Abstract:
:The pathogenesis and progression of hypertensive heart disease are unclear; however, both involve a genetic predisposition and environmental influences. To test the role of exogenous factors, we examined the hearts of spontaneously hypertensive rats (SHR) exposed to noise stress and ethanol intake. Twenty-two SHR and nine normotensive Wistar rats (NWR) were continuously exposed to a 65 db, 4 and 250 Hz tone for 52 weeks. Twelve of these SHR aged 20-22 weeks were concomitantly given 20% ethanol in their drinking water up to week 52. Eight SHR and 12 NWR served as controls. We examined hemodynamic parameters, the cardiac configuration, the cardiac microvasculature, interstitial tissue, and ischemic myocardial lesions. We found that noise stress significantly increased the microvessel wall area, the number of microvessels with an outer diameter > 19 microns, the degree of cardiac fibrosis, and the extent of ischemic myocardial lesions in SHR, but not in NWR. These effects were all ameliorated and the diastolic blood pressure was lowered by the ingestion of ethanol. Cardiac weights and dimensions, heart rate and dp/dtmax were not influenced by either noise or ethanol intake. These results suggest that hypertensive heart disease in SHR can be aggravated by noise stress. Ethanol ameliorates these changes by mechanisms which remain to be explored.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Herrmann HJ,Rohde HG,Schulze W,Eichhorn C,Luft FCdoi
10.1007/BF00794951subject
Has Abstractpub_date
1994-11-01 00:00:00pages
510-23issue
6eissn
0300-8428issn
1435-1803journal_volume
89pub_type
杂志文章abstract::We studied TTX-sensitive Na channels in dissociated single ventricular cells from neonatal rats using the patch clamp method for single channel and whole cell recording. In both cases, slowly inactivating or window currents were observed that decayed in a biexponential fashion. Customary models of Na current kinetics ...
journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906462
更新日期:1983-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:
更新日期:1991-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF02005337
更新日期:1982-07-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-009-0013-7
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pub_type: 杂志文章,评审
doi:10.1007/BF00795358
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2002-03-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1992-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-09-01 00:00:00