Abstract:
:To evaluate the hypothesis that maintenance of the integrity of myocardial membrane systems and prevention of Ca2+ influx into the cell are significant in the survival of ischaemic tissue, the effect of trifluoperazine and lysolecithin, were tested on the recovery of globally ischaemic rat hearts. Trifluoperazine increases membrane stabilization, inhibits calmodulin and binds to other Ca2+-dependent proteins. Lysolecithin, on the other hand, has a detergent action on myocardial cell membranes and facilitates Ca2+ ingress in ischaemic tissue. With trifluoperazine (2.45 microM), added before induction of ischaemia or during reperfusion only, hearts subjected to 40 min normothermic ischaemic cardiac arrest recovered mechanically. Untreated hearts failed after 20 min of ischaemia. The drug had no effect on tissue high energy phosphate levels or mitochondrial oxidative phosphorylation. Conversely, lysolecithin (2.5-10 microM) caused all hearts to fail after being subjected to 15 min ischaemia. Mechanical failure during reperfusion of such hearts was associated with a significant reduction in tissue ATP and CrP levels. Trifluoperazine counteracted the harmful effects of lysolecithin to a limited extent.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Lochner A,van Niekerk I,Kotzé JCdoi
10.1007/BF01908180subject
Has Abstractpub_date
1985-07-01 00:00:00pages
363-76issue
4eissn
0300-8428issn
1435-1803journal_volume
80pub_type
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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journal_title:Basic research in cardiology
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pub_type: 杂志文章
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更新日期:1987-11-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-006-0621-4
更新日期:2006-11-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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更新日期:1984-07-01 00:00:00
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更新日期:2010-05-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-004-0498-4
更新日期:2005-01-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-012-0289-x
更新日期:2012-09-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-012-0292-2
更新日期:2012-09-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2000-10-01 00:00:00
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journal_title:Basic research in cardiology
pub_type: 杂志文章
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更新日期:1997-02-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s003950050207
更新日期:1998-01-01 00:00:00