Protein kinase C alpha and epsilon phosphorylation of troponin and myosin binding protein C reduce Ca2+ sensitivity in human myocardium.

abstract：:The influence of decapitation, ketamine and thiopental anesthesia on some properties of rat heart mitochondria was compared. Polarographic analysis were performed, oxygen consumption rates, respiratory control index, ADP : O ratio and oxidation of exogenous NADH were determined. Electronmicroscopic and gasometric exam...

journal_title：Basic research in cardiology

authors： Dutkiewicz T,Chelstowski K

更新日期：1981-03-01 00:00:00

abstract：:Ventricular remodeling following nonfatal myocardial infarction includes an excentric hypertrophy of the surviving myocardium, associated with hemodynamic overload. Disseminated cardiomyocyte apoptosis and phenotype changes of the surviving myocardium, such as a labile calcium homeostasis of the hypertrophied cardiomy...

journal_title：Basic research in cardiology

authors： Holtz J

更新日期：1998-01-01 00:00:00

abstract：:Pressure-overloaded cardiac hypertrophy was induced by abdominal aortic constriction in 10-week-old male Wistar rats. 24-26 weeks after aortic constriction, the hearts were excised and a myocardial mechanical study was performed using isolated left ventricular papillary muscles. There was no significant difference in ...

journal_title：Basic research in cardiology

authors： Takeda N,Ohkubo T,Nakamura I,Suzuki H,Nagano M

更新日期：1987-07-01 00:00:00

abstract：:In this report we review the replacement (i.e., scarring) and reactive (i.e., perivascular and interstitial fibrosis) fibrous tissue responses found in the myocardium in response to effector hormones of the renin-angiotensin-aldosterone system. Experimental data are presented to indicate: a) endogenous or exogenous el...

journal_title：Basic research in cardiology

authors： Weber KT,Brilla CG,Campbell SE,Guarda E,Zhou G,Sriram K

更新日期：1993-01-01 00:00:00

abstract：:Mitochondria in largely postmitotic cells (e.g. cardiomyocytes, neurons or skeletal muscle myotubes) have a limited life span of a few weeks. Their replacement during normal turnover requires an intergenomic coordination between the mitochondrial genome (mtDNA, encoding for 13 protein subunits of the respiratory chain...

journal_title：Basic research in cardiology

authors： Szibor M,Holtz J

更新日期：2003-07-01 00:00:00

abstract：:Studies were carried out in 39 barbiturate-anesthetized dogs to determine whether the renin-angiotensin system is important in control of hemodynamics and coronary flow during myocardial ischemia. Plasma renin activity (PRA) was 2.2 +/- 0.4 ng x ml-l x hr-1 immediately before coronary artery occlusion (CAO) and increa...

journal_title：Basic research in cardiology

authors： Ertl G,Alexander RW,Kloner RA

更新日期：1983-09-01 00:00:00

abstract：:Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing ...

journal_title：Basic research in cardiology

authors： Vanhoutte L,Gerber BL,Gallez B,Po C,Magat J,Balligand JL,Feron O,Moniotte S

更新日期：2016-07-01 00:00:00

abstract：AIMS:There is a need for better identification of patients at high risk for malignant arrhythmias who would benefit from implantable cardioverter defibrillators (ICD). The purpose of this study was to assess whether the C825T polymorphism in the G-protein beta3 subunit gene, GNB3, might serve as a genetic marker for re...

journal_title：Basic research in cardiology

authors： Wieneke H,Naber CN,Piaszek L,Sack S,Frey UH,Heusch G,Erbel R,Siffert W

更新日期：2006-09-01 00:00:00

abstract：:Myocytes isolated from guinea pig ventricles were voltage-clamped using patch pipettes in the whole-cell configuration. For proper voltage control fast Na+ current was blocked by TTX or inactivated by an appropriate prepulse. Zero-load cell shortening was monitored by a photoelectric device. The mechanical response to...

journal_title：Basic research in cardiology

authors： Meyer R,Haas HG,Wiemer J

更新日期：1989-03-01 00:00:00

abstract：:Exercise training is a well-known non-pharmacological strategy for the prevention and treatment of cardiovascular diseases. Despite the established phenotypic knowledge, the molecular signature of exercise-induced cardiac remodeling remains poorly characterized. The great majority of studies dedicated to this topic us...

journal_title：Basic research in cardiology

authors： Ferreira R,Moreira-Gonçalves D,Azevedo AL,Duarte JA,Amado F,Vitorino R

更新日期：2015-01-01 00:00:00

abstract：:The concept of metabolic coronary flow control provides a rationale for the close relationship of coronary flow and myocardial metabolic rate of oxygen. The concept is based on the presence of an oxygen (metabolic) sensor coupled functionally to effector mechanisms, which control vascular tone. Four modes of metabolic...

journal_title：Basic research in cardiology

authors： Deussen A,Brand M,Pexa A,Weichsel J

更新日期：2006-11-01 00:00:00

abstract：:An orifice equation for the non-invasive measurement of mitral-valve area is demonstrated. It is shown that by combining this expression with the assumption of mitral-valve area invariance an orifice equation for the non-invasive assessment of cardiac output in conditions of mitral stenosis using simple echographicall...

journal_title：Basic research in cardiology

authors： Seitz WS,Spiel MS,Operschall J,Pachinger O,Klicpera M

更新日期：1983-01-01 00:00:00

abstract：:The pathogenesis and progression of hypertensive heart disease are unclear; however, both involve a genetic predisposition and environmental influences. To test the role of exogenous factors, we examined the hearts of spontaneously hypertensive rats (SHR) exposed to noise stress and ethanol intake. Twenty-two SHR and ...

journal_title：Basic research in cardiology

authors： Herrmann HJ,Rohde HG,Schulze W,Eichhorn C,Luft FC

更新日期：1994-11-01 00:00:00

abstract：:The purpose of this study was to determine if decreased heart function after hypoxia followed by reoxygenation (H-R) is associated with increased degradation of cardiac myosin light chain 1 (MLC1) by matrix metalloproteinase-2 (MMP-2), and to investigate the effects of the increased level of peroxynitrite in the heart...

journal_title：Basic research in cardiology

authors： Doroszko A,Polewicz D,Sawicka J,Richardson JS,Cheung PY,Sawicki G

更新日期：2009-11-01 00:00:00

abstract：:In this report, we showed that a previous enterovirus exposure in ordinary mice with normal T cell function, but not in T cell-deficient mice, can influence development of myocardial inflammation with a second virus exposure. Inoculation of 4-week-old male BALB/c-nu/+ (euthymic and normal T cell function) mice with am...

journal_title：Basic research in cardiology

authors： Kishimoto C,Hiraoka Y,Takada H

更新日期：2001-09-01 00:00:00

abstract：:The effects of regional hypoxemia and ischemia on epicardial electrogram were studied in anesthetized, open-chest dogs. The left circumflex artery (LCx) was cannulated and perfused with either arterial blood or hypoxic solution. A contact electrode for recording monophasic action potential (MAP) was applied to the epi...

journal_title：Basic research in cardiology

authors： Ikeno E,Kubota I,Kondo T,Yamaki M,Shibata T,Tomoike H

更新日期：1995-11-01 00:00:00

abstract：:The sympathetic and parasympathetic nervous system play a powerful role in controlling cardiac function by activating adrenergic and muscarinic receptors. In the human heart there exist alpha1-, beta1- and beta2-adrenoceptors and M2-muscarinic receptors and possibly also (prejunctional) alpha2-adrenoceptors. Beta1- an...

journal_title：Basic research in cardiology

authors： Brodde OE,Bruck H,Leineweber K,Seyfarth T

更新日期：2001-11-01 00:00:00

abstract：:Myocardial mechanics and oxygen consumption were studied in right ventricular papillary muscles taken from cats pretreated with cristalline L-thyroxine (1 mg/kg/day, i.p.) 8-18 days prior to the examination. Isotonic afterloaded and isometric contractions were employed. Oxygen consumption was determined polarographica...

journal_title：Basic research in cardiology

authors： Strauer BE,Scherpe A

更新日期：1975-05-01 00:00:00

abstract：:Nitroglycerin (GTN) and other organic nitrates are widely used vasodilators. Their side effects are development of nitrate tolerance and endothelial dysfunction. Given the potential of GTN to induce nitro-oxidative stress, we investigated the interaction between nitro-oxidative DNA damage and vascular dysfunction in e...

journal_title：Basic research in cardiology

authors： Mikhed Y,Fahrer J,Oelze M,Kröller-Schön S,Steven S,Welschof P,Zinßius E,Stamm P,Kashani F,Roohani S,Kress JM,Ullmann E,Tran LP,Schulz E,Epe B,Kaina B,Münzel T,Daiber A

更新日期：2016-07-01 00:00:00

abstract：:The developmental profiles of the protective mechanisms of heart against peroxidative injury during neonatal growth was examined in the pigs of three different age groups. Lipid peroxidation expressed in terms of malonaldehyde formation was considerably higher in the pig hearts of the 8-10 day age group compared to th...

journal_title：Basic research in cardiology

authors： Das DK,Engelman RM,Flansaas D,Otani H,Rousou J,Breyer RH

更新日期：1987-01-01 00:00:00

abstract：:We previously demonstrated the presence of components for a renin-angiotensin system in fibroblasts cultured from neonatal rat ventricles, the regulation of expression of which has not been studied. Since glucocorticoids and beta-adrenergic stimuli have been implicated in cardiac hypertrophy, and function as regulator...

journal_title：Basic research in cardiology

authors： Dostal DE,Booz GW,Baker KM

更新日期：2000-12-01 00:00:00

abstract：:To investigate the effect of nifedipine on hypercalcemic electrocardiographical alterations, steadily increasing hypercalcemia was induced in guinea-pigs by continuous calcium gluconate infusion until cardiac arrest occurred. During the experimental time the electrocardiograms were continuously recorded and compared i...

journal_title：Basic research in cardiology

authors： Schäfer W,Schäfer A,Schäfer H

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:Chemokines control the migration of leukocytes to inflamed tissue, and in particular monocyte chemoattractant protein (MCP)-1 has been implicated in the pathogenesis of several cardiovascular disorders such as chronic heart failure (CHF) and myocarditis. We hypothesised that MCP-1 may directly contribute to a...

journal_title：Basic research in cardiology

authors： Damås JK,Aukrust P,Ueland T,Odegaard A,Eiken HG,Gullestad L,Sejersted OM,Christensen G

更新日期：2001-07-01 00:00:00

abstract：:The aim of this study was to clarify the role of altered diabetic vascular reactivity in ischaemic heart disease. In diabetic condition, the necrotic area of myocardial infarction was significantly extended and myocardial oedema failed to develop after administration of norepinephrine 2 or 48 hours after ligation of t...

journal_title：Basic research in cardiology

authors： Palik I,Koltai MZ,Kolonics I,Wagner M,Pogátsa G

更新日期：1982-09-01 00:00:00

abstract：:Cardiac excitation-contraction (EC) coupling consumes vast amounts of cellular energy, most of which is produced in mitochondria by oxidative phosphorylation. In order to adapt the constantly varying workload of the heart to energy supply, tight coupling mechanisms are essential to maintain cellular pools of ATP, phos...

journal_title：Basic research in cardiology

authors： Maack C,O'Rourke B

更新日期：2007-09-01 00:00:00

abstract：:An adult rat heart myocyte preparation was used to study the uptake and metabolism of the 1-14C-labelled fatty acids decanoate, laurate, myristate, and palmitate. Metabolism was saturable, but free fatty acid accumulation was not. Use of metabolic inhibitors indicated that metabolism and not uptake was rate limiting a...

journal_title：Basic research in cardiology

authors： DeGrella RF,Light RJ

更新日期：1985-01-01 00:00:00

abstract：:Recent findings on the induction of anti-apoptotic gene expression in ischemic/reperfused hearts encouraged us to investigate whether ischemic/reperfused hearts may be protected against apoptosis induction. To analyze this hypothesis we performed studies on isolated perfused hearts of rat. For apoptosis induction, hea...

journal_title：Basic research in cardiology

authors： Hofstaetter B,Taimor G,Inserte J,Garcia-Dorado D,Piper HM

更新日期：2002-11-01 00:00:00

abstract：:8 mm long sections of common carotid arteries of conscious, freely moving rabbits were electrically stimulated with DC-impulses by chronically implanted gold-electrodes daily for 1/2 h or two times 1/2 h per day for 4--6 weeks. The electrodes were arranged in such a way that the wall was stimulated transmurally, In th...

journal_title：Basic research in cardiology

authors： Betz E,Schlote W

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Reopening of the infarct-related coronary artery is the treatment of choice in the clinical setting of acute myocardial infarction. Nevertheless the removal of the total occlusion obtained either by thrombolysis or by primary angioplasty is followed by the ischemia/reperfusion sequelae. One of many proposed ...

journal_title：Basic research in cardiology

authors： Schäfer U,Kurz T,Jain D,Hartmann F,Dendorfer A,Tölg R,Raasch W,Dominiak P,Katus H,Richardt G

更新日期：2002-09-01 00:00:00

abstract：:Carotid baroreceptor stimulation (CBS) has been shown to improve cardiac dysfunction and pathological structure remodelling. This study aimed to investigate the effects of CBS on the ventricular electrophysiological properties in canines with chronic heart failure (CHF). Thirty-eight beagles were randomized into contr...

journal_title：Basic research in cardiology

authors： Wang J,Dai M,Cao Q,Yu Q,Luo Q,Shu L,Zhang Y,Bao M

更新日期：2019-09-09 00:00:00