Abstract:
:Verapamil alleviates symptoms in patients with hypertrophic cardiomyopathy (HCM), but the underlying mechanism of improvement remains speculative. Baseline and dipyridamole myocardial blood flow (MBF) were measured in 15 HCM patients (14 men, 42 +/- 10 years), before and after 4 weeks of verapamil SR 480 mg daily, using 15O labelled water the positron emission tomography (PET). Subendocardial (endo) and subepicardial (epi) MBF was measured in the septum (thickness 25.4 +/- 5.8 mm). Pre-treatment baseline whole heart MBF was 1.02 +/- 0.28 ml/min/g and 1.01 +/- 0.30 ml/min/g on treatment (p = ns). Dipyridamole MBF was 1.39 +/- 0.31 ml/min/g off treatment and 1.23 +/- 0.34 ml/min/g on treatment (p = ns). Coronary flow reserve (dipyridamole/resting MBF) was 1.45 +/- 0.52 and 1.30 +/- 0.51, respectively (p = ns). At baseline, the septal endo/epi MBF ratio was uniform off and on treatment (1.13 +/- 0.18 vs 1.18 +/- 0.21, p = ns). Before treatment, the endo/epi ratio following dipyridamole decreased to 0.93 +/- 0.24 (p < 0.01 vs baseline) and 5/15 (33%) patients had a ratio < 0.8 which would suggest subendocardial underperfusion. During treatment, the endo/epi ratio following dipyridamole was no more different from baseline (1.06 +/- 0.24, p = ns vs baseline) and 2/14 (14%) patients had an endo/epi < 0.8. PET can be successfully used to determine transmural MBF in vivo in patients with hypertrophied ventricles. Despite symptomatic improvement, high dose verapamil therapy does not increase total MBF in patients with HCM but may improve septal transmural MBF distribution during dipyridamole in some patients.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Choudhury L,Elliott P,Rimoldi O,Ryan M,Lammertsma AA,Boyd H,McKenna WJ,Camici PGdoi
10.1007/s003950050126keywords:
subject
Has Abstractpub_date
1999-02-01 00:00:00pages
49-59issue
1eissn
0300-8428issn
1435-1803journal_volume
94pub_type
临床试验,杂志文章abstract::In order to clarify the genesis of the characteristic pressure and flow pulse contours of the common carotid artery of man, at first transcutaneous pulse recordings were carried out on healthy resting subjects during breathing of room air and of a mixture of 95% O2 and 5% CO2 (Carbogen). The latter was used to cause v...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907041
更新日期:1977-11-01 00:00:00
abstract::Therapeutic angiogenesis improves tissue ischemia by supplementing and supporting the intrinsic process of angiogenesis. Besides direct administration of angiogenic growth factor proteins, injection of naked DNA, non-viral vectors and viral vector constructs carrying angiogenic genes have been used. A novel approach i...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-004-0447-x
更新日期:2004-03-01 00:00:00
abstract::K201 has previously been shown to reduce diastolic contractions in vivo during β-adrenergic stimulation and elevated extracellular calcium concentration ([Ca(2+)](o)). The present study characterised the effect of K201 on electrically stimulated and spontaneous diastolic sarcoplasmic reticulum (SR)-mediated Ca(2+) rel...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-011-0218-4
更新日期:2011-11-01 00:00:00
abstract::Denervation deprives the heart of its normal adrenergic and cholinergic control via the sympathetic and parasympathetic pathways. In a heart which is blood supplied by a donor animal of the same species, normal contractility is maintained, probably by blood borne catecholamines or possibly by unknown inotropic agents ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907778
更新日期:1976-01-01 00:00:00
abstract::The focal adhesion and microfilament-associated protein VASP is a major substrate of both cAMP- and cGMP-dependent protein kinase in intact human platelets. The recent elucidation of the primary VASP structure and identity of VASP binding proteins suggest that VASP is an important component of focal contacts which lin...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788712
更新日期:1996-09-01 00:00:00
abstract::The influence of perfusion pressure (5-8 kPa) on coronary flow and myocardial Ca2+-washout during Ca2+-free perfusion, and on the occurrence of calcium paradox after subsequent Ca2+-reperfusion, was studied in isolated, stimulated, rat heart ventricles. During the Ca2+-free perfusion period (3 min) the following chang...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907580
更新日期:1980-03-01 00:00:00
abstract:OBJECTIVES:Single electrical field shocks are able to induce ventricular fibrillation (VF) if applied during the vulnerable period. During this period, a shock can either prolong the action potential duration or induce a new action potential. Whether the occurrence of different shock responses contributes to the induct...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00803755
更新日期:1997-02-01 00:00:00
abstract::The effects of regional hypoxemia and ischemia on epicardial electrogram were studied in anesthetized, open-chest dogs. The left circumflex artery (LCx) was cannulated and perfused with either arterial blood or hypoxic solution. A contact electrode for recording monophasic action potential (MAP) was applied to the epi...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788537
更新日期:1995-11-01 00:00:00
abstract::It is generally believed that the increased contractility and tachycardia of the hyperthyroid heart are a result of thyroid hormone-induced alterations of the mechanical and electrical properties of the heart, respectively. We compared the contractility (dP/dtmax) and the spontaneous beating rate of hyperthyroid and e...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906958
更新日期:1988-11-01 00:00:00
abstract::In an attempt to clarify the mechanism of sarcoplasmic reticulum (SR) dysfunction during the genesis of irreversible damage in the ischemic-reperfused myocardium, the changes in SR Ca2(+)-pumping ATPase (Ca2(+)-activated, Mg2(+)-dependent ATPase; Ca2(+)-ATPase) activity were studied during ischemia and subsequent repe...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01931495
更新日期:1990-09-01 00:00:00
abstract::Perfusion of isoprenaline in the dog may induce left ventricular hypertrophy (LVH), and this effect is suppressed by propranolol. Cultured foetal cardiomyocytes exposed to catecholamines show an increase in protein synthesis and RNA turnover. In spontaneously hypertensive rats (SHR), and perhaps in man, sympatholytic ...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:
更新日期:1991-01-01 00:00:00
abstract::Using an isolated rat heart preparation (Langendorff perfusion, perfusion pressure 100 cm H2O) the response of the hypertrophied heart (spontaneous hypertensive rats lv/bw ratio 3.6 +/- 0.5) to global normothermic (30 min) and hypothermic (25 degrees C, 120 min) ischemic and cardioplegic arrest and reperfusion (30 min...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/978-3-662-11374-5_12
更新日期:1986-01-01 00:00:00
abstract::In anaesthetized, artificially respirated mongrel dogs, the intravenous infusion of oxprenolol (0.3 mg and 1 mg/kg over 10 minutes) led to an increase in heart rate and cardiac output. Blood pressure in the pulmonary capillaries and right atrium, and vascular resistance were reduced. The pressure in the aorta was tran...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906388
更新日期:1975-09-01 00:00:00
abstract::The purpose of this study was to determine if decreased heart function after hypoxia followed by reoxygenation (H-R) is associated with increased degradation of cardiac myosin light chain 1 (MLC1) by matrix metalloproteinase-2 (MMP-2), and to investigate the effects of the increased level of peroxynitrite in the heart...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-009-0035-1
更新日期:2009-11-01 00:00:00
abstract::A canine model for a standardized induction of collaterals is presented with a fixed external constrictor that is not designed to induce an occlusion of the coronary artery and at least over the timespan of 6 weeks does not impair perfusion under resting conditions in the myocardium-at-risk. The coronary constriction ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01906671
更新日期:1983-03-01 00:00:00
abstract::N,N-dimethylsphingosine (DMS) has been documented to be in vitro protective against myocardial ischemia-reperfusion injury (IRI) and can recruit CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs), which may participate in the cardioprotection. We hypothesized that when in vivo applied after a myocardial ischemia, DMS ma...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0548-3
更新日期:2016-05-01 00:00:00
abstract::Hearts preconditioned by brief ischemia are characterized by a reduced rate of cellular purine metabolite production during subsequent prolonged ischemia; the purpose of this study was to determine if transient exogenous adenosine pretreatment can mimic this phenomenon. The accumulation of interstitial fluid (ISF) pur...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00796210
更新日期:1997-12-01 00:00:00
abstract::The molecular mechanisms through which ghrelin exerts its cardioprotective effects during cardiac remodeling post-myocardial infarction (MI) are poorly understood. The aim of this study was to investigate whether the cardioprotection mechanisms are mediated by modulation of JAK/STAT signaling and what triggers this mo...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-018-0671-4
更新日期:2018-02-01 00:00:00
abstract::For the quantitative evaluation of myocardial damage induced by isoprenaline (ISO) a method based on the uptake of 203Hg-labelled Mercurascan (MSC) in the heart was used. The increase of myocardial uptake of MSC in ISO-treated rats over control values was very rapid and might be directly proportional to the number of ...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01910409
更新日期:1977-09-01 00:00:00
abstract::Apart from local heterogeneities of myocardial blood flow, the regulation of vascular tone is equally complex. Changes in vascular tone are essential for the adaptation of coronary blood flow to varying metabolic demands. The majority of coronary vascular resistance is found in the microcirculation, that is, in vessel...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s003950050114
更新日期:1998-12-01 00:00:00
abstract::Protection from postconditioning has been documented in in situ animal models and it has been proposed that it is targeting circulating leukocytes. We therefore tested whether postconditioning can protect leukocyte-free, buffer-perfused rabbit hearts. Infarct size was measured with triphenyltetrazolium staining. In co...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-004-0498-4
更新日期:2005-01-01 00:00:00
abstract::To evaluate the hypothesis that maintenance of the integrity of myocardial membrane systems and prevention of Ca2+ influx into the cell are significant in the survival of ischaemic tissue, the effect of trifluoperazine and lysolecithin, were tested on the recovery of globally ischaemic rat hearts. Trifluoperazine incr...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908180
更新日期:1985-07-01 00:00:00
abstract::Complete length-tension diagrams of myocardium were measured on isolated papillary muscles of cat right ventricle. These diagrams clearly demonstrate that irrespective of loading conditions there is no uniform maxima curve. As a function of preload the curves of afterloaded isotonic maxima obey totally separate nonlin...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01907862
更新日期:1985-11-01 00:00:00
abstract::We chronically implanted hygroscopic occluders around the left circumflex coronary artery in 49 anesthetized young male domestic pigs and we studied the development of a collateral circulation at 4, 8, 12, and 26 weeks after implantation. At these time intervals groups of animals were again anesthetized, the hearts we...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF01908204
更新日期:1989-09-01 00:00:00
abstract::Cardiovascular cell therapy offers the first real potential to treat the underlying injuries associated with cardiac and vascular disease. By delivering appropriate exogenous cells to an injury site, the potential exists to mitigate injury or even to begin to reverse damage. Based on their inordinate pre-clinical prom...
journal_title:Basic research in cardiology
pub_type: 杂志文章,评审
doi:10.1007/s00395-004-0558-z
更新日期:2005-11-01 00:00:00
abstract::Pentostatin (2-deoxycoformycin) is a potent inhibitor of adenosine deaminase and has been demonstrated to augment endogenous adenosine levels during regional and global myocardial ischemia. Based on the rationale that increasing endogenous adenosine during ischemia may be cardioprotective, the objective of this study ...
journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF00789447
更新日期:1995-03-01 00:00:00
abstract::Sirtuin 3 (Sirt3) is an NAD(+)-dependent mitochondrial deacetylase associated with superoxide dismutase 2 (SOD2)-mediated protection from oxidative stress. We have reported accelerated weight gain and impaired metabolic flexibility in atherosclerotic Sirt3 (-/-) mice. Oxidative stress is a hallmark of endothelial dysf...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/s00395-016-0552-7
更新日期:2016-05-01 00:00:00
abstract::Atrophy of the rat heart induced by hemodynamic unloading after heterotopic transplantation is associated with impaired relaxation while systolic function remains normal when compared to the heart of the recipient animal. To identify possible underlying mechanisms for the above, we studied some aspects of membrane cal...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00788540
更新日期:1995-11-01 00:00:00
abstract:AIMS:We studied the capability of heart rate (HR) adjusted change in multichannel magnetocardiogram (MCG) to detect exercise-induced ischemia. METHODS AND RESULTS:The MCG and 12-lead ECG were recorded simultaneously during supine exercise testing in 17 healthy controls and 24 patients with single vessel coronary arter...
journal_title:Basic research in cardiology
pub_type: 临床试验,杂志文章
doi:10.1007/s395-002-8391-y
更新日期:2002-01-01 00:00:00
abstract::In vivo studies have shown that sympathetic nerve stimulation improves the transmural distribution of myocardial perfusion by increasing the endocardial/epicardial flow ratio; however, the mechanism of this effect is unknown. During nerve stimulation both norepinephrine (NE) and neuropeptide Y (NPY) are released, eith...
journal_title:Basic research in cardiology
pub_type: 杂志文章
doi:10.1007/BF00797913
更新日期:1995-07-01 00:00:00