Abstract:
:Alterations in myocardial membrane phospholipids may play an important role in the pathogenesis of ischaemic myocardial cell injury. Studies in canine myocardium, perfused rat heart, and cultured myocardial cells have demonstrated that the accumulation of free arachidonic acid correlates with the development of irreversible cell injury. Accumulation of other phospholipid hydrolysis products, including amphiphilic compounds such as lysophosphatidylcholine, has also been reported. The biochemical mechanisms which are responsible for phospholipid hydrolysis and arachidonic acid accumulation during ischaemia are unknown. This manuscript provides a synopsis of previous work in this field and suggests new directions for the field of myocardial phospholipid metabolism.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Sen A,Buja LM,Willerson JT,Chien KRdoi
10.1007/978-3-662-08390-1_15subject
Has Abstractpub_date
1987-01-01 00:00:00pages
121-5eissn
0300-8428issn
1435-1803journal_volume
82 Suppl 1pub_type
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