The microvascular response to growth factors in the hamster cheek pouch.

abstract：:A reproducible tourniquet-shock has been produced in hind limbs of dogs by unilateral and bilateral extremity ischemia. The following parameters have been measured for analysing the function of the cardiovascular system: mean aortic pressure, heart rate, cardiac output, intraventricular pressure and left ventricular p...

journal_title：Basic research in cardiology

authors： Stock W,Geppert E,Haase W,Isselhard W

更新日期：1976-03-01 00:00:00

abstract：:Because of the close anatomical association between the ventricles, the volume of one ventricle can directly affect the volume and pressure within the other ventricle. To study the mechanical coupling between the ventricles, we modeled the right and left ventricles as a two-compartment model with right wall (Crw), sep...

journal_title：Basic research in cardiology

authors： Santamore WP,Shaffer T,Hughes D

更新日期：1986-09-01 00:00:00

abstract：:The success of therapies targeting myocardial reperfusion injury is limited, while the cardioprotective impact of mitigating ischemia-related damage remains less explored. We have recently shown in a pig model that the intravenous administration of a modified atorvastatin preparation during ischemia attenuates the ris...

journal_title：Basic research in cardiology

authors： Mendieta G,Ben-Aicha S,Casani L,Badimon L,Sabate M,Vilahur G

更新日期：2019-11-28 00:00:00

abstract：:Hypoxia leads to an elevation of the pulmonary vascular resistance (pvR) in pigs. This alteration of the hemodynamic was accompanied by a slight increase of intraparenchymatous concentrations of cyclic GMP (cGMP), while cycle AMP (cAMP) levels were not different from values, measured during normoxia. beta-adrenergic a...

journal_title：Basic research in cardiology

authors： Kaukel E,Beier W,Lanser K,Sill V

更新日期：1977-09-01 00:00:00

abstract：:The quantitative predominance of free and total cholesterol over the amount of mural calcium is a most significant criterion of healthy human coronary arteries during the whole life span (0-90 years). However, this normal ratio increasingly changes as soon as arteriosclerotic alterations of the coronary walls set in. ...

journal_title：Basic research in cardiology

authors： Frey M,Just H

更新日期：1994-01-01 00:00:00

abstract：:Perfusion of isoprenaline in the dog may induce left ventricular hypertrophy (LVH), and this effect is suppressed by propranolol. Cultured foetal cardiomyocytes exposed to catecholamines show an increase in protein synthesis and RNA turnover. In spontaneously hypertensive rats (SHR), and perhaps in man, sympatholytic ...

journal_title：Basic research in cardiology

authors： Rorive G,Carlier P,Smelten N,Zgheib A

更新日期：1991-01-01 00:00:00

abstract：:The proximal segments of the left coronary artery are foreshortended in the usual projections. By additional cranio-caudal (half axial) projections the X-ray beam can be directed perpendicular to these segments. In some patients lesions especially of the left main coronary artery or the proximal LAD can be seen or acc...

journal_title：Basic research in cardiology

authors： Rentrop P

更新日期：1976-01-01 00:00:00

abstract：:In this report, we showed that a previous enterovirus exposure in ordinary mice with normal T cell function, but not in T cell-deficient mice, can influence development of myocardial inflammation with a second virus exposure. Inoculation of 4-week-old male BALB/c-nu/+ (euthymic and normal T cell function) mice with am...

journal_title：Basic research in cardiology

authors： Kishimoto C,Hiraoka Y,Takada H

更新日期：2001-09-01 00:00:00

abstract：:The PKC hypothesis and its variants are attractive but unproved. The chief difficulty is the lack of an objective means to assess whether or not PKC has been activated in hearts preconditioned in vivo with ischemia or in hearts preconditioned by pharmacologic means. The strongest evidence is supporting the PKC hypothe...

journal_title：Basic research in cardiology

authors： Jennings RB

更新日期：1997-01-01 00:00:00

abstract：:A methodological approach based on Frank's pressure-volume (P-V) diagram and model calculations for analyzing the determinants of stroke volume (SV) under conditions of altered ventricular geometrical configuration is discussed with respect to the underlying geometrical models. The approach is generalized in the sense...

journal_title：Basic research in cardiology

authors： Dierberger B,Brändle M,Gülch RW,Jacob R

更新日期：1991-03-01 00:00:00

abstract：:We previously demonstrated the presence of components for a renin-angiotensin system in fibroblasts cultured from neonatal rat ventricles, the regulation of expression of which has not been studied. Since glucocorticoids and beta-adrenergic stimuli have been implicated in cardiac hypertrophy, and function as regulator...

journal_title：Basic research in cardiology

authors： Dostal DE,Booz GW,Baker KM

更新日期：2000-12-01 00:00:00

abstract：:Hearts preconditioned by brief ischemia are characterized by a reduced rate of cellular purine metabolite production during subsequent prolonged ischemia; the purpose of this study was to determine if transient exogenous adenosine pretreatment can mimic this phenomenon. The accumulation of interstitial fluid (ISF) pur...

journal_title：Basic research in cardiology

authors： Manthei SA,Van Wylen DG

更新日期：1997-12-01 00:00:00

abstract：:Pressure-overloaded cardiac hypertrophy was induced by abdominal aortic constriction in 10-week-old male Wistar rats. 24-26 weeks after aortic constriction, the hearts were excised and a myocardial mechanical study was performed using isolated left ventricular papillary muscles. There was no significant difference in ...

journal_title：Basic research in cardiology

authors： Takeda N,Ohkubo T,Nakamura I,Suzuki H,Nagano M

更新日期：1987-07-01 00:00:00

abstract：:During long-term treatment with amiodarone, slowing of conduction through the atrioventricular node, a prolongation of the QT-interval, and a prolongation of the atrial and ventricular myocardial refractoriness always developed. During short-term treatment, these effects were not found, except for depression of the AV...

journal_title：Basic research in cardiology

authors： Stark G,Stark U,Windisch M,Vicenzi M,Eggenreich U,Nagl S,Kral K,Pilger E,Tritthart HA

更新日期：1991-03-01 00:00:00

abstract：:Elevation of cardiac troponin I (cTnI) is a well-known complication after percutaneous coronary interventions (PCI). The aims of this study were to quantify the extent of coronary microembolization during elective PCI, to identify predisposing anatomical and procedural factors, and to evaluate its impact on long-term ...

journal_title：Basic research in cardiology

authors： Otto S,Seeber M,Fujita B,Kretzschmar D,Ferrari M,Goebel B,Figulla HR,Poerner TC

更新日期：2012-09-01 00:00:00

abstract：:The effects of increased perfusion pressure and epinephrine stimulation on the contractile parameters and glucose transport in the isolated perfused hearts of control and ketotic diabetic rats were studied. An increase in perfusion pressure from 60 mm Hg to 100 mm Hg resulted in increases in coronary flow and peak aor...

journal_title：Basic research in cardiology

authors： Murthy VK,Bauman MD,Shipp JC

更新日期：1983-05-01 00:00:00

abstract：:This study aimed to analyze the role of endothelial progenitor cell (EPC)-derived angiogenic factors and chemokines in the multistep process driving angiogenesis with a focus on the recently discovered macrophage migration inhibitory factor (MIF)/chemokine receptor axis. Primary murine and murine embryonic EPCs (eEPCs...

journal_title：Basic research in cardiology

authors： Kanzler I,Tuchscheerer N,Steffens G,Simsekyilmaz S,Konschalla S,Kroh A,Simons D,Asare Y,Schober A,Bucala R,Weber C,Bernhagen J,Liehn EA

更新日期：2013-01-01 00:00:00

abstract：:Recent findings on the induction of anti-apoptotic gene expression in ischemic/reperfused hearts encouraged us to investigate whether ischemic/reperfused hearts may be protected against apoptosis induction. To analyze this hypothesis we performed studies on isolated perfused hearts of rat. For apoptosis induction, hea...

journal_title：Basic research in cardiology

authors： Hofstaetter B,Taimor G,Inserte J,Garcia-Dorado D,Piper HM

更新日期：2002-11-01 00:00:00

abstract：:It is shown that hypertrophied rat myocardium exhibits marked prolongation of its action potential during non-essential changes both in the resting potential, as well as in the amplitude of the action potential, and during a moderate but nonsignificant reduction in the maximum upstroke velocity. When examining action ...

journal_title：Basic research in cardiology

authors： Gülch RW

更新日期：1980-01-01 00:00:00

abstract：:The ability of the rhesus monkey to form coronary collaterals was tested in ten animals. Ameroid constrictors were implanted on the left circumflex coronary artery and allowed to remain for 12 weeks. One animal died of an acute myocardial infarction nine days after surgery; the remaining animals survived without clini...

journal_title：Basic research in cardiology

authors： Buss DD,Hyde DM,Steffey EP

更新日期：1983-09-01 00:00:00

abstract：:Studies were carried out in 39 barbiturate-anesthetized dogs to determine whether the renin-angiotensin system is important in control of hemodynamics and coronary flow during myocardial ischemia. Plasma renin activity (PRA) was 2.2 +/- 0.4 ng x ml-l x hr-1 immediately before coronary artery occlusion (CAO) and increa...

journal_title：Basic research in cardiology

authors： Ertl G,Alexander RW,Kloner RA

更新日期：1983-09-01 00:00:00

abstract：:The genetic defect in the cardiomyopathic (CM) hamster is a mutation in the glycoprotein-sarcoglycan (a component of the dystrophin-glycoprotein complex). Apoptosis has been identified in skeletal muscle of dystrophin-deficient mice, and therefore the role of myocardial apoptosis in relation to oncosis in causing myoc...

journal_title：Basic research in cardiology

authors： Ryoke T,Gu Y,Ikeda Y,Martone ME,Oh SS,Jeon ES,Knowlton KU,Ross J Jr

更新日期：2002-01-01 00:00:00

abstract：:Rate or frequency-dependence is a characteristic property of antiarrhythmic drugs belonging to the Vaughan William classes I and III. The rate-dependence of class I drugs (i.e., increasing blockade of fast Na(+)-channels with faster rates) results from periodical drug binding to Na(+)-channel sites which are preferabl...

journal_title：Basic research in cardiology

authors： Weirich J,Antoni H

更新日期：1998-01-01 00:00:00

abstract：:Pentostatin (2-deoxycoformycin) is a potent inhibitor of adenosine deaminase and has been demonstrated to augment endogenous adenosine levels during regional and global myocardial ischemia. Based on the rationale that increasing endogenous adenosine during ischemia may be cardioprotective, the objective of this study ...

journal_title：Basic research in cardiology

authors： McClanahan TB,Ignasiak DP,Martin BJ,Mertz TE,Gallagher KP

更新日期：1995-03-01 00:00:00

abstract：:Epidemiological studies have repeatedly demonstrated a beneficial effect of moderate alcohol consumption on the incidence of coronary heart disease, myocardial infarction and overall mortality. The latter increases with excessive alcohol consumption. Although most epidemiological studies demonstrate a beneficial effec...

journal_title：Basic research in cardiology

authors： Flesch M,Rosenkranz S,Erdmann E,Böhm M

更新日期：2001-04-01 00:00:00

abstract：:If everything happens strictly according to the natural laws, which meet extremum principles, in what way can the possibility for life be characterised, so that the optimization processes of evolution can take place? Is it legitimate to "enlarge" the natural laws by certain laws of conservation? The question then aris...

journal_title：Basic research in cardiology

authors： Deppert W

更新日期：1993-01-01 00:00:00

abstract：:The effects of a c-myc antisense phosphorothioate DNA oligonucleotide were assessed on the proliferation rate of human arterial smooth muscle cells (HSMCs). Compared to a control oligonucleotide the antisense oligonucleotide suppressed the proliferation of HSMCs in a concentration-dependent manner without a major cyto...

journal_title：Basic research in cardiology

authors： Ebbecke M,Unterberg C,Buchwald A,Stöhr S,Wiegand V

更新日期：1992-11-01 00:00:00

abstract：:Enzymes involved in the metabolism nitric oxide (NO) and reactive oxygen species (ROS) may play a role for the decreased availability of NO in atherosclerosis. We, therefore, hypothesized that the pattern of gene expression of these enzymes is altered in atherosclerosis. Myocardial tissue from patients with coronary h...

journal_title：Basic research in cardiology

authors： Chen X,Niroomand F,Liu Z,Zankl A,Katus HA,Jahn L,Tiefenbacher CP

更新日期：2006-07-01 00:00:00

abstract：:Receptor binding studies usually show heterogenic characteristics of the binding isotherm. Scatchard transformation for graphical linearization of the data presentation affects the data inhomogeneously with respect to the experimental error. Thus a non-linear fitting procedure should be preferred for data analysis. Fu...

journal_title：Basic research in cardiology

authors： Wellstein A,Palm D

更新日期：1984-01-01 00:00:00

abstract：:From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationshi...

journal_title：Basic research in cardiology

authors： Rizzo P,Vieceli Dalla Sega F,Fortini F,Marracino L,Rapezzi C,Ferrari R

更新日期：2020-04-09 00:00:00