Ca(2+)-activated K+ channels in human smooth muscle cells of coronary atherosclerotic plaques and coronary media segments.

abstract：:The effects of 3 hours of ischemia and 1 hour of reperfusion on biochemical, physiological and ultrastructural parameters were studied in 12 dogs. In the ischemic subendocardium without reperfusion, mitochondrial losses of adenine (ATP + ADP + AMP) and pyridine (NAD + NADH) nucleotides far exceeded those observed in w...

journal_title：Basic research in cardiology

authors： Regitz V,Paulson DJ,Hodach RJ,Little SE,Schaper W,Shug AL

更新日期：1984-03-01 00:00:00

abstract：:It is generally believed that the increased contractility and tachycardia of the hyperthyroid heart are a result of thyroid hormone-induced alterations of the mechanical and electrical properties of the heart, respectively. We compared the contractility (dP/dtmax) and the spontaneous beating rate of hyperthyroid and e...

journal_title：Basic research in cardiology

authors： Wheatley AM,Butkow N,Marcus RH,Lippe IT,Rosendorff C

更新日期：1988-11-01 00:00:00

abstract：:In the control perfused working rat hearts subjected to 25 min global ischemia, reperfusion resulted in a 50% recovery of the hemodynamic functions. A concentration-dependent improvement of this recovery and a reduction of the postischemic lactate dehydrogenase (LDH) release was caused by calmidazolium (CMZ), trifluop...

journal_title：Basic research in cardiology

authors： Beresewicz A

更新日期：1989-11-01 00:00:00

abstract：:To determine the effect of magnesium on myocardial function and oxidative metabolism after reperfusion, isolated rat hearts perfused retrogradely with erythrocyte-enriched medium (0.4 mM palmitate bound to 0.4 mM albumin, 11 mM glucose) were subjected to 60 minutes of no-flow ischemia followed by 60 minutes of reperfu...

journal_title：Basic research in cardiology

authors： Tamm C,Papageorgiou I,Tardy I,Mermillod B,Rutishauser W,Lerch R

更新日期：1994-07-01 00:00:00

abstract：:For 219 children between 3 and 15 years with the most frequent congenital and acquired heart failures it was investigated in what way the STI differ consistently from the corresponding standard values. It was found that all the STI of children with cardiovascular diseases can vary from the normal values scaled by hear...

journal_title：Basic research in cardiology

authors： Braun U,Rautenburg HW

更新日期：1978-07-01 00:00:00

abstract：:Elevation of cardiac troponin I (cTnI) is a well-known complication after percutaneous coronary interventions (PCI). The aims of this study were to quantify the extent of coronary microembolization during elective PCI, to identify predisposing anatomical and procedural factors, and to evaluate its impact on long-term ...

journal_title：Basic research in cardiology

authors： Otto S,Seeber M,Fujita B,Kretzschmar D,Ferrari M,Goebel B,Figulla HR,Poerner TC

更新日期：2012-09-01 00:00:00

abstract：:SIRT6, a member of the NAD(+)-dependent class III deacetylase sirtuin family, has been revealed to play important roles in promoting cellular resistance against oxidative stress. The formation of reactive oxygen species (ROS) and oxidative stress are the crucial mechanisms underlying cellular damage and dysfunction in...

journal_title：Basic research in cardiology

authors： Wang XX,Wang XL,Tong MM,Gan L,Chen H,Wu SS,Chen JX,Li RL,Wu Y,Zhang HY,Zhu Y,Li YX,He JH,Wang M,Jiang W

更新日期：2016-03-01 00:00:00

abstract：:The sympathetic and parasympathetic nervous system play a powerful role in controlling cardiac function by activating adrenergic and muscarinic receptors. In the human heart there exist alpha1-, beta1- and beta2-adrenoceptors and M2-muscarinic receptors and possibly also (prejunctional) alpha2-adrenoceptors. Beta1- an...

journal_title：Basic research in cardiology

authors： Brodde OE,Bruck H,Leineweber K,Seyfarth T

更新日期：2001-11-01 00:00:00

abstract：:The effects of chronic intake of dietary alcohol upon left ventricular function, activities of myocardial antioxidant enzymes, reduced glutathione (GSH) content and lipoperoxidation (measured as the formation of diene conjugates and lipid-soluble fluorescence) were studied in adult domestic Nicholas turkeys. The non-i...

journal_title：Basic research in cardiology

authors： Edes I,Piros G,Forster T,Csanady M

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVES:Single electrical field shocks are able to induce ventricular fibrillation (VF) if applied during the vulnerable period. During this period, a shock can either prolong the action potential duration or induce a new action potential. Whether the occurrence of different shock responses contributes to the induct...

journal_title：Basic research in cardiology

authors： Kirchhof PF,Fabritz CL,Behrens S,Franz MR

更新日期：1997-02-01 00:00:00

abstract：AIMS:There is a need for better identification of patients at high risk for malignant arrhythmias who would benefit from implantable cardioverter defibrillators (ICD). The purpose of this study was to assess whether the C825T polymorphism in the G-protein beta3 subunit gene, GNB3, might serve as a genetic marker for re...

journal_title：Basic research in cardiology

authors： Wieneke H,Naber CN,Piaszek L,Sack S,Frey UH,Heusch G,Erbel R,Siffert W

更新日期：2006-09-01 00:00:00

abstract：:Calcium transport functions of mitochondria and sarcoplasmic reticulum (SR) were studied without prior extraction using isolated rat heart myocytes permeabilized with saponin. Calcium uptake by SR was rapid and its affinity was high in comparison to calcium uptake by mitochondria, which had a higher capacity. The sens...

journal_title：Basic research in cardiology

authors： Kaminishi T,Kako KJ

更新日期：1989-05-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a leading cause of heart failure and sudden death in adolescents and young adults. Recently, the role of the Hippo/YAP pathway has been investigated in the pathogenesis of HCM, although the detailed molecular mechanisms largely remain elusive. In this study, we demonstrated an up-r...

journal_title：Basic research in cardiology

authors： Wang P,Mao B,Luo W,Wei B,Jiang W,Liu D,Song L,Ji G,Yang Z,Lai YQ,Yuan Z

更新日期：2014-01-01 00:00:00

abstract：:The isolated working rabbit heart preparation was used to study whether the "contractile machinery" remains unchanged in globally stunned myocardium. The function of the heart has been measured in nonischemic and postischemic conditions. The effect of isoprenaline or calcium chloride administration in both conditions ...

journal_title：Basic research in cardiology

authors： Andres J,Moczarska A,Stepkowski D,Kakol I

更新日期：1991-05-01 00:00:00

abstract：:Although it has long been recognized that thyroid hormone is an effective positive inotrope, its efficacy in supporting hemodynamics in the acute setting of ischaemia and reperfusion (R) without worsening reperfusion injury remains largely unknown. Thus, we investigated the effects of triiodothyronine (T3) on reperfus...

journal_title：Basic research in cardiology

authors： Pantos C,Mourouzis I,Saranteas T,Clavé G,Ligeret H,Noack-Fraissignes P,Renard PY,Massonneau M,Perimenis P,Spanou D,Kostopanagiotou G,Cokkinos DV

更新日期：2009-01-01 00:00:00

abstract：:Implicit in attempts to characterize and purify biologically active factors is the premise that the bioassay system employed will show a progressive increase in the response as the concentration of the responsible factor increases. We employed the hamster cheek pouch to assay the neovascularization potential of growth...

journal_title：Basic research in cardiology

authors： Orlandi C,Paskins-Hurlburt AJ,Hollenberg NK

更新日期：1986-05-01 00:00:00

abstract：:Isolated rat hearts were perfused by the recirculating Langendorff mode under normoxic conditions for 60 min. The Krebs-Ringer buffer was supplemented with 10 mM glucose + 12 IU/l insulin and either [U-14C]-fructose-1,6-bisphosphate (together with 5 mM cold fructose-1,6-bisphosphate) or [U-14C]-fructose (together with...

journal_title：Basic research in cardiology

authors： Tavazzi B,Starnes JW,Lazzarino G,Di Pierro D,Nuutinen EM,Giardina B

更新日期：1992-05-01 00:00:00

abstract：:A computer model is presented for simulation of the spread of activation and repolarization in ventricular myocardium. The program calculating the activation sequence is based on an algorithm similar to Huygen's principle of constructing wavefronts. Physiological parameters of the heart, such as areas of early activat...

journal_title：Basic research in cardiology

authors： Wach P,Killmann R,Dienstl F,Eichtinger C

更新日期：1989-07-01 00:00:00

abstract：:It is shown that hypertrophied rat myocardium exhibits marked prolongation of its action potential during non-essential changes both in the resting potential, as well as in the amplitude of the action potential, and during a moderate but nonsignificant reduction in the maximum upstroke velocity. When examining action ...

journal_title：Basic research in cardiology

authors： Gülch RW

更新日期：1980-01-01 00:00:00

abstract：:The available data clearly suggest large alterations in myocardial eicosanoid generation during myocardial ischaemia and demonstrate important actions of eicosanoids on myocardial function during ischaemic conditions. These actions include direct effects on the injured myocardium as well as influences on other target ...

journal_title：Basic research in cardiology

authors： Schrör K

更新日期：1987-01-01 00:00:00

abstract：:The capillary wall, due to its diffusional resistance, causes concentration differences between the vascular space and the interstitial space for substances which are released or taken up by the heart. Estimation of capillary transfer and interstitial concentration in isolated hearts, however, indicates a variable dif...

journal_title：Basic research in cardiology

authors： Kammermeier H,Wein B,Gerards P,Lang U,Wendtland B,Schmitz D,Rose H

更新日期：1985-01-01 00:00:00

abstract：:Dopexamine is a newly developed sympathetic catecholamine which combines dopaminergic (DA-1) and beta 2-adrenergic agonist activity with only minor beta 1-adrenergic action. Thereby, this compound exerts systemic and preferential renal vasodilation, causing afterload reduction, increases in cardiac output, and improve...

journal_title：Basic research in cardiology

authors： Meinertz T,Drexler H,Just H

更新日期：1989-01-01 00:00:00

abstract：:The hemodynamic and metabolic effects of acetate were studied in rats in vivo and in the isolated perfused heart. Hemodynamic parameters, myocardial phosphagens, inorganic phosphate, and adenosine were measured in vivo. Acetate uptake, coronary flow, O2 consumption, parameters of the cellular energy state, and hypoxan...

journal_title：Basic research in cardiology

authors： Kiviluoma KT,Karhunen M,Lapinlampi T,Peuhkurinen KJ,Hassinen IE

更新日期：1988-07-01 00:00:00

abstract：:Total cholesterol, phospholipids, and triglycerides in serum were studied during myocardial infarction in a patient group treated with glucose, insulin and potassium (GIK), and a conventionally treated group. There was no difference in the typical changes of cholesterol and phospholipids between the groups, but the GI...

journal_title：Basic research in cardiology

authors： Kirkeby OJ,Risöe C,Kirkeby K,Hjermann I

更新日期：1983-11-01 00:00:00

abstract：:The pathogenesis of atherosclerosis is a multifactorial process. A possible anti-atherosclerotic drug should therefore interfere with different targets that are important during the development of an atherosclerotic lesion. Two of the early events are the activated migration and proliferation of arterial smooth muscle...

journal_title：Basic research in cardiology

authors： Wülfroth P,Grünwald J

更新日期：1989-05-01 00:00:00

abstract：:In the isometrically contracting rat trabecular muscle strip preparation, contracture tension was induced either by 10 min of hypoxia (low contracture tension) or by 30 min of joint oxygen and glucose withdrawal (severe contracture tension) at optimum length. Using stepwise 0.1 mm releases, length-tension relationship...

journal_title：Basic research in cardiology

authors： Holubarsch C,Jacob R

更新日期：1981-11-01 00:00:00

abstract：:The PKC hypothesis and its variants are attractive but unproved. The chief difficulty is the lack of an objective means to assess whether or not PKC has been activated in hearts preconditioned in vivo with ischemia or in hearts preconditioned by pharmacologic means. The strongest evidence is supporting the PKC hypothe...

journal_title：Basic research in cardiology

authors： Jennings RB

更新日期：1997-01-01 00:00:00

abstract：:K201 has previously been shown to reduce diastolic contractions in vivo during β-adrenergic stimulation and elevated extracellular calcium concentration ([Ca(2+)](o)). The present study characterised the effect of K201 on electrically stimulated and spontaneous diastolic sarcoplasmic reticulum (SR)-mediated Ca(2+) rel...

journal_title：Basic research in cardiology

authors： Elliott EB,Hasumi H,Otani N,Matsuda T,Matsuda R,Kaneko N,Smith GL,Loughrey CM

更新日期：2011-11-01 00:00:00

abstract：:Both the severity and duration of postischemic myocardial dysfunction ("stunned" myocardium) are unpredictable and may vary considerably between subjects that underwent apparently similar ischemic insults. To explain this heterogeneous response of the heart to ischemia and reperfusion, we investigated the determinants...

journal_title：Basic research in cardiology

authors： Wouters PF,Van de Velde M,Van Aken H,Flameng W

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Reopening of the infarct-related coronary artery is the treatment of choice in the clinical setting of acute myocardial infarction. Nevertheless the removal of the total occlusion obtained either by thrombolysis or by primary angioplasty is followed by the ischemia/reperfusion sequelae. One of many proposed ...

journal_title：Basic research in cardiology

authors： Schäfer U,Kurz T,Jain D,Hartmann F,Dendorfer A,Tölg R,Raasch W,Dominiak P,Katus H,Richardt G

更新日期：2002-09-01 00:00:00