Abstract：
:An ischaemia-like state in cultured heart cells has been obtained by markedly restricting the volume of extracellular medium combined with total deprivation of oxygen (anoxia) and glucose. Cellular injury, as reflected by the release of both cytoplasmic and lysosomal enzymes was significantly greater than during anoxia alone (oxygen deprivation with a larger extracellular volume). This is most likely due to inadequate washout of metabolites during "ischaemia" rather than reduced energy production since glycolytic flux as reflected by lactate production was similar in both experimental states. Glucose administration during either anoxia or "ischaemia" delayed enzyme release. We believe that cytoplasmic enzymes are released mainly during the reversible period of oxygen deprivation, while lysosomal enzyme release reflects the onset or irreversible injury, occurring at a time when ATP levels and glycogen stores are almost completely exhausted.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Vemuri R,Heller M,Pinson Asubject
Has Abstractpub_date
1985-01-01 00:00:00pages
165-9eissn
0300-8428issn
1435-1803journal_volume
80 Suppl 2pub_type
杂志文章abstract：:The cardiac organ manifestation of arterial hypertension comprises the myocardium itself with left-ventricular hypertrophy, the interstitium with perivascular and interstitial fibrosis, and the coronary circulation with disease of large and small coronary arteries. The consequences of the sum and interactions of these...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-662-30769-4_22
更新日期：1991-01-01 00:00:00
abstract：:MicroRNAs (miRNAs) are important regulators of adaptive and maladaptive responses in cardiovascular diseases and hence are considered to be potential therapeutical targets. However, their role as novel biomarkers for the diagnosis of cardiovascular diseases still needs to be systematically evaluated. We assessed here ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-010-0123-2
更新日期：2011-01-01 00:00:00
abstract：:Our understanding of what constitutes "normal" collagen organization in wound healing after myocardial injury and how such organization is achieved is still in its infancy. However, once this knowledge has been obtained, it may suggest methods of enhancing or even optimizing healing, and thus provide us with the possi...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950050201
更新日期：1998-01-01 00:00:00
abstract：:Increasing the frequency of steady state stimulation increases the rate of mechanical restitution in hypothermic (27 degrees C) guinea pig papillary muscles. In this paper we have investigated the influences of the calcium antagonist nifedipine and of reduced extracellular calcium concentration on this phenomenon. We ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00798259
更新日期：1993-03-01 00:00:00
abstract：:It is generally believed that the increased contractility and tachycardia of the hyperthyroid heart are a result of thyroid hormone-induced alterations of the mechanical and electrical properties of the heart, respectively. We compared the contractility (dP/dtmax) and the spontaneous beating rate of hyperthyroid and e...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906958
更新日期：1988-11-01 00:00:00
abstract：:Perfusion of isoprenaline in the dog may induce left ventricular hypertrophy (LVH), and this effect is suppressed by propranolol. Cultured foetal cardiomyocytes exposed to catecholamines show an increase in protein synthesis and RNA turnover. In spontaneously hypertensive rats (SHR), and perhaps in man, sympatholytic ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：
更新日期：1991-01-01 00:00:00
abstract：:The hypothesis was tested that vardenafil, a PDE5 inhibitor, specifically enhances coronary vasodilation during acidosis. In isolated constant pressure perfused guinea pig hearts, infusion of vardenafil ( journal_title：Basic research in cardiology pub_type： 杂志文章 doi：10.1007/s00395-006-0630-3 更新日期：2007-03-01 00:00:00
abstract：:The concept of metabolic coronary flow control provides a rationale for the close relationship of coronary flow and myocardial metabolic rate of oxygen. The concept is based on the presence of an oxygen (metabolic) sensor coupled functionally to effector mechanisms, which control vascular tone. Four modes of metabolic...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-006-0621-4
更新日期：2006-11-01 00:00:00
abstract：:To understand the effect of transcription regulation in modulating cardiac aging, we sought to study the role of serum response factor (SRF), a key transcription factor in the heart that is normally increased with senescence and also in congestive heart failure. A Tet-Off gene expression system was used for cardiac-sp...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-006-0634-z
更新日期：2007-05-01 00:00:00
abstract：:We tested the hypothesis that isoproterenol would increase myocardial work and O2 consumption at reduced efficiency and that both left ventricular hypertrophy and chemical sympathectomy would lead to changes in this myocardial efficiency response. Left ventricular hypertrophy was produced by aortic valve plication in ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00789303
更新日期：1996-07-01 00:00:00
abstract：:The influence of PGI2 and iloprost on the contents of high energy phosphates, cAMP, glycolytic metabolites and on cardiac performance was investigated in open-chest dogs subjected to 3 h of ischaemia, induced by occlusion of the left anterior descending coronary artery. The administration of drugs for 2 h, starting 1 ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907227
更新日期：1987-11-01 00:00:00
abstract：:Successive ischemic episodes are commonly seen in clinical and experimental cardiology. Although prolonged abnormalities of the canine myocardium have been described following a single ischemic episode, it is not known whether myocardial injury is cumulative following multiple ischemic episodes. Dogs were subjected to...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908148
更新日期：1984-07-01 00:00:00
abstract：:Because of the close anatomical association between the ventricles, the volume of one ventricle can directly affect the volume and pressure within the other ventricle. To study the mechanical coupling between the ventricles, we modeled the right and left ventricles as a two-compartment model with right wall (Crw), sep...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907759
更新日期：1986-09-01 00:00:00
abstract：:In open-chest pigs during severe myocardial ischemia [K+]e, [Ca2+]e and [H+]e increase, [Na+]e increases transiently reaching control values after 30 min. Extracellular osmolality of the ischemic area increases due to an H2O-shift from the ECS to the ICS. The increase of [Na+]e and [Ca2+]e must b explained by the shri...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908341
更新日期：1981-07-01 00:00:00
abstract：:Myocytes isolated from guinea pig ventricles were voltage-clamped using patch pipettes in the whole-cell configuration. For proper voltage control fast Na+ current was blocked by TTX or inactivated by an appropriate prepulse. Zero-load cell shortening was monitored by a photoelectric device. The mechanical response to...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907923
更新日期：1989-03-01 00:00:00
abstract：:The genetic defect in the cardiomyopathic (CM) hamster is a mutation in the glycoprotein-sarcoglycan (a component of the dystrophin-glycoprotein complex). Apoptosis has been identified in skeletal muscle of dystrophin-deficient mice, and therefore the role of myocardial apoptosis in relation to oncosis in causing myoc...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s395-002-8389-4
更新日期：2002-01-01 00:00:00
abstract：:This study was designed to evaluate whether the decreased early survival rate of diabetic rats submitted to acute experimental myocardial infarction can be improved by pretreatment with lidocaine. Male Wistar rats (+/- 210 g) were rendered diabetic with i.v. injection of streptozotocin (50 mg/kg), and only those prese...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907132
更新日期：1990-07-01 00:00:00
abstract：:Coronary artery disease (CAD), also known as ischemic heart disease (IHD), is the leading cause of mortality in the western world, with developing countries showing a similar trend. With the increased understanding of the role of the immune system and inflammation in coronary artery disease, it was shown that macropha...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-016-0554-5
更新日期：2016-07-01 00:00:00
abstract：:Energy turnover of the left ventricle does not differ in isovolumic contractions and contractions where pressure is released from peak to zero. This experimental result corresponds to predictions from a time varying elastance model of the mechanical and energetic properties of the left ventricle. To assess the validit...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11289-2_5
更新日期：1987-01-01 00:00:00
abstract：:Necrosis is a type of cell death characterized by a gain in cell volume, swelling of organelles, rupture of the plasma membrane and subsequent loss of intracellular contents. For a long time, the process has been considered as a merely accidental and uncontrolled form of cell death, but accumulating evidence suggests ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-011-0192-x
更新日期：2011-09-01 00:00:00
abstract：:A canine model for a standardized induction of collaterals is presented with a fixed external constrictor that is not designed to induce an occlusion of the coronary artery and at least over the timespan of 6 weeks does not impair perfusion under resting conditions in the myocardium-at-risk. The coronary constriction ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906671
更新日期：1983-03-01 00:00:00
abstract：:Ex vivo multicellular preparations are essential tools to study tissue physiology. Among them, the recent methodological and technological developments in living myocardial slices (LMS) are attracting increasing interest by the cardiac research field. Despite this, this research model remains poorly perceived and util...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-020-00822-y
更新日期：2020-09-10 00:00:00
abstract：:Hypertrophic cardiomyopathy (HCM) is a leading cause of heart failure and sudden death in adolescents and young adults. Recently, the role of the Hippo/YAP pathway has been investigated in the pathogenesis of HCM, although the detailed molecular mechanisms largely remain elusive. In this study, we demonstrated an up-r...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-014-0435-8
更新日期：2014-01-01 00:00:00
abstract：:We hypothesized that nandrolone (ND)-abuse induces cardiac hypertrophy, increases myocardial susceptibility to ischemia/reperfusion (I/R) injury, and reduces responsiveness to postconditioning (PostC) cardioprotection. Wistar-rats were ND treated for 2 weeks (short_ND) or 10 weeks (long_ND). Vehicle-treated rats serve...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-010-0143-y
更新日期：2011-05-01 00:00:00
abstract：:The concentration of fibroblast growth factor 23 (FGF23) rises progressively in renal failure (RF). High FGF23 concentrations have been consistently associated with adverse cardiovascular outcomes or death, in chronic kidney disease (CKD), heart failure or liver cirrhosis. We identified the mechanisms whereby high con...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-020-0810-6
更新日期：2020-07-22 00:00:00
abstract：:The purpose of this study was to determine the effect of acute and chronic propranolol on heart size and regional O2 supply/consumption variables in thyroxine (T4)-treated rabbit hearts. New Zealand white rabbits were given 0.5 mg/kg T4 for 3 or 16 days with and without concomitant 2 mg/kg propranolol. Another group w...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907360
更新日期：1988-05-01 00:00:00
abstract：:Mitochondrial dysfunction is an underlying cause of ischemia-reperfusion injury. In particular, ischemic injury induces dramatic increases in mitochondrial permeability, thereby instigating a chain of events that leads to both apoptotic and necrotic cardiomyocyte death. The mitochondrial permeability transition (MPT) ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-009-0004-8
更新日期：2009-03-01 00:00:00
abstract：:Autologous bone marrow mononuclear cell (BM-MNC) therapy for patients with ST-segment elevation myocardial infarction (STEMI) has produced inconsistent results, possibly due to BM-MNC product heterogeneity. Patient-specific cardiovascular risk factors (CRFs) may contribute to variations in BM-MNC composition. We sough...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-016-0592-z
更新日期：2017-01-01 00:00:00
abstract：:The endothelin (ET) family of peptides have potent vascular, cardiac and renal actions which may be of pathophysiological importance in congestive heart failure (CHF). In vivo studies with selective and non-selective ET receptor antagonists are required to clarify the role of ET in the pathophysiology of CHF and deter...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/BF00810520
更新日期：1996-01-01 00:00:00
abstract：:The flow pattern and the paths of fluid particles in a saccular aneurysm located at the bifurcation of an intracranial arterial segment are investigated with a numerical method. A normal physiological flow pattern was assumed as input to the studied segment. The theoretical study is carried out for two different Reyno...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907101
更新日期：1988-01-01 00:00:00
