Ischemic event characteristics determine the extent of myocardial stunning in conscious dogs.

abstract：:During long-term treatment with amiodarone, slowing of conduction through the atrioventricular node, a prolongation of the QT-interval, and a prolongation of the atrial and ventricular myocardial refractoriness always developed. During short-term treatment, these effects were not found, except for depression of the AV...

journal_title：Basic research in cardiology

authors： Stark G,Stark U,Windisch M,Vicenzi M,Eggenreich U,Nagl S,Kral K,Pilger E,Tritthart HA

更新日期：1991-03-01 00:00:00

abstract：:Ex vivo multicellular preparations are essential tools to study tissue physiology. Among them, the recent methodological and technological developments in living myocardial slices (LMS) are attracting increasing interest by the cardiac research field. Despite this, this research model remains poorly perceived and util...

journal_title：Basic research in cardiology

authors： Watson SA,Dendorfer A,Thum T,Perbellini F

更新日期：2020-09-10 00:00:00

abstract：:In the human heart several isoforms of the sodium pump (Na,K-ATPase, the cardiac glycoside receptor) are expressed (alpha1beta1, alpha2beta1, and alpha3beta1). Their expression is regulated in a highly specific manner, so that there are region specific differences in the expression pattern. The isoform expression patt...

journal_title：Basic research in cardiology

authors： Müller-Ehmsen J,McDonough AA,Farley RA,Schwinger RH

更新日期：2002-01-01 00:00:00

abstract：:Intermittent, normobaric hypoxia confers robust cardioprotection against ischemia-induced myocardial infarction and lethal ventricular arrhythmias. δ-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) have been implicated in cardioprotective phenomena, but their roles in intermittent hypoxia are unknown...

journal_title：Basic research in cardiology

authors： Estrada JA,Williams AG Jr,Sun J,Gonzalez L,Downey HF,Caffrey JL,Mallet RT

更新日期：2016-03-01 00:00:00

abstract：:Because of the close anatomical association between the ventricles, the volume of one ventricle can directly affect the volume and pressure within the other ventricle. To study the mechanical coupling between the ventricles, we modeled the right and left ventricles as a two-compartment model with right wall (Crw), sep...

journal_title：Basic research in cardiology

authors： Santamore WP,Shaffer T,Hughes D

更新日期：1986-09-01 00:00:00

abstract：:Age-related changes in the myocardial energy metabolism were studied in spontaneously hypertensive (SHR) rats of 5-15 weeks of age. Systolic blood pressure increased rapidly during 5 to 10 weeks of age (developing phase) and attained a plateau level at 10 to 15 weeks (sustained phase). Even during the developing phase...

journal_title：Basic research in cardiology

authors： Shimamoto N,Goto N,Tanabe M,Imamoto T,Fujiwara S,Hirata M

更新日期：1982-07-01 00:00:00

abstract：:Exercise training is a well-known non-pharmacological strategy for the prevention and treatment of cardiovascular diseases. Despite the established phenotypic knowledge, the molecular signature of exercise-induced cardiac remodeling remains poorly characterized. The great majority of studies dedicated to this topic us...

journal_title：Basic research in cardiology

authors： Ferreira R,Moreira-Gonçalves D,Azevedo AL,Duarte JA,Amado F,Vitorino R

更新日期：2015-01-01 00:00:00

abstract：:Ventricular remodeling following nonfatal myocardial infarction includes an excentric hypertrophy of the surviving myocardium, associated with hemodynamic overload. Disseminated cardiomyocyte apoptosis and phenotype changes of the surviving myocardium, such as a labile calcium homeostasis of the hypertrophied cardiomy...

journal_title：Basic research in cardiology

authors： Holtz J

更新日期：1998-01-01 00:00:00

abstract：:Guinea-pig left atria were loaded with 10 microCi 7-[3H]noradrenaline, and noradrenaline release from sympathetic nerve endings was then elicited by refractory period field stimulation. When one pulse of 0.2 ms duration was applied during each refractory period, the resulting transmitter release was halved by 3 x 10(-...

journal_title：Basic research in cardiology

authors： Brasch H

更新日期：1993-11-01 00:00:00

abstract：:Dietary intake of unsaturated fatty acid of eicosapentaenoic acid (EPA) is thought to reduce the size and incidence of myocardial infarction. These beneficial effects are postulated to be due to chronic antithrombotic properties of EPA itself. We studied the possible direct effects of EPA on vascular smooth muscle as ...

journal_title：Basic research in cardiology

authors： Yanagisawa A,Lefer AM

更新日期：1987-03-01 00:00:00

abstract：:We tested the hypothesis that in isolated cardiac myocytes, the negative functional effects of cyclic GMP would be blunted when the level of cyclic AMP was increased and that this interaction would be altered in renal hypertensive (One-Kidney-One-Clip, 1K1C) cardiac hypertrophic rabbits. Using isolated control and 1K1...

journal_title：Basic research in cardiology

authors： Patel KN,Yan L,Gandhi A,Scholz PM,Weiss HR

更新日期：2001-02-01 00:00:00

abstract：:Cardiac physiology and hypertrophy are regulated by the phosphorylation status of many proteins, which is partly controlled by a poorly defined type 2A protein phosphatase-alpha4 intracellular signalling axis. Quantitative PCR analysis revealed that mRNA levels of the type 2A catalytic subunits were differentially exp...

journal_title：Basic research in cardiology

authors： Eleftheriadou O,Boguslavskyi A,Longman MR,Cowan J,Francois A,Heads RJ,Wadzinski BE,Ryan A,Shattock MJ,Snabaitis AK

更新日期：2017-07-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a leading cause of heart failure and sudden death in adolescents and young adults. Recently, the role of the Hippo/YAP pathway has been investigated in the pathogenesis of HCM, although the detailed molecular mechanisms largely remain elusive. In this study, we demonstrated an up-r...

journal_title：Basic research in cardiology

authors： Wang P,Mao B,Luo W,Wei B,Jiang W,Liu D,Song L,Ji G,Yang Z,Lai YQ,Yuan Z

更新日期：2014-01-01 00:00:00

abstract：:Ca2+ overload followed by after-contractions was induced by perfusion of mammalian papillary muscles with O-K0+, high Ca2+ solution. The effect of lipotrophic agents (dexamethasone, indomethacin) or free radical scavengers (alpha-tocopherol, reduced glutathione, synthetic antioxidant) was tested at different stages of...

journal_title：Basic research in cardiology

authors： Saxon ME

更新日期：1985-07-01 00:00:00

abstract：:Delta-opioid receptors are known to participate in the protection found following ischemic preconditioning (IPC), but the role of kappa-receptors in IPC is currently controversial. Langendorff-perfused rat hearts received 35 min regional ischemia and 2 h reperfusion. PC (2 cycles 5 min global ischemia) substantially r...

journal_title：Basic research in cardiology

authors： Aitchison KA,Baxter GF,Awan MM,Smith RM,Yellon DM,Opie LH

更新日期：2000-02-01 00:00:00

abstract：:Urapidil (URA) is used to treat acute hypertension in patients with coronary artery disease, but the effect of URA on the performance of ischemic myocardium has not yet been investigated. The present study was intended to assess the function of ischemic myocardium following URA administration. In eight anesthetized (p...

journal_title：Basic research in cardiology

authors： Schad H,Heimisch W,Barankay A,Hesse S,Mendler N

更新日期：1990-05-01 00:00:00

abstract：:In the human ventricle two isoforms of the phosphorylatable myosin light chain (MPLC) are expressed. These two forms are designated with increasing acidity as LC-2 and LC-2*. In the normal human heart the relation between LC-2/LC-2*-expression is 70/30, suggesting the existence of three different myosin isoenzymes (MP...

journal_title：Basic research in cardiology

authors： Morano I

更新日期：1992-01-01 00:00:00

abstract：:An orifice equation for the non-invasive measurement of mitral-valve area is demonstrated. It is shown that by combining this expression with the assumption of mitral-valve area invariance an orifice equation for the non-invasive assessment of cardiac output in conditions of mitral stenosis using simple echographicall...

journal_title：Basic research in cardiology

authors： Seitz WS,Spiel MS,Operschall J,Pachinger O,Klicpera M

更新日期：1983-01-01 00:00:00

abstract：:Myocardial lipoprotein lipase (LPL) activity during ischaemia has not been fully understood, although it plays an important role in regulating myocardial fatty acid metabolism. In this experiment, the effects of ischaemia (Experiment A) and anoxia (Experiment B) on two distinct fractions of LPL, i.e. functional and no...

journal_title：Basic research in cardiology

authors： Mochizuki S,Murase T,Yamaoka H,Ishiki M,Tada N,Nagano M

更新日期：1987-01-01 00:00:00

abstract：AIMS:There is a need for better identification of patients at high risk for malignant arrhythmias who would benefit from implantable cardioverter defibrillators (ICD). The purpose of this study was to assess whether the C825T polymorphism in the G-protein beta3 subunit gene, GNB3, might serve as a genetic marker for re...

journal_title：Basic research in cardiology

authors： Wieneke H,Naber CN,Piaszek L,Sack S,Frey UH,Heusch G,Erbel R,Siffert W

更新日期：2006-09-01 00:00:00

abstract：:Hypertension and resulting left ventricular hypertrophy was induced in young male Wistar rats (60 to 70 days old) by narrowing of one renal artery (Goldblatt II). 8 and 24 weeks after operation, myocardial oxygen consumption was measured on a modified in situ heart-lung preparation with nearly isovolumetric left ventr...

journal_title：Basic research in cardiology

authors： Kissling G,Rupp H,Malloy L,Jacob R

更新日期：1982-05-01 00:00:00

abstract：:In open-chest pigs during severe myocardial ischemia [K+]e, [Ca2+]e and [H+]e increase, [Na+]e increases transiently reaching control values after 30 min. Extracellular osmolality of the ischemic area increases due to an H2O-shift from the ECS to the ICS. The increase of [Na+]e and [Ca2+]e must b explained by the shri...

journal_title：Basic research in cardiology

authors： Friedrich R,Hirche H,Kebbel U,Zylka V,Bissig R

更新日期：1981-07-01 00:00:00

abstract：:Conflicting data on the inotropic effect of insulin are present in the literature suggesting a positive inotropic property or no inotropic effect or even a negative influence. To clarify the reason for these diverging findings, dose-response curves of insulin have been performed in isolated working rat and guinea pig ...

journal_title：Basic research in cardiology

authors： Schmidt HD,Koch M

更新日期：2002-07-01 00:00:00

abstract：:Since the discovery of a novel mechanism of cell death that differs from traditional necrosis, i.e., apoptosis, there have been numerous studies concluding that increased apoptosis augments myocardial infarction and heart failure and that limiting apoptosis protects the heart. Importantly, the vast majority of cells i...

journal_title：Basic research in cardiology

authors： Jose Corbalan J,Vatner DE,Vatner SF

更新日期：2016-05-01 00:00:00

abstract：:Sprouty1 (Spry1) is a negative modulator of receptor tyrosine kinase signaling, but its role in cardiomyocyte survival has not been elucidated. The aim of this study was to investigate the potential role of cardiomyocyte Spry1 in cardiac ischemia-reperfusion (I/R) injury. Infarct areas of mouse hearts showed an increa...

journal_title：Basic research in cardiology

authors： Alakoski T,Ulvila J,Yrjölä R,Vainio L,Magga J,Szabo Z,Licht JD,Kerkelä R

更新日期：2019-01-11 00:00:00

abstract：:N,N-dimethylsphingosine (DMS) has been documented to be in vitro protective against myocardial ischemia-reperfusion injury (IRI) and can recruit CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), which may participate in the cardioprotection. We hypothesized that when in vivo applied after a myocardial ischemia, DMS ma...

journal_title：Basic research in cardiology

authors： Fang J,Hu F,Ke D,Yan Y,Liao Z,Yuan X,Wu L,Jiang Q,Chen L

更新日期：2016-05-01 00:00:00

abstract：:Disregarding the influence of thickness on elevated strength of isolated preparations inevitably leads to erroneous tension-frequency relations, especially in the range of high frequencies. Thus, much of the confusion in interpreting the atypical negative staircase phenomenon of the rat heart is due to this. In view o...

journal_title：Basic research in cardiology

authors： Gülch RW,Ebrecht G

更新日期：1987-01-01 00:00:00

abstract：:In order to clarify the genesis of the characteristic pressure and flow pulse contours of the common carotid artery of man, at first transcutaneous pulse recordings were carried out on healthy resting subjects during breathing of room air and of a mixture of 95% O2 and 5% CO2 (Carbogen). The latter was used to cause v...

journal_title：Basic research in cardiology

authors： Busse R,Bauer RD,Schabert A,Summa Y,Zinecker U,Wetterer E

更新日期：1977-11-01 00:00:00

abstract：:Heat shock protein 70 (Hsp70) has been shown to have an anti-apoptotic function, but its mechanism is not clear in heart. In this study, we examined the effect of Hsp70 deletion on AIF-induced apoptosis during ischemia/reperfusion (I/R) in vivo. Although Hsp70 KO and WT mice demonstrated similar amounts of AIF release...

journal_title：Basic research in cardiology

authors： Choudhury S,Bae S,Ke Q,Lee JY,Kim J,Kang PM

更新日期：2011-05-01 00:00:00

abstract：:Increased activity of the sympathetic system is an important feature contributing to the pathogenesis and progression of chronic heart failure. While the mechanisms and consequences of enhanced norepinephrine release from sympathetic nerves have been intensely studied, the role of the adrenal gland in the development ...

journal_title：Basic research in cardiology

authors： Schneider J,Lother A,Hein L,Gilsbach R

更新日期：2011-06-01 00:00:00