1,2-diacylglycerol content in myocardium from spontaneously hypertensive rats during the development of hypertension.

abstract：:The purpose of this study was to determine the effect of acute and chronic propranolol on heart size and regional O2 supply/consumption variables in thyroxine (T4)-treated rabbit hearts. New Zealand white rabbits were given 0.5 mg/kg T4 for 3 or 16 days with and without concomitant 2 mg/kg propranolol. Another group w...

journal_title：Basic research in cardiology

authors： Grover GJ,Houghton JM,Weiss HR

更新日期：1988-05-01 00:00:00

abstract：:In this report, we showed that a previous enterovirus exposure in ordinary mice with normal T cell function, but not in T cell-deficient mice, can influence development of myocardial inflammation with a second virus exposure. Inoculation of 4-week-old male BALB/c-nu/+ (euthymic and normal T cell function) mice with am...

journal_title：Basic research in cardiology

authors： Kishimoto C,Hiraoka Y,Takada H

更新日期：2001-09-01 00:00:00

abstract：:The antiarrhythmic effect of carbocromene (Intensain) was studied in 17 anaesthetized dogs. Ventricular tachycardia was induced by infusion of K-strophanthin (mean dose: 154 mug/kg i.v.). In 25 out of 26 experiments carbocromene (4 mg/kg i.v.) was effective. Ventricular tachycardia was converted to sinus rhythm in 16 ...

journal_title：Basic research in cardiology

authors： Carp CI,Scholtholt J,Nitz RE

更新日期：1975-07-01 00:00:00

abstract：:A rapid change in length of cat papillary muscle induces two reciprocal diastolic and systolic processes: stretching causes a viscoelastic relaxation of the muscle. The opposite behavior is observed after abrupt releases when - subsequent to an increase in resting tension - diastolic force attains its new equilibrium....

journal_title：Basic research in cardiology

authors： Maisch B

更新日期：1976-07-01 00:00:00

abstract：:Atherosclerotic plaque rupture is the key event in the pathogenesis of acute coronary syndromes and it also occurs during coronary interventions. Atherosclerotic plaque rupture does not always result in complete thrombotic occlusion of the epicardial coronary artery with subsequent impending myocardial infarction, but...

journal_title：Basic research in cardiology

authors： Skyschally A,Leineweber K,Gres P,Haude M,Erbel R,Heusch G

更新日期：2006-09-01 00:00:00

abstract：:The behavior of Ca(2+)-activated K+ channels of large conductance (BKCa) in smooth muscle cells, which were obtained from atherosclerotic plaque material (SMCP) and from media segments (SMCM) of human coronary arteries, were compared using the patch-clamp technique. Voltage-clamp protocols in cell-attached patches rev...

journal_title：Basic research in cardiology

authors： Wiecha J,Schläger B,Voisard R,Hannekum A,Mattfeldt T,Hombach V

更新日期：1997-08-01 00:00:00

abstract：OBJECTIVE:The clinical usefulness of class III antiarrhythmic drugs for the treatment of tachyarrhythmias is limited by their potential proarrhythmic effects, mainly torsades-depointes (TdP). The goal of this experimental study was to develop an isolated whole-heart model exhibiting typical characteristics of class III...

journal_title：Basic research in cardiology

authors： Johna R,Mertens H,Haverkamp W,Eckardt L,Niederbröker T,Borggrefe M,Breithardt G

更新日期：1998-04-01 00:00:00

abstract：:The influence of cardiac cholinergic activation was studied in rats and cats on the induction and maintenance of ventricular fibrillation (VF). Acetylcholine (ACH 2-25 micrograms/kg), in doses which did not cause bradycardia or hypotension, induced appearance of spontaneous VF (duration 2-60 sec.) in 9/20 rats which h...

journal_title：Basic research in cardiology

authors： Amitzur G,Manoach M,Weinstock M

更新日期：1984-11-01 00:00:00

abstract：:We investigated the force-frequency relationship (0.5-3 Hz) in non-failing human myocardium and in end-stage failing human myocardium due to dilated cardiomyopathy or subacute myocarditis. In non-failing myocardium, force of contraction increased with increasing stimulation frequency. In end-stage heart failure, the f...

journal_title：Basic research in cardiology

authors： Pieske B,Hasenfuss G,Holubarsch C,Schwinger R,Böhm M,Just H

更新日期：1992-01-01 00:00:00

abstract：:The clinical use of positive inotropic agents has been associated with increased mortality, with proarrhythmia speculated to be a contributing factor. This study compares the arrhythmogenic potentials of six positive inotropic agents representing different mechanistic classes: the beta-adrenergic agonist dobutamine, t...

journal_title：Basic research in cardiology

authors： Stump GL,Wallace AA,Gilberto DB,Gehret JR,Lynch JJ Jr

更新日期：2000-06-01 00:00:00

abstract：:Energy turnover of the left ventricle does not differ in isovolumic contractions and contractions where pressure is released from peak to zero. This experimental result corresponds to predictions from a time varying elastance model of the mechanical and energetic properties of the left ventricle. To assess the validit...

journal_title：Basic research in cardiology

authors： Elzinga G,Duwel CM,Mast F,Westerhof N

更新日期：1987-01-01 00:00:00

abstract：:We have recently gained evidence that segmental coronary microvascular diameters, and therefore resistances, are controlled by myogenic and endothelial responses to pressure and flow. Furthermore, intact heart studies are demonstrating that these mechanisms may interact importantly with the metabolic mechanisms primar...

journal_title：Basic research in cardiology

authors： Jones CJ,Kuo L,Davis MJ,Chilian WM

更新日期：1993-01-01 00:00:00

abstract：:A canine model for a standardized induction of collaterals is presented with a fixed external constrictor that is not designed to induce an occlusion of the coronary artery and at least over the timespan of 6 weeks does not impair perfusion under resting conditions in the myocardium-at-risk. The coronary constriction ...

journal_title：Basic research in cardiology

authors： Gottwik M,Wüsten B,Hofmann M,Puschmann S,Nienaber C,Schaper W

更新日期：1983-03-01 00:00:00

abstract：:In the chronically volume-overloaded canine heart due to AV-block evaluations of cardiac function were performed during the development of hypertrophy and at stable hypertrophy. In an early stage (1 and 2 weeks of AV-block) when no or only a slight increase of cardiac muscle occurred, contractility measured from dP/dt...

journal_title：Basic research in cardiology

authors： Wüsten B,Flameng W,Schaper W

更新日期：1977-03-01 00:00:00

abstract：:The flow pattern and the paths of fluid particles in a saccular aneurysm located at the bifurcation of an intracranial arterial segment are investigated with a numerical method. A normal physiological flow pattern was assumed as input to the studied segment. The theoretical study is carried out for two different Reyno...

journal_title：Basic research in cardiology

authors： Perktold K,Kenner T,Hilbert D,Spork B,Florian H

更新日期：1988-01-01 00:00:00

abstract：:The terminal complement complex C5b-9 is known to participate in inflammatory processes including atherosclerosis. Inflammation appears to be a direct consequence of C5b-9-mediated cell stimulation. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors may exert anti-inflammatory effects on vascular cel...

journal_title：Basic research in cardiology

authors： Viedt C,Shen W,Fei J,Kamimura M,Hänsch GM,Katus HA,Kreuzer J

更新日期：2003-11-01 00:00:00

abstract：:Long QT syndrome is a potentially life-threatening disease characterized by delayed repolarization of cardiomyocytes, QT interval prolongation in the electrocardiogram, and a high risk for sudden cardiac death caused by ventricular arrhythmia. The genetic type 3 of this syndrome (LQT3) is caused by gain-of-function mu...

journal_title：Basic research in cardiology

authors： Malan D,Zhang M,Stallmeyer B,Müller J,Fleischmann BK,Schulze-Bahr E,Sasse P,Greber B

更新日期：2016-03-01 00:00:00

abstract：:Ultrasonic techniques for the measurement of ventricular dimensions are widely used in acute and chronic experiments. Implantation of ultrasonic crystals is associated with reversible and irreversible myocardial damage which might limit the interpretation of the obtained results, in particular during acute experiments...

journal_title：Basic research in cardiology

authors： Schipke J,Heusch G,Schulz R,Thämer V

更新日期：1987-07-01 00:00:00

abstract：:We have used x-ray microangiography to investigate the influence of EDRF and endothelin-1 on arterial diameters (70-800 microns) at bifurcations in the isolated rabbit ear and the "optimality" of its branching geometry. The median value of the junction exponent x (which is given by d0x = d1x + d2x, where d0, d1 and d2...

journal_title：Basic research in cardiology

authors： Griffith TM,Edwards DH,Randall MD

更新日期：1991-01-01 00:00:00

abstract：:Epidemiological studies have repeatedly demonstrated a beneficial effect of moderate alcohol consumption on the incidence of coronary heart disease, myocardial infarction and overall mortality. The latter increases with excessive alcohol consumption. Although most epidemiological studies demonstrate a beneficial effec...

journal_title：Basic research in cardiology

authors： Flesch M,Rosenkranz S,Erdmann E,Böhm M

更新日期：2001-04-01 00:00:00

abstract：:The authors have retracted this article [1] because of modifications in the control lanes of Figs. 2a and 8a of the COX1 blot obtained for 18-week-old rats (rotation, horizontal flipping and re-use of the control lanes for the 35-week-old rats blot). In light of the concerns raised, the conclusions drawn in this artic...

journal_title：Basic research in cardiology

authors： Vargas LA,Velasquez FC,Alvarez BV

更新日期：2018-04-18 00:00:00

abstract：:The aim of this study was to investigate the mechanism of beta-adrenergic preconditioning (BPC). The roles of adenosine and its receptor subtypes, the generation of oxygen free radicals (ROS) and activation of the K(ATP) channels as well as the phosphoinositide-3-kinase (PI(3)K)/PKB/Akt and extracellular signal-regula...

journal_title：Basic research in cardiology

authors： Salie R,Moolman JA,Lochner A

更新日期：2012-09-01 00:00:00

abstract：:Sympathetic neural remodeling, which involves the inflammatory response, plays an important role in ventricular arrhythmias (VAs) after myocardial infarction (MI). Adrenergic receptors on macrophages potentially modulate the inflammatory response. We hypothesized that the increased level of catecholamines activates ma...

journal_title：Basic research in cardiology

authors： Lyu J,Wang M,Kang X,Xu H,Cao Z,Yu T,Huang K,Wu J,Wei X,Lei Q

更新日期：2020-08-07 00:00:00

abstract：:Cardiovascular cell therapy offers the first real potential to treat the underlying injuries associated with cardiac and vascular disease. By delivering appropriate exogenous cells to an injury site, the potential exists to mitigate injury or even to begin to reverse damage. Based on their inordinate pre-clinical prom...

journal_title：Basic research in cardiology

authors： Ott HC,McCue J,Taylor DA

更新日期：2005-11-01 00:00:00

abstract：:Coronary vasomotion of normal, stenotic, and poststenotic vessel segments was studied in 18 patients with coronary artery disease at rest, during submaximal bicycle exercise, and 5 min after sublingual nitroglycerin or oral isosorbide-dinitrate (ISDN) spray. Patients were divided into two groups: group 1 consisted of ...

journal_title：Basic research in cardiology

authors： Gaglione A,Hess OM,Haemmerli C,Suter T,Kirkeeide RL,Osenberg HP,Muser M,Anliker M,Gould KL,Krayenbuehl HP

更新日期：1990-01-01 00:00:00

abstract：:A method is theoretically described to test the accuracy of various lead system of the ecg. The priniciple of this method consists in the following procedure. The heart position is changed maximally in a proband by varying the position of the body and by deep inspiration and exspiration. If the lead field is parallel,...

journal_title：Basic research in cardiology

authors： Hiltmann WD,Schaefer H

更新日期：1975-01-01 00:00:00

abstract：:Vasoconstrictory and vasodilatory hormone systems may be important in the regulation of peripheral vascular resistance and renal hemodynamics in the early phase of heart failure. The activity of the renin-angiotensin-aldosterone system (RAAS), the sympathetic nervous activity, and, as possible counterregulating system...

journal_title：Basic research in cardiology

authors： Holmer SR,Riegger AJ,Notheis WF,Kromer EP,Kochsiek K

更新日期：1987-03-01 00:00:00

abstract：:The endothelin (ET) family of peptides have potent vascular, cardiac and renal actions which may be of pathophysiological importance in congestive heart failure (CHF). In vivo studies with selective and non-selective ET receptor antagonists are required to clarify the role of ET in the pathophysiology of CHF and deter...

journal_title：Basic research in cardiology

authors： Love MP,McMurray JJ

更新日期：1996-01-01 00:00:00

abstract：:The capillary wall, due to its diffusional resistance, causes concentration differences between the vascular space and the interstitial space for substances which are released or taken up by the heart. Estimation of capillary transfer and interstitial concentration in isolated hearts, however, indicates a variable dif...

journal_title：Basic research in cardiology

authors： Kammermeier H,Wein B,Gerards P,Lang U,Wendtland B,Schmitz D,Rose H

更新日期：1985-01-01 00:00:00

abstract：:The effects of the potassium channel openers (KCO), cromakalim or pinacidil, were evaluated in an anesthetized porcine model of pacing- and ischemia-induced ventricular fibrillation (VF). Hearts were paced at 180 bpm and the left anterior descending coronary artery was occluded until VF was induced. Reproducible times...

journal_title：Basic research in cardiology

authors： D'Alonzo AJ,Hess TA,Darbenzio RB,Sewter JC,Conder ML,McCullough JR

更新日期：1994-03-01 00:00:00