Therapeutic angiogenesis. Devising new strategies based on past experiences.

abstract：:Transient receptor potential melastatin-7 (TRPM7) channels have been recently reported in human atrial fibroblasts and are believed to mediate fibrogenesis in human atrial fibrillation. The present study investigates whether TRPM7 channels are expressed in human atrial myocytes using whole-cell patch voltage-clamp, RT...

journal_title：Basic research in cardiology

authors： Zhang YH,Sun HY,Chen KH,Du XL,Liu B,Cheng LC,Li X,Jin MW,Li GR

更新日期：2012-09-01 00:00:00

abstract：:Mitochondrial dysfunction is an underlying cause of ischemia-reperfusion injury. In particular, ischemic injury induces dramatic increases in mitochondrial permeability, thereby instigating a chain of events that leads to both apoptotic and necrotic cardiomyocyte death. The mitochondrial permeability transition (MPT) ...

journal_title：Basic research in cardiology

authors： Baines CP

更新日期：2009-03-01 00:00:00

abstract：:To investigate the effect of nifedipine on hypercalcemic electrocardiographical alterations, steadily increasing hypercalcemia was induced in guinea-pigs by continuous calcium gluconate infusion until cardiac arrest occurred. During the experimental time the electrocardiograms were continuously recorded and compared i...

journal_title：Basic research in cardiology

authors： Schäfer W,Schäfer A,Schäfer H

更新日期：1982-01-01 00:00:00

abstract：:A major limitation in long-term studies of quiescent adult cadiomyocytes in culture has been the decline in contractile properties of the cells over time. Regular contracting cardiomyocyte cultures may represent a more physiological model. The aim of the present study was to investigate the mechanical properties and c...

journal_title：Basic research in cardiology

authors： Holt E,Lunde PK,Sejersted OM,Christensen G

更新日期：1997-10-01 00:00:00

abstract：:Hypoxia leads to an elevation of the pulmonary vascular resistance (pvR) in pigs. This alteration of the hemodynamic was accompanied by a slight increase of intraparenchymatous concentrations of cyclic GMP (cGMP), while cycle AMP (cAMP) levels were not different from values, measured during normoxia. beta-adrenergic a...

journal_title：Basic research in cardiology

authors： Kaukel E,Beier W,Lanser K,Sill V

更新日期：1977-09-01 00:00:00

abstract：:The focal adhesion and microfilament-associated protein VASP is a major substrate of both cAMP- and cGMP-dependent protein kinase in intact human platelets. The recent elucidation of the primary VASP structure and identity of VASP binding proteins suggest that VASP is an important component of focal contacts which lin...

journal_title：Basic research in cardiology

authors： Markert T,Krenn V,Leebmann J,Walter U

更新日期：1996-09-01 00:00:00

abstract：:Recent studies have demonstrated the presence of autoantibodies against alpha(1)-adrenoceptor (alpha(1)-AAB) in the serum of patients with primary hypertension, and that these autoantibodies exert adrenergic-agonist-like effects. However, their role in the development of hypertension remains unclear. The current study...

journal_title：Basic research in cardiology

authors： Yan L,Xu Y,Yao H,Xue W,Tian J,Ren H,Wu Y,Yang G,Ma XL,Liu H

更新日期：2009-09-01 00:00:00

abstract：:There is no doubt that major advances have been made in cardiac electrophysiology using single heart cells. Accurate analysis of rapid inward sodium current and the second inward current carried by calcium has resulted in a major re-examination of the steps involved in excitation-contraction coupling in the heart. Fut...

journal_title：Basic research in cardiology

authors： Powell T

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVES:Single electrical field shocks are able to induce ventricular fibrillation (VF) if applied during the vulnerable period. During this period, a shock can either prolong the action potential duration or induce a new action potential. Whether the occurrence of different shock responses contributes to the induct...

journal_title：Basic research in cardiology

authors： Kirchhof PF,Fabritz CL,Behrens S,Franz MR

更新日期：1997-02-01 00:00:00

abstract：:Cardioprotection aims at infarct size reduction and improvement of clinical outcome from myocardial infarction. The translation of cardioprotection from preclinical and promising proof-of-concept studies to clinical benefit for patients has been largely disappointing. Almost all of these studies which did not translat...

journal_title：Basic research in cardiology

authors： Heusch G

更新日期：2019-10-15 00:00:00

abstract：:Transformation of structural, functional, metabolic and molecular characteristics is induced by stimulating fast-twitch muscles with the frequency pattern of a motoneuron normally innervating a slow-twitch muscle. These changes correspond to a transition of a "fast-white" into a "slow-red" muscle. Intermittent stimula...

journal_title：Basic research in cardiology

authors： Pette D,Heilmann C

更新日期：1977-03-01 00:00:00

abstract：:Complete length-tension diagrams of myocardium were measured on isolated papillary muscles of cat right ventricle. These diagrams clearly demonstrate that irrespective of loading conditions there is no uniform maxima curve. As a function of preload the curves of afterloaded isotonic maxima obey totally separate nonlin...

journal_title：Basic research in cardiology

authors： Gülch RW

更新日期：1985-11-01 00:00:00

abstract：:Recent studies demonstrated that NADPH oxidase 2 (NOX2) expression in myocardium after ischemia-reperfusion (IR) is significantly upregulated. However, the underlying mechanisms remain unknown. This study aims to determine if nuclear cardiac myosin light chain 2 (MYL2), a well-known regulatory subunit of myosin, funct...

journal_title：Basic research in cardiology

authors： Zhang YS,Liu B,Luo XJ,Li TB,Zhang JJ,Peng JJ,Zhang XJ,Ma QL,Hu CP,Li YJ,Peng J,Li Q

更新日期：2015-01-01 00:00:00

abstract：:Receptor for advanced glycation end products (RAGE) and connective tissue growth factor (CTGF) play a key role in diabetic myocardial fibrosis, and peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation has been reported to reduce RAGE and CTGF expression. This study investigated the effects of the P...

journal_title：Basic research in cardiology

authors： Ihm SH,Chang K,Kim HY,Baek SH,Youn HJ,Seung KB,Kim JH

更新日期：2010-05-01 00:00:00

abstract：:The flow pattern and the paths of fluid particles in a saccular aneurysm located at the bifurcation of an intracranial arterial segment are investigated with a numerical method. A normal physiological flow pattern was assumed as input to the studied segment. The theoretical study is carried out for two different Reyno...

journal_title：Basic research in cardiology

authors： Perktold K,Kenner T,Hilbert D,Spork B,Florian H

更新日期：1988-01-01 00:00:00

abstract：:The terminal complement complex C5b-9 is known to participate in inflammatory processes including atherosclerosis. Inflammation appears to be a direct consequence of C5b-9-mediated cell stimulation. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors may exert anti-inflammatory effects on vascular cel...

journal_title：Basic research in cardiology

authors： Viedt C,Shen W,Fei J,Kamimura M,Hänsch GM,Katus HA,Kreuzer J

更新日期：2003-11-01 00:00:00

abstract：:Calcium transport functions of mitochondria and sarcoplasmic reticulum (SR) were studied without prior extraction using isolated rat heart myocytes permeabilized with saponin. Calcium uptake by SR was rapid and its affinity was high in comparison to calcium uptake by mitochondria, which had a higher capacity. The sens...

journal_title：Basic research in cardiology

authors： Kaminishi T,Kako KJ

更新日期：1989-05-01 00:00:00

abstract：:An increased occurrence of hypertension has been reported among leg-amputees. In order to investigate whether leg amputation is followed by an elevation of sympathetic tone, possibly enhanced by continuous mechanical irritation of the amputation stump by wearing a prosthesis, blood pressure (BP), pulse-rate (PR) and p...

journal_title：Basic research in cardiology

authors： Grubeck-Loebenstein B,Korn A,Waldhäusl W

更新日期：1981-05-01 00:00:00

abstract：:Ultrasonic techniques for the measurement of ventricular dimensions are widely used in acute and chronic experiments. Implantation of ultrasonic crystals is associated with reversible and irreversible myocardial damage which might limit the interpretation of the obtained results, in particular during acute experiments...

journal_title：Basic research in cardiology

authors： Schipke J,Heusch G,Schulz R,Thämer V

更新日期：1987-07-01 00:00:00

abstract：:Cardiac hypertrophy which occurs during chronic mechanical overload is one of the numerous examples of biological adaptation to environmental requirements. As such, it is obtained at random by trial and error, and adaptation represents the sum of various modifications in gene expression, including the shift in isoform...

journal_title：Basic research in cardiology

authors： Chevalier B,Charlemagne D,Callens-el Amrani F,Carre F,Moalic JM,Delcayre C,Mansier P,Swynghedauw B

更新日期：1992-01-01 00:00:00

abstract：:We chronically implanted hygroscopic occluders around the left circumflex coronary artery in 49 anesthetized young male domestic pigs and we studied the development of a collateral circulation at 4, 8, 12, and 26 weeks after implantation. At these time intervals groups of animals were again anesthetized, the hearts we...

journal_title：Basic research in cardiology

authors： Görge G,Schmidt T,Ito BR,Pantely GA,Schaper W

更新日期：1989-09-01 00:00:00

abstract：:Adult epicardial cells are required for endogenous cardiac repair. After myocardial injury, they are reactivated, undergo epithelial-to-mesenchymal transformation (EMT) and migrate into the injured myocardium where they generate various cell types, including coronary smooth muscle cells and cardiac interstitial fibrob...

journal_title：Basic research in cardiology

authors： Bax NA,van Oorschot AA,Maas S,Braun J,van Tuyn J,de Vries AA,Groot AC,Goumans MJ

更新日期：2011-09-01 00:00:00

abstract：:The genetic defect in the cardiomyopathic (CM) hamster is a mutation in the glycoprotein-sarcoglycan (a component of the dystrophin-glycoprotein complex). Apoptosis has been identified in skeletal muscle of dystrophin-deficient mice, and therefore the role of myocardial apoptosis in relation to oncosis in causing myoc...

journal_title：Basic research in cardiology

authors： Ryoke T,Gu Y,Ikeda Y,Martone ME,Oh SS,Jeon ES,Knowlton KU,Ross J Jr

更新日期：2002-01-01 00:00:00

abstract：:Recent publications shown mitochondrial localization of the enzyme nitric oxide synthase (NOS) in a number of tissues. However, conflicting results about mitochondrial NOS (mtNOS) immunoreactivity and enzymatic activity are available to date in the literature. In this study we purified mitochondria from rat hearts and...

journal_title：Basic research in cardiology

authors： Zanella B,Giordano E,Muscari C,Zini M,Guarnieri C

更新日期：2004-05-01 00:00:00

abstract：:Mitochondria in largely postmitotic cells (e.g. cardiomyocytes, neurons or skeletal muscle myotubes) have a limited life span of a few weeks. Their replacement during normal turnover requires an intergenomic coordination between the mitochondrial genome (mtDNA, encoding for 13 protein subunits of the respiratory chain...

journal_title：Basic research in cardiology

authors： Szibor M,Holtz J

更新日期：2003-07-01 00:00:00

abstract：:Ventricular and atrial cardiac muscle cells isolated from the adult rat have been cultured and characterized. Once established in culture these myocytes resemble morphologically their in vivo counterparts except that they are flattened on the surface of the culture flask. These cultured cells possess differentiated ul...

journal_title：Basic research in cardiology

authors： Claycomb WC

更新日期：1985-01-01 00:00:00

abstract：:Successive ischemic episodes are commonly seen in clinical and experimental cardiology. Although prolonged abnormalities of the canine myocardium have been described following a single ischemic episode, it is not known whether myocardial injury is cumulative following multiple ischemic episodes. Dogs were subjected to...

journal_title：Basic research in cardiology

authors： Lange R,Ingwall JS,Hale SL,Alker KJ,Kloner RA

更新日期：1984-07-01 00:00:00

abstract：:Recent reports indicate that elevating DNA glycosylase/AP lyase repair enzyme activity offers marked cytoprotection in cultured cells and a variety of injury models. In this study, we measured the effect of EndoIII, a fusion protein construct that traffics Endonuclease III, a DNA glycosylase/AP lyase, to the mitochond...

journal_title：Basic research in cardiology

authors： Yang XM,Cui L,White J,Kuck J,Ruchko MV,Wilson GL,Alexeyev M,Gillespie MN,Downey JM,Cohen MV

更新日期：2015-03-01 00:00:00

abstract：:N,N-dimethylsphingosine (DMS) has been documented to be in vitro protective against myocardial ischemia-reperfusion injury (IRI) and can recruit CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), which may participate in the cardioprotection. We hypothesized that when in vivo applied after a myocardial ischemia, DMS ma...

journal_title：Basic research in cardiology

authors： Fang J,Hu F,Ke D,Yan Y,Liao Z,Yuan X,Wu L,Jiang Q,Chen L

更新日期：2016-05-01 00:00:00

abstract：:In recent years research has shown that muscle is capable of reacting to mechanical stimuli by altering biochemical processes. Myocardium is probably the source of a biochemical factor, or factors which activate myocardial protein synthesis. In experimentally induced cardiac hypertrophy adaptive alterations have been ...

journal_title：Basic research in cardiology

authors： Kölbel F,Schreiber V

更新日期：1983-07-01 00:00:00