Abstract:
:Using an isolated rat heart preparation (Langendorff perfusion, perfusion pressure 100 cm H2O) the response of the hypertrophied heart (spontaneous hypertensive rats lv/bw ratio 3.6 +/- 0.5) to global normothermic (30 min) and hypothermic (25 degrees C, 120 min) ischemic and cardioplegic arrest and reperfusion (30 min) was examined and compared with normal hearts (Wistar rats lv/bw ratio 2.0 +/- 0.3). St. Thomas solution and verapamil (2 mg/l Ringer solution) were used as cardioplegic agents. Before ischemia hypertrophied hearts had a significantly higher pressure-rate product, a lower myocardial perfusion/g myocardium and a lower myocardial ATP and adenine nucleotide content. Unmodified ischemia reduced myocardial function in the hypertrophied hearts to a greater degree than in normal hearts in both normo- and hypothermia. St. Thomas solution and verapamil protected significantly the myocardial function in the normal and hypertrophied heart after normothermic ischemia in a similar manner (60-70% of the initial value). In the hypertrophied ventricle ATP decay and adenine nucleotide loss was greater in verapamil than in St. Thomas solution treated hearts. In hypothermic ischemia only St. Thomas solution protected left ventricular function and adenine nucleotide loss in both normal and hypertrophied hearts. Verapamil was ineffective in the normal ventricle and protected left ventricular function but not the ATP and adenine nucleotide decay in the hypertrophied heart.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Fenchel G,Storf R,Hoffmeister HE,Heller Wdoi
10.1007/978-3-662-11374-5_12subject
Has Abstractpub_date
1986-01-01 00:00:00pages
117-25eissn
0300-8428issn
1435-1803journal_volume
81 Suppl 1pub_type
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906357
更新日期:1977-03-01 00:00:00
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907227
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908341
更新日期:1981-07-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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更新日期:1988-05-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01914339
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pub_type: 杂志文章
doi:10.1007/s00395-011-0181-0
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journal_title:Basic research in cardiology
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doi:10.1007/s00395-016-0571-4
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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更新日期:1989-05-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907778
更新日期:1976-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-07-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/978-3-642-72474-9_17
更新日期:1992-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00789447
更新日期:1995-03-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950050207
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906525
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:
更新日期:1991-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01935807
更新日期:1984-01-01 00:00:00
abstract::The influence of decapitation, ketamine and thiopental anesthesia on some properties of rat heart mitochondria was compared. Polarographic analysis were performed, oxygen consumption rates, respiratory control index, ADP : O ratio and oxidation of exogenous NADH were determined. Electronmicroscopic and gasometric exam...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907952
更新日期:1981-03-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-005-0577-9
更新日期:2006-05-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章
doi:10.1007/BF01907206
更新日期:1983-11-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00803755
更新日期:1997-02-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-017-0626-1
更新日期:2017-07-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906959
更新日期:1988-11-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908160
更新日期:1981-01-01 00:00:00