Differential effect of nicotinic acid derivatives on smooth muscle and endothelial cell proliferation.

abstract：:The concept of metabolic coronary flow control provides a rationale for the close relationship of coronary flow and myocardial metabolic rate of oxygen. The concept is based on the presence of an oxygen (metabolic) sensor coupled functionally to effector mechanisms, which control vascular tone. Four modes of metabolic...

journal_title：Basic research in cardiology

authors： Deussen A,Brand M,Pexa A,Weichsel J

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Reopening of the infarct-related coronary artery is the treatment of choice in the clinical setting of acute myocardial infarction. Nevertheless the removal of the total occlusion obtained either by thrombolysis or by primary angioplasty is followed by the ischemia/reperfusion sequelae. One of many proposed ...

journal_title：Basic research in cardiology

authors： Schäfer U,Kurz T,Jain D,Hartmann F,Dendorfer A,Tölg R,Raasch W,Dominiak P,Katus H,Richardt G

更新日期：2002-09-01 00:00:00

abstract：:Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing ...

journal_title：Basic research in cardiology

authors： Vanhoutte L,Gerber BL,Gallez B,Po C,Magat J,Balligand JL,Feron O,Moniotte S

更新日期：2016-07-01 00:00:00

abstract：:A major limitation in long-term studies of quiescent adult cadiomyocytes in culture has been the decline in contractile properties of the cells over time. Regular contracting cardiomyocyte cultures may represent a more physiological model. The aim of the present study was to investigate the mechanical properties and c...

journal_title：Basic research in cardiology

authors： Holt E,Lunde PK,Sejersted OM,Christensen G

更新日期：1997-10-01 00:00:00

abstract：:Apart from local heterogeneities of myocardial blood flow, the regulation of vascular tone is equally complex. Changes in vascular tone are essential for the adaptation of coronary blood flow to varying metabolic demands. The majority of coronary vascular resistance is found in the microcirculation, that is, in vessel...

journal_title：Basic research in cardiology

authors： Tiefenbacher CP,Chilian WM

更新日期：1998-12-01 00:00:00

abstract：:The hormone-sensitive adenylate cyclase is a multi-component system embedded in the lipid bilayer of the plasma membrane and serves as a signal transduction system for various membrane receptors. The complete system consists of various receptor molecules, which sensitize the external ligands, the effector enzyme adeny...

journal_title：Basic research in cardiology

authors： Jakobs KH,Minuth M,Bauer S,Grandt R,Greiner C,Zubin P

更新日期：1986-01-01 00:00:00

abstract：:The article describes a method for monitoring the total energy output and oxygen uptake of isolated perfused rat hearts with working left ventricles. Twenty-two unpaced hearts (rates 4-4.5 bs-1) were separately investigated inside a flow micro-calorimeter (one minute for 90% thermal response) at 37 degrees C. They pum...

journal_title：Basic research in cardiology

authors： Niesler RA,Fouche J,Peiser FE

更新日期：1985-09-01 00:00:00

abstract：:It is commonly thought that the optimal method for intracoronary administration of cells is to stop coronary flow during cell infusion, in order to prolong cell/vascular wall contact, enhance adhesion, and promote extravasation of cells into the interstitial space. However, occlusion of a coronary artery with a balloo...

journal_title：Basic research in cardiology

authors： Keith MC,Tokita Y,Tang XL,Ghafghazi S,Moore JB 4th,Hong KU,Elmore JB,Amraotkar AR,Guo H,Ganzel BL,Grubb KJ,Flaherty MP,Vajravelu BN,Wysoczynski M,Bolli R

更新日期：2015-09-01 00:00:00

abstract：:Endothelin-1 elicited a concentration-dependent positive inotropic effect on the isolated rabbit, guinea pig, and rat, but not on the dog ventricular myocardium. The duration of isometric contractions was prolonged by endothelin-1 in a concentration-dependent manner, mainly by prolongation of relaxation time. Phorbol ...

journal_title：Basic research in cardiology

authors： Endoh M,Takanashi M

更新日期：1991-01-01 00:00:00

abstract：:In the control perfused working rat hearts subjected to 25 min global ischemia, reperfusion resulted in a 50% recovery of the hemodynamic functions. A concentration-dependent improvement of this recovery and a reduction of the postischemic lactate dehydrogenase (LDH) release was caused by calmidazolium (CMZ), trifluop...

journal_title：Basic research in cardiology

authors： Beresewicz A

更新日期：1989-11-01 00:00:00

abstract：:To understand the effect of transcription regulation in modulating cardiac aging, we sought to study the role of serum response factor (SRF), a key transcription factor in the heart that is normally increased with senescence and also in congestive heart failure. A Tet-Off gene expression system was used for cardiac-sp...

journal_title：Basic research in cardiology

authors： Azhar G,Zhang X,Wang S,Zhong Y,Quick CM,Wei JY

更新日期：2007-05-01 00:00:00

abstract：:The effects of increased perfusion pressure and epinephrine stimulation on the contractile parameters and glucose transport in the isolated perfused hearts of control and ketotic diabetic rats were studied. An increase in perfusion pressure from 60 mm Hg to 100 mm Hg resulted in increases in coronary flow and peak aor...

journal_title：Basic research in cardiology

authors： Murthy VK,Bauman MD,Shipp JC

更新日期：1983-05-01 00:00:00

abstract：:Recent studies demonstrated that NADPH oxidase 2 (NOX2) expression in myocardium after ischemia-reperfusion (IR) is significantly upregulated. However, the underlying mechanisms remain unknown. This study aims to determine if nuclear cardiac myosin light chain 2 (MYL2), a well-known regulatory subunit of myosin, funct...

journal_title：Basic research in cardiology

authors： Zhang YS,Liu B,Luo XJ,Li TB,Zhang JJ,Peng JJ,Zhang XJ,Ma QL,Hu CP,Li YJ,Peng J,Li Q

更新日期：2015-01-01 00:00:00

abstract：:Perfusion of isoprenaline in the dog may induce left ventricular hypertrophy (LVH), and this effect is suppressed by propranolol. Cultured foetal cardiomyocytes exposed to catecholamines show an increase in protein synthesis and RNA turnover. In spontaneously hypertensive rats (SHR), and perhaps in man, sympatholytic ...

journal_title：Basic research in cardiology

authors： Rorive G,Carlier P,Smelten N,Zgheib A

更新日期：1991-01-01 00:00:00

abstract：:Hypertension and resulting left ventricular hypertrophy was induced in young male Wistar rats (60 to 70 days old) by narrowing of one renal artery (Goldblatt II). 8 and 24 weeks after operation, myocardial oxygen consumption was measured on a modified in situ heart-lung preparation with nearly isovolumetric left ventr...

journal_title：Basic research in cardiology

authors： Kissling G,Rupp H,Malloy L,Jacob R

更新日期：1982-05-01 00:00:00

abstract：:The effect of i.v. ergonovine tartrate infusions (0.05-20 micrograms/kg/min, 12 minutes duration) on coronary arteries was studied in 14 conscious dogs instrumented to continuously measure vascular diameter by an ultrasonic dimension gauge using 10-MHz piezoelectric crystals. Ergonovine induced a biphasic coronary res...

journal_title：Basic research in cardiology

authors： Holtz J,Held W,Sommer O,Kühne G,Bassenge E

更新日期：1982-05-01 00:00:00

abstract：:We measured the amount of 1,2-diacylglycerol (DAG) and its fatty acid composition in hamster hearts of various ages because 1,2-DAG has been recognized to be one of the intracellular second messengers. The highest level in 1,2-DAG was detected in 30-day-old hamster hearts. The heart weight increased about 2.5 times be...

journal_title：Basic research in cardiology

authors： Okumura K,Yamada Y,Kondo J,Hashimoto H,Ito T,Ogawa K

更新日期：1990-03-01 00:00:00

abstract：:A simplified single-plane angiocardiographic method for the measurement of the left ventricular volumes in the reindeer heart has been developed, on the assumption that the left ventricle forms half a revolution ellipsoid. On the basis of a study of 30 ventricular casts the following formulae were constructed for the ...

journal_title：Basic research in cardiology

authors： Timisjärvi J,Hirvonen L,Kiviniitty K,Linnaluoto M

更新日期：1977-07-01 00:00:00

abstract：:Although it has long been recognized that thyroid hormone is an effective positive inotrope, its efficacy in supporting hemodynamics in the acute setting of ischaemia and reperfusion (R) without worsening reperfusion injury remains largely unknown. Thus, we investigated the effects of triiodothyronine (T3) on reperfus...

journal_title：Basic research in cardiology

authors： Pantos C,Mourouzis I,Saranteas T,Clavé G,Ligeret H,Noack-Fraissignes P,Renard PY,Massonneau M,Perimenis P,Spanou D,Kostopanagiotou G,Cokkinos DV

更新日期：2009-01-01 00:00:00

abstract：:There is no doubt that major advances have been made in cardiac electrophysiology using single heart cells. Accurate analysis of rapid inward sodium current and the second inward current carried by calcium has resulted in a major re-examination of the steps involved in excitation-contraction coupling in the heart. Fut...

journal_title：Basic research in cardiology

authors： Powell T

更新日期：1985-01-01 00:00:00

abstract：:Affinity labelling of the digitalis receptor has indicated that it is situated on the N-terminal part of the alpha-subunit of the (Na+,K+)ATPase. Biochemical and pharmacological properties of the (Na+,K+)ATPase studied on intact chick embryonic hearts and under heart cell culture conditions have indicated the existenc...

journal_title：Basic research in cardiology

authors： Lazdunski M,Kazazoglou T,Renaud JF,Rossi B

更新日期：1984-01-01 00:00:00

abstract：:From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationshi...

journal_title：Basic research in cardiology

authors： Rizzo P,Vieceli Dalla Sega F,Fortini F,Marracino L,Rapezzi C,Ferrari R

更新日期：2020-04-09 00:00:00

abstract：:Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dep...

journal_title：Basic research in cardiology

authors： Andreadou I,Iliodromitis EK,Szabo C,Papapetropoulos A

更新日期：2015-09-01 00:00:00

abstract：:We chronically implanted hygroscopic occluders around the left circumflex coronary artery in 49 anesthetized young male domestic pigs and we studied the development of a collateral circulation at 4, 8, 12, and 26 weeks after implantation. At these time intervals groups of animals were again anesthetized, the hearts we...

journal_title：Basic research in cardiology

authors： Görge G,Schmidt T,Ito BR,Pantely GA,Schaper W

更新日期：1989-09-01 00:00:00

abstract：:Experiments were performed to determine the relative contributions of direct Ca(2+)-entry through the L-type Ca(2+)-current and of Ca(2+)-release from the sarcoplasmic reticulum (s.r.) to the intracellular [Ca2+]i-transient in isolated human atrial and ventricular myocytes from patients with severe heart failure and f...

journal_title：Basic research in cardiology

authors： Beuckelmann DJ

更新日期：1997-01-01 00:00:00

abstract：:We tested the hypotheses that myocardial infarction in mice would lead to progressively worsening heart failure 12-18 weeks later and that exercise testing would provide a suitable means to evaluate left ventricular function sequentially. C57BL/6 mice (n = 69) underwent left coronary artery ligation (n = 50) or thorac...

journal_title：Basic research in cardiology

authors： Bayat H,Swaney JS,Ander AN,Dalton N,Kennedy BP,Hammond HK,Roth DM

更新日期：2002-05-01 00:00:00

abstract：:Adult epicardial cells are required for endogenous cardiac repair. After myocardial injury, they are reactivated, undergo epithelial-to-mesenchymal transformation (EMT) and migrate into the injured myocardium where they generate various cell types, including coronary smooth muscle cells and cardiac interstitial fibrob...

journal_title：Basic research in cardiology

authors： Bax NA,van Oorschot AA,Maas S,Braun J,van Tuyn J,de Vries AA,Groot AC,Goumans MJ

更新日期：2011-09-01 00:00:00

abstract：:SIRT6, a member of the NAD(+)-dependent class III deacetylase sirtuin family, has been revealed to play important roles in promoting cellular resistance against oxidative stress. The formation of reactive oxygen species (ROS) and oxidative stress are the crucial mechanisms underlying cellular damage and dysfunction in...

journal_title：Basic research in cardiology

authors： Wang XX,Wang XL,Tong MM,Gan L,Chen H,Wu SS,Chen JX,Li RL,Wu Y,Zhang HY,Zhu Y,Li YX,He JH,Wang M,Jiang W

更新日期：2016-03-01 00:00:00

abstract：:Experimental evidence indicates that ischemic glycolysis improves myocardial tolerance to low flow ischemia and anoxia, and cellular membrane disruption signals and/or causes transition to irreversible ischemic injury. The objective of this study was to determine the impact of ischemic glycolysis on membrane integrity...

journal_title：Basic research in cardiology

authors： Askenasy N

更新日期：2001-11-01 00:00:00

abstract：:32 patients were studied by His-bundle recordings to examine the extent to which frequency and autonomic nervous system influence the conduction velocity in the subdivisions (atrium, AV-node, His-Purkinje system) of the normal PR-interval. The measurements were performed during sinus rhythm and three electrically indu...

journal_title：Basic research in cardiology

authors： Runge M,Luckmann E,Narula OS

更新日期：1976-11-01 00:00:00