Abstract：
:In anaesthetized, artificially respirated mongrel dogs, the intravenous infusion of oxprenolol (0.3 mg and 1 mg/kg over 10 minutes) led to an increase in heart rate and cardiac output. Blood pressure in the pulmonary capillaries and right atrium, and vascular resistance were reduced. The pressure in the aorta was transiently decreased. Infusion of propranolol in the same doses was followed by a decrease in heart rate and cardiac output. The calculated peripheral resistances, pulmonary capillary pressure and right-atrial pressure increased slightly. Pressure in the aorta diminished slightly. In the light of the present results, it is evident that the intrinsic sympathomimetic activity of oxprenolol has a significant bearing on its haemodynamic effects in the anaesthetized dog.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Stepanek J,Brunner Hdoi
10.1007/BF01906388keywords:
subject
Has Abstractpub_date
1975-09-01 00:00:00pages
574-83issue
5eissn
0300-8428issn
1435-1803journal_volume
70pub_type
杂志文章abstract：:Calcium transport functions of mitochondria and sarcoplasmic reticulum (SR) were studied without prior extraction using isolated rat heart myocytes permeabilized with saponin. Calcium uptake by SR was rapid and its affinity was high in comparison to calcium uptake by mitochondria, which had a higher capacity. The sens...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907975
更新日期：1989-05-01 00:00:00
abstract：:It was previously reported that inhibition of carnitine synthesis by 3-(2,2,2-trimethyl-hydrazinium) propionate (MET-88) restores left ventricular (LV) systolic and diastolic function in rats with myocardial infarction (MI). Preservation of the calcium uptake function of sarcoplasmic reticulum Ca2+-ATPase (SERCA2) is ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950070032
更新日期：2000-10-01 00:00:00
abstract：:A major limitation in long-term studies of quiescent adult cadiomyocytes in culture has been the decline in contractile properties of the cells over time. Regular contracting cardiomyocyte cultures may represent a more physiological model. The aim of the present study was to investigate the mechanical properties and c...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788941
更新日期：1997-10-01 00:00:00
abstract：:The effects of a c-myc antisense phosphorothioate DNA oligonucleotide were assessed on the proliferation rate of human arterial smooth muscle cells (HSMCs). Compared to a control oligonucleotide the antisense oligonucleotide suppressed the proliferation of HSMCs in a concentration-dependent manner without a major cyto...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788668
更新日期：1992-11-01 00:00:00
abstract：:Previous studies indicated that the increase in protein kinase C (PKC)-mediated myofilament protein phosphorylation observed in failing myocardium might be detrimental for contractile function. This study was designed to reveal and compare the effects of PKCalpha- and PKCepsilon-mediated phosphorylation on myofilament...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-009-0053-z
更新日期：2010-03-01 00:00:00
abstract：:Mitochondrial dysfunction is an underlying cause of ischemia-reperfusion injury. In particular, ischemic injury induces dramatic increases in mitochondrial permeability, thereby instigating a chain of events that leads to both apoptotic and necrotic cardiomyocyte death. The mitochondrial permeability transition (MPT) ...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-009-0004-8
更新日期：2009-03-01 00:00:00
abstract：:The developmental profiles of the protective mechanisms of heart against peroxidative injury during neonatal growth was examined in the pigs of three different age groups. Lipid peroxidation expressed in terms of malonaldehyde formation was considerably higher in the pig hearts of the 8-10 day age group compared to th...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907051
更新日期：1987-01-01 00:00:00
abstract：:To determine the effect of magnesium on myocardial function and oxidative metabolism after reperfusion, isolated rat hearts perfused retrogradely with erythrocyte-enriched medium (0.4 mM palmitate bound to 0.4 mM albumin, 11 mM glucose) were subjected to 60 minutes of no-flow ischemia followed by 60 minutes of reperfu...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00795204
更新日期：1994-07-01 00:00:00
abstract：:Atherosclerotic plaque rupture is the key event in the pathogenesis of acute coronary syndromes and it also occurs during coronary interventions. Atherosclerotic plaque rupture does not always result in complete thrombotic occlusion of the epicardial coronary artery with subsequent impending myocardial infarction, but...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-006-0616-1
更新日期：2006-09-01 00:00:00
abstract：:Ischemic heart disease is the main cause of death worldwide and is accelerated by increased levels of low-density lipoprotein cholesterol (LDL-C). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a potent circulating regulator of LDL-C through its ability to induce degradation of the LDL receptor (LDLR) in the...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-017-0619-0
更新日期：2017-05-01 00:00:00
abstract：:Coronary artery disease (CAD), also known as ischemic heart disease (IHD), is the leading cause of mortality in the western world, with developing countries showing a similar trend. With the increased understanding of the role of the immune system and inflammation in coronary artery disease, it was shown that macropha...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-016-0554-5
更新日期：2016-07-01 00:00:00
abstract：:A canine model for a standardized induction of collaterals is presented with a fixed external constrictor that is not designed to induce an occlusion of the coronary artery and at least over the timespan of 6 weeks does not impair perfusion under resting conditions in the myocardium-at-risk. The coronary constriction ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906671
更新日期：1983-03-01 00:00:00
abstract：:The aim of the present study was to evaluate the expression of hedgehog (Hh) signaling molecules and the chemotactic activity of Sonic hedgehog (Shh) in monocytes from control (CTR) and diabetic patients with or without coronary artery disease (CAD). Previously several studies demonstrated that exogenous administratio...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-009-0047-x
更新日期：2010-01-01 00:00:00
abstract：:We compared the effects of linagliptin (Lina, a DPP4 inhibitor) and GLP-1 receptor activation by exenatide followed by exendin-4 in an infusion pump (EX) on infarct size (IS), post-infarction activation of the inflammasome and remodeling in wild-type (WT) and db/db diabetic mice. Mice underwent 30 min ischemia followe...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-019-0743-0
更新日期：2019-08-06 00:00:00
abstract：:The purpose of this study was to determine if decreased heart function after hypoxia followed by reoxygenation (H-R) is associated with increased degradation of cardiac myosin light chain 1 (MLC1) by matrix metalloproteinase-2 (MMP-2), and to investigate the effects of the increased level of peroxynitrite in the heart...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-009-0035-1
更新日期：2009-11-01 00:00:00
abstract：:The influence of cardiac cholinergic activation was studied in rats and cats on the induction and maintenance of ventricular fibrillation (VF). Acetylcholine (ACH 2-25 micrograms/kg), in doses which did not cause bradycardia or hypotension, induced appearance of spontaneous VF (duration 2-60 sec.) in 9/20 rats which h...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908386
更新日期：1984-11-01 00:00:00
abstract：:In open-chest pigs during severe myocardial ischemia [K+]e, [Ca2+]e and [H+]e increase, [Na+]e increases transiently reaching control values after 30 min. Extracellular osmolality of the ischemic area increases due to an H2O-shift from the ECS to the ICS. The increase of [Na+]e and [Ca2+]e must b explained by the shri...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908341
更新日期：1981-07-01 00:00:00
abstract：:Acute ischemia is a well-known inductor of extracellular matrix (ECM) remodeling, which leads to the development of congestive heart failure and is associated with left ventricular dilatation. Here we investigate the timecourse of ECM processing with release of endostatin (ES) and other low-molecular-weight fragments ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-009-0013-7
更新日期：2009-09-01 00:00:00
abstract：:We hypothesized that nandrolone (ND)-abuse induces cardiac hypertrophy, increases myocardial susceptibility to ischemia/reperfusion (I/R) injury, and reduces responsiveness to postconditioning (PostC) cardioprotection. Wistar-rats were ND treated for 2 weeks (short_ND) or 10 weeks (long_ND). Vehicle-treated rats serve...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-010-0143-y
更新日期：2011-05-01 00:00:00
abstract：:The concentration of fibroblast growth factor 23 (FGF23) rises progressively in renal failure (RF). High FGF23 concentrations have been consistently associated with adverse cardiovascular outcomes or death, in chronic kidney disease (CKD), heart failure or liver cirrhosis. We identified the mechanisms whereby high con...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-020-0810-6
更新日期：2020-07-22 00:00:00
abstract：:A new experimental in-vitro model is described, which was used for studying prostacyclin (PGI2)-thromboxane A2 (TXA2)-interactions. Langendorff hearts of guinea pigs are perfused at constant volume with Krebs-Henseleit buffer and washed human platelets (4 x 10(8)/min). PGI2 and TXA2 release are measured by bioassay. T...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908344
更新日期：1981-09-01 00:00:00
abstract：:The endothelin (ET) family of peptides have potent vascular, cardiac and renal actions which may be of pathophysiological importance in congestive heart failure (CHF). In vivo studies with selective and non-selective ET receptor antagonists are required to clarify the role of ET in the pathophysiology of CHF and deter...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/BF00810520
更新日期：1996-01-01 00:00:00
abstract：:The terminal complement complex C5b-9 is known to participate in inflammatory processes including atherosclerosis. Inflammation appears to be a direct consequence of C5b-9-mediated cell stimulation. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors may exert anti-inflammatory effects on vascular cel...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-003-0437-4
更新日期：2003-11-01 00:00:00
abstract：:Dopexamine is a newly developed sympathetic catecholamine which combines dopaminergic (DA-1) and beta 2-adrenergic agonist activity with only minor beta 1-adrenergic action. Thereby, this compound exerts systemic and preferential renal vasodilation, causing afterload reduction, increases in cardiac output, and improve...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/BF02650357
更新日期：1989-01-01 00:00:00
abstract：:The effects of the potassium channel openers (KCO), cromakalim or pinacidil, were evaluated in an anesthetized porcine model of pacing- and ischemia-induced ventricular fibrillation (VF). Hearts were paced at 180 bpm and the left anterior descending coronary artery was occluded until VF was induced. Reproducible times...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788735
更新日期：1994-03-01 00:00:00
abstract：:We chronically implanted hygroscopic occluders around the left circumflex coronary artery in 49 anesthetized young male domestic pigs and we studied the development of a collateral circulation at 4, 8, 12, and 26 weeks after implantation. At these time intervals groups of animals were again anesthetized, the hearts we...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908204
更新日期：1989-09-01 00:00:00
abstract：:PDE3 cyclic nucleotide phosphodiesterase inhibitors raise cAMP and cGMP content in cardiac and vascular myocytes. Their administration to patients with dilated cardiomyopathy leads to improvements in hemodynamic parameters in the short term but reduces survival with chronic administration. The reasons for this 'biphas...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950200035
更新日期：2002-01-01 00:00:00
abstract：:Delta-opioid receptors are known to participate in the protection found following ischemic preconditioning (IPC), but the role of kappa-receptors in IPC is currently controversial. Langendorff-perfused rat hearts received 35 min regional ischemia and 2 h reperfusion. PC (2 cycles 5 min global ischemia) substantially r...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950050001
更新日期：2000-02-01 00:00:00
abstract：:Intermittent, normobaric hypoxia confers robust cardioprotection against ischemia-induced myocardial infarction and lethal ventricular arrhythmias. δ-Opioid receptor (DOR) signaling and reactive oxygen species (ROS) have been implicated in cardioprotective phenomena, but their roles in intermittent hypoxia are unknown...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-016-0538-5
更新日期：2016-03-01 00:00:00
abstract：:To understand the effect of transcription regulation in modulating cardiac aging, we sought to study the role of serum response factor (SRF), a key transcription factor in the heart that is normally increased with senescence and also in congestive heart failure. A Tet-Off gene expression system was used for cardiac-sp...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-006-0634-z
更新日期：2007-05-01 00:00:00
