Mitochondrial damage during myocardial ischemia.

abstract：:Transgenic and gene knockout rodent models are primordial to study pathophysiological processes in cardiovascular research. Over time, cardiac MRI has become a gold standard for in vivo evaluation of such models. Technical advances have led to the development of magnets with increasingly high field strength, allowing ...

journal_title：Basic research in cardiology

authors： Vanhoutte L,Gerber BL,Gallez B,Po C,Magat J,Balligand JL,Feron O,Moniotte S

更新日期：2016-07-01 00:00:00

abstract：:A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These cons...

journal_title：Basic research in cardiology

authors： Zucker IH,Gilmore JP

更新日期：1977-07-01 00:00:00

abstract：:In an attempt to clarify the mechanism of sarcoplasmic reticulum (SR) dysfunction during the genesis of irreversible damage in the ischemic-reperfused myocardium, the changes in SR Ca2(+)-pumping ATPase (Ca2(+)-activated, Mg2(+)-dependent ATPase; Ca2(+)-ATPase) activity were studied during ischemia and subsequent repe...

journal_title：Basic research in cardiology

authors： Yoshida Y,Shiga T,Imai S

更新日期：1990-09-01 00:00:00

abstract：:Transient receptor potential melastatin-7 (TRPM7) channels have been recently reported in human atrial fibroblasts and are believed to mediate fibrogenesis in human atrial fibrillation. The present study investigates whether TRPM7 channels are expressed in human atrial myocytes using whole-cell patch voltage-clamp, RT...

journal_title：Basic research in cardiology

authors： Zhang YH,Sun HY,Chen KH,Du XL,Liu B,Cheng LC,Li X,Jin MW,Li GR

更新日期：2012-09-01 00:00:00

abstract：:Heart failure has been divided into several different forms depending on etiology, clinical course and pathophysiology of left ventricular (LV) dysfunction. Systolic and diastolic dysfunction are characterized by a reduced cardiac output with normal (= diastolic dysfunction) or depressed (= systolic dysfunction) LV pu...

journal_title：Basic research in cardiology

authors： Matter C,Nagel E,Stuber M,Boesiger P,Hess OM

更新日期：1996-01-01 00:00:00

abstract：:Local photodynamic therapy was used to prevent neointimal hyperplasia after stenting. Slotted tube stents were placed with 16 atmospheres in porcine femoral arteries with the external diameter to match the diameter at 10 atmospheres. Animals were randomly allocated to Group 1 (stenting only); or Group 2 with stenting,...

journal_title：Basic research in cardiology

authors： Valassis G,Pragst I,Adolfs C,Paclik D,Wiens F,Vogel-Wiens C,Milz S,Gonschior P

更新日期：2002-03-01 00:00:00

abstract：:Toxic peroxides result when oxygen radicals react with various peroxidic precursors in tissue or blood. A colorimetric method based on reactions of malondialdehyde (MDA), a key intermediate in the formation of peroxides, has been described in fresh tissues. The present report adapts this assay to measure MDA levels in...

journal_title：Basic research in cardiology

authors： Liedtke AJ,Mahar CQ,Ytrehus K,Mjøs OD

更新日期：1984-09-01 00:00:00

abstract：:Ultrasonic techniques for the measurement of ventricular dimensions are widely used in acute and chronic experiments. Implantation of ultrasonic crystals is associated with reversible and irreversible myocardial damage which might limit the interpretation of the obtained results, in particular during acute experiments...

journal_title：Basic research in cardiology

authors： Schipke J,Heusch G,Schulz R,Thämer V

更新日期：1987-07-01 00:00:00

abstract：:Ex vivo multicellular preparations are essential tools to study tissue physiology. Among them, the recent methodological and technological developments in living myocardial slices (LMS) are attracting increasing interest by the cardiac research field. Despite this, this research model remains poorly perceived and util...

journal_title：Basic research in cardiology

authors： Watson SA,Dendorfer A,Thum T,Perbellini F

更新日期：2020-09-10 00:00:00

abstract：:Age-related changes in the myocardial energy metabolism were studied in spontaneously hypertensive (SHR) rats of 5-15 weeks of age. Systolic blood pressure increased rapidly during 5 to 10 weeks of age (developing phase) and attained a plateau level at 10 to 15 weeks (sustained phase). Even during the developing phase...

journal_title：Basic research in cardiology

authors： Shimamoto N,Goto N,Tanabe M,Imamoto T,Fujiwara S,Hirata M

更新日期：1982-07-01 00:00:00

abstract：:It is generally believed that the increased contractility and tachycardia of the hyperthyroid heart are a result of thyroid hormone-induced alterations of the mechanical and electrical properties of the heart, respectively. We compared the contractility (dP/dtmax) and the spontaneous beating rate of hyperthyroid and e...

journal_title：Basic research in cardiology

authors： Wheatley AM,Butkow N,Marcus RH,Lippe IT,Rosendorff C

更新日期：1988-11-01 00:00:00

abstract：:In anaesthetized, artificially respirated mongrel dogs, the intravenous infusion of oxprenolol (0.3 mg and 1 mg/kg over 10 minutes) led to an increase in heart rate and cardiac output. Blood pressure in the pulmonary capillaries and right atrium, and vascular resistance were reduced. The pressure in the aorta was tran...

journal_title：Basic research in cardiology

authors： Stepanek J,Brunner H

更新日期：1975-09-01 00:00:00

abstract：:The effects of regional hypoxemia and ischemia on epicardial electrogram were studied in anesthetized, open-chest dogs. The left circumflex artery (LCx) was cannulated and perfused with either arterial blood or hypoxic solution. A contact electrode for recording monophasic action potential (MAP) was applied to the epi...

journal_title：Basic research in cardiology

authors： Ikeno E,Kubota I,Kondo T,Yamaki M,Shibata T,Tomoike H

更新日期：1995-11-01 00:00:00

abstract：:Impaired nitric oxide (NO)-soluble guanylate cyclase (sGC)-cGMP signaling is involved in the pathogenesis of ischemic heart diseases, yet the impact of long-term sGC activation on progressive cardiac remodeling and heart failure after myocardial infarction (MI) has not been explored. Moreover, it is unknown whether st...

journal_title：Basic research in cardiology

authors： Fraccarollo D,Galuppo P,Motschenbacher S,Ruetten H,Schäfer A,Bauersachs J

更新日期：2014-07-01 00:00:00

abstract：:We measured the amount of 1,2-diacylglycerol (DAG) and its fatty acid composition in hamster hearts of various ages because 1,2-DAG has been recognized to be one of the intracellular second messengers. The highest level in 1,2-DAG was detected in 30-day-old hamster hearts. The heart weight increased about 2.5 times be...

journal_title：Basic research in cardiology

authors： Okumura K,Yamada Y,Kondo J,Hashimoto H,Ito T,Ogawa K

更新日期：1990-03-01 00:00:00

abstract：:It is shown that hypertrophied rat myocardium exhibits marked prolongation of its action potential during non-essential changes both in the resting potential, as well as in the amplitude of the action potential, and during a moderate but nonsignificant reduction in the maximum upstroke velocity. When examining action ...

journal_title：Basic research in cardiology

authors： Gülch RW

更新日期：1980-01-01 00:00:00

abstract：:Carotid baroreceptor stimulation (CBS) has been shown to improve cardiac dysfunction and pathological structure remodelling. This study aimed to investigate the effects of CBS on the ventricular electrophysiological properties in canines with chronic heart failure (CHF). Thirty-eight beagles were randomized into contr...

journal_title：Basic research in cardiology

authors： Wang J,Dai M,Cao Q,Yu Q,Luo Q,Shu L,Zhang Y,Bao M

更新日期：2019-09-09 00:00:00

abstract：:The proximal segments of the left coronary artery are foreshortended in the usual projections. By additional cranio-caudal (half axial) projections the X-ray beam can be directed perpendicular to these segments. In some patients lesions especially of the left main coronary artery or the proximal LAD can be seen or acc...

journal_title：Basic research in cardiology

authors： Rentrop P

更新日期：1976-01-01 00:00:00

abstract：:Patients with insulin resistance and type 2 diabetes have poor cardiac outcomes following myocardial infarction (MI). The mitochondrial uncoupling protein 3 (UCP3) is down-regulated in the heart with insulin resistance. We hypothesized that decreased UCP3 levels contribute to poor cardiac recovery following ischemia/r...

journal_title：Basic research in cardiology

authors： Edwards KS,Ashraf S,Lomax TM,Wiseman JM,Hall ME,Gava FN,Hall JE,Hosler JP,Harmancey R

更新日期：2018-10-29 00:00:00

abstract：:Mitochondria in largely postmitotic cells (e.g. cardiomyocytes, neurons or skeletal muscle myotubes) have a limited life span of a few weeks. Their replacement during normal turnover requires an intergenomic coordination between the mitochondrial genome (mtDNA, encoding for 13 protein subunits of the respiratory chain...

journal_title：Basic research in cardiology

authors： Szibor M,Holtz J

更新日期：2003-07-01 00:00:00

abstract：:We previously demonstrated the presence of components for a renin-angiotensin system in fibroblasts cultured from neonatal rat ventricles, the regulation of expression of which has not been studied. Since glucocorticoids and beta-adrenergic stimuli have been implicated in cardiac hypertrophy, and function as regulator...

journal_title：Basic research in cardiology

authors： Dostal DE,Booz GW,Baker KM

更新日期：2000-12-01 00:00:00

abstract：:The pathogenesis and progression of hypertensive heart disease are unclear; however, both involve a genetic predisposition and environmental influences. To test the role of exogenous factors, we examined the hearts of spontaneously hypertensive rats (SHR) exposed to noise stress and ethanol intake. Twenty-two SHR and ...

journal_title：Basic research in cardiology

authors： Herrmann HJ,Rohde HG,Schulze W,Eichhorn C,Luft FC

更新日期：1994-11-01 00:00:00

abstract：:Epidemiological studies have repeatedly demonstrated a beneficial effect of moderate alcohol consumption on the incidence of coronary heart disease, myocardial infarction and overall mortality. The latter increases with excessive alcohol consumption. Although most epidemiological studies demonstrate a beneficial effec...

journal_title：Basic research in cardiology

authors： Flesch M,Rosenkranz S,Erdmann E,Böhm M

更新日期：2001-04-01 00:00:00

abstract：:The influence of PGI2 and iloprost on the contents of high energy phosphates, cAMP, glycolytic metabolites and on cardiac performance was investigated in open-chest dogs subjected to 3 h of ischaemia, induced by occlusion of the left anterior descending coronary artery. The administration of drugs for 2 h, starting 1 ...

journal_title：Basic research in cardiology

authors： Pissarek M,Goos H,Nöhring J,Graff J,Buller G,Beyerdörfer I,Mest HJ,Lindenau KF,Krause EG

更新日期：1987-11-01 00:00:00

abstract：:It is commonly thought that the optimal method for intracoronary administration of cells is to stop coronary flow during cell infusion, in order to prolong cell/vascular wall contact, enhance adhesion, and promote extravasation of cells into the interstitial space. However, occlusion of a coronary artery with a balloo...

journal_title：Basic research in cardiology

authors： Keith MC,Tokita Y,Tang XL,Ghafghazi S,Moore JB 4th,Hong KU,Elmore JB,Amraotkar AR,Guo H,Ganzel BL,Grubb KJ,Flaherty MP,Vajravelu BN,Wysoczynski M,Bolli R

更新日期：2015-09-01 00:00:00

abstract：:We tested the hypothesis that isoproterenol would increase myocardial work and O2 consumption at reduced efficiency and that both left ventricular hypertrophy and chemical sympathectomy would lead to changes in this myocardial efficiency response. Left ventricular hypertrophy was produced by aortic valve plication in ...

journal_title：Basic research in cardiology

authors： Scholz PM,Kedem J,Cheinberg BV,Weiss HR

更新日期：1996-07-01 00:00:00

abstract：:We have characterized the aerobic blood-perfused isolated heart model evaluating the hemodynamics and metabolism of both the blood donor animal and the isolated organ. Anaesthesia of the blood donor with sodium pentobarbital (30 mg/kg) increases arterial concentration of non esterified fatty acids (NEFA) from 80 +/- 6...

journal_title：Basic research in cardiology

authors： Pasini E,Solfrini R,Bachetti T,Marino M,Bernocchi P,Visioli F,Ferrari R

更新日期：1999-06-01 00:00:00

abstract：:The focal adhesion and microfilament-associated protein VASP is a major substrate of both cAMP- and cGMP-dependent protein kinase in intact human platelets. The recent elucidation of the primary VASP structure and identity of VASP binding proteins suggest that VASP is an important component of focal contacts which lin...

journal_title：Basic research in cardiology

authors： Markert T,Krenn V,Leebmann J,Walter U

更新日期：1996-09-01 00:00:00

abstract：:During myocardial ischemia, both the myocardial and serum TNFalpha concentrations are rapidly increased within the area at risk. With prolongation of ischemia and development of cardiomyocyte necrosis, the TNFalpha concentration increases also in the surrounding viable portions of the myocardium. Indeed, in the scenar...

journal_title：Basic research in cardiology

authors： Schulz R,Aker S,Belosjorow S,Heusch G

更新日期：2004-01-01 00:00:00

abstract：:Receptor for advanced glycation end products (RAGE) is associated with inflammation and the progression of cardiovascular diseases. The current study tested the hypothesis that RAGE is involved in the pathogenesis of aortic valve (AV) calcification. Pioglitazone attenuated AV calcification in experimental hypercholest...

journal_title：Basic research in cardiology

authors： Li F,Cai Z,Chen F,Shi X,Zhang Q,Chen S,Shi J,Wang DW,Dong N

更新日期：2012-11-01 00:00:00