Abstract:
:Using isolated canine small (right coronary branch, left coronary branch; o. d. 0.4-0.8 mm) and large (left coronary, circumflex; o. d. 1-2 mm) coronary arteries, the beta-adrenergic antagonist dl-propranolol (5 X 10(-7) to 5 X 10(-5) m/l) was found to produce concentration-dependent contractions. Interestingly, most of these contractile events take place with concentrations of propranolol (0.1-1 microgram/ml) found in the blood of patients who are taking this drug for various therapeutic reasons. These propranolol-induced contractions were enhanced in Krebs-Ringer solution containing slightly elevated (weak contractile) concentrations of potassium (15 mmol/l). Experiments with specific pharmacologic antagonists indicated that propranolol-induced contractions on canine coronary arteries can not be mediated by release (or inhibition) of catecholamines, histamine, serotonin or acetylcholine. Propranolol contractions could be released by low concentrations of potassium ions (4 mmol/l), suggesting that the beta receptor antagonist might inactive coronary arterial membrane Na+, K+-ATPase. Other experiments demonstrated that propranolol can enhance coronary arterial membrane permeability to calcium ions; these observations suggest that propranolol might sensitize coronary vascular smooth muscle cells to calcium ions. Removal of calcium ions from the Krebs-Ringer solution or addition of the calcium entry blocker, verapamil, prevented completely the propranolol-induced contractions. Catecholamines (i.e., epinephrine, norepinephrine, isoproterenol), which normally induce relaxation on these isolated coronary arteries, always induced contraction after use of dl-propranolol. Overall, these experiments suggest that the so-called "beta-blocker poisoning" sometimes noted with propranolol in patients might be brought about by four actions of this drug acting in concert: 1. direct coronary arterial vasospasm; 2. an unmasking of normally silent alpha-adrenergic receptors, thus allowing circulating and released catecholamines to induce potent coronary constriction; 3. attenuation of membrane Na+, K+-ATPase activity, and 4. an enhancement of coronary vascular smooth muscle membrane permeability to calcium ions.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Turlapaty PD,Altura BMdoi
10.1007/BF01908132subject
Has Abstractpub_date
1982-01-01 00:00:00pages
68-81issue
1eissn
0300-8428issn
1435-1803journal_volume
77pub_type
杂志文章abstract::Atherosclerotic plaque rupture is the key event in the pathogenesis of acute coronary syndromes and it also occurs during coronary interventions. Atherosclerotic plaque rupture does not always result in complete thrombotic occlusion of the epicardial coronary artery with subsequent impending myocardial infarction, but...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-006-0616-1
更新日期:2006-09-01 00:00:00
abstract::Verapamil alleviates symptoms in patients with hypertrophic cardiomyopathy (HCM), but the underlying mechanism of improvement remains speculative. Baseline and dipyridamole myocardial blood flow (MBF) were measured in 15 HCM patients (14 men, 42 +/- 10 years), before and after 4 weeks of verapamil SR 480 mg daily, usi...
journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章
doi:10.1007/s003950050126
更新日期:1999-02-01 00:00:00
abstract::Nitroglycerin (GTN) and other organic nitrates are widely used vasodilators. Their side effects are development of nitrate tolerance and endothelial dysfunction. Given the potential of GTN to induce nitro-oxidative stress, we investigated the interaction between nitro-oxidative DNA damage and vascular dysfunction in e...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0571-4
更新日期:2016-07-01 00:00:00
abstract::Beta-blockers have been shown to reduce the risk of coronary events and reduce the mortality of patients with hypertension and in those who have had a myocardial infarction. Furthermore, the evidence for long-term benefits in these two patient groups are much more convincing for beta-blockers than for other therapeuti...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950070006
更新日期:2000-01-01 00:00:00
abstract::Cardiac glycosides like ouabain are used in the therapy of heart failure and atrial fibrillation. They exert a positive inotropic effect on cardiomyocytes by inhibiting the plasma membrane sodium pump (Na,K-ATPase), decreasing the Ca-extrusion by the sarcolemmal cardiac sodium/calcium exchanger (NCX) and increasing th...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-003-0396-9
更新日期:2003-03-01 00:00:00
abstract::Dopexamine is a newly developed sympathetic catecholamine which combines dopaminergic (DA-1) and beta 2-adrenergic agonist activity with only minor beta 1-adrenergic action. Thereby, this compound exerts systemic and preferential renal vasodilation, causing afterload reduction, increases in cardiac output, and improve...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/BF02650357
更新日期:1989-01-01 00:00:00
abstract::A study of substrate selection in the isolated heart was made using 13C NMR isotopomer analysis, a method that unequivocally identifies relative substrate utilization. This technique has several advantages over conventional approaches used to study this problem. It detects the labeling of metabolic end-products presen...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788500
更新日期:1995-09-01 00:00:00
abstract::Two-weekly echocardiographic examinations were conducted in nine SHHF-Mc-fa(cp) rats in comparison with eight age-matched Wistar rats. In the SHHF-rats, characterized by progressive LV-dilation and decreasing contractile function between 77-87 weeks of age, left ventricular (LV) hypertrophy was most sensitively demons...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-003-0401-3
更新日期:2003-09-01 00:00:00
abstract::There is no doubt that major advances have been made in cardiac electrophysiology using single heart cells. Accurate analysis of rapid inward sodium current and the second inward current carried by calcium has resulted in a major re-examination of the steps involved in excitation-contraction coupling in the heart. Fut...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/978-3-662-11041-6_17
更新日期:1985-01-01 00:00:00
abstract::Persistent inflammatory responses participate in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We hypothesized that regulatory T (Treg) cells modulate inflammatory responses, attenuate ventricular remodeling and subsequently improve cardiac function after MI. Acute MI was induced...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-011-0232-6
更新日期:2012-01-01 00:00:00
abstract::An increased occurrence of hypertension has been reported among leg-amputees. In order to investigate whether leg amputation is followed by an elevation of sympathetic tone, possibly enhanced by continuous mechanical irritation of the amputation stump by wearing a prosthesis, blood pressure (BP), pulse-rate (PR) and p...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907771
更新日期:1981-05-01 00:00:00
abstract::The capillary wall, due to its diffusional resistance, causes concentration differences between the vascular space and the interstitial space for substances which are released or taken up by the heart. Estimation of capillary transfer and interstitial concentration in isolated hearts, however, indicates a variable dif...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::Cardioprotection aims at infarct size reduction and improvement of clinical outcome from myocardial infarction. The translation of cardioprotection from preclinical and promising proof-of-concept studies to clinical benefit for patients has been largely disappointing. Almost all of these studies which did not translat...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-019-0756-8
更新日期:2019-10-15 00:00:00
abstract::Ultrasonic techniques for the measurement of ventricular dimensions are widely used in acute and chronic experiments. Implantation of ultrasonic crystals is associated with reversible and irreversible myocardial damage which might limit the interpretation of the obtained results, in particular during acute experiments...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907029
更新日期:1987-07-01 00:00:00
abstract::Total cholesterol, phospholipids, and triglycerides in serum were studied during myocardial infarction in a patient group treated with glucose, insulin and potassium (GIK), and a conventionally treated group. There was no difference in the typical changes of cholesterol and phospholipids between the groups, but the GI...
journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章
doi:10.1007/BF01907206
更新日期:1983-11-01 00:00:00
abstract::Recent studies demonstrated that NADPH oxidase 2 (NOX2) expression in myocardium after ischemia-reperfusion (IR) is significantly upregulated. However, the underlying mechanisms remain unknown. This study aims to determine if nuclear cardiac myosin light chain 2 (MYL2), a well-known regulatory subunit of myosin, funct...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-015-0494-5
更新日期:2015-01-01 00:00:00
abstract::A rat Langendorff heart preparation, perfused at constant pressure, was used to evaluate the role of K(ATP) channels in respiratory acidosis-induced coronary hyperemia. Prior administration of glibenclamide, an inhibitor of K(ATP) channels, reduced basal flow rates and eliminated the hyperemia associated with hypercap...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s003950050169
更新日期:2000-04-01 00:00:00
abstract::Atrophy of the rat heart induced by hemodynamic unloading after heterotopic transplantation is associated with impaired relaxation while systolic function remains normal when compared to the heart of the recipient animal. To identify possible underlying mechanisms for the above, we studied some aspects of membrane cal...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788540
更新日期:1995-11-01 00:00:00
abstract::K201 has previously been shown to reduce diastolic contractions in vivo during β-adrenergic stimulation and elevated extracellular calcium concentration ([Ca(2+)](o)). The present study characterised the effect of K201 on electrically stimulated and spontaneous diastolic sarcoplasmic reticulum (SR)-mediated Ca(2+) rel...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-011-0218-4
更新日期:2011-11-01 00:00:00
abstract::Ventricular and atrial cardiac muscle cells isolated from the adult rat have been cultured and characterized. Once established in culture these myocytes resemble morphologically their in vivo counterparts except that they are flattened on the surface of the culture flask. These cultured cells possess differentiated ul...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::The effects of 3 hours of ischemia and 1 hour of reperfusion on biochemical, physiological and ultrastructural parameters were studied in 12 dogs. In the ischemic subendocardium without reperfusion, mitochondrial losses of adenine (ATP + ADP + AMP) and pyridine (NAD + NADH) nucleotides far exceeded those observed in w...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908307
更新日期:1984-03-01 00:00:00
abstract::A model of vascular endothelial cell is proposed to describe the mechanisms by which cytosolic calcium (Cai) is modulated and endothelium-derived relaxing factor (EDRF) and prostacyclin (PGI2) are released when the cell is stimulated by agonist. The intracellular Ca2+ store of the model cell is comprised of a superfic...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00796518
更新日期:1992-07-01 00:00:00
abstract::An ischaemia-like state in cultured heart cells has been obtained by markedly restricting the volume of extracellular medium combined with total deprivation of oxygen (anoxia) and glucose. Cellular injury, as reflected by the release of both cytoplasmic and lysosomal enzymes was significantly greater than during anoxi...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::The cardiac organ manifestation of arterial hypertension comprises the myocardium itself with left-ventricular hypertrophy, the interstitium with perivascular and interstitial fibrosis, and the coronary circulation with disease of large and small coronary arteries. The consequences of the sum and interactions of these...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/978-3-662-30769-4_22
更新日期:1991-01-01 00:00:00
abstract::The role of the cardiac current Ik1 in arrhythmogenesis remains highly controversal. To gain further insights into the mechanisms of IK1 involvement in cardiac excitability, we studied the susceptibility of transgenic mice with altered IK1 to arrhythmia during various pharmacological and physiological challenges. Arrh...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-007-0659-y
更新日期:2007-09-01 00:00:00
abstract::The effect of isoproterenol perfusion on cAMP levels and phosphorylase activity was investigated in the spontaneously hypertensive rat (SHR) and Kyoto Wistar normotensive control rat (WKY) heart. The basal force of contraction in physiological salt solution perfused hearts was comparable between SHR and WKY. However, ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907217
更新日期:1983-11-01 00:00:00
abstract:OBJECTIVE:Cardiac stunning is the consequence of a brief cardiac ischemia. The underlying mechanism is not completely understood. METHODS:Here we induced cardiac transient ischemia in conscious instrumented dogs by means of an occluder in the left anterior descending coronary artery (LAD). Contractile performance, mon...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-005-0577-9
更新日期:2006-05-01 00:00:00
abstract::The antiarrhythmic effect of carbocromene (Intensain) was studied in 17 anaesthetized dogs. Ventricular tachycardia was induced by infusion of K-strophanthin (mean dose: 154 mug/kg i.v.). In 25 out of 26 experiments carbocromene (4 mg/kg i.v.) was effective. Ventricular tachycardia was converted to sinus rhythm in 16 ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01914339
更新日期:1975-07-01 00:00:00
abstract::Myocardial stunning, a transient contractile dysfunction that appears following a brief period of ischemia, is at least partly due to the production of oxygen-derived free radicals. The objective of the present study was to determine whether the Ginkgo biloba extract EGb761, which has antioxidant properties in vitro, ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-003-0380-4
更新日期:2003-02-01 00:00:00
abstract::Epidemiological studies have repeatedly demonstrated a beneficial effect of moderate alcohol consumption on the incidence of coronary heart disease, myocardial infarction and overall mortality. The latter increases with excessive alcohol consumption. Although most epidemiological studies demonstrate a beneficial effec...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950170062
更新日期:2001-04-01 00:00:00