Abstract：
:Sarcoplasmic reticulum (SR) from left ventricles of rats that developed spontaneous hypertension was studied in vitro. Similar increases of left ventricular mass were found when grouping the animals into mild and severe hypertensives (average systolic arterial pressure of 168 +/- 4 and 202 +/- 6 mmHg, respectively). The amount of SR protein (mg/g of left ventricle) was higher when obtained from hypertrophic ventricles of both hypertensive groups than from ventricles of the control group. The result agreed with the enhanced Ca2+ uptake exhibited by left ventricular homogenates of the hypertensive groups. Consequently, Ca2+ uptake in SR microsomes isolated per gram of left ventricle (nmol Ca2+/g muscle) was 51.62 +/- 10.06 and 64.99 +/- 12.84 in mildly and severely hypertensive groups vs. 17.37 +/- 5.79 in the control group (P less than 0.05). The SR microsomes obtained from ventricles of hypertensive rats showed an enhanced Ca2+ activated ATPase activity that was not accompanied by increased Ca2+ uptake at saturating calcium concentrations, but by increased affinity for calcium (K'app. of 1.09 +/- 0.28 and 2.67 +/- 0.16 microM in SR microsomes of hypertrophic and control ventricles respectively; P less than 0.05). The rates of calcium loss, measured in SR vesicles passively loaded with 45Ca, were similar when assayed in SR obtained from ventricles of both hypertensive and normal rats. These results enable us to suggest that in hearts of rats presenting spontaneous hypertension, the function of the SR system could account for a normal handling of cytosolic calcium. They might support the absence of mechanical alterations described in hearts of young rats of the SHR strain.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Cuneo ME,Grassi de Gende AOdoi
10.1007/BF01907362subject
Has Abstractpub_date
1988-05-01 00:00:00pages
286-95issue
3eissn
0300-8428issn
1435-1803journal_volume
83pub_type
杂志文章abstract：:Ischaemic preconditioning has not been demonstrated to reduce infarct size following global ischaemia in murine myocardium. Eighteen mouse hearts were isolated, perfused in the Langendorff mode, and randomised to control or preconditioning groups. Preconditioned hearts received four periods of five minutes global isch...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950050106
更新日期：1998-10-01 00:00:00
abstract：:This study was aimed to assess the relationship among the voltage-dependent processes underlying the excitation-contraction coupling, viz. force restitution (FR), transmembrane Ca fluxes and Ca release. The experiments (n = 22) were performed on voltage-clamped dog trabeculae in which force and slow inward current wer...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00795054
更新日期：1992-09-01 00:00:00
abstract：:Epidemiological studies have repeatedly demonstrated a beneficial effect of moderate alcohol consumption on the incidence of coronary heart disease, myocardial infarction and overall mortality. The latter increases with excessive alcohol consumption. Although most epidemiological studies demonstrate a beneficial effec...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950170062
更新日期：2001-04-01 00:00:00
abstract：:Successive ischemic episodes are commonly seen in clinical and experimental cardiology. Although prolonged abnormalities of the canine myocardium have been described following a single ischemic episode, it is not known whether myocardial injury is cumulative following multiple ischemic episodes. Dogs were subjected to...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908148
更新日期：1984-07-01 00:00:00
abstract：:An orifice equation for the non-invasive measurement of mitral-valve area is demonstrated. It is shown that by combining this expression with the assumption of mitral-valve area invariance an orifice equation for the non-invasive assessment of cardiac output in conditions of mitral stenosis using simple echographicall...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01923191
更新日期：1983-01-01 00:00:00
abstract：:The renin angiotensin system and endothelium-derived vasoactive substances are both important regulators of vascular tone. Recent evidence suggests that the two systems may be tightly interconnected and drugs interfering with one system may also affect the other. Beside the circulating renin angiotensin system, a vasc...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-642-72497-8_2
更新日期：1993-01-01 00:00:00
abstract：:Recent findings on the induction of anti-apoptotic gene expression in ischemic/reperfused hearts encouraged us to investigate whether ischemic/reperfused hearts may be protected against apoptosis induction. To analyze this hypothesis we performed studies on isolated perfused hearts of rat. For apoptosis induction, hea...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950200053
更新日期：2002-11-01 00:00:00
abstract：:Disregarding the influence of thickness on elevated strength of isolated preparations inevitably leads to erroneous tension-frequency relations, especially in the range of high frequencies. Thus, much of the confusion in interpreting the atypical negative staircase phenomenon of the rat heart is due to this. In view o...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11289-2_25
更新日期：1987-01-01 00:00:00
abstract：:Guinea-pig left atria were loaded with 10 microCi 7-[3H]noradrenaline, and noradrenaline release from sympathetic nerve endings was then elicited by refractory period field stimulation. When one pulse of 0.2 ms duration was applied during each refractory period, the resulting transmitter release was halved by 3 x 10(-...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788873
更新日期：1993-11-01 00:00:00
abstract：:Calcium transport functions of mitochondria and sarcoplasmic reticulum (SR) were studied without prior extraction using isolated rat heart myocytes permeabilized with saponin. Calcium uptake by SR was rapid and its affinity was high in comparison to calcium uptake by mitochondria, which had a higher capacity. The sens...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907975
更新日期：1989-05-01 00:00:00
abstract：BACKGROUND:The phytosterol guggulsterone is a potent anti-inflammatory mediator with less side effects than classic steroids. This study assesses the impact of guggulsterone on tissue factor (TF) expression and thrombus formation. METHODS AND RESULTS:Guggulsterone inhibited TNF-alpha-induced endothelial TF protein exp...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-008-0757-5
更新日期：2009-05-01 00:00:00
abstract：:Because of the close anatomical association between the ventricles, the volume of one ventricle can directly affect the volume and pressure within the other ventricle. To study the mechanical coupling between the ventricles, we modeled the right and left ventricles as a two-compartment model with right wall (Crw), sep...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907759
更新日期：1986-09-01 00:00:00
abstract：:Regional glucose utilization of the developing fetal feline heart was assessed during three stages of gestation and compared with the maternal heart and non-pregnant controls. The specific aims were to determine: 1) if glucose utilization by the whole heart changes from early to late gestation; 2) if there are differe...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02191527
更新日期：1991-07-01 00:00:00
abstract：:Cardiac hypertrophy which occurs during chronic mechanical overload is one of the numerous examples of biological adaptation to environmental requirements. As such, it is obtained at random by trial and error, and adaptation represents the sum of various modifications in gene expression, including the shift in isoform...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-642-72474-9_15
更新日期：1992-01-01 00:00:00
abstract：:A previous study indicated that 5 mg/kg aspirin can reverse the cardioprotective effects of thromboxane A2 synthetase inhibitors. We determined in the present study if this dose of aspirin can also reverse the protective effects of the thromboxane A2/PGH2 receptor antagonist SQ 30,741 in the same model of coronary occ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02190542
更新日期：1991-03-01 00:00:00
abstract：:We describe diastolic properties of the myocardium in terms of stress-strain relations. In a mathematical analysis, the equation sigma = alpha(e beta.epsilon-1) of the stress-strain curve can be changed by an increase in the exponent beta or the multiplicative constant alpha. It can be experimentally shown that in hyp...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11289-2_26
更新日期：1987-01-01 00:00:00
abstract：:The capillary wall, due to its diffusional resistance, causes concentration differences between the vascular space and the interstitial space for substances which are released or taken up by the heart. Estimation of capillary transfer and interstitial concentration in isolated hearts, however, indicates a variable dif...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The effects of increased perfusion pressure and epinephrine stimulation on the contractile parameters and glucose transport in the isolated perfused hearts of control and ketotic diabetic rats were studied. An increase in perfusion pressure from 60 mm Hg to 100 mm Hg resulted in increases in coronary flow and peak aor...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907437
更新日期：1983-05-01 00:00:00
abstract：:The carnitine system functions in the transport of activated acyl groups over the mitochondrial inner membrane, and is needed for oxidation of long-chain fatty acids by all mitochondria. The rate of cardiac fatty acid oxidation is determined by availability of fatty acids, oxygen and the activity of carnitine palmitoy...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-662-08390-1_8
更新日期：1987-01-01 00:00:00
abstract：:Cardiac physiology and hypertrophy are regulated by the phosphorylation status of many proteins, which is partly controlled by a poorly defined type 2A protein phosphatase-alpha4 intracellular signalling axis. Quantitative PCR analysis revealed that mRNA levels of the type 2A catalytic subunits were differentially exp...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-017-0625-2
更新日期：2017-07-01 00:00:00
abstract：:We chronically implanted hygroscopic occluders around the left circumflex coronary artery in 49 anesthetized young male domestic pigs and we studied the development of a collateral circulation at 4, 8, 12, and 26 weeks after implantation. At these time intervals groups of animals were again anesthetized, the hearts we...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908204
更新日期：1989-09-01 00:00:00
abstract：:Ultrasonic techniques for the measurement of ventricular dimensions are widely used in acute and chronic experiments. Implantation of ultrasonic crystals is associated with reversible and irreversible myocardial damage which might limit the interpretation of the obtained results, in particular during acute experiments...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907029
更新日期：1987-07-01 00:00:00
abstract：:During myocardial ischemia, both the myocardial and serum TNFalpha concentrations are rapidly increased within the area at risk. With prolongation of ischemia and development of cardiomyocyte necrosis, the TNFalpha concentration increases also in the surrounding viable portions of the myocardium. Indeed, in the scenar...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-003-0431-x
更新日期：2004-01-01 00:00:00
abstract：:Atherosclerotic plaques impair vascular function and can lead to arterial obstruction and tissue ischaemia. Rupture of an atherosclerotic plaque within a coronary artery can result in an acute myocardial infarction, which is responsible for significant morbidity and mortality worldwide. Prompt reperfusion can salvage ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-020-00829-5
更新日期：2020-11-30 00:00:00
abstract：:Exercise is an efficient strategy for myocardial protection against ischemia-reperfusion (IR) injury. Although endothelial nitric oxide synthase (eNOS) is phosphorylated and activated during exercise, its role in exercise-induced cardioprotection remains unknown. This study investigated whether modulation of eNOS acti...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-013-0389-2
更新日期：2013-11-01 00:00:00
abstract：:We have characterized the aerobic blood-perfused isolated heart model evaluating the hemodynamics and metabolism of both the blood donor animal and the isolated organ. Anaesthesia of the blood donor with sodium pentobarbital (30 mg/kg) increases arterial concentration of non esterified fatty acids (NEFA) from 80 +/- 6...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950050145
更新日期：1999-06-01 00:00:00
abstract：:The ability of the rhesus monkey to form coronary collaterals was tested in ten animals. Ameroid constrictors were implanted on the left circumflex coronary artery and allowed to remain for 12 weeks. One animal died of an acute myocardial infarction nine days after surgery; the remaining animals survived without clini...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906462
更新日期：1983-09-01 00:00:00
abstract：:The effect of isoproterenol perfusion on cAMP levels and phosphorylase activity was investigated in the spontaneously hypertensive rat (SHR) and Kyoto Wistar normotensive control rat (WKY) heart. The basal force of contraction in physiological salt solution perfused hearts was comparable between SHR and WKY. However, ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907217
更新日期：1983-11-01 00:00:00
abstract：:Alterations in myocardial membrane phospholipids may play an important role in the pathogenesis of ischaemic myocardial cell injury. Studies in canine myocardium, perfused rat heart, and cultured myocardial cells have demonstrated that the accumulation of free arachidonic acid correlates with the development of irreve...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/978-3-662-08390-1_15
更新日期：1987-01-01 00:00:00
abstract：:Impaired nitric oxide (NO)-soluble guanylate cyclase (sGC)-cGMP signaling is involved in the pathogenesis of ischemic heart diseases, yet the impact of long-term sGC activation on progressive cardiac remodeling and heart failure after myocardial infarction (MI) has not been explored. Moreover, it is unknown whether st...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-014-0421-1
更新日期：2014-07-01 00:00:00
