Abstract：
:The purpose of this study was to determine the effect of acute and chronic propranolol on heart size and regional O2 supply/consumption variables in thyroxine (T4)-treated rabbit hearts. New Zealand white rabbits were given 0.5 mg/kg T4 for 3 or 16 days with and without concomitant 2 mg/kg propranolol. Another group was given 16 days of propranolol alone and another 3-day T4 group was given 2 mg/kg propranolol 1 h before the experiment began. Another group served as control. Myocardial blood flows were determined using radioactive microspheres and small arteriolar and venous O2 saturations were determined using microspectrophotometry. Treatment with T4 for 3 or 16 days increased the heart weight/body weight ratio, myocardial blood flow, and regional O2 consumption. 16-day T4 treatment resulted in myocardial flow 195% and O2 consumption 300% above control group values. When propranolol was given chronically along with T4, heart weight/body weight ratios did not increase to the degree seen with 3 or 16 days of T4, alone. Propranolol given acutely in 3-day T4-treated animals, resulted in a reduced O2 consumption and O2 extraction, though not to the extent seen with chronic propranolol treatment of T4-treated animals. Acute propranolol treatment slightly reduced myocardial blood flow in 3-day T4-treated animals, while chronic treatment significantly reduced it. Chronic propranolol treatment in 16-day T4-treated animals resulted in a significant reduction in flow and O2 consumption. Thus, T4 treatment increased O2 consumption, flow, and heart size and these effects could be attenuated using acute and chronic propranolol.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Grover GJ,Houghton JM,Weiss HRdoi
10.1007/BF01907360subject
Has Abstractpub_date
1988-05-01 00:00:00pages
268-76issue
3eissn
0300-8428issn
1435-1803journal_volume
83pub_type
杂志文章abstract：:Myocardial lipoprotein lipase (LPL) activity during ischaemia has not been fully understood, although it plays an important role in regulating myocardial fatty acid metabolism. In this experiment, the effects of ischaemia (Experiment A) and anoxia (Experiment B) on two distinct fractions of LPL, i.e. functional and no...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-08390-1_6
更新日期：1987-01-01 00:00:00
abstract：:Energy turnover of the left ventricle does not differ in isovolumic contractions and contractions where pressure is released from peak to zero. This experimental result corresponds to predictions from a time varying elastance model of the mechanical and energetic properties of the left ventricle. To assess the validit...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11289-2_5
更新日期：1987-01-01 00:00:00
abstract：:MicroRNAs (miRNAs) are important regulators of adaptive and maladaptive responses in cardiovascular diseases and hence are considered to be potential therapeutical targets. However, their role as novel biomarkers for the diagnosis of cardiovascular diseases still needs to be systematically evaluated. We assessed here ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-010-0123-2
更新日期：2011-01-01 00:00:00
abstract：:Sirtuin 3 (Sirt3) is an NAD(+)-dependent mitochondrial deacetylase associated with superoxide dismutase 2 (SOD2)-mediated protection from oxidative stress. We have reported accelerated weight gain and impaired metabolic flexibility in atherosclerotic Sirt3 (-/-) mice. Oxidative stress is a hallmark of endothelial dysf...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-016-0552-7
更新日期：2016-05-01 00:00:00
abstract：:It is shown that hypertrophied rat myocardium exhibits marked prolongation of its action potential during non-essential changes both in the resting potential, as well as in the amplitude of the action potential, and during a moderate but nonsignificant reduction in the maximum upstroke velocity. When examining action ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02001397
更新日期：1980-01-01 00:00:00
abstract：:Beta-blockers have been shown to reduce the risk of coronary events and reduce the mortality of patients with hypertension and in those who have had a myocardial infarction. Furthermore, the evidence for long-term benefits in these two patient groups are much more convincing for beta-blockers than for other therapeuti...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950070006
更新日期：2000-01-01 00:00:00
abstract：:An orifice equation for the non-invasive measurement of mitral-valve area is demonstrated. It is shown that by combining this expression with the assumption of mitral-valve area invariance an orifice equation for the non-invasive assessment of cardiac output in conditions of mitral stenosis using simple echographicall...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01923191
更新日期：1983-01-01 00:00:00
abstract：:1. Studies on three models of cardiac hypertrophy (aortic constriction, application of isoproterenol, daily administrations of 3,3'5-triiodo-L-thyronine, respectively) reveal that the enhancement of de novo synthesis of adenine nucleotides occurs very early during the development of cardiac hypertorphy and always prec...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906368
更新日期：1977-03-01 00:00:00
abstract：:The proximal segments of the left coronary artery are foreshortended in the usual projections. By additional cranio-caudal (half axial) projections the X-ray beam can be directed perpendicular to these segments. In some patients lesions especially of the left main coronary artery or the proximal LAD can be seen or acc...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907787
更新日期：1976-01-01 00:00:00
abstract：:Denervation deprives the heart of its normal adrenergic and cholinergic control via the sympathetic and parasympathetic pathways. In a heart which is blood supplied by a donor animal of the same species, normal contractility is maintained, probably by blood borne catecholamines or possibly by unknown inotropic agents ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907778
更新日期：1976-01-01 00:00:00
abstract：:We hypothesized that nandrolone (ND)-abuse induces cardiac hypertrophy, increases myocardial susceptibility to ischemia/reperfusion (I/R) injury, and reduces responsiveness to postconditioning (PostC) cardioprotection. Wistar-rats were ND treated for 2 weeks (short_ND) or 10 weeks (long_ND). Vehicle-treated rats serve...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-010-0143-y
更新日期：2011-05-01 00:00:00
abstract：:In vivo studies have shown that sympathetic nerve stimulation improves the transmural distribution of myocardial perfusion by increasing the endocardial/epicardial flow ratio; however, the mechanism of this effect is unknown. During nerve stimulation both norepinephrine (NE) and neuropeptide Y (NPY) are released, eith...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00797913
更新日期：1995-07-01 00:00:00
abstract：:N,N-dimethylsphingosine (DMS) has been documented to be in vitro protective against myocardial ischemia-reperfusion injury (IRI) and can recruit CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), which may participate in the cardioprotection. We hypothesized that when in vivo applied after a myocardial ischemia, DMS ma...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-016-0548-3
更新日期：2016-05-01 00:00:00
abstract：AIMS:A delayed myocardial protection extends between 24 and 96 h after ischemic preconditioning in animals. To test for this phenomenon in humans, subjects with stable angina were subjected to exercise test-induced myocardial ischemia and the effect of this "preconditioning" ischemic insult on the exercise-induced myoc...
journal_title：Basic research in cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s003950070042
更新日期：2000-10-01 00:00:00
abstract：:Cardiac glycosides like ouabain are used in the therapy of heart failure and atrial fibrillation. They exert a positive inotropic effect on cardiomyocytes by inhibiting the plasma membrane sodium pump (Na,K-ATPase), decreasing the Ca-extrusion by the sarcolemmal cardiac sodium/calcium exchanger (NCX) and increasing th...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-003-0396-9
更新日期：2003-03-01 00:00:00
abstract：:Atherosclerotic plaques impair vascular function and can lead to arterial obstruction and tissue ischaemia. Rupture of an atherosclerotic plaque within a coronary artery can result in an acute myocardial infarction, which is responsible for significant morbidity and mortality worldwide. Prompt reperfusion can salvage ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-020-00829-5
更新日期：2020-11-30 00:00:00
abstract：:The aim of this study was to clarify the role of altered diabetic vascular reactivity in ischaemic heart disease. In diabetic condition, the necrotic area of myocardial infarction was significantly extended and myocardial oedema failed to develop after administration of norepinephrine 2 or 48 hours after ligation of t...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907942
更新日期：1982-09-01 00:00:00
abstract：:It is generally believed that the increased contractility and tachycardia of the hyperthyroid heart are a result of thyroid hormone-induced alterations of the mechanical and electrical properties of the heart, respectively. We compared the contractility (dP/dtmax) and the spontaneous beating rate of hyperthyroid and e...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906958
更新日期：1988-11-01 00:00:00
abstract：:It is commonly thought that the optimal method for intracoronary administration of cells is to stop coronary flow during cell infusion, in order to prolong cell/vascular wall contact, enhance adhesion, and promote extravasation of cells into the interstitial space. However, occlusion of a coronary artery with a balloo...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-015-0503-8
更新日期：2015-09-01 00:00:00
abstract：:Pentostatin (2-deoxycoformycin) is a potent inhibitor of adenosine deaminase and has been demonstrated to augment endogenous adenosine levels during regional and global myocardial ischemia. Based on the rationale that increasing endogenous adenosine during ischemia may be cardioprotective, the objective of this study ...
journal_title：Basic research in cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00789447
更新日期：1995-03-01 00:00:00
abstract：:We describe diastolic properties of the myocardium in terms of stress-strain relations. In a mathematical analysis, the equation sigma = alpha(e beta.epsilon-1) of the stress-strain curve can be changed by an increase in the exponent beta or the multiplicative constant alpha. It can be experimentally shown that in hyp...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11289-2_26
更新日期：1987-01-01 00:00:00
abstract：:The influence of perfusion pressure (5-8 kPa) on coronary flow and myocardial Ca2+-washout during Ca2+-free perfusion, and on the occurrence of calcium paradox after subsequent Ca2+-reperfusion, was studied in isolated, stimulated, rat heart ventricles. During the Ca2+-free perfusion period (3 min) the following chang...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907580
更新日期：1980-03-01 00:00:00
abstract：:Urapidil (URA) is used to treat acute hypertension in patients with coronary artery disease, but the effect of URA on the performance of ischemic myocardium has not yet been investigated. The present study was intended to assess the function of ischemic myocardium following URA administration. In eight anesthetized (p...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907115
更新日期：1990-05-01 00:00:00
abstract：:Cardiomyopathy is one of the most common causes of chronic heart failure worldwide. Mutations in the gene encoding nexilin (NEXN) occur in patients with both hypertrophic and dilated cardiomyopathy (DCM); however, little is known about the pathophysiological mechanisms and relevance of NEXN to these disorders. Here, w...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-015-0522-5
更新日期：2016-01-01 00:00:00
abstract：:We investigated the force-frequency relationship (0.5-3 Hz) in non-failing human myocardium and in end-stage failing human myocardium due to dilated cardiomyopathy or subacute myocarditis. In non-failing myocardium, force of contraction increased with increasing stimulation frequency. In end-stage heart failure, the f...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-642-72474-9_17
更新日期：1992-01-01 00:00:00
abstract：:The effect of 0.1 mg/kg Verapamil on the extent of the ischemic area following ligation of a branch of the left descending coronary artery was studied in anesthetized open chest dogs. The sum of the ST-segment elevation during the entire period of occlusion in the epicardial ECG was 15 mV in control infarction compare...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01905620
更新日期：1975-03-01 00:00:00
abstract：:Cardiac alpha- and beta-adrenoceptors and the positive inotropic effects of several adenylate cyclase dependent and independent agents have been measured in papillary muscle strips from patients without, as well as with moderate and severe heart failure. The number of beta-adrenoceptors was found to be decreased depen...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02650352
更新日期：1989-01-01 00:00:00
abstract：:In dog myocardium, the changes in the levels of creatine phosphate, inorganic phosphate, ATP, ADP, AMP, adenosine and inosine with 8 min of ischemia and subsequent reperfusion for 2, 4, 8, 16 and 32 min have been followed. Creatine phosphate and inorganic phosphate recovered completely within a few minutes as did the ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907461
更新日期：1986-07-01 00:00:00
abstract：:Reperfusion following various intervals of coronary occlusion has produced conflicting results: increase in infarct size, especially with hemorrhage into the tissue, was reported as well as salvage of ischemic myocardium. To examine the problem and for the validation of our own method for infarct size measurement, whi...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907838
更新日期：1980-07-01 00:00:00
abstract：:We chronically implanted hygroscopic occluders around the left circumflex coronary artery in 49 anesthetized young male domestic pigs and we studied the development of a collateral circulation at 4, 8, 12, and 26 weeks after implantation. At these time intervals groups of animals were again anesthetized, the hearts we...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908204
更新日期：1989-09-01 00:00:00
