Abstract:
:The hormone-sensitive adenylate cyclase is a multi-component system embedded in the lipid bilayer of the plasma membrane and serves as a signal transduction system for various membrane receptors. The complete system consists of various receptor molecules, which sensitize the external ligands, the effector enzyme adenylate cyclase, which catalyzes the formation of cyclic AMP from ATP, and two guanine nucleotide-binding regulatory proteins (N or G proteins), which transduce the signals from the receptors to the adenylate cyclase. Depending on the receptor type activated by a ligand, stimulatory or inhibitory, either the stimulatory or the inhibitory N protein is activated and induces stimulation or inhibition of adenylate cyclase with subsequent increase or decrease in cellular cyclic AMP levels. In this paper, the mechanisms of this hormonal signal transduction system and its regulation will briefly reviewed, with some emphasis on the cardiac system.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Jakobs KH,Minuth M,Bauer S,Grandt R,Greiner C,Zubin Pdoi
10.1007/BF01907422subject
Has Abstractpub_date
1986-01-01 00:00:00pages
1-9issue
1eissn
0300-8428issn
1435-1803journal_volume
81pub_type
杂志文章abstract:AIMS:A delayed myocardial protection extends between 24 and 96 h after ischemic preconditioning in animals. To test for this phenomenon in humans, subjects with stable angina were subjected to exercise test-induced myocardial ischemia and the effect of this "preconditioning" ischemic insult on the exercise-induced myoc...
journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s003950070042
更新日期:2000-10-01 00:00:00
abstract::Autologous bone marrow mononuclear cell (BM-MNC) therapy for patients with ST-segment elevation myocardial infarction (STEMI) has produced inconsistent results, possibly due to BM-MNC product heterogeneity. Patient-specific cardiovascular risk factors (CRFs) may contribute to variations in BM-MNC composition. We sough...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0592-z
更新日期:2017-01-01 00:00:00
abstract::Coronary vasomotion of normal, stenotic, and poststenotic vessel segments was studied in 18 patients with coronary artery disease at rest, during submaximal bicycle exercise, and 5 min after sublingual nitroglycerin or oral isosorbide-dinitrate (ISDN) spray. Patients were divided into two groups: group 1 consisted of ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/978-3-662-11038-6_28
更新日期:1990-01-01 00:00:00
abstract::Hypertension and resulting left ventricular hypertrophy was induced in young male Wistar rats (60 to 70 days old) by narrowing of one renal artery (Goldblatt II). 8 and 24 weeks after operation, myocardial oxygen consumption was measured on a modified in situ heart-lung preparation with nearly isovolumetric left ventr...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908041
更新日期:1982-05-01 00:00:00
abstract::An ischaemia-like state in cultured heart cells has been obtained by markedly restricting the volume of extracellular medium combined with total deprivation of oxygen (anoxia) and glucose. Cellular injury, as reflected by the release of both cytoplasmic and lysosomal enzymes was significantly greater than during anoxi...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::Cardiac glycosides like ouabain are used in the therapy of heart failure and atrial fibrillation. They exert a positive inotropic effect on cardiomyocytes by inhibiting the plasma membrane sodium pump (Na,K-ATPase), decreasing the Ca-extrusion by the sarcolemmal cardiac sodium/calcium exchanger (NCX) and increasing th...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-003-0396-9
更新日期:2003-03-01 00:00:00
abstract::In this report, we showed that a previous enterovirus exposure in ordinary mice with normal T cell function, but not in T cell-deficient mice, can influence development of myocardial inflammation with a second virus exposure. Inoculation of 4-week-old male BALB/c-nu/+ (euthymic and normal T cell function) mice with am...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s003950170025
更新日期:2001-09-01 00:00:00
abstract::Intermittent, normobaric hypoxia confers robust cardioprotection against ischemia-induced myocardial infarction and lethal ventricular arrhythmias. δ-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) have been implicated in cardioprotective phenomena, but their roles in intermittent hypoxia are unknown...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0538-5
更新日期:2016-03-01 00:00:00
abstract::Studies were carried out in 39 barbiturate-anesthetized dogs to determine whether the renin-angiotensin system is important in control of hemodynamics and coronary flow during myocardial ischemia. Plasma renin activity (PRA) was 2.2 +/- 0.4 ng x ml-l x hr-1 immediately before coronary artery occlusion (CAO) and increa...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906463
更新日期:1983-09-01 00:00:00
abstract:OBJECTIVES:Single electrical field shocks are able to induce ventricular fibrillation (VF) if applied during the vulnerable period. During this period, a shock can either prolong the action potential duration or induce a new action potential. Whether the occurrence of different shock responses contributes to the induct...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00803755
更新日期:1997-02-01 00:00:00
abstract::It is generally believed that the increased contractility and tachycardia of the hyperthyroid heart are a result of thyroid hormone-induced alterations of the mechanical and electrical properties of the heart, respectively. We compared the contractility (dP/dtmax) and the spontaneous beating rate of hyperthyroid and e...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906958
更新日期:1988-11-01 00:00:00
abstract::Atherosclerotic coronary arteries are more calcified in patients with than without chronic kidney disease (CKD). We addressed the potential for coronary microvascular obstruction in patients with and without CKD during stenting for saphenous vein aorto-coronary graft (SVG) stenosis under protection with a distal occlu...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-012-0303-3
更新日期:2012-11-01 00:00:00
abstract::Sarcoplasmic reticulum (SR) from left ventricles of rats that developed spontaneous hypertension was studied in vitro. Similar increases of left ventricular mass were found when grouping the animals into mild and severe hypertensives (average systolic arterial pressure of 168 +/- 4 and 202 +/- 6 mmHg, respectively). T...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907362
更新日期:1988-05-01 00:00:00
abstract::We measured the amount of 1,2-diacylglycerol (DAG) and its fatty acid composition in hamster hearts of various ages because 1,2-DAG has been recognized to be one of the intracellular second messengers. The highest level in 1,2-DAG was detected in 30-day-old hamster hearts. The heart weight increased about 2.5 times be...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906969
更新日期:1990-03-01 00:00:00
abstract::The hypothesis was tested that vardenafil, a PDE5 inhibitor, specifically enhances coronary vasodilation during acidosis. In isolated constant pressure perfused guinea pig hearts, infusion of vardenafil ( journal_title:Basic research in cardiology pub_type: 杂志文章 doi:10.1007/s00395-006-0630-3 更新日期:2007-03-01 00:00:00
abstract::Previous studies indicated that the increase in protein kinase C (PKC)-mediated myofilament protein phosphorylation observed in failing myocardium might be detrimental for contractile function. This study was designed to reveal and compare the effects of PKCalpha- and PKCepsilon-mediated phosphorylation on myofilament...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-009-0053-z
更新日期:2010-03-01 00:00:00
abstract::Adult epicardial cells are required for endogenous cardiac repair. After myocardial injury, they are reactivated, undergo epithelial-to-mesenchymal transformation (EMT) and migrate into the injured myocardium where they generate various cell types, including coronary smooth muscle cells and cardiac interstitial fibrob...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-011-0181-0
更新日期:2011-09-01 00:00:00
abstract::Age-related changes in the myocardial energy metabolism were studied in spontaneously hypertensive (SHR) rats of 5-15 weeks of age. Systolic blood pressure increased rapidly during 5 to 10 weeks of age (developing phase) and attained a plateau level at 10 to 15 weeks (sustained phase). Even during the developing phase...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02005337
更新日期:1982-07-01 00:00:00
abstract::Rate or frequency-dependence is a characteristic property of antiarrhythmic drugs belonging to the Vaughan William classes I and III. The rate-dependence of class I drugs (i.e., increasing blockade of fast Na(+)-channels with faster rates) results from periodical drug binding to Na(+)-channel sites which are preferabl...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950050236
更新日期:1998-01-01 00:00:00
abstract::Ex vivo multicellular preparations are essential tools to study tissue physiology. Among them, the recent methodological and technological developments in living myocardial slices (LMS) are attracting increasing interest by the cardiac research field. Despite this, this research model remains poorly perceived and util...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-020-00822-y
更新日期:2020-09-10 00:00:00
abstract::Using an isolated rat heart preparation (Langendorff perfusion, perfusion pressure 100 cm H2O) the response of the hypertrophied heart (spontaneous hypertensive rats lv/bw ratio 3.6 +/- 0.5) to global normothermic (30 min) and hypothermic (25 degrees C, 120 min) ischemic and cardioplegic arrest and reperfusion (30 min...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/978-3-662-11374-5_12
更新日期:1986-01-01 00:00:00
abstract::Both the severity and duration of postischemic myocardial dysfunction ("stunned" myocardium) are unpredictable and may vary considerably between subjects that underwent apparently similar ischemic insults. To explain this heterogeneous response of the heart to ischemia and reperfusion, we investigated the determinants...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00799686
更新日期:1996-03-01 00:00:00
abstract:AIMS:There is a need for better identification of patients at high risk for malignant arrhythmias who would benefit from implantable cardioverter defibrillators (ICD). The purpose of this study was to assess whether the C825T polymorphism in the G-protein beta3 subunit gene, GNB3, might serve as a genetic marker for re...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-006-0600-9
更新日期:2006-09-01 00:00:00
abstract::Total global ischaemia of the normothermic working rat heart caused an initial positive inotropic response characterized by vigorous contractions. After +/- 15 s this response reached a peak whereafter the isotonic contraction amplitude started to decline. After +/- 3.5 min the heart ceased to beat. The low level of h...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906862
更新日期:1987-05-01 00:00:00
abstract::Recent reports indicate that elevating DNA glycosylase/AP lyase repair enzyme activity offers marked cytoprotection in cultured cells and a variety of injury models. In this study, we measured the effect of EndoIII, a fusion protein construct that traffics Endonuclease III, a DNA glycosylase/AP lyase, to the mitochond...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-014-0459-0
更新日期:2015-03-01 00:00:00
abstract::Exercise training is a well-known non-pharmacological strategy for the prevention and treatment of cardiovascular diseases. Despite the established phenotypic knowledge, the molecular signature of exercise-induced cardiac remodeling remains poorly characterized. The great majority of studies dedicated to this topic us...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-014-0454-5
更新日期:2015-01-01 00:00:00
abstract::We have compared in open-chest dogs the evolution of adenine nucleotides and creatine phosphate to that of regional mechanical function during ischemia and reperfusion. Reperfusion restored normal value of creatine phosphate whereas adenine nucleotide level remained depressed. The percentage of systolic shortening, wh...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908316
更新日期:1982-11-01 00:00:00
abstract::The role of the cardiac current Ik1 in arrhythmogenesis remains highly controversal. To gain further insights into the mechanisms of IK1 involvement in cardiac excitability, we studied the susceptibility of transgenic mice with altered IK1 to arrhythmia during various pharmacological and physiological challenges. Arrh...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-007-0659-y
更新日期:2007-09-01 00:00:00
abstract::Disregarding the influence of thickness on elevated strength of isolated preparations inevitably leads to erroneous tension-frequency relations, especially in the range of high frequencies. Thus, much of the confusion in interpreting the atypical negative staircase phenomenon of the rat heart is due to this. In view o...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/978-3-662-11289-2_25
更新日期:1987-01-01 00:00:00
abstract::Six dogs were subjected to an acute stenosis of the left anterior descending coronary artery. The mean aortic pressure was fixed with a windkessel and an occluder on four different levels. A significant decrease of coronary blood flow and poststenotic coronary pressure was closely related to the level of mean aortic ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906456
更新日期:1976-05-01 00:00:00