Abstract：
:Phospholamban is a regulatory phosphoprotein which modulates the active transport of Ca2+ by the cardiac sarcoplasmic reticular Ca(2+)-ATPase enzyme (SERCA2) into the lumen of the sarcoplasmic reticulum. Phospholamban, which is a reversible inhibitor of SERCA2, represses the enzyme's activity, and this inhibition is relieved upon phosphorylation of phospholamban in response to beta-adrenergic stimulation. In this way, phospholamban is an important regulator of SERCA2-mediated myocardial relaxation during diastole. This report centers on the hypothesis that the relative levels of phospholamban: SERCA2 in cardiac muscle plays an important role in the muscle's overall contractility status. This hypothesis was tested by comparing the contractile parameters of: a) murine atrial and ventricular muscles, which differentially express phospholamban, and b) murine wild-type and phospholamban knock-out hearts. These comparisons revealed that atrial muscles, which have a 4.2-fold lower phospholamban: SERCA2 ratio than ventricular muscles, exhibited rates of force development and relaxation of tension, which were three-fold faster that these parameters for ventricular muscles. Similar comparisons were made via analyses of left-ventricular pressure development recorded for isolated, work-performing hearts from wild-type and phospholamban knock-out mice. In these studies, hearts from phospholamban knock-out mice, which were devoid of phospholamban, exhibited enhanced parameters of left-ventricular contractility in comparison to wild-type hearts. These results suggest that the relative phospholamban: SERCA2 ratio is critical in the regulation of myocardial contractility and alterations in this ratio may contribute to the functional deterioration observed during heart failure.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Koss KL,Grupp IL,Kranias EGdoi
10.1007/BF00794064subject
Has Abstractpub_date
1997-01-01 00:00:00pages
17-24eissn
0300-8428issn
1435-1803journal_volume
92 Suppl 1pub_type
杂志文章abstract：:During long-term treatment with amiodarone, slowing of conduction through the atrioventricular node, a prolongation of the QT-interval, and a prolongation of the atrial and ventricular myocardial refractoriness always developed. During short-term treatment, these effects were not found, except for depression of the AV...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02190546
更新日期：1991-03-01 00:00:00
abstract：AIMS:Atrial fibrillation (AF) shortens the atrial action potential and the atrial refractory period. These changes promote persistence of AF. Pharmacological prolongation of atrial action potential duration (APD) may therefore help to prevent recurrent AF. In addition to prolonging APD, sodium channel blockers may prev...
journal_title：Basic research in cardiology
pub_type： 杂志文章,随机对照试验
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更新日期：2005-03-01 00:00:00
abstract：:To understand the effect of transcription regulation in modulating cardiac aging, we sought to study the role of serum response factor (SRF), a key transcription factor in the heart that is normally increased with senescence and also in congestive heart failure. A Tet-Off gene expression system was used for cardiac-sp...
journal_title：Basic research in cardiology
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doi：10.1007/s00395-006-0634-z
更新日期：2007-05-01 00:00:00
abstract：:A study of substrate selection in the isolated heart was made using 13C NMR isotopomer analysis, a method that unequivocally identifies relative substrate utilization. This technique has several advantages over conventional approaches used to study this problem. It detects the labeling of metabolic end-products presen...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788500
更新日期：1995-09-01 00:00:00
abstract：:Calcium transport functions of mitochondria and sarcoplasmic reticulum (SR) were studied without prior extraction using isolated rat heart myocytes permeabilized with saponin. Calcium uptake by SR was rapid and its affinity was high in comparison to calcium uptake by mitochondria, which had a higher capacity. The sens...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907975
更新日期：1989-05-01 00:00:00
abstract：:The hypothesis was tested that vardenafil, a PDE5 inhibitor, specifically enhances coronary vasodilation during acidosis. In isolated constant pressure perfused guinea pig hearts, infusion of vardenafil ( journal_title：Basic research in cardiology pub_type： 杂志文章 doi：10.1007/s00395-006-0630-3 更新日期：2007-03-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-015-0494-5
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907742
更新日期：1979-05-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01931495
更新日期：1990-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-006-0600-9
更新日期：2006-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906958
更新日期：1988-11-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-020-0813-3
更新日期：2020-08-07 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-006-0589-0
更新日期：2006-07-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-011-0232-6
更新日期：2012-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906959
更新日期：1988-11-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-020-00822-y
更新日期：2020-09-10 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907365
更新日期：1988-05-01 00:00:00
abstract：:A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These cons...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02023598
更新日期：1977-07-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-003-0454-3
更新日期：2004-05-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950050207
更新日期：1998-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01910409
更新日期：1977-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907051
更新日期：1987-01-01 00:00:00
abstract：:Rate or frequency-dependence is a characteristic property of antiarrhythmic drugs belonging to the Vaughan William classes I and III. The rate-dependence of class I drugs (i.e., increasing blockade of fast Na(+)-channels with faster rates) results from periodical drug binding to Na(+)-channel sites which are preferabl...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950050236
更新日期：1998-01-01 00:00:00
abstract：:Six dogs were subjected to an acute stenosis of the left anterior descending coronary artery. The mean aortic pressure was fixed with a windkessel and an occluder on four different levels. A significant decrease of coronary blood flow and poststenotic coronary pressure was closely related to the level of mean aortic ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906456
更新日期：1976-05-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-642-72477-0_5
更新日期：1992-01-01 00:00:00
abstract：:In the isometrically contracting rat trabecular muscle strip preparation, contracture tension was induced either by 10 min of hypoxia (low contracture tension) or by 30 min of joint oxygen and glucose withdrawal (severe contracture tension) at optimum length. Using stepwise 0.1 mm releases, length-tension relationship...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908059
更新日期：1981-11-01 00:00:00
abstract：:N,N-dimethylsphingosine (DMS) has been documented to be in vitro protective against myocardial ischemia-reperfusion injury (IRI) and can recruit CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), which may participate in the cardioprotection. We hypothesized that when in vivo applied after a myocardial ischemia, DMS ma...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-016-0548-3
更新日期：2016-05-01 00:00:00
abstract：:Exercise training is a well-known non-pharmacological strategy for the prevention and treatment of cardiovascular diseases. Despite the established phenotypic knowledge, the molecular signature of exercise-induced cardiac remodeling remains poorly characterized. The great majority of studies dedicated to this topic us...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-014-0454-5
更新日期：2015-01-01 00:00:00
abstract：:Vasoconstrictory and vasodilatory hormone systems may be important in the regulation of peripheral vascular resistance and renal hemodynamics in the early phase of heart failure. The activity of the renin-angiotensin-aldosterone system (RAAS), the sympathetic nervous activity, and, as possible counterregulating system...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907058
更新日期：1987-03-01 00:00:00
