Abstract：
:In dog myocardium, the changes in the levels of creatine phosphate, inorganic phosphate, ATP, ADP, AMP, adenosine and inosine with 8 min of ischemia and subsequent reperfusion for 2, 4, 8, 16 and 32 min have been followed. Creatine phosphate and inorganic phosphate recovered completely within a few minutes as did the energy charge. However, total nucleotides remained depressed, the decrease being compensated for by the increase in inosine levels during ischemia. There was a rapid removal of the latter with reperfusion. Low oral doses of mioflazine (2.5 mg X kg-1), given 2.5 h before LAD occlusion, did not affect the pattern of changes seen in control animals, except for the nucleosides. The drug induced a complete reversal of the adenosine to inosine ratio during ischemia and a remarkable prolongation of the accumulation within the tissue of mainly adenosine during early reperfusion and inosine afterwards. Assuming that the main action of mioflazine is through inhibition of nucleoside transport, the present results provide interesting information about the mechanism of release, metabolism and final washout of adenosine.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Van Belle H,Xhonneux R,Flameng W,Wynants Jdoi
10.1007/BF01907461subject
Has Abstractpub_date
1986-07-01 00:00:00pages
407-16issue
4eissn
0300-8428issn
1435-1803journal_volume
81pub_type
杂志文章abstract：:Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing ...
journal_title：Basic research in cardiology
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journal_title：Basic research in cardiology
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Basic research in cardiology
pub_type： 杂志文章
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更新日期：1988-07-01 00:00:00
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journal_title：Basic research in cardiology
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journal_title：Basic research in cardiology
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journal_title：Basic research in cardiology
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更新日期：1976-09-01 00:00:00
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journal_title：Basic research in cardiology
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pub_type： 杂志文章,评审
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更新日期：1990-01-01 00:00:00
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pub_type： 杂志文章,评审
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