Transformation of morphological, functional and metabolic properties of fast-twitch muscle as induced by long-term electrical stimulation.


:Transformation of structural, functional, metabolic and molecular characteristics is induced by stimulating fast-twitch muscles with the frequency pattern of a motoneuron normally innervating a slow-twitch muscle. These changes correspond to a transition of a "fast-white" into a "slow-red" muscle. Intermittent stimulation (8 h/d) does not affect the system but causes alterations of the sarcoplasmic reticulum which lead to changes in time to peak and half relaxation time. Continuous stimulation (24 h/d) induces a transformation of the muscle also at the level of the myosin system.


Basic Res Cardiol


Pette D,Heilmann C




Has Abstract


1977-03-01 00:00:00












  • Estimates of free-radical production in rat and swine hearts: method and application of measuring malondialdehyde levels in fresh and frozen myocardium.

    abstract::Toxic peroxides result when oxygen radicals react with various peroxidic precursors in tissue or blood. A colorimetric method based on reactions of malondialdehyde (MDA), a key intermediate in the formation of peroxides, has been described in fresh tissues. The present report adapts this assay to measure MDA levels in...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Liedtke AJ,Mahar CQ,Ytrehus K,Mjøs OD

    更新日期:1984-09-01 00:00:00

  • Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation.

    abstract::Protection from postconditioning has been documented in in situ animal models and it has been proposed that it is targeting circulating leukocytes. We therefore tested whether postconditioning can protect leukocyte-free, buffer-perfused rabbit hearts. Infarct size was measured with triphenyltetrazolium staining. In co...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Yang XM,Philipp S,Downey JM,Cohen MV

    更新日期:2005-01-01 00:00:00

  • Ca(2+)-activated K+ channels in human smooth muscle cells of coronary atherosclerotic plaques and coronary media segments.

    abstract::The behavior of Ca(2+)-activated K+ channels of large conductance (BKCa) in smooth muscle cells, which were obtained from atherosclerotic plaque material (SMCP) and from media segments (SMCM) of human coronary arteries, were compared using the patch-clamp technique. Voltage-clamp protocols in cell-attached patches rev...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Wiecha J,Schläger B,Voisard R,Hannekum A,Mattfeldt T,Hombach V

    更新日期:1997-08-01 00:00:00

  • DNA-PKcs promotes cardiac ischemia reperfusion injury through mitigating BI-1-governed mitochondrial homeostasis.

    abstract::DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel inducer to promote mitochondrial apoptosis and suppress tumor growth in a variety of cells although its role in cardiovascular diseases remains obscure. This study was designed to examine the role of DNA-PKcs in cardiac ischemia reperfusion (IR) inju...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Zhou H,Toan S,Zhu P,Wang J,Ren J,Zhang Y

    更新日期:2020-01-09 00:00:00

  • Physiological and therapeutic regulation of PCSK9 activity in cardiovascular disease.

    abstract::Ischemic heart disease is the main cause of death worldwide and is accelerated by increased levels of low-density lipoprotein cholesterol (LDL-C). Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a potent circulating regulator of LDL-C through its ability to induce degradation of the LDL receptor (LDLR) in the...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章,评审


    authors: Glerup S,Schulz R,Laufs U,Schlüter KD

    更新日期:2017-05-01 00:00:00

  • Longer term effects of ouabain on the contractility of rat isolated cardiomyocytes and on the expression of Ca and Na regulating proteins.

    abstract::Cardiac glycosides like ouabain are used in the therapy of heart failure and atrial fibrillation. They exert a positive inotropic effect on cardiomyocytes by inhibiting the plasma membrane sodium pump (Na,K-ATPase), decreasing the Ca-extrusion by the sarcolemmal cardiac sodium/calcium exchanger (NCX) and increasing th...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Müller-Ehmsen J,Nickel J,Zobel C,Hirsch I,Bölck B,Brixius K,Schwinger RH

    更新日期:2003-03-01 00:00:00

  • A theoretical and experimental model of ventricular interdependence.

    abstract::Because of the close anatomical association between the ventricles, the volume of one ventricle can directly affect the volume and pressure within the other ventricle. To study the mechanical coupling between the ventricles, we modeled the right and left ventricles as a two-compartment model with right wall (Crw), sep...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Santamore WP,Shaffer T,Hughes D

    更新日期:1986-09-01 00:00:00

  • Mechanisms involved in coronary artery dilatation during respiratory acidosis in the isolated perfused rat heart.

    abstract::A rat Langendorff heart preparation, perfused at constant pressure, was used to evaluate the role of K(ATP) channels in respiratory acidosis-induced coronary hyperemia. Prior administration of glibenclamide, an inhibitor of K(ATP) channels, reduced basal flow rates and eliminated the hyperemia associated with hypercap...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Phillis JW,Song D,O'Regan MH

    更新日期:2000-04-01 00:00:00

  • High expression of the focal adhesion- and microfilament-associated protein VASP in vascular smooth muscle and endothelial cells of the intact human vessel wall.

    abstract::The focal adhesion and microfilament-associated protein VASP is a major substrate of both cAMP- and cGMP-dependent protein kinase in intact human platelets. The recent elucidation of the primary VASP structure and identity of VASP binding proteins suggest that VASP is an important component of focal contacts which lin...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Markert T,Krenn V,Leebmann J,Walter U

    更新日期:1996-09-01 00:00:00

  • Alterations of the force-frequency relationship in the failing human heart depend on the underlying cardiac disease.

    abstract::We investigated the force-frequency relationship (0.5-3 Hz) in non-failing human myocardium and in end-stage failing human myocardium due to dilated cardiomyopathy or subacute myocarditis. In non-failing myocardium, force of contraction increased with increasing stimulation frequency. In end-stage heart failure, the f...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Pieske B,Hasenfuss G,Holubarsch C,Schwinger R,Böhm M,Just H

    更新日期:1992-01-01 00:00:00

  • Transmural regulation of myocardial perfusion by neuropeptide Y.

    abstract::In vivo studies have shown that sympathetic nerve stimulation improves the transmural distribution of myocardial perfusion by increasing the endocardial/epicardial flow ratio; however, the mechanism of this effect is unknown. During nerve stimulation both norepinephrine (NE) and neuropeptide Y (NPY) are released, eith...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Gutterman DD,Morgan DA

    更新日期:1995-07-01 00:00:00

  • Myogenic and flow-dependent control mechanisms in the coronary microcirculation.

    abstract::We have recently gained evidence that segmental coronary microvascular diameters, and therefore resistances, are controlled by myogenic and endothelial responses to pressure and flow. Furthermore, intact heart studies are demonstrating that these mechanisms may interact importantly with the metabolic mechanisms primar...

    journal_title:Basic research in cardiology

    pub_type: 社论


    authors: Jones CJ,Kuo L,Davis MJ,Chilian WM

    更新日期:1993-01-01 00:00:00

  • Regional myocardial glucose utilization by developing fetal and maternal hearts.

    abstract::Regional glucose utilization of the developing fetal feline heart was assessed during three stages of gestation and compared with the maternal heart and non-pregnant controls. The specific aims were to determine: 1) if glucose utilization by the whole heart changes from early to late gestation; 2) if there are differe...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Kostreva DR,Wood JD

    更新日期:1991-07-01 00:00:00

  • TNFalpha in ischemia/reperfusion injury and heart failure.

    abstract::During myocardial ischemia, both the myocardial and serum TNFalpha concentrations are rapidly increased within the area at risk. With prolongation of ischemia and development of cardiomyocyte necrosis, the TNFalpha concentration increases also in the surrounding viable portions of the myocardium. Indeed, in the scenar...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章,评审


    authors: Schulz R,Aker S,Belosjorow S,Heusch G

    更新日期:2004-01-01 00:00:00

  • Better identification of patients who benefit from implantable cardioverter defibrillators by genotyping the G protein beta3 subunit (GNB3) C825T polymorphism.

    abstract:AIMS:There is a need for better identification of patients at high risk for malignant arrhythmias who would benefit from implantable cardioverter defibrillators (ICD). The purpose of this study was to assess whether the C825T polymorphism in the G-protein beta3 subunit gene, GNB3, might serve as a genetic marker for re...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Wieneke H,Naber CN,Piaszek L,Sack S,Frey UH,Heusch G,Erbel R,Siffert W

    更新日期:2006-09-01 00:00:00

  • Interaction between the opposing functional effects of cyclic AMP and cyclic GMP in hypertrophic cardiac myocytes.

    abstract::We tested the hypothesis that in isolated cardiac myocytes, the negative functional effects of cyclic GMP would be blunted when the level of cyclic AMP was increased and that this interaction would be altered in renal hypertensive (One-Kidney-One-Clip, 1K1C) cardiac hypertrophic rabbits. Using isolated control and 1K1...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Patel KN,Yan L,Gandhi A,Scholz PM,Weiss HR

    更新日期:2001-02-01 00:00:00

  • Function and energy-rich phosphate content of the hypertrophied ventricle after global ischemia and reperfusion.

    abstract::Using an isolated rat heart preparation (Langendorff perfusion, perfusion pressure 100 cm H2O) the response of the hypertrophied heart (spontaneous hypertensive rats lv/bw ratio 3.6 +/- 0.5) to global normothermic (30 min) and hypothermic (25 degrees C, 120 min) ischemic and cardioplegic arrest and reperfusion (30 min...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Fenchel G,Storf R,Hoffmeister HE,Heller W

    更新日期:1986-01-01 00:00:00

  • Functional consequences of acute collagen degradation studied in crystalloid perfused rat hearts.

    abstract:OBJECTIVES:The impact of acute collagen disruption by the disulfide donor, 5,5'-dithio-2-nitrobenzoic acid (DTNB) on ventricular properties was tested in rat hearts. METHODS:Collagen was degraded acutely in 13 isolated, isovolumically contracting rat hearts by perfusion with 1 mM DTNB added to Krebs-Henseleit solution...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Todaka K,Jiang T,Chapman JT,Gu A,Zhu SM,Herzog E,Hochman JS,Steinberg SF,Burkhoff D

    更新日期:1997-06-01 00:00:00

  • Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue.

    abstract::The assessment of proarrhythmic risks of drugs remains challenging. To evaluate the suitability of rat engineered heart tissue (EHT) for detecting proarrhythmic effects. We monitored drug effects on spontaneous contractile activity and, in selected cases, on action potentials (sharp microelectrode) and Ca2+ transients...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Eder A,Hansen A,Uebeler J,Schulze T,Neuber C,Schaaf S,Yuan L,Christ T,Vos MA,Eschenhagen T

    更新日期:2014-01-01 00:00:00

  • Reduced serine-16 and threonine-17 phospholamban phosphorylation in stunning of conscious dogs: no evidence for any involvement of protein kinase A or protein phosphatases.

    abstract:OBJECTIVE:Cardiac stunning is the consequence of a brief cardiac ischemia. The underlying mechanism is not completely understood. METHODS:Here we induced cardiac transient ischemia in conscious instrumented dogs by means of an occluder in the left anterior descending coronary artery (LAD). Contractile performance, mon...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Weber T,Neumann J,Meissner A,Grosse Hartlage M,Van Aken H,Hanske G,Schmitz W,Boknik P

    更新日期:2006-05-01 00:00:00

  • Microembolization and myonecrosis during elective percutaneous coronary interventions in diabetic patients: an intracoronary Doppler ultrasound study with 2-year clinical follow-up.

    abstract::Elevation of cardiac troponin I (cTnI) is a well-known complication after percutaneous coronary interventions (PCI). The aims of this study were to quantify the extent of coronary microembolization during elective PCI, to identify predisposing anatomical and procedural factors, and to evaluate its impact on long-term ...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Otto S,Seeber M,Fujita B,Kretzschmar D,Ferrari M,Goebel B,Figulla HR,Poerner TC

    更新日期:2012-09-01 00:00:00

  • Coronary collateral development in the rhesus monkey (Macaca mulatta).

    abstract::The ability of the rhesus monkey to form coronary collaterals was tested in ten animals. Ameroid constrictors were implanted on the left circumflex coronary artery and allowed to remain for 12 weeks. One animal died of an acute myocardial infarction nine days after surgery; the remaining animals survived without clini...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Buss DD,Hyde DM,Steffey EP

    更新日期:1983-09-01 00:00:00

  • Substrate selection in the isolated working rat heart: effects of reperfusion, afterload, and concentration.

    abstract::A study of substrate selection in the isolated heart was made using 13C NMR isotopomer analysis, a method that unequivocally identifies relative substrate utilization. This technique has several advantages over conventional approaches used to study this problem. It detects the labeling of metabolic end-products presen...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Jeffrey FM,Diczku V,Sherry AD,Malloy CR

    更新日期:1995-09-01 00:00:00

  • Ischemia/reperfusion injury is increased and cardioprotection by a postconditioning protocol is lost as cardiac hypertrophy develops in nandrolone treated rats.

    abstract::We hypothesized that nandrolone (ND)-abuse induces cardiac hypertrophy, increases myocardial susceptibility to ischemia/reperfusion (I/R) injury, and reduces responsiveness to postconditioning (PostC) cardioprotection. Wistar-rats were ND treated for 2 weeks (short_ND) or 10 weeks (long_ND). Vehicle-treated rats serve...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Penna C,Tullio F,Perrelli MG,Moro F,Abbadessa G,Piccione F,Carriero V,Racca S,Pagliaro P

    更新日期:2011-05-01 00:00:00

  • LXR activation inhibits chemokine-induced CD4-positive lymphocyte migration.

    abstract::Migration of CD4-positive lymphocytes into the vessel wall is a critical step in atherogenesis. Recent data suggest that CD4-positive lymphocytes express the nuclear transcription factors Liver-X-Receptor (LXR) alpha and beta with an effect of LXR activators on TH1-cytokine release from these cells. However, the role ...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Walcher D,Vasic D,Heinz P,Bach H,Durst R,Hausauer A,Hombach V,Marx N

    更新日期:2010-07-01 00:00:00

  • A constraint on possible stoichiometries of myocardial sodium-calcium exchange.

    abstract::We have examined the sodium-calcium exchange stoichiometry in Langendorff-perfused rabbit hearts using gamma-emitting tracers under conditions of sodium pump inhibition. Following a 60-min perfusion with 10(-5) acetylstrophanthidin, and extracellular concentrations [Na]o = 70 mM and [Ca]o = 300 microM, intracellular s...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Axelsen PH,Bassingthwaighte JB

    更新日期:1988-05-01 00:00:00

  • Chronic acetaminophen attenuates age-associated increases in cardiac ROS and apoptosis in the Fischer Brown Norway rat.

    abstract::There is a growing need for pharmacological agents to manage cardiovascular disease in the rapidly growing elderly population. Here, we determine if acetaminophen is efficacious in decreasing age-related increases in cardiac reactive oxygen species (ROS) and apoptosis in aging Fischer 344 X Brown Norway rats. Compared...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Kakarla SK,Fannin JC,Keshavarzian S,Katta A,Paturi S,Nalabotu SK,Wu M,Rice KM,Manzoor K,Walker EM Jr,Blough ER

    更新日期:2010-07-01 00:00:00

  • Alanine, glutamate, and ammonia exchanges in acutely ischemic swine myocardium.

    abstract::Coronary artery disease causes an increase in glutamate uptake and alanine output by the heart. We assessed the effects of acute myocardial ischemia on alanine and glutamate exchange and ammonia production in 10 anesthetized open-chest domestic swine (46.9 +/- 0.7 kg). Coronary blood flow was controlled through an ext...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Hacker TA,Hall JL,Stone CK,Stanley WC

    更新日期:1992-03-01 00:00:00

  • Regulation of angiotensinogen gene expression and protein in neonatal rat cardiac fibroblasts by glucocorticoid and beta-adrenergic stimulation.

    abstract::We previously demonstrated the presence of components for a renin-angiotensin system in fibroblasts cultured from neonatal rat ventricles, the regulation of expression of which has not been studied. Since glucocorticoids and beta-adrenergic stimuli have been implicated in cardiac hypertrophy, and function as regulator...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Dostal DE,Booz GW,Baker KM

    更新日期:2000-12-01 00:00:00

  • Long-term thyroid hormone administration reshapes left ventricular chamber and improves cardiac function after myocardial infarction in rats.

    abstract::Thyroid hormone (TH) is critical for tissue differentiation at early stages of development, induces physiological hypertrophy and regulates the expression of important contractile proteins such as myosin heavy chain (MHC) isoform and calcium cycling proteins. Furthermore, TH seems to control the response to stress by ...

    journal_title:Basic research in cardiology

    pub_type: 杂志文章


    authors: Pantos C,Mourouzis I,Markakis K,Tsagoulis N,Panagiotou M,Cokkinos DV

    更新日期:2008-07-01 00:00:00