Abstract:
:To determine the effect of magnesium on myocardial function and oxidative metabolism after reperfusion, isolated rat hearts perfused retrogradely with erythrocyte-enriched medium (0.4 mM palmitate bound to 0.4 mM albumin, 11 mM glucose) were subjected to 60 minutes of no-flow ischemia followed by 60 minutes of reperfusion. Untreated postischemic hearts exhibited after 15 minutes of reperfusion recovery of myocardial oxygen consumption to 65% of the preischemic value despite persistent depression of left ventricular isovolumic pressure development to 21%. Magnesium (15 mM) administered during the initial 30 minutes of reperfusion reduced myocardial oxygen consumption of reperfuse myocardium by 35%. Oxidation of [1-14C]palmitate was slightly more reduced (-55%) than oxidation of [U-14C]glucose (-42%). Magnesium did not influence ultimate recovery of contractile function and cumulative myocardial release of creatine kinase. Thus, 15 mM magnesium administered during reperfusion elicited a reduction of oxidative metabolism. However, magnesium did not modify myocardial injury.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Tamm C,Papageorgiou I,Tardy I,Mermillod B,Rutishauser W,Lerch Rdoi
10.1007/BF00795204subject
Has Abstractpub_date
1994-07-01 00:00:00pages
366-79issue
4eissn
0300-8428issn
1435-1803journal_volume
89pub_type
杂志文章abstract::Mesenchymal stromal cells (MSCs) exhibit antiapoptotic and proangiogenic functions in models of myocardial infarction which may be mediated by secreted small extracellular vesicles (sEVs). However, MSCs have frequently been harvested from aged or diseased patients, while the isolated sEVs often contain high levels of ...
journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01927866
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/978-3-642-72474-9_15
更新日期:1992-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788500
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907115
更新日期:1990-05-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
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更新日期:1987-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-03-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788726
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journal_title:Basic research in cardiology
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更新日期:1999-12-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907029
更新日期:1987-07-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906948
更新日期:1989-11-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908127
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907101
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-003-0421-z
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abstract::Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia with a strong genetic component. Molecular pathways involving the homeodomain transcription factor Shox2 control the development and function of the cardiac conduction system in mouse and zebrafish. Here we report the analysis of human SHOX2 as a potent...
journal_title:Basic research in cardiology
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更新日期:2016-05-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788712
更新日期:1996-09-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
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更新日期:2020-11-30 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01905620
更新日期:1975-03-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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更新日期:1992-09-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-006-0621-4
更新日期:2006-11-01 00:00:00