Antiproliferative effects of a c-myc antisense oligonucleotide on human arterial smooth muscle cells.

abstract：:Parathyroid hormone-related peptide (PTHrP) was found to improve contractile function of stunned myocardium in pigs. The peptide is released from coronary endothelial cells during ischemia and significantly improves post-ischemic recovery. The present study was aimed to decide whether such an induction of contractile ...

journal_title：Basic research in cardiology

authors： Lütteke D,Ross G,Abdallah Y,Schäfer C,Piper HM,Schlüter KD

更新日期：2005-07-01 00:00:00

abstract：:Increased afterload results in 'pathological' cardiac hypertrophy, the most important risk factor for the development of heart failure. Current in vitro models fall short in deciphering the mechanisms of hypertrophy induced by afterload enhancement. The aim of this study was to develop an experimental model that allow...

journal_title：Basic research in cardiology

authors： Hirt MN,Sörensen NA,Bartholdt LM,Boeddinghaus J,Schaaf S,Eder A,Vollert I,Stöhr A,Schulze T,Witten A,Stoll M,Hansen A,Eschenhagen T

更新日期：2012-11-01 00:00:00

abstract：:This study was designed to identify mechanisms responsible for coronary vasodilation in response to progressive decreases in hematocrit. Isovolemic hemodilution was produced in open-chest, anesthetized swine via concurrent removal of 500 ml of arterial blood and the addition of 500 ml of 37 °C saline or synthetic plas...

journal_title：Basic research in cardiology

authors： Kiel AM,Goodwill AG,Noblet JN,Barnard AL,Sassoon DJ,Tune JD

更新日期：2017-09-30 00:00:00

abstract：AIMS:There is a need for better identification of patients at high risk for malignant arrhythmias who would benefit from implantable cardioverter defibrillators (ICD). The purpose of this study was to assess whether the C825T polymorphism in the G-protein beta3 subunit gene, GNB3, might serve as a genetic marker for re...

journal_title：Basic research in cardiology

authors： Wieneke H,Naber CN,Piaszek L,Sack S,Frey UH,Heusch G,Erbel R,Siffert W

更新日期：2006-09-01 00:00:00

abstract：:Isolated rat hearts were perfused by the recirculating Langendorff mode under normoxic conditions for 60 min. The Krebs-Ringer buffer was supplemented with 10 mM glucose + 12 IU/l insulin and either [U-14C]-fructose-1,6-bisphosphate (together with 5 mM cold fructose-1,6-bisphosphate) or [U-14C]-fructose (together with...

journal_title：Basic research in cardiology

authors： Tavazzi B,Starnes JW,Lazzarino G,Di Pierro D,Nuutinen EM,Giardina B

更新日期：1992-05-01 00:00:00

abstract：:From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationshi...

journal_title：Basic research in cardiology

authors： Rizzo P,Vieceli Dalla Sega F,Fortini F,Marracino L,Rapezzi C,Ferrari R

更新日期：2020-04-09 00:00:00

abstract：:The capillary wall, due to its diffusional resistance, causes concentration differences between the vascular space and the interstitial space for substances which are released or taken up by the heart. Estimation of capillary transfer and interstitial concentration in isolated hearts, however, indicates a variable dif...

journal_title：Basic research in cardiology

authors： Kammermeier H,Wein B,Gerards P,Lang U,Wendtland B,Schmitz D,Rose H

更新日期：1985-01-01 00:00:00

abstract：:In Langendorff-perfused guinea pig hearts, local myocardial perfusion was evaluated by analysis of FITC-dextran-150 elution kinetics after bolus injection. Locally estimated half-times of the monoexponential elution curves showed good correlation with global undisturbed coronary flow. After ligation of the left anteri...

journal_title：Basic research in cardiology

authors： Rösen R,Marsen A,Klaus W

更新日期：1984-01-01 00:00:00

abstract：:The purpose of this study was to determine the effect of acute and chronic propranolol on heart size and regional O2 supply/consumption variables in thyroxine (T4)-treated rabbit hearts. New Zealand white rabbits were given 0.5 mg/kg T4 for 3 or 16 days with and without concomitant 2 mg/kg propranolol. Another group w...

journal_title：Basic research in cardiology

authors： Grover GJ,Houghton JM,Weiss HR

更新日期：1988-05-01 00:00:00

abstract：:Increasing the frequency of steady state stimulation increases the rate of mechanical restitution in hypothermic (27 degrees C) guinea pig papillary muscles. In this paper we have investigated the influences of the calcium antagonist nifedipine and of reduced extracellular calcium concentration on this phenomenon. We ...

journal_title：Basic research in cardiology

authors： Spencer CI,Mörner SE,Noble MI,Seed WA

更新日期：1993-03-01 00:00:00

abstract：:This study aimed to analyze the role of endothelial progenitor cell (EPC)-derived angiogenic factors and chemokines in the multistep process driving angiogenesis with a focus on the recently discovered macrophage migration inhibitory factor (MIF)/chemokine receptor axis. Primary murine and murine embryonic EPCs (eEPCs...

journal_title：Basic research in cardiology

authors： Kanzler I,Tuchscheerer N,Steffens G,Simsekyilmaz S,Konschalla S,Kroh A,Simons D,Asare Y,Schober A,Bucala R,Weber C,Bernhagen J,Liehn EA

更新日期：2013-01-01 00:00:00

abstract：:Total global ischaemia of the normothermic working rat heart caused an initial positive inotropic response characterized by vigorous contractions. After +/- 15 s this response reached a peak whereafter the isotonic contraction amplitude started to decline. After +/- 3.5 min the heart ceased to beat. The low level of h...

journal_title：Basic research in cardiology

authors： Steinmann CM,Lochner A,Niesler RA

更新日期：1987-05-01 00:00:00

abstract：:It is generally believed that the increased contractility and tachycardia of the hyperthyroid heart are a result of thyroid hormone-induced alterations of the mechanical and electrical properties of the heart, respectively. We compared the contractility (dP/dtmax) and the spontaneous beating rate of hyperthyroid and e...

journal_title：Basic research in cardiology

authors： Wheatley AM,Butkow N,Marcus RH,Lippe IT,Rosendorff C

更新日期：1988-11-01 00:00:00

abstract：:Recent publications shown mitochondrial localization of the enzyme nitric oxide synthase (NOS) in a number of tissues. However, conflicting results about mitochondrial NOS (mtNOS) immunoreactivity and enzymatic activity are available to date in the literature. In this study we purified mitochondria from rat hearts and...

journal_title：Basic research in cardiology

authors： Zanella B,Giordano E,Muscari C,Zini M,Guarnieri C

更新日期：2004-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are important regulators of adaptive and maladaptive responses in cardiovascular diseases and hence are considered to be potential therapeutical targets. However, their role as novel biomarkers for the diagnosis of cardiovascular diseases still needs to be systematically evaluated. We assessed here ...

journal_title：Basic research in cardiology

authors： Meder B,Keller A,Vogel B,Haas J,Sedaghat-Hamedani F,Kayvanpour E,Just S,Borries A,Rudloff J,Leidinger P,Meese E,Katus HA,Rottbauer W

更新日期：2011-01-01 00:00:00

abstract：:To determine the effect of magnesium on myocardial function and oxidative metabolism after reperfusion, isolated rat hearts perfused retrogradely with erythrocyte-enriched medium (0.4 mM palmitate bound to 0.4 mM albumin, 11 mM glucose) were subjected to 60 minutes of no-flow ischemia followed by 60 minutes of reperfu...

journal_title：Basic research in cardiology

authors： Tamm C,Papageorgiou I,Tardy I,Mermillod B,Rutishauser W,Lerch R

更新日期：1994-07-01 00:00:00

abstract：:Ceramide has been shown to be a key signaling molecule involved in the apoptotic effect of tumor necrosis factor alpha (TNF-alpha) and other cytokines. Given the importance of cytokines such as TNF-alpha in myocardial ischemia-reperfusion injury, we hypothesize that ceramide is increased during ischemia or reperfusion...

journal_title：Basic research in cardiology

authors： Zhang DX,Fryer RM,Hsu AK,Zou AP,Gross GJ,Campbell WB,Li PL

更新日期：2001-05-01 00:00:00

abstract：:If everything happens strictly according to the natural laws, which meet extremum principles, in what way can the possibility for life be characterised, so that the optimization processes of evolution can take place? Is it legitimate to "enlarge" the natural laws by certain laws of conservation? The question then aris...

journal_title：Basic research in cardiology

authors： Deppert W

更新日期：1993-01-01 00:00:00

abstract：:Recent reports indicate that elevating DNA glycosylase/AP lyase repair enzyme activity offers marked cytoprotection in cultured cells and a variety of injury models. In this study, we measured the effect of EndoIII, a fusion protein construct that traffics Endonuclease III, a DNA glycosylase/AP lyase, to the mitochond...

journal_title：Basic research in cardiology

authors： Yang XM,Cui L,White J,Kuck J,Ruchko MV,Wilson GL,Alexeyev M,Gillespie MN,Downey JM,Cohen MV

更新日期：2015-03-01 00:00:00

abstract：:We tested the hypothesis that in isolated cardiac myocytes, the negative functional effects of cyclic GMP would be blunted when the level of cyclic AMP was increased and that this interaction would be altered in renal hypertensive (One-Kidney-One-Clip, 1K1C) cardiac hypertrophic rabbits. Using isolated control and 1K1...

journal_title：Basic research in cardiology

authors： Patel KN,Yan L,Gandhi A,Scholz PM,Weiss HR

更新日期：2001-02-01 00:00:00

abstract：:Isolated cells obtained from adult myocardium are proving invaluable for a wide range of studies concerned with the mechanisms underlying many important cardiological processes. Although care must always be taken to ensure that the single myocyte is an appropriate model for the particular question to be researched, it...

journal_title：Basic research in cardiology

authors： Powell T

更新日期：1985-01-01 00:00:00

abstract：:Hemodynamics and myocardial contractility were evaluated in five unanesthetized calves during acute hypocapnic and isocapnic hypoxia and during acute hypocapnic hypoxia with beta-adrenergic blockade. Both hypocapnic and isocapnic hypoxia, with mean PaO2 levels of 33.1 and 39.1 mm Hg respectively, produced a decline in...

journal_title：Basic research in cardiology

authors： Buss DD,Bisgard GE

更新日期：1976-09-01 00:00:00

abstract：:The purpose of this study was to determine the effects of bradykinin (BK), substance P (SP) and histamine on plasma exudation in the skin of conscious dogs with and without pacing-induced heart failure. We also determined the role tissue angiotensin I-converting enzyme (ACE) and neutral endopeptidase (NEP) play in mod...

journal_title：Basic research in cardiology

authors： Rubinstein I,Müns G,Zucker IH

更新日期：1994-09-01 00:00:00

abstract：:Nitric oxide (NO) exerts several effects on myocardial contraction, including enhancement of relaxation and diastolic function, modulation of beta-adrenergic inotropic responses, and inotropic effects in the absence of agonist pre-stimulation. Different effects have been observed in different species and preparations,...

journal_title：Basic research in cardiology

authors： Prendergast BD,MacCarthy P,Wilson JF,Shah AM

更新日期：1998-08-01 00:00:00

abstract：:In the isometrically contracting rat trabecular muscle strip preparation, contracture tension was induced either by 10 min of hypoxia (low contracture tension) or by 30 min of joint oxygen and glucose withdrawal (severe contracture tension) at optimum length. Using stepwise 0.1 mm releases, length-tension relationship...

journal_title：Basic research in cardiology

authors： Holubarsch C,Jacob R

更新日期：1981-11-01 00:00:00

abstract：:An increased occurrence of hypertension has been reported among leg-amputees. In order to investigate whether leg amputation is followed by an elevation of sympathetic tone, possibly enhanced by continuous mechanical irritation of the amputation stump by wearing a prosthesis, blood pressure (BP), pulse-rate (PR) and p...

journal_title：Basic research in cardiology

authors： Grubeck-Loebenstein B,Korn A,Waldhäusl W

更新日期：1981-05-01 00:00:00

abstract：:A rat Langendorff heart preparation, perfused at constant pressure, was used to evaluate the role of K(ATP) channels in respiratory acidosis-induced coronary hyperemia. Prior administration of glibenclamide, an inhibitor of K(ATP) channels, reduced basal flow rates and eliminated the hyperemia associated with hypercap...

journal_title：Basic research in cardiology

authors： Phillis JW,Song D,O'Regan MH

更新日期：2000-04-01 00:00:00

abstract：:The available data clearly suggest large alterations in myocardial eicosanoid generation during myocardial ischaemia and demonstrate important actions of eicosanoids on myocardial function during ischaemic conditions. These actions include direct effects on the injured myocardium as well as influences on other target ...

journal_title：Basic research in cardiology

authors： Schrör K

更新日期：1987-01-01 00:00:00

abstract：:It has been investigated whether calcium- and verapamil-dependent sensitivities of carotis baroreceptors also exist in man. To answer this question, we pre- and postoperatively measured changes in heart rate during carotid sinus stimulation before and after intravenous administration of 5 mg verapamil in 23 patients w...

journal_title：Basic research in cardiology

authors： Behrmann C,Runge M,Ringe JD

更新日期：1992-09-01 00:00:00

abstract：:A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These cons...

journal_title：Basic research in cardiology

authors： Zucker IH,Gilmore JP

更新日期：1977-07-01 00:00:00