The platelet-perfused in-vitro heart: an alternative model for studying the role of endogenous prostacyclin and thromboxane in control of coronary perfusion.

abstract：:Hypertension and resulting left ventricular hypertrophy was induced in young male Wistar rats (60 to 70 days old) by narrowing of one renal artery (Goldblatt II). 8 and 24 weeks after operation, myocardial oxygen consumption was measured on a modified in situ heart-lung preparation with nearly isovolumetric left ventr...

journal_title：Basic research in cardiology

authors： Kissling G,Rupp H,Malloy L,Jacob R

更新日期：1982-05-01 00:00:00

abstract：:Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing ...

journal_title：Basic research in cardiology

authors： Vanhoutte L,Gerber BL,Gallez B,Po C,Magat J,Balligand JL,Feron O,Moniotte S

更新日期：2016-07-01 00:00:00

abstract：:The aim of this study was to investigate the mechanism of beta-adrenergic preconditioning (BPC). The roles of adenosine and its receptor subtypes, the generation of oxygen free radicals (ROS) and activation of the K(ATP) channels as well as the phosphoinositide-3-kinase (PI(3)K)/PKB/Akt and extracellular signal-regula...

journal_title：Basic research in cardiology

authors： Salie R,Moolman JA,Lochner A

更新日期：2012-09-01 00:00:00

abstract：:In the control perfused working rat hearts subjected to 25 min global ischemia, reperfusion resulted in a 50% recovery of the hemodynamic functions. A concentration-dependent improvement of this recovery and a reduction of the postischemic lactate dehydrogenase (LDH) release was caused by calmidazolium (CMZ), trifluop...

journal_title：Basic research in cardiology

authors： Beresewicz A

更新日期：1989-11-01 00:00:00

abstract：:Increasing the frequency of steady state stimulation increases the rate of mechanical restitution in hypothermic (27 degrees C) guinea pig papillary muscles. In this paper we have investigated the influences of the calcium antagonist nifedipine and of reduced extracellular calcium concentration on this phenomenon. We ...

journal_title：Basic research in cardiology

authors： Spencer CI,Mörner SE,Noble MI,Seed WA

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVES:The impact of acute collagen disruption by the disulfide donor, 5,5'-dithio-2-nitrobenzoic acid (DTNB) on ventricular properties was tested in rat hearts. METHODS:Collagen was degraded acutely in 13 isolated, isovolumically contracting rat hearts by perfusion with 1 mM DTNB added to Krebs-Henseleit solution...

journal_title：Basic research in cardiology

authors： Todaka K,Jiang T,Chapman JT,Gu A,Zhu SM,Herzog E,Hochman JS,Steinberg SF,Burkhoff D

更新日期：1997-06-01 00:00:00

abstract：:The developmental profiles of the protective mechanisms of heart against peroxidative injury during neonatal growth was examined in the pigs of three different age groups. Lipid peroxidation expressed in terms of malonaldehyde formation was considerably higher in the pig hearts of the 8-10 day age group compared to th...

journal_title：Basic research in cardiology

authors： Das DK,Engelman RM,Flansaas D,Otani H,Rousou J,Breyer RH

更新日期：1987-01-01 00:00:00

abstract：:Ceramide has been shown to be a key signaling molecule involved in the apoptotic effect of tumor necrosis factor alpha (TNF-alpha) and other cytokines. Given the importance of cytokines such as TNF-alpha in myocardial ischemia-reperfusion injury, we hypothesize that ceramide is increased during ischemia or reperfusion...

journal_title：Basic research in cardiology

authors： Zhang DX,Fryer RM,Hsu AK,Zou AP,Gross GJ,Campbell WB,Li PL

更新日期：2001-05-01 00:00:00

abstract：:Both the severity and duration of postischemic myocardial dysfunction ("stunned" myocardium) are unpredictable and may vary considerably between subjects that underwent apparently similar ischemic insults. To explain this heterogeneous response of the heart to ischemia and reperfusion, we investigated the determinants...

journal_title：Basic research in cardiology

authors： Wouters PF,Van de Velde M,Van Aken H,Flameng W

更新日期：1996-03-01 00:00:00

abstract：:Elucidation of the subcellular mechanism of myocardial ischemic preconditioning should be facilitated by precise knowledge of the biology of the cardioprotective response. Any proposed molecular mechanism for preconditioning must be initiated during the required ischemic stress period. The studies reported in this pap...

journal_title：Basic research in cardiology

authors： Schwartz LM,Jennings RB,Reimer KA

更新日期：1997-04-01 00:00:00

abstract：:In open-chest pigs during severe myocardial ischemia [K+]e, [Ca2+]e and [H+]e increase, [Na+]e increases transiently reaching control values after 30 min. Extracellular osmolality of the ischemic area increases due to an H2O-shift from the ECS to the ICS. The increase of [Na+]e and [Ca2+]e must b explained by the shri...

journal_title：Basic research in cardiology

authors： Friedrich R,Hirche H,Kebbel U,Zylka V,Bissig R

更新日期：1981-07-01 00:00:00

abstract：:Transient receptor potential melastatin-7 (TRPM7) channels have been recently reported in human atrial fibroblasts and are believed to mediate fibrogenesis in human atrial fibrillation. The present study investigates whether TRPM7 channels are expressed in human atrial myocytes using whole-cell patch voltage-clamp, RT...

journal_title：Basic research in cardiology

authors： Zhang YH,Sun HY,Chen KH,Du XL,Liu B,Cheng LC,Li X,Jin MW,Li GR

更新日期：2012-09-01 00:00:00

abstract：:The effects of increased perfusion pressure and epinephrine stimulation on the contractile parameters and glucose transport in the isolated perfused hearts of control and ketotic diabetic rats were studied. An increase in perfusion pressure from 60 mm Hg to 100 mm Hg resulted in increases in coronary flow and peak aor...

journal_title：Basic research in cardiology

authors： Murthy VK,Bauman MD,Shipp JC

更新日期：1983-05-01 00:00:00

abstract：:The purpose of this study was to determine if decreased heart function after hypoxia followed by reoxygenation (H-R) is associated with increased degradation of cardiac myosin light chain 1 (MLC1) by matrix metalloproteinase-2 (MMP-2), and to investigate the effects of the increased level of peroxynitrite in the heart...

journal_title：Basic research in cardiology

authors： Doroszko A,Polewicz D,Sawicka J,Richardson JS,Cheung PY,Sawicki G

更新日期：2009-11-01 00:00:00

abstract：:An orifice equation for the non-invasive measurement of mitral-valve area is demonstrated. It is shown that by combining this expression with the assumption of mitral-valve area invariance an orifice equation for the non-invasive assessment of cardiac output in conditions of mitral stenosis using simple echographicall...

journal_title：Basic research in cardiology

authors： Seitz WS,Spiel MS,Operschall J,Pachinger O,Klicpera M

更新日期：1983-01-01 00:00:00

abstract：:We tested the hypothesis that in isolated cardiac myocytes, the negative functional effects of cyclic GMP would be blunted when the level of cyclic AMP was increased and that this interaction would be altered in renal hypertensive (One-Kidney-One-Clip, 1K1C) cardiac hypertrophic rabbits. Using isolated control and 1K1...

journal_title：Basic research in cardiology

authors： Patel KN,Yan L,Gandhi A,Scholz PM,Weiss HR

更新日期：2001-02-01 00:00:00

abstract：:Recent publications shown mitochondrial localization of the enzyme nitric oxide synthase (NOS) in a number of tissues. However, conflicting results about mitochondrial NOS (mtNOS) immunoreactivity and enzymatic activity are available to date in the literature. In this study we purified mitochondria from rat hearts and...

journal_title：Basic research in cardiology

authors： Zanella B,Giordano E,Muscari C,Zini M,Guarnieri C

更新日期：2004-05-01 00:00:00

abstract：:We compared the effects of linagliptin (Lina, a DPP4 inhibitor) and GLP-1 receptor activation by exenatide followed by exendin-4 in an infusion pump (EX) on infarct size (IS), post-infarction activation of the inflammasome and remodeling in wild-type (WT) and db/db diabetic mice. Mice underwent 30 min ischemia followe...

journal_title：Basic research in cardiology

authors： Birnbaum Y,Tran D,Bajaj M,Ye Y

更新日期：2019-08-06 00:00:00

abstract：:Phospholamban is a regulatory phosphoprotein which modulates the active transport of Ca2+ by the cardiac sarcoplasmic reticular Ca(2+)-ATPase enzyme (SERCA2) into the lumen of the sarcoplasmic reticulum. Phospholamban, which is a reversible inhibitor of SERCA2, represses the enzyme's activity, and this inhibition is r...

journal_title：Basic research in cardiology

authors： Koss KL,Grupp IL,Kranias EG

更新日期：1997-01-01 00:00:00

abstract：:A computer model is presented for simulation of the spread of activation and repolarization in ventricular myocardium. The program calculating the activation sequence is based on an algorithm similar to Huygen's principle of constructing wavefronts. Physiological parameters of the heart, such as areas of early activat...

journal_title：Basic research in cardiology

authors： Wach P,Killmann R,Dienstl F,Eichtinger C

更新日期：1989-07-01 00:00:00

abstract：:The endothelin (ET) family of peptides have potent vascular, cardiac and renal actions which may be of pathophysiological importance in congestive heart failure (CHF). In vivo studies with selective and non-selective ET receptor antagonists are required to clarify the role of ET in the pathophysiology of CHF and deter...

journal_title：Basic research in cardiology

authors： Love MP,McMurray JJ

更新日期：1996-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are important regulators of adaptive and maladaptive responses in cardiovascular diseases and hence are considered to be potential therapeutical targets. However, their role as novel biomarkers for the diagnosis of cardiovascular diseases still needs to be systematically evaluated. We assessed here ...

journal_title：Basic research in cardiology

authors： Meder B,Keller A,Vogel B,Haas J,Sedaghat-Hamedani F,Kayvanpour E,Just S,Borries A,Rudloff J,Leidinger P,Meese E,Katus HA,Rottbauer W

更新日期：2011-01-01 00:00:00

abstract：:A method is theoretically described to test the accuracy of various lead system of the ecg. The priniciple of this method consists in the following procedure. The heart position is changed maximally in a proband by varying the position of the body and by deep inspiration and exspiration. If the lead field is parallel,...

journal_title：Basic research in cardiology

authors： Hiltmann WD,Schaefer H

更新日期：1975-01-01 00:00:00

abstract：:The aim of this study was to examine the effect of ischemic preconditioning on the releases of cardiac troponin T (TnT) during reperfusion in isolated rat hearts. Experiments were done on 22 rat hearts, which were perfused according to the method of Langendorff and were divided into the control group (n = 14) and the ...

journal_title：Basic research in cardiology

authors： Yamahara Y,Asayama J,Kobara M,Ohta B,Matsumoto T,Miyazaki H,Tatsumi T,Ishibashi K,Inoue M,Inoue D

更新日期：1994-05-01 00:00:00

abstract：:Apart from local heterogeneities of myocardial blood flow, the regulation of vascular tone is equally complex. Changes in vascular tone are essential for the adaptation of coronary blood flow to varying metabolic demands. The majority of coronary vascular resistance is found in the microcirculation, that is, in vessel...

journal_title：Basic research in cardiology

authors： Tiefenbacher CP,Chilian WM

更新日期：1998-12-01 00:00:00

abstract：:It was previously reported that inhibition of carnitine synthesis by 3-(2,2,2-trimethyl-hydrazinium) propionate (MET-88) restores left ventricular (LV) systolic and diastolic function in rats with myocardial infarction (MI). Preservation of the calcium uptake function of sarcoplasmic reticulum Ca2+-ATPase (SERCA2) is ...

journal_title：Basic research in cardiology

authors： Yonekura K,Eto Y,Yokoyama I,Matsumoto A,Sugiura S,Momomura S,Kirimoto T,Hayashi Y,Omata M,Aoyagi T

更新日期：2000-10-01 00:00:00

abstract：:The stroke volume at rest of 81 test subjects with no evident cardiac or circulatory dysfunction was determined by impedance cardiography and the measurements were repeated after 11 weeks. In order to attain comparable and reproducible conditions, 44 test subjects were chosen who showed heart rates at rest not higher ...

journal_title：Basic research in cardiology

authors： Stick C,Büchsel R

更新日期：1978-11-01 00:00:00

abstract：:Heart failure has been divided into several different forms depending on etiology, clinical course and pathophysiology of left ventricular (LV) dysfunction. Systolic and diastolic dysfunction are characterized by a reduced cardiac output with normal (= diastolic dysfunction) or depressed (= systolic dysfunction) LV pu...

journal_title：Basic research in cardiology

authors： Matter C,Nagel E,Stuber M,Boesiger P,Hess OM

更新日期：1996-01-01 00:00:00

abstract：:The concentration of fibroblast growth factor 23 (FGF23) rises progressively in renal failure (RF). High FGF23 concentrations have been consistently associated with adverse cardiovascular outcomes or death, in chronic kidney disease (CKD), heart failure or liver cirrhosis. We identified the mechanisms whereby high con...

journal_title：Basic research in cardiology

authors： Lindner M,Mehel H,David A,Leroy C,Burtin M,Friedlander G,Terzi F,Mika D,Fischmeister R,Prié D

更新日期：2020-07-22 00:00:00

abstract：:Colloidal iron staining, calcium binding and enzyme activities were studied in the isolated rat heart sarcolemma. Colloidal iron staining of the sarcolemma revealed a high density of negatively charged sites associated with the cell surface. This membrane fraction was found to have calcium binding activity at both low...

journal_title：Basic research in cardiology

authors： Matsukubo MP,Singal PK,Dhalla NS

更新日期：1981-01-01 00:00:00