TNFalpha in ischemia/reperfusion injury and heart failure.

abstract：:Epidemiological studies have repeatedly demonstrated a beneficial effect of moderate alcohol consumption on the incidence of coronary heart disease, myocardial infarction and overall mortality. The latter increases with excessive alcohol consumption. Although most epidemiological studies demonstrate a beneficial effec...

journal_title：Basic research in cardiology

authors： Flesch M,Rosenkranz S,Erdmann E,Böhm M

更新日期：2001-04-01 00:00:00

abstract：:In order to clarify the genesis of the characteristic pressure and flow pulse contours of the common carotid artery of man, at first transcutaneous pulse recordings were carried out on healthy resting subjects during breathing of room air and of a mixture of 95% O2 and 5% CO2 (Carbogen). The latter was used to cause v...

journal_title：Basic research in cardiology

authors： Busse R,Bauer RD,Schabert A,Summa Y,Zinecker U,Wetterer E

更新日期：1977-11-01 00:00:00

abstract：:Regional glucose utilization of the developing fetal feline heart was assessed during three stages of gestation and compared with the maternal heart and non-pregnant controls. The specific aims were to determine: 1) if glucose utilization by the whole heart changes from early to late gestation; 2) if there are differe...

journal_title：Basic research in cardiology

authors： Kostreva DR,Wood JD

更新日期：1991-07-01 00:00:00

abstract：:It was previously reported that inhibition of carnitine synthesis by 3-(2,2,2-trimethyl-hydrazinium) propionate (MET-88) restores left ventricular (LV) systolic and diastolic function in rats with myocardial infarction (MI). Preservation of the calcium uptake function of sarcoplasmic reticulum Ca2+-ATPase (SERCA2) is ...

journal_title：Basic research in cardiology

authors： Yonekura K,Eto Y,Yokoyama I,Matsumoto A,Sugiura S,Momomura S,Kirimoto T,Hayashi Y,Omata M,Aoyagi T

更新日期：2000-10-01 00:00:00

abstract：:Although it has long been recognized that thyroid hormone is an effective positive inotrope, its efficacy in supporting hemodynamics in the acute setting of ischaemia and reperfusion (R) without worsening reperfusion injury remains largely unknown. Thus, we investigated the effects of triiodothyronine (T3) on reperfus...

journal_title：Basic research in cardiology

authors： Pantos C,Mourouzis I,Saranteas T,Clavé G,Ligeret H,Noack-Fraissignes P,Renard PY,Massonneau M,Perimenis P,Spanou D,Kostopanagiotou G,Cokkinos DV

更新日期：2009-01-01 00:00:00

abstract：:Nitric oxide (NO) exerts several effects on myocardial contraction, including enhancement of relaxation and diastolic function, modulation of beta-adrenergic inotropic responses, and inotropic effects in the absence of agonist pre-stimulation. Different effects have been observed in different species and preparations,...

journal_title：Basic research in cardiology

authors： Prendergast BD,MacCarthy P,Wilson JF,Shah AM

更新日期：1998-08-01 00:00:00

abstract：:The characterization of various ion transport systems has led to a better understanding of the effects, which seem to take part in the impairment of ischemic and reperfused cardiac tissue. This review discusses the role of the Na+/H+ exchange system in the pathophysiology of ischemia and reperfusion and the beneficial...

journal_title：Basic research in cardiology

authors： Scholz W,Albus U

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVE:Two types of hemodynamic overload, pressure and volume overload, result in morphologically distinct types of cardiac remodeling. We explored the possibility that distinct hemodynamic overload may differentially activate the signal transduction pathway. METHODS:Pressure and volume overload were induced by tho...

journal_title：Basic research in cardiology

authors： Miyamoto T,Takeishi Y,Takahashi H,Shishido T,Arimoto T,Tomoike H,Kubota I

更新日期：2004-09-01 00:00:00

abstract：:The effects of regional hypoxemia and ischemia on epicardial electrogram were studied in anesthetized, open-chest dogs. The left circumflex artery (LCx) was cannulated and perfused with either arterial blood or hypoxic solution. A contact electrode for recording monophasic action potential (MAP) was applied to the epi...

journal_title：Basic research in cardiology

authors： Ikeno E,Kubota I,Kondo T,Yamaki M,Shibata T,Tomoike H

更新日期：1995-11-01 00:00:00

abstract：:The role of miR-92a on vascular remodelling after injury is currently unknown. Thus, the aim of the present study was to evaluate the role of miR-92a on rat endothelial and vascular smooth muscle cells proliferation and migration in vitro as well as after balloon injury or arterial stenting in vivo. MiR-92a was highly...

journal_title：Basic research in cardiology

authors： Iaconetti C,Polimeni A,Sorrentino S,Sabatino J,Pironti G,Esposito G,Curcio A,Indolfi C

更新日期：2012-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) are important regulators of adaptive and maladaptive responses in cardiovascular diseases and hence are considered to be potential therapeutical targets. However, their role as novel biomarkers for the diagnosis of cardiovascular diseases still needs to be systematically evaluated. We assessed here ...

journal_title：Basic research in cardiology

authors： Meder B,Keller A,Vogel B,Haas J,Sedaghat-Hamedani F,Kayvanpour E,Just S,Borries A,Rudloff J,Leidinger P,Meese E,Katus HA,Rottbauer W

更新日期：2011-01-01 00:00:00

abstract：:The effects of increased perfusion pressure and epinephrine stimulation on the contractile parameters and glucose transport in the isolated perfused hearts of control and ketotic diabetic rats were studied. An increase in perfusion pressure from 60 mm Hg to 100 mm Hg resulted in increases in coronary flow and peak aor...

journal_title：Basic research in cardiology

authors： Murthy VK,Bauman MD,Shipp JC

更新日期：1983-05-01 00:00:00

abstract：:The influence of decapitation, ketamine and thiopental anesthesia on some properties of rat heart mitochondria was compared. Polarographic analysis were performed, oxygen consumption rates, respiratory control index, ADP : O ratio and oxidation of exogenous NADH were determined. Electronmicroscopic and gasometric exam...

journal_title：Basic research in cardiology

authors： Dutkiewicz T,Chelstowski K

更新日期：1981-03-01 00:00:00

abstract：:Denervation deprives the heart of its normal adrenergic and cholinergic control via the sympathetic and parasympathetic pathways. In a heart which is blood supplied by a donor animal of the same species, normal contractility is maintained, probably by blood borne catecholamines or possibly by unknown inotropic agents ...

journal_title：Basic research in cardiology

authors： Reichel H

更新日期：1976-01-01 00:00:00

abstract：:Myocardial stunning, a transient contractile dysfunction that appears following a brief period of ischemia, is at least partly due to the production of oxygen-derived free radicals. The objective of the present study was to determine whether the Ginkgo biloba extract EGb761, which has antioxidant properties in vitro, ...

journal_title：Basic research in cardiology

authors： Rioufol G,Pietri S,Culcasi M,Loufoua J,Staat P,Pop C,Drieu K,Ovize M

更新日期：2003-02-01 00:00:00

abstract：:Mobilization of triacylglycerol stored in heart cells is accomplished by the combined action of lysosomal (acid) lipase and microsomal monoacylglycerol lipase or carboxylesterase. Non(heparin)-releasable neutral or alkaline lipase is similar to non(readily)-releasable lipoprotein lipase (LPL). The enzyme is mainly loc...

journal_title：Basic research in cardiology

authors： Hülsmann WC,Stam H,Jansen H

更新日期：1984-05-01 00:00:00

abstract：:Transient receptor potential melastatin-7 (TRPM7) channels have been recently reported in human atrial fibroblasts and are believed to mediate fibrogenesis in human atrial fibrillation. The present study investigates whether TRPM7 channels are expressed in human atrial myocytes using whole-cell patch voltage-clamp, RT...

journal_title：Basic research in cardiology

authors： Zhang YH,Sun HY,Chen KH,Du XL,Liu B,Cheng LC,Li X,Jin MW,Li GR

更新日期：2012-09-01 00:00:00

abstract：:Increased afterload results in 'pathological' cardiac hypertrophy, the most important risk factor for the development of heart failure. Current in vitro models fall short in deciphering the mechanisms of hypertrophy induced by afterload enhancement. The aim of this study was to develop an experimental model that allow...

journal_title：Basic research in cardiology

authors： Hirt MN,Sörensen NA,Bartholdt LM,Boeddinghaus J,Schaaf S,Eder A,Vollert I,Stöhr A,Schulze T,Witten A,Stoll M,Hansen A,Eschenhagen T

更新日期：2012-11-01 00:00:00

abstract：:The ability of the rhesus monkey to form coronary collaterals was tested in ten animals. Ameroid constrictors were implanted on the left circumflex coronary artery and allowed to remain for 12 weeks. One animal died of an acute myocardial infarction nine days after surgery; the remaining animals survived without clini...

journal_title：Basic research in cardiology

authors： Buss DD,Hyde DM,Steffey EP

更新日期：1983-09-01 00:00:00

abstract：:Cardiomyopathy is one of the most common causes of chronic heart failure worldwide. Mutations in the gene encoding nexilin (NEXN) occur in patients with both hypertrophic and dilated cardiomyopathy (DCM); however, little is known about the pathophysiological mechanisms and relevance of NEXN to these disorders. Here, w...

journal_title：Basic research in cardiology

authors： Aherrahrou Z,Schlossarek S,Stoelting S,Klinger M,Geertz B,Weinberger F,Kessler T,Aherrahrou R,Moreth K,Bekeredjian R,Hrabě de Angelis M,Just S,Rottbauer W,Eschenhagen T,Schunkert H,Carrier L,Erdmann J

更新日期：2016-01-01 00:00:00

abstract：:Protection from postconditioning has been documented in in situ animal models and it has been proposed that it is targeting circulating leukocytes. We therefore tested whether postconditioning can protect leukocyte-free, buffer-perfused rabbit hearts. Infarct size was measured with triphenyltetrazolium staining. In co...

journal_title：Basic research in cardiology

authors： Yang XM,Philipp S,Downey JM,Cohen MV

更新日期：2005-01-01 00:00:00

abstract：:PDE3 cyclic nucleotide phosphodiesterase inhibitors raise cAMP and cGMP content in cardiac and vascular myocytes. Their administration to patients with dilated cardiomyopathy leads to improvements in hemodynamic parameters in the short term but reduces survival with chronic administration. The reasons for this 'biphas...

journal_title：Basic research in cardiology

authors： Movsesian MA

更新日期：2002-01-01 00:00:00

abstract：:Reperfusion following various intervals of coronary occlusion has produced conflicting results: increase in infarct size, especially with hemorrhage into the tissue, was reported as well as salvage of ischemic myocardium. To examine the problem and for the validation of our own method for infarct size measurement, whi...

journal_title：Basic research in cardiology

authors： Hofmann M,Hofmann M,Genth K,Schaper W

更新日期：1980-07-01 00:00:00

abstract：:The capillary wall, due to its diffusional resistance, causes concentration differences between the vascular space and the interstitial space for substances which are released or taken up by the heart. Estimation of capillary transfer and interstitial concentration in isolated hearts, however, indicates a variable dif...

journal_title：Basic research in cardiology

authors： Kammermeier H,Wein B,Gerards P,Lang U,Wendtland B,Schmitz D,Rose H

更新日期：1985-01-01 00:00:00

abstract：:Rate or frequency-dependence is a characteristic property of antiarrhythmic drugs belonging to the Vaughan William classes I and III. The rate-dependence of class I drugs (i.e., increasing blockade of fast Na(+)-channels with faster rates) results from periodical drug binding to Na(+)-channel sites which are preferabl...

journal_title：Basic research in cardiology

authors： Weirich J,Antoni H

更新日期：1998-01-01 00:00:00

abstract：:The proximal segments of the left coronary artery are foreshortended in the usual projections. By additional cranio-caudal (half axial) projections the X-ray beam can be directed perpendicular to these segments. In some patients lesions especially of the left main coronary artery or the proximal LAD can be seen or acc...

journal_title：Basic research in cardiology

authors： Rentrop P

更新日期：1976-01-01 00:00:00

abstract：:The behavior of Ca(2+)-activated K+ channels of large conductance (BKCa) in smooth muscle cells, which were obtained from atherosclerotic plaque material (SMCP) and from media segments (SMCM) of human coronary arteries, were compared using the patch-clamp technique. Voltage-clamp protocols in cell-attached patches rev...

journal_title：Basic research in cardiology

authors： Wiecha J,Schläger B,Voisard R,Hannekum A,Mattfeldt T,Hombach V

更新日期：1997-08-01 00:00:00

abstract：:It is commonly thought that the optimal method for intracoronary administration of cells is to stop coronary flow during cell infusion, in order to prolong cell/vascular wall contact, enhance adhesion, and promote extravasation of cells into the interstitial space. However, occlusion of a coronary artery with a balloo...

journal_title：Basic research in cardiology

authors： Keith MC,Tokita Y,Tang XL,Ghafghazi S,Moore JB 4th,Hong KU,Elmore JB,Amraotkar AR,Guo H,Ganzel BL,Grubb KJ,Flaherty MP,Vajravelu BN,Wysoczynski M,Bolli R

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:Cardiac stunning is the consequence of a brief cardiac ischemia. The underlying mechanism is not completely understood. METHODS:Here we induced cardiac transient ischemia in conscious instrumented dogs by means of an occluder in the left anterior descending coronary artery (LAD). Contractile performance, mon...

journal_title：Basic research in cardiology

authors： Weber T,Neumann J,Meissner A,Grosse Hartlage M,Van Aken H,Hanske G,Schmitz W,Boknik P

更新日期：2006-05-01 00:00:00

abstract：:The relationship between ischemic contracture and no-reflow phenomenon was studied in 59 isolated rat hearts during global ischemia. The contracture was measured by a water-filled balloon catheter placed in the left ventricular lumen. The time of onset of contracture was changed by preischemic infusion with buffer con...

journal_title：Basic research in cardiology

authors： Lipasti JA,Nevalainen TJ,Alanen KA

更新日期：1982-07-01 00:00:00