Abstract：
:In the control perfused working rat hearts subjected to 25 min global ischemia, reperfusion resulted in a 50% recovery of the hemodynamic functions. A concentration-dependent improvement of this recovery and a reduction of the postischemic lactate dehydrogenase (LDH) release was caused by calmidazolium (CMZ), trifluoperazine (TFP), and chlorpromazine (CPZ) added prior to ischemia. The drugs were not effective when added only to the reperfusate. The concentrations of CMZ, TFP, and CPZ producing the half-maximal effects were 2.5 X 10(-9) M, 1.5 X 10(-7) M and 3 X 10(-7) M, respectively. Prolongation of the ischemic period caused a progressive deterioration of the functional recovery of the hearts while the total postischemic LDH release showed, at the same time, an initial gradual rise followed by a later decay. In untreated hearts the duration of ischemia resulting in 50% loss of hemodynamic function and in a maximal LDH release was 25 min. TFP (10(-6) M) and CMZ (10(-7) M) prolonged these times by 4-7 min and 5-10 min. respectively. TFP, CPZ, and CMZ protected the erythrocytes from osmotic hemolysis. The maximum anti-hemolytic activity was produced by 3 X 10(-6) M CMZ, 3 X 10(-5) M TFP, and 10(-4) CPZ. The concentration-dependency of this effect was not affected by low concentrations of sodium dodecyl sulphate (SDS). Neither TFP nor CMZ prevented the hemolysis produced by 10(-3) M SDS. It is concluded that the delay in the development of the ischemic injury produced by TFP and CMZ is due to the effects of these drugs as calmodulin antagonists rather than as membrane stabilizers.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Beresewicz Adoi
10.1007/BF01906948subject
Has Abstractpub_date
1989-11-01 00:00:00pages
631-45issue
6eissn
0300-8428issn
1435-1803journal_volume
84pub_type
杂志文章abstract：:Toxic peroxides result when oxygen radicals react with various peroxidic precursors in tissue or blood. A colorimetric method based on reactions of malondialdehyde (MDA), a key intermediate in the formation of peroxides, has been described in fresh tissues. The present report adapts this assay to measure MDA levels in...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01910480
更新日期：1984-09-01 00:00:00
abstract：:A method is theoretically described to test the accuracy of various lead system of the ecg. The priniciple of this method consists in the following procedure. The heart position is changed maximally in a proband by varying the position of the body and by deep inspiration and exspiration. If the lead field is parallel,...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1975-01-01 00:00:00
abstract：:In the not so distant past, the idea of using beta-blockers as a primary therapy for congestive heart failure to improve symptoms and prognosis seemed paradoxical. The cardiac community reacted with skepticism when, in 1975, the pioneering report of Waagstein et al. appeared in the British Heart Journal. Since then nu...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950070015
更新日期：2000-01-01 00:00:00
abstract：:Reperfusion following various intervals of coronary occlusion has produced conflicting results: increase in infarct size, especially with hemorrhage into the tissue, was reported as well as salvage of ischemic myocardium. To examine the problem and for the validation of our own method for infarct size measurement, whi...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907838
更新日期：1980-07-01 00:00:00
abstract：:Colloidal iron staining, calcium binding and enzyme activities were studied in the isolated rat heart sarcolemma. Colloidal iron staining of the sarcolemma revealed a high density of negatively charged sites associated with the cell surface. This membrane fraction was found to have calcium binding activity at both low...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908160
更新日期：1981-01-01 00:00:00
abstract：:We investigated whether atrial natriuretic peptide (ANP) given just prior to reperfusion reduces infarction in rabbit hearts and whether protection is related to activation of protein kinase G (PKG). Isolated rabbit hearts were subjected to a 30-min period of regional ischemia; treated hearts received a 20-min infusio...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-006-0587-2
更新日期：2006-07-01 00:00:00
abstract：:32 patients were studied by His-bundle recordings to examine the extent to which frequency and autonomic nervous system influence the conduction velocity in the subdivisions (atrium, AV-node, His-Purkinje system) of the normal PR-interval. The measurements were performed during sinus rhythm and three electrically indu...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1976-11-01 00:00:00
abstract：:Implicit in attempts to characterize and purify biologically active factors is the premise that the bioassay system employed will show a progressive increase in the response as the concentration of the responsible factor increases. We employed the hamster cheek pouch to assay the neovascularization potential of growth...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907406
更新日期：1986-05-01 00:00:00
abstract：:The antiarrhythmic effect of carbocromene (Intensain) was studied in 17 anaesthetized dogs. Ventricular tachycardia was induced by infusion of K-strophanthin (mean dose: 154 mug/kg i.v.). In 25 out of 26 experiments carbocromene (4 mg/kg i.v.) was effective. Ventricular tachycardia was converted to sinus rhythm in 16 ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01914339
更新日期：1975-07-01 00:00:00
abstract：:In the newborn several situations of hyperinsulinism can be associated with myocardial hypertrophy and increased contractility. Insulin and the insulin-like growth factors (IGF) are derived from a common ancestral molecule. Insulin exerts mainly metabolic action, whereas the IGFs promote cell multiplication and differ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906959
更新日期：1988-11-01 00:00:00
abstract：:From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationshi...
journal_title：Basic research in cardiology
pub_type： 社论
doi：10.1007/s00395-020-0791-5
更新日期：2020-04-09 00:00:00
abstract：:The effects of increased perfusion pressure and epinephrine stimulation on the contractile parameters and glucose transport in the isolated perfused hearts of control and ketotic diabetic rats were studied. An increase in perfusion pressure from 60 mm Hg to 100 mm Hg resulted in increases in coronary flow and peak aor...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907437
更新日期：1983-05-01 00:00:00
abstract：:In order to clarify the genesis of the characteristic pressure and flow pulse contours of the common carotid artery of man, at first transcutaneous pulse recordings were carried out on healthy resting subjects during breathing of room air and of a mixture of 95% O2 and 5% CO2 (Carbogen). The latter was used to cause v...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907041
更新日期：1977-11-01 00:00:00
abstract：:Regional glucose utilization of the developing fetal feline heart was assessed during three stages of gestation and compared with the maternal heart and non-pregnant controls. The specific aims were to determine: 1) if glucose utilization by the whole heart changes from early to late gestation; 2) if there are differe...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02191527
更新日期：1991-07-01 00:00:00
abstract：:Hemodynamics and myocardial contractility were evaluated in five unanesthetized calves during acute hypocapnic and isocapnic hypoxia and during acute hypocapnic hypoxia with beta-adrenergic blockade. Both hypocapnic and isocapnic hypoxia, with mean PaO2 levels of 33.1 and 39.1 mm Hg respectively, produced a decline in...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01909762
更新日期：1976-09-01 00:00:00
abstract：:Pressure-overloaded cardiac hypertrophy was induced by abdominal aortic constriction in 10-week-old male Wistar rats. 24-26 weeks after aortic constriction, the hearts were excised and a myocardial mechanical study was performed using isolated left ventricular papillary muscles. There was no significant difference in ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907024
更新日期：1987-07-01 00:00:00
abstract：:The article describes a method for monitoring the total energy output and oxygen uptake of isolated perfused rat hearts with working left ventricles. Twenty-two unpaced hearts (rates 4-4.5 bs-1) were separately investigated inside a flow micro-calorimeter (one minute for 90% thermal response) at 37 degrees C. They pum...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907920
更新日期：1985-09-01 00:00:00
abstract：:A reproducible tourniquet-shock has been produced in hind limbs of dogs by unilateral and bilateral extremity ischemia. The following parameters have been measured for analysing the function of the cardiovascular system: mean aortic pressure, heart rate, cardiac output, intraventricular pressure and left ventricular p...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01927866
更新日期：1976-03-01 00:00:00
abstract：:A model of vascular endothelial cell is proposed to describe the mechanisms by which cytosolic calcium (Cai) is modulated and endothelium-derived relaxing factor (EDRF) and prostacyclin (PGI2) are released when the cell is stimulated by agonist. The intracellular Ca2+ store of the model cell is comprised of a superfic...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00796518
更新日期：1992-07-01 00:00:00
abstract：:Sprouty1 (Spry1) is a negative modulator of receptor tyrosine kinase signaling, but its role in cardiomyocyte survival has not been elucidated. The aim of this study was to investigate the potential role of cardiomyocyte Spry1 in cardiac ischemia-reperfusion (I/R) injury. Infarct areas of mouse hearts showed an increa...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-018-0713-y
更新日期：2019-01-11 00:00:00
abstract：:Exercise training is a well-known non-pharmacological strategy for the prevention and treatment of cardiovascular diseases. Despite the established phenotypic knowledge, the molecular signature of exercise-induced cardiac remodeling remains poorly characterized. The great majority of studies dedicated to this topic us...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-014-0454-5
更新日期：2015-01-01 00:00:00
abstract：:A methodological approach based on Frank's pressure-volume (P-V) diagram and model calculations for analyzing the determinants of stroke volume (SV) under conditions of altered ventricular geometrical configuration is discussed with respect to the underlying geometrical models. The approach is generalized in the sense...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02190551
更新日期：1991-03-01 00:00:00
abstract：:In the human ventricle two isoforms of the phosphorylatable myosin light chain (MPLC) are expressed. These two forms are designated with increasing acidity as LC-2 and LC-2*. In the normal human heart the relation between LC-2/LC-2*-expression is 70/30, suggesting the existence of three different myosin isoenzymes (MP...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-642-72474-9_11
更新日期：1992-01-01 00:00:00
abstract：:Six dogs were subjected to an acute stenosis of the left anterior descending coronary artery. The mean aortic pressure was fixed with a windkessel and an occluder on four different levels. A significant decrease of coronary blood flow and poststenotic coronary pressure was closely related to the level of mean aortic ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906456
更新日期：1976-05-01 00:00:00
abstract：:This study was aimed to assess the relationship among the voltage-dependent processes underlying the excitation-contraction coupling, viz. force restitution (FR), transmembrane Ca fluxes and Ca release. The experiments (n = 22) were performed on voltage-clamped dog trabeculae in which force and slow inward current wer...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00795054
更新日期：1992-09-01 00:00:00
abstract：:The characterization of various ion transport systems has led to a better understanding of the effects, which seem to take part in the impairment of ischemic and reperfused cardiac tissue. This review discusses the role of the Na+/H+ exchange system in the pathophysiology of ischemia and reperfusion and the beneficial...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/BF00795411
更新日期：1993-09-01 00:00:00
abstract：:Rate or frequency-dependence is a characteristic property of antiarrhythmic drugs belonging to the Vaughan William classes I and III. The rate-dependence of class I drugs (i.e., increasing blockade of fast Na(+)-channels with faster rates) results from periodical drug binding to Na(+)-channel sites which are preferabl...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950050236
更新日期：1998-01-01 00:00:00
abstract：:Ceramide has been shown to be a key signaling molecule involved in the apoptotic effect of tumor necrosis factor alpha (TNF-alpha) and other cytokines. Given the importance of cytokines such as TNF-alpha in myocardial ischemia-reperfusion injury, we hypothesize that ceramide is increased during ischemia or reperfusion...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950170057
更新日期：2001-05-01 00:00:00
abstract：:Phospholamban is a regulatory phosphoprotein which modulates the active transport of Ca2+ by the cardiac sarcoplasmic reticular Ca(2+)-ATPase enzyme (SERCA2) into the lumen of the sarcoplasmic reticulum. Phospholamban, which is a reversible inhibitor of SERCA2, represses the enzyme's activity, and this inhibition is r...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00794064
更新日期：1997-01-01 00:00:00
abstract：:Increase of Ca2+ concentration to 7.5 mM in the presence of 10 mM or 20 mM caffeine shifted length-tension relationships of 5 rat trabecular muscles and 5 cat papillary muscles to higher tensions. At 1max diastolic tension was enhanced from (formula: see text), for all measured points of stress-strain relationships af...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906525
更新日期：1978-09-01 00:00:00
