Abstract:
:Autologous bone marrow mononuclear cell (BM-MNC) therapy for patients with ST-segment elevation myocardial infarction (STEMI) has produced inconsistent results, possibly due to BM-MNC product heterogeneity. Patient-specific cardiovascular risk factors (CRFs) may contribute to variations in BM-MNC composition. We sought to identify associations between BM-MNC subset frequencies and specific CRFs in STEMI patients. Bone marrow was collected from 191 STEMI patients enrolled in the CCTRN TIME and LateTIME trials. Relationships between BM-MNC subsets and CRFs were determined with multivariate analyses. An assessment of CRFs showed that hyperlipidemia and hypertension were associated with a higher frequency of CD11b+ cells (P = 0.045 and P = 0.016, respectively). In addition, we found that females had lower frequencies of CD11b+ (P = 0.018) and CD45+CD14+ (P = 0.028) cells than males, age was inversely associated with the frequency of CD45+CD31+ cells (P = 0.001), smoking was associated with a decreased frequency of CD45+CD31+ cells (P = 0.013), glucose level was positively associated with the frequency of CD45+CD3+ cells, and creatinine level (an indicator of renal function) was inversely associated with the frequency of CD45+CD3+ cells (P = 0.015). In conclusion, the frequencies of monocytic, lymphocytic, and angiogenic BM-MNCs varied in relation to patients' CRFs. These phenotypic variations may affect cell therapy outcomes and might be an important consideration when selecting patients for and reviewing results from autologous cell therapy trials.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Contreras A,Orozco AF,Resende M,Schutt RC,Traverse JH,Henry TD,Lai D,Cooke JP,Bolli R,Cohen ML,Moyé L,Pepine CJ,Yang PC,Perin EC,Willerson JT,Taylor DA,Cardiovascular Cell Therapy Research Network (CCTRN).doi
10.1007/s00395-016-0592-zsubject
Has Abstractpub_date
2017-01-01 00:00:00pages
3issue
1eissn
0300-8428issn
1435-1803pii
10.1007/s00395-016-0592-zjournal_volume
112pub_type
杂志文章abstract::Experimental evidence indicates that ischemic glycolysis improves myocardial tolerance to low flow ischemia and anoxia, and cellular membrane disruption signals and/or causes transition to irreversible ischemic injury. The objective of this study was to determine the impact of ischemic glycolysis on membrane integrity...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s003950170013
更新日期:2001-11-01 00:00:00
abstract::The influence of norepinephrine on ventricular overdrive suppression and attendant potassium shifts has been studied in isolated perfused canine hearts with complete atrioventricular block. It was found that: 1) there is a potassium loss during the drive and a potassium uptake after the drive); 2) reducing the driving...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906299
更新日期:1977-01-01 00:00:00
abstract::Cardioprotection aims at infarct size reduction and improvement of clinical outcome from myocardial infarction. The translation of cardioprotection from preclinical and promising proof-of-concept studies to clinical benefit for patients has been largely disappointing. Almost all of these studies which did not translat...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-019-0756-8
更新日期:2019-10-15 00:00:00
abstract:OBJECTIVE:Chemokines control the migration of leukocytes to inflamed tissue, and in particular monocyte chemoattractant protein (MCP)-1 has been implicated in the pathogenesis of several cardiovascular disorders such as chronic heart failure (CHF) and myocarditis. We hypothesised that MCP-1 may directly contribute to a...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s003950170042
更新日期:2001-07-01 00:00:00
abstract::From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationshi...
journal_title:Basic research in cardiology
pub_type: 社论
doi:10.1007/s00395-020-0791-5
更新日期:2020-04-09 00:00:00
abstract::8 mm long sections of common carotid arteries of conscious, freely moving rabbits were electrically stimulated with DC-impulses by chronically implanted gold-electrodes daily for 1/2 h or two times 1/2 h per day for 4--6 weeks. The electrodes were arranged in such a way that the wall was stimulated transmurally, In th...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907681
更新日期:1979-01-01 00:00:00
abstract::The PKC hypothesis and its variants are attractive but unproved. The chief difficulty is the lack of an objective means to assess whether or not PKC has been activated in hearts preconditioned in vivo with ischemia or in hearts preconditioned by pharmacologic means. The strongest evidence is supporting the PKC hypothe...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00797206
更新日期:1997-01-01 00:00:00
abstract::The effect of i.v. ergonovine tartrate infusions (0.05-20 micrograms/kg/min, 12 minutes duration) on coronary arteries was studied in 14 conscious dogs instrumented to continuously measure vascular diameter by an ultrasonic dimension gauge using 10-MHz piezoelectric crystals. Ergonovine induced a biphasic coronary res...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908043
更新日期:1982-05-01 00:00:00
abstract::The effect of isoproterenol perfusion on cAMP levels and phosphorylase activity was investigated in the spontaneously hypertensive rat (SHR) and Kyoto Wistar normotensive control rat (WKY) heart. The basal force of contraction in physiological salt solution perfused hearts was comparable between SHR and WKY. However, ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907217
更新日期:1983-11-01 00:00:00
abstract::The carnitine system functions in the transport of activated acyl groups over the mitochondrial inner membrane, and is needed for oxidation of long-chain fatty acids by all mitochondria. The rate of cardiac fatty acid oxidation is determined by availability of fatty acids, oxygen and the activity of carnitine palmitoy...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/978-3-662-08390-1_8
更新日期:1987-01-01 00:00:00
abstract::The stroke volume at rest of 81 test subjects with no evident cardiac or circulatory dysfunction was determined by impedance cardiography and the measurements were repeated after 11 weeks. In order to attain comparable and reproducible conditions, 44 test subjects were chosen who showed heart rates at rest not higher ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906800
更新日期:1978-11-01 00:00:00
abstract::Myocardial mechanics and oxygen consumption were studied in right ventricular papillary muscles taken from cats pretreated with cristalline L-thyroxine (1 mg/kg/day, i.p.) 8-18 days prior to the examination. Isotonic afterloaded and isometric contractions were employed. Oxygen consumption was determined polarographica...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01905508
更新日期:1975-05-01 00:00:00
abstract::Mitochondrial dysfunction is an underlying cause of ischemia-reperfusion injury. In particular, ischemic injury induces dramatic increases in mitochondrial permeability, thereby instigating a chain of events that leads to both apoptotic and necrotic cardiomyocyte death. The mitochondrial permeability transition (MPT) ...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-009-0004-8
更新日期:2009-03-01 00:00:00
abstract::Total cholesterol, phospholipids, and triglycerides in serum were studied during myocardial infarction in a patient group treated with glucose, insulin and potassium (GIK), and a conventionally treated group. There was no difference in the typical changes of cholesterol and phospholipids between the groups, but the GI...
journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章
doi:10.1007/BF01907206
更新日期:1983-11-01 00:00:00
abstract::Urapidil (URA) is used to treat acute hypertension in patients with coronary artery disease, but the effect of URA on the performance of ischemic myocardium has not yet been investigated. The present study was intended to assess the function of ischemic myocardium following URA administration. In eight anesthetized (p...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907115
更新日期:1990-05-01 00:00:00
abstract::A rapid change in length of cat papillary muscle induces two reciprocal diastolic and systolic processes: stretching causes a viscoelastic relaxation of the muscle. The opposite behavior is observed after abrupt releases when - subsequent to an increase in resting tension - diastolic force attains its new equilibrium....
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01910780
更新日期:1976-07-01 00:00:00
abstract:AIMS:A delayed myocardial protection extends between 24 and 96 h after ischemic preconditioning in animals. To test for this phenomenon in humans, subjects with stable angina were subjected to exercise test-induced myocardial ischemia and the effect of this "preconditioning" ischemic insult on the exercise-induced myoc...
journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s003950070042
更新日期:2000-10-01 00:00:00
abstract::Reperfusion following various intervals of coronary occlusion has produced conflicting results: increase in infarct size, especially with hemorrhage into the tissue, was reported as well as salvage of ischemic myocardium. To examine the problem and for the validation of our own method for infarct size measurement, whi...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907838
更新日期:1980-07-01 00:00:00
abstract::Coronary vasomotion of normal, stenotic, and poststenotic vessel segments was studied in 18 patients with coronary artery disease at rest, during submaximal bicycle exercise, and 5 min after sublingual nitroglycerin or oral isosorbide-dinitrate (ISDN) spray. Patients were divided into two groups: group 1 consisted of ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/978-3-662-11038-6_28
更新日期:1990-01-01 00:00:00
abstract::1,2-Diacylglycerol (DAG) has been considered to play an important role as an activator of protein kinase C in the signal transduction of inositol phospholipid metabolism. To examine the relation of 1,2-DAG in heart tissues to cardiac hypertrophy associated with hypertension, we measured the amount of 1,2-DAG in sponta...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01931491
更新日期:1990-09-01 00:00:00
abstract::We have recently gained evidence that segmental coronary microvascular diameters, and therefore resistances, are controlled by myogenic and endothelial responses to pressure and flow. Furthermore, intact heart studies are demonstrating that these mechanisms may interact importantly with the metabolic mechanisms primar...
journal_title:Basic research in cardiology
pub_type: 社论
doi:10.1007/BF00788525
更新日期:1993-01-01 00:00:00
abstract::An orifice equation for the non-invasive measurement of mitral-valve area is demonstrated. It is shown that by combining this expression with the assumption of mitral-valve area invariance an orifice equation for the non-invasive assessment of cardiac output in conditions of mitral stenosis using simple echographicall...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01923191
更新日期:1983-01-01 00:00:00
abstract::An increased occurrence of hypertension has been reported among leg-amputees. In order to investigate whether leg amputation is followed by an elevation of sympathetic tone, possibly enhanced by continuous mechanical irritation of the amputation stump by wearing a prosthesis, blood pressure (BP), pulse-rate (PR) and p...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907771
更新日期:1981-05-01 00:00:00
abstract::A major limitation in long-term studies of quiescent adult cadiomyocytes in culture has been the decline in contractile properties of the cells over time. Regular contracting cardiomyocyte cultures may represent a more physiological model. The aim of the present study was to investigate the mechanical properties and c...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788941
更新日期:1997-10-01 00:00:00
abstract::For 219 children between 3 and 15 years with the most frequent congenital and acquired heart failures it was investigated in what way the STI differ consistently from the corresponding standard values. It was found that all the STI of children with cardiovascular diseases can vary from the normal values scaled by hear...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906520
更新日期:1978-07-01 00:00:00
abstract::In situ hearts and isolated cardiomyocytes from heterozygous connexin 43-deficient (Cx43+/-) mice cannot be protected by ischemic preconditioning or diazoxide. We have now addressed the role of connexin 43 in ischemic postconditioning (PC). Wild type (WT) and Cx43+/- mice were subjected to 30 min coronary occlusion an...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-006-0589-0
更新日期:2006-07-01 00:00:00
abstract::Diseases accompanied by severe cardiac impairment like sepsis and chronic uremia are frequently linked to an increase in cytokine release. In order to investigate possible toxic effects of the immune mediators on myocardial cells, we studied the contractility of cardiac myocytes and the de novo formation of stress pro...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00795385
更新日期:1992-01-01 00:00:00
abstract::Cardiac hypertrophy which occurs during chronic mechanical overload is one of the numerous examples of biological adaptation to environmental requirements. As such, it is obtained at random by trial and error, and adaptation represents the sum of various modifications in gene expression, including the shift in isoform...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-72474-9_15
更新日期:1992-01-01 00:00:00
abstract::Verapamil, at a dose of 1 mg/kg, was given intravenously to anesthetized cats one hour after coronary artery occlusion. Verapamil significantly reduced mean arterial blood pressure, but produced an increase in heart rate, partially offsetting the reduction in myocardial oxygen demand resulting from the reduction in pr...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907648
更新日期:1979-09-01 00:00:00
abstract::Myocardial ischemia and infarction are the most common substrates for life-threatening ventricular tachyarrhythmias. Experimental and clinical evidence suggests that enhanced activity of the sympathetic nervous system plays an important role in the genesis of ischemia-related arrhythmias. In animal experiments, beta-b...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/978-3-662-11038-6_24
更新日期:1990-01-01 00:00:00