Long-term culture and characterization of the adult ventricular and atrial cardiac muscle cell.

abstract：:To investigate the effect of nifedipine on hypercalcemic electrocardiographical alterations, steadily increasing hypercalcemia was induced in guinea-pigs by continuous calcium gluconate infusion until cardiac arrest occurred. During the experimental time the electrocardiograms were continuously recorded and compared i...

journal_title：Basic research in cardiology

authors： Schäfer W,Schäfer A,Schäfer H

更新日期：1982-01-01 00:00:00

abstract：:Nitric oxide (NO) exerts several effects on myocardial contraction, including enhancement of relaxation and diastolic function, modulation of beta-adrenergic inotropic responses, and inotropic effects in the absence of agonist pre-stimulation. Different effects have been observed in different species and preparations,...

journal_title：Basic research in cardiology

authors： Prendergast BD,MacCarthy P,Wilson JF,Shah AM

更新日期：1998-08-01 00:00:00

abstract：:Increase of Ca2+ concentration to 7.5 mM in the presence of 10 mM or 20 mM caffeine shifted length-tension relationships of 5 rat trabecular muscles and 5 cat papillary muscles to higher tensions. At 1max diastolic tension was enhanced from (formula: see text), for all measured points of stress-strain relationships af...

journal_title：Basic research in cardiology

authors： Holubarsch C,Jacob R

更新日期：1978-09-01 00:00:00

abstract：:Reperfusion following various intervals of coronary occlusion has produced conflicting results: increase in infarct size, especially with hemorrhage into the tissue, was reported as well as salvage of ischemic myocardium. To examine the problem and for the validation of our own method for infarct size measurement, whi...

journal_title：Basic research in cardiology

authors： Hofmann M,Hofmann M,Genth K,Schaper W

更新日期：1980-07-01 00:00:00

abstract：BACKGROUND:The phytosterol guggulsterone is a potent anti-inflammatory mediator with less side effects than classic steroids. This study assesses the impact of guggulsterone on tissue factor (TF) expression and thrombus formation. METHODS AND RESULTS:Guggulsterone inhibited TNF-alpha-induced endothelial TF protein exp...

journal_title：Basic research in cardiology

authors： Gebhard C,Stämpfli SF,Gebhard CE,Akhmedov A,Breitenstein A,Camici GG,Holy EW,Lüscher TF,Tanner FC

更新日期：2009-05-01 00:00:00

abstract：:We investigated whether atrial natriuretic peptide (ANP) given just prior to reperfusion reduces infarction in rabbit hearts and whether protection is related to activation of protein kinase G (PKG). Isolated rabbit hearts were subjected to a 30-min period of regional ischemia; treated hearts received a 20-min infusio...

journal_title：Basic research in cardiology

authors： Yang XM,Philipp S,Downey JM,Cohen MV

更新日期：2006-07-01 00:00:00

abstract：:In the isometrically contracting rat trabecular muscle strip preparation, contracture tension was induced either by 10 min of hypoxia (low contracture tension) or by 30 min of joint oxygen and glucose withdrawal (severe contracture tension) at optimum length. Using stepwise 0.1 mm releases, length-tension relationship...

journal_title：Basic research in cardiology

authors： Holubarsch C,Jacob R

更新日期：1981-11-01 00:00:00

abstract：:If everything happens strictly according to the natural laws, which meet extremum principles, in what way can the possibility for life be characterised, so that the optimization processes of evolution can take place? Is it legitimate to "enlarge" the natural laws by certain laws of conservation? The question then aris...

journal_title：Basic research in cardiology

authors： Deppert W

更新日期：1993-01-01 00:00:00

abstract：:SIRT6, a member of the NAD(+)-dependent class III deacetylase sirtuin family, has been revealed to play important roles in promoting cellular resistance against oxidative stress. The formation of reactive oxygen species (ROS) and oxidative stress are the crucial mechanisms underlying cellular damage and dysfunction in...

journal_title：Basic research in cardiology

authors： Wang XX,Wang XL,Tong MM,Gan L,Chen H,Wu SS,Chen JX,Li RL,Wu Y,Zhang HY,Zhu Y,Li YX,He JH,Wang M,Jiang W

更新日期：2016-03-01 00:00:00

abstract：:Guinea-pig left atria were loaded with 10 microCi 7-[3H]noradrenaline, and noradrenaline release from sympathetic nerve endings was then elicited by refractory period field stimulation. When one pulse of 0.2 ms duration was applied during each refractory period, the resulting transmitter release was halved by 3 x 10(-...

journal_title：Basic research in cardiology

authors： Brasch H

更新日期：1993-11-01 00:00:00

abstract：:Using isolated canine small (right coronary branch, left coronary branch; o. d. 0.4-0.8 mm) and large (left coronary, circumflex; o. d. 1-2 mm) coronary arteries, the beta-adrenergic antagonist dl-propranolol (5 X 10(-7) to 5 X 10(-5) m/l) was found to produce concentration-dependent contractions. Interestingly, most ...

journal_title：Basic research in cardiology

authors： Turlapaty PD,Altura BM

更新日期：1982-01-01 00:00:00

abstract：:The renin angiotensin system and endothelium-derived vasoactive substances are both important regulators of vascular tone. Recent evidence suggests that the two systems may be tightly interconnected and drugs interfering with one system may also affect the other. Beside the circulating renin angiotensin system, a vasc...

journal_title：Basic research in cardiology

authors： Lüscher TF

更新日期：1993-01-01 00:00:00

abstract：:Ceramide has been shown to be a key signaling molecule involved in the apoptotic effect of tumor necrosis factor alpha (TNF-alpha) and other cytokines. Given the importance of cytokines such as TNF-alpha in myocardial ischemia-reperfusion injury, we hypothesize that ceramide is increased during ischemia or reperfusion...

journal_title：Basic research in cardiology

authors： Zhang DX,Fryer RM,Hsu AK,Zou AP,Gross GJ,Campbell WB,Li PL

更新日期：2001-05-01 00:00:00

abstract：:Hypertrophic cardiomyopathy (HCM) is a leading cause of heart failure and sudden death in adolescents and young adults. Recently, the role of the Hippo/YAP pathway has been investigated in the pathogenesis of HCM, although the detailed molecular mechanisms largely remain elusive. In this study, we demonstrated an up-r...

journal_title：Basic research in cardiology

authors： Wang P,Mao B,Luo W,Wei B,Jiang W,Liu D,Song L,Ji G,Yang Z,Lai YQ,Yuan Z

更新日期：2014-01-01 00:00:00

abstract：:Low-flow perfusion of paced (5 Hz) rat heart Langendorff preparation with Tyrode solution for 60 min caused a reduction or disappearance of left ventricular pressure amplitude. After 60 min of low-flow perfusion myocardial concentrations of high energy phosphates, as well as the energy charged potential, were diminish...

journal_title：Basic research in cardiology

authors： Streller I,Walland A

更新日期：1990-01-01 00:00:00

abstract：:Cardioprotection aims at infarct size reduction and improvement of clinical outcome from myocardial infarction. The translation of cardioprotection from preclinical and promising proof-of-concept studies to clinical benefit for patients has been largely disappointing. Almost all of these studies which did not translat...

journal_title：Basic research in cardiology

authors： Heusch G

更新日期：2019-10-15 00:00:00

abstract：:The assessment of endothelium-mediated modulation of coronary vasomotor tone in the intact human circulation under physiologic conditions requires very precise determination of both epicardial artery diameters, reflecting effects within the conduit vessels, as well as coronary blood flow, reflecting effects within the...

journal_title：Basic research in cardiology

authors： Wollschläger H,Zeiher AM,Drexler H,Just H

更新日期：1991-01-01 00:00:00

abstract：:To evaluate the hypothesis that maintenance of the integrity of myocardial membrane systems and prevention of Ca2+ influx into the cell are significant in the survival of ischaemic tissue, the effect of trifluoperazine and lysolecithin, were tested on the recovery of globally ischaemic rat hearts. Trifluoperazine incr...

journal_title：Basic research in cardiology

authors： Lochner A,van Niekerk I,Kotzé JC

更新日期：1985-07-01 00:00:00

abstract：:The influence of PGI2 and iloprost on the contents of high energy phosphates, cAMP, glycolytic metabolites and on cardiac performance was investigated in open-chest dogs subjected to 3 h of ischaemia, induced by occlusion of the left anterior descending coronary artery. The administration of drugs for 2 h, starting 1 ...

journal_title：Basic research in cardiology

authors： Pissarek M,Goos H,Nöhring J,Graff J,Buller G,Beyerdörfer I,Mest HJ,Lindenau KF,Krause EG

更新日期：1987-11-01 00:00:00

abstract：:Persistent inflammatory responses participate in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We hypothesized that regulatory T (Treg) cells modulate inflammatory responses, attenuate ventricular remodeling and subsequently improve cardiac function after MI. Acute MI was induced...

journal_title：Basic research in cardiology

authors： Tang TT,Yuan J,Zhu ZF,Zhang WC,Xiao H,Xia N,Yan XX,Nie SF,Liu J,Zhou SF,Li JJ,Yao R,Liao MY,Tu X,Liao YH,Cheng X

更新日期：2012-01-01 00:00:00

abstract：:The stroke volume at rest of 81 test subjects with no evident cardiac or circulatory dysfunction was determined by impedance cardiography and the measurements were repeated after 11 weeks. In order to attain comparable and reproducible conditions, 44 test subjects were chosen who showed heart rates at rest not higher ...

journal_title：Basic research in cardiology

authors： Stick C,Büchsel R

更新日期：1978-11-01 00:00:00

abstract：:Heat shock protein 70 (Hsp70) has been shown to have an anti-apoptotic function, but its mechanism is not clear in heart. In this study, we examined the effect of Hsp70 deletion on AIF-induced apoptosis during ischemia/reperfusion (I/R) in vivo. Although Hsp70 KO and WT mice demonstrated similar amounts of AIF release...

journal_title：Basic research in cardiology

authors： Choudhury S,Bae S,Ke Q,Lee JY,Kim J,Kang PM

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:The clinical usefulness of class III antiarrhythmic drugs for the treatment of tachyarrhythmias is limited by their potential proarrhythmic effects, mainly torsades-depointes (TdP). The goal of this experimental study was to develop an isolated whole-heart model exhibiting typical characteristics of class III...

journal_title：Basic research in cardiology

authors： Johna R,Mertens H,Haverkamp W,Eckardt L,Niederbröker T,Borggrefe M,Breithardt G

更新日期：1998-04-01 00:00:00

abstract：:A rat Langendorff heart preparation, perfused at constant pressure, was used to evaluate the role of K(ATP) channels in respiratory acidosis-induced coronary hyperemia. Prior administration of glibenclamide, an inhibitor of K(ATP) channels, reduced basal flow rates and eliminated the hyperemia associated with hypercap...

journal_title：Basic research in cardiology

authors： Phillis JW,Song D,O'Regan MH

更新日期：2000-04-01 00:00:00

abstract：:8 mm long sections of common carotid arteries of conscious, freely moving rabbits were electrically stimulated with DC-impulses by chronically implanted gold-electrodes daily for 1/2 h or two times 1/2 h per day for 4--6 weeks. The electrodes were arranged in such a way that the wall was stimulated transmurally, In th...

journal_title：Basic research in cardiology

authors： Betz E,Schlote W

更新日期：1979-01-01 00:00:00

abstract：:The ability of the rhesus monkey to form coronary collaterals was tested in ten animals. Ameroid constrictors were implanted on the left circumflex coronary artery and allowed to remain for 12 weeks. One animal died of an acute myocardial infarction nine days after surgery; the remaining animals survived without clini...

journal_title：Basic research in cardiology

authors： Buss DD,Hyde DM,Steffey EP

更新日期：1983-09-01 00:00:00

abstract：:Alterations in myocardial membrane phospholipids may play an important role in the pathogenesis of ischaemic myocardial cell injury. Studies in canine myocardium, perfused rat heart, and cultured myocardial cells have demonstrated that the accumulation of free arachidonic acid correlates with the development of irreve...

journal_title：Basic research in cardiology

authors： Sen A,Buja LM,Willerson JT,Chien KR

更新日期：1987-01-01 00:00:00

abstract：:Increasing the frequency of steady state stimulation increases the rate of mechanical restitution in hypothermic (27 degrees C) guinea pig papillary muscles. In this paper we have investigated the influences of the calcium antagonist nifedipine and of reduced extracellular calcium concentration on this phenomenon. We ...

journal_title：Basic research in cardiology

authors： Spencer CI,Mörner SE,Noble MI,Seed WA

更新日期：1993-03-01 00:00:00

abstract：:Endothelin-1 elicited a concentration-dependent positive inotropic effect on the isolated rabbit, guinea pig, and rat, but not on the dog ventricular myocardium. The duration of isometric contractions was prolonged by endothelin-1 in a concentration-dependent manner, mainly by prolongation of relaxation time. Phorbol ...

journal_title：Basic research in cardiology

authors： Endoh M,Takanashi M

更新日期：1991-01-01 00:00:00

abstract：:PDE3 cyclic nucleotide phosphodiesterase inhibitors raise cAMP and cGMP content in cardiac and vascular myocytes. Their administration to patients with dilated cardiomyopathy leads to improvements in hemodynamic parameters in the short term but reduces survival with chronic administration. The reasons for this 'biphas...

journal_title：Basic research in cardiology

authors： Movsesian MA

更新日期：2002-01-01 00:00:00