The effect of isolation on myocardial properties.

abstract：:Ca2+ overload followed by after-contractions was induced by perfusion of mammalian papillary muscles with O-K0+, high Ca2+ solution. The effect of lipotrophic agents (dexamethasone, indomethacin) or free radical scavengers (alpha-tocopherol, reduced glutathione, synthetic antioxidant) was tested at different stages of...

journal_title：Basic research in cardiology

authors： Saxon ME

更新日期：1985-07-01 00:00:00

abstract：:The endothelin (ET) family of peptides have potent vascular, cardiac and renal actions which may be of pathophysiological importance in congestive heart failure (CHF). In vivo studies with selective and non-selective ET receptor antagonists are required to clarify the role of ET in the pathophysiology of CHF and deter...

journal_title：Basic research in cardiology

authors： Love MP,McMurray JJ

更新日期：1996-01-01 00:00:00

abstract：:The aim of this study was to examine the effect of ischemic preconditioning on the releases of cardiac troponin T (TnT) during reperfusion in isolated rat hearts. Experiments were done on 22 rat hearts, which were perfused according to the method of Langendorff and were divided into the control group (n = 14) and the ...

journal_title：Basic research in cardiology

authors： Yamahara Y,Asayama J,Kobara M,Ohta B,Matsumoto T,Miyazaki H,Tatsumi T,Ishibashi K,Inoue M,Inoue D

更新日期：1994-05-01 00:00:00

abstract：:Transformation of structural, functional, metabolic and molecular characteristics is induced by stimulating fast-twitch muscles with the frequency pattern of a motoneuron normally innervating a slow-twitch muscle. These changes correspond to a transition of a "fast-white" into a "slow-red" muscle. Intermittent stimula...

journal_title：Basic research in cardiology

authors： Pette D,Heilmann C

更新日期：1977-03-01 00:00:00

abstract：:Verapamil alleviates symptoms in patients with hypertrophic cardiomyopathy (HCM), but the underlying mechanism of improvement remains speculative. Baseline and dipyridamole myocardial blood flow (MBF) were measured in 15 HCM patients (14 men, 42 +/- 10 years), before and after 4 weeks of verapamil SR 480 mg daily, usi...

journal_title：Basic research in cardiology

authors： Choudhury L,Elliott P,Rimoldi O,Ryan M,Lammertsma AA,Boyd H,McKenna WJ,Camici PG

更新日期：1999-02-01 00:00:00

abstract：:The mitochondrial electrochemical gradient (Δp), which comprises the pH gradient (ΔpH) and the membrane potential (ΔΨ), is crucial in controlling energy transduction. During myocardial ischemia and reperfusion (IR), mitochondrial dysfunction mediates superoxide (·O2-) and H2O2 overproduction leading to oxidative injur...

journal_title：Basic research in cardiology

authors： Kang PT,Chen CL,Lin P,Chilian WM,Chen YR

更新日期：2017-07-01 00:00:00

abstract：:To evaluate the hypothesis that maintenance of the integrity of myocardial membrane systems and prevention of Ca2+ influx into the cell are significant in the survival of ischaemic tissue, the effect of trifluoperazine and lysolecithin, were tested on the recovery of globally ischaemic rat hearts. Trifluoperazine incr...

journal_title：Basic research in cardiology

authors： Lochner A,van Niekerk I,Kotzé JC

更新日期：1985-07-01 00:00:00

abstract：:The role of miR-92a on vascular remodelling after injury is currently unknown. Thus, the aim of the present study was to evaluate the role of miR-92a on rat endothelial and vascular smooth muscle cells proliferation and migration in vitro as well as after balloon injury or arterial stenting in vivo. MiR-92a was highly...

journal_title：Basic research in cardiology

authors： Iaconetti C,Polimeni A,Sorrentino S,Sabatino J,Pironti G,Esposito G,Curcio A,Indolfi C

更新日期：2012-09-01 00:00:00

abstract：:Over the past decade, hydrogen sulfide has emerged as an important cardioprotective molecule with potential for clinical applications. Although several pathways have been proposed to mediate the beneficial effects of H2S, the NO/cGMP axis has attracted significant attention. Recent evidence has suggested that cGMP-dep...

journal_title：Basic research in cardiology

authors： Andreadou I,Iliodromitis EK,Szabo C,Papapetropoulos A

更新日期：2015-09-01 00:00:00

abstract：:Elevation of cardiac troponin I (cTnI) is a well-known complication after percutaneous coronary interventions (PCI). The aims of this study were to quantify the extent of coronary microembolization during elective PCI, to identify predisposing anatomical and procedural factors, and to evaluate its impact on long-term ...

journal_title：Basic research in cardiology

authors： Otto S,Seeber M,Fujita B,Kretzschmar D,Ferrari M,Goebel B,Figulla HR,Poerner TC

更新日期：2012-09-01 00:00:00

abstract：:This study was aimed to assess the relationship among the voltage-dependent processes underlying the excitation-contraction coupling, viz. force restitution (FR), transmembrane Ca fluxes and Ca release. The experiments (n = 22) were performed on voltage-clamped dog trabeculae in which force and slow inward current wer...

journal_title：Basic research in cardiology

authors： Bravený P,Simurda J,Simurdová M

更新日期：1992-09-01 00:00:00

abstract：:The hemodynamic and metabolic effects of acetate were studied in rats in vivo and in the isolated perfused heart. Hemodynamic parameters, myocardial phosphagens, inorganic phosphate, and adenosine were measured in vivo. Acetate uptake, coronary flow, O2 consumption, parameters of the cellular energy state, and hypoxan...

journal_title：Basic research in cardiology

authors： Kiviluoma KT,Karhunen M,Lapinlampi T,Peuhkurinen KJ,Hassinen IE

更新日期：1988-07-01 00:00:00

abstract：:Recent publications shown mitochondrial localization of the enzyme nitric oxide synthase (NOS) in a number of tissues. However, conflicting results about mitochondrial NOS (mtNOS) immunoreactivity and enzymatic activity are available to date in the literature. In this study we purified mitochondria from rat hearts and...

journal_title：Basic research in cardiology

authors： Zanella B,Giordano E,Muscari C,Zini M,Guarnieri C

更新日期：2004-05-01 00:00:00

abstract：:We compared the effects of linagliptin (Lina, a DPP4 inhibitor) and GLP-1 receptor activation by exenatide followed by exendin-4 in an infusion pump (EX) on infarct size (IS), post-infarction activation of the inflammasome and remodeling in wild-type (WT) and db/db diabetic mice. Mice underwent 30 min ischemia followe...

journal_title：Basic research in cardiology

authors： Birnbaum Y,Tran D,Bajaj M,Ye Y

更新日期：2019-08-06 00:00:00

abstract：:Coronary artery disease (CAD), also known as ischemic heart disease (IHD), is the leading cause of mortality in the western world, with developing countries showing a similar trend. With the increased understanding of the role of the immune system and inflammation in coronary artery disease, it was shown that macropha...

journal_title：Basic research in cardiology

authors： Jansen MF,Hollander MR,van Royen N,Horrevoets AJ,Lutgens E

更新日期：2016-07-01 00:00:00

abstract：:Although epicardial blood flow can be restored by an early intervention in most cases, a lack of adequate reperfusion at the microvascular level is often a limiting prognostic factor of acute myocardial infarction (AMI). Our group has recently found that paracrine factors secreted from apoptotic peripheral blood monon...

journal_title：Basic research in cardiology

authors： Hoetzenecker K,Assinger A,Lichtenauer M,Mildner M,Schweiger T,Starlinger P,Jakab A,Berényi E,Pavo N,Zimmermann M,Gabriel C,Plass C,Gyöngyösi M,Volf I,Ankersmit HJ

更新日期：2012-09-01 00:00:00

abstract：:The concentration of fibroblast growth factor 23 (FGF23) rises progressively in renal failure (RF). High FGF23 concentrations have been consistently associated with adverse cardiovascular outcomes or death, in chronic kidney disease (CKD), heart failure or liver cirrhosis. We identified the mechanisms whereby high con...

journal_title：Basic research in cardiology

authors： Lindner M,Mehel H,David A,Leroy C,Burtin M,Friedlander G,Terzi F,Mika D,Fischmeister R,Prié D

更新日期：2020-07-22 00:00:00

abstract：:The stroke volume at rest of 81 test subjects with no evident cardiac or circulatory dysfunction was determined by impedance cardiography and the measurements were repeated after 11 weeks. In order to attain comparable and reproducible conditions, 44 test subjects were chosen who showed heart rates at rest not higher ...

journal_title：Basic research in cardiology

authors： Stick C,Büchsel R

更新日期：1978-11-01 00:00:00

abstract：:Ventricular and atrial cardiac muscle cells isolated from the adult rat have been cultured and characterized. Once established in culture these myocytes resemble morphologically their in vivo counterparts except that they are flattened on the surface of the culture flask. These cultured cells possess differentiated ul...

journal_title：Basic research in cardiology

authors： Claycomb WC

更新日期：1985-01-01 00:00:00

abstract：:Affinity labelling of the digitalis receptor has indicated that it is situated on the N-terminal part of the alpha-subunit of the (Na+,K+)ATPase. Biochemical and pharmacological properties of the (Na+,K+)ATPase studied on intact chick embryonic hearts and under heart cell culture conditions have indicated the existenc...

journal_title：Basic research in cardiology

authors： Lazdunski M,Kazazoglou T,Renaud JF,Rossi B

更新日期：1984-01-01 00:00:00

abstract：:Although it has long been recognized that thyroid hormone is an effective positive inotrope, its efficacy in supporting hemodynamics in the acute setting of ischaemia and reperfusion (R) without worsening reperfusion injury remains largely unknown. Thus, we investigated the effects of triiodothyronine (T3) on reperfus...

journal_title：Basic research in cardiology

authors： Pantos C,Mourouzis I,Saranteas T,Clavé G,Ligeret H,Noack-Fraissignes P,Renard PY,Massonneau M,Perimenis P,Spanou D,Kostopanagiotou G,Cokkinos DV

更新日期：2009-01-01 00:00:00

abstract：:In the chronically volume-overloaded canine heart due to AV-block evaluations of cardiac function were performed during the development of hypertrophy and at stable hypertrophy. In an early stage (1 and 2 weeks of AV-block) when no or only a slight increase of cardiac muscle occurred, contractility measured from dP/dt...

journal_title：Basic research in cardiology

authors： Wüsten B,Flameng W,Schaper W

更新日期：1977-03-01 00:00:00

abstract：:Light in the near-infrared (NIR) region between 700-900 nm can penetrate deep into living tissue, thereby offering a unique opportunity to use near-infrared fluorescence (NIRF) imaging techniques to detect and visualize fluorescent probes in-vivo. In the past few years, many novel NIR fluorescent probes have been desi...

journal_title：Basic research in cardiology

authors： Klohs J,Wunder A,Licha K

更新日期：2008-03-01 00:00:00

abstract：:Ischaemic preconditioning is one of the most potent experimental modalities known to decrease infarct size after ischaemia and reperfusion. Much interest has been stimulated by the phenomenon of remote ischaemic conditioning (RIC), in which the preconditioning stimulus is applied to a limb remote from the heart to sti...

journal_title：Basic research in cardiology

authors： Davidson SM,Selvaraj P,He D,Boi-Doku C,Yellon RL,Vicencio JM,Yellon DM

更新日期：2013-09-01 00:00:00

abstract：:Cardiac disease is associated with deleterious emission of mitochondrial reactive oxygen species (mito-ROS), as well as enhanced oxidation and activity of the sarcoplasmic reticulum (SR) Ca2+ release channel, the ryanodine receptor (RyR2). The transfer of Ca2+ from the SR via RyR2 to mitochondria is thought to play a ...

journal_title：Basic research in cardiology

authors： Hamilton S,Terentyeva R,Martin B,Perger F,Li J,Stepanov A,Bonilla IM,Knollmann BC,Radwański PB,Györke S,Belevych AE,Terentyev D

更新日期：2020-05-22 00:00:00

abstract：:Adult epicardial cells are required for endogenous cardiac repair. After myocardial injury, they are reactivated, undergo epithelial-to-mesenchymal transformation (EMT) and migrate into the injured myocardium where they generate various cell types, including coronary smooth muscle cells and cardiac interstitial fibrob...

journal_title：Basic research in cardiology

authors： Bax NA,van Oorschot AA,Maas S,Braun J,van Tuyn J,de Vries AA,Groot AC,Goumans MJ

更新日期：2011-09-01 00:00:00

abstract：:To determine the effect of magnesium on myocardial function and oxidative metabolism after reperfusion, isolated rat hearts perfused retrogradely with erythrocyte-enriched medium (0.4 mM palmitate bound to 0.4 mM albumin, 11 mM glucose) were subjected to 60 minutes of no-flow ischemia followed by 60 minutes of reperfu...

journal_title：Basic research in cardiology

authors： Tamm C,Papageorgiou I,Tardy I,Mermillod B,Rutishauser W,Lerch R

更新日期：1994-07-01 00:00:00

abstract：:The effect of 0.1 mg/kg Verapamil on the extent of the ischemic area following ligation of a branch of the left descending coronary artery was studied in anesthetized open chest dogs. The sum of the ST-segment elevation during the entire period of occlusion in the epicardial ECG was 15 mV in control infarction compare...

journal_title：Basic research in cardiology

authors： Wende W,Bleifeld W,Meyer J,Stühlen HW

更新日期：1975-03-01 00:00:00

abstract：:Myocardial mechanics and oxygen consumption were studied in right ventricular papillary muscles taken from cats pretreated with cristalline L-thyroxine (1 mg/kg/day, i.p.) 8-18 days prior to the examination. Isotonic afterloaded and isometric contractions were employed. Oxygen consumption was determined polarographica...

journal_title：Basic research in cardiology

authors： Strauer BE,Scherpe A

更新日期：1975-05-01 00:00:00

abstract：:Persistent inflammatory responses participate in the pathogenesis of adverse ventricular remodeling after myocardial infarction (MI). We hypothesized that regulatory T (Treg) cells modulate inflammatory responses, attenuate ventricular remodeling and subsequently improve cardiac function after MI. Acute MI was induced...

journal_title：Basic research in cardiology

authors： Tang TT,Yuan J,Zhu ZF,Zhang WC,Xiao H,Xia N,Yan XX,Nie SF,Liu J,Zhou SF,Li JJ,Yao R,Liao MY,Tu X,Liao YH,Cheng X

更新日期：2012-01-01 00:00:00