Abstract：
:In vivo studies have shown that sympathetic nerve stimulation improves the transmural distribution of myocardial perfusion by increasing the endocardial/epicardial flow ratio; however, the mechanism of this effect is unknown. During nerve stimulation both norepinephrine (NE) and neuropeptide Y (NPY) are released, either or both of which may exert vasoconstrictor effects. The present studies were performed to examine the effects of these two cotransmitters on the transmural distribution of myocardial perfusion in a canine model. In anesthetized open-chest dogs, during maximal coronary vasodilation with intracoronary adenosine, both neuropeptide Y (29.7 micrograms/min) and norepinephrine (0.5-2.0 micrograms/min) reduced myocardial perfusion to a greater extent in the epicardium than in the subendocardium. The endo/epi ratio with adenosine alone was 1.11 +/- 0.02. Norepinephrine increased this by 80%, neuropeptide Y by 20%, and the combination of the two by 76% (P < 0.05 for all three vs. adenosine). Neuropeptide Y alone constricted the coronary vasculature but did not alter transmural flow. Thus neuropeptide Y preferentially reduces myocardial perfusion in the epicardium. We speculate that neuronally released neuropeptide Y contributes importantly to the transmural distribution of myocardial perfusion during sympathetic nerve stimulation.
journal_name
Basic Res Cardioljournal_title
Basic research in cardiologyauthors
Gutterman DD,Morgan DAdoi
10.1007/BF00797913subject
Has Abstractpub_date
1995-07-01 00:00:00pages
348-55issue
4eissn
0300-8428issn
1435-1803journal_volume
90pub_type
杂志文章abstract：:Short repeated cycles of peripheral ischemia/reperfusion (I/R) can protect distant organs from subsequent prolonged I/R injury; a phenomenon known as remote ischemic preconditioning (RIPC). A RIPC-mediated release of humoral factors might play a key role in this protection and vascular endothelial cells are potential ...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-015-0474-9
更新日期：2015-03-01 00:00:00
abstract：:This study was designed to identify mechanisms responsible for coronary vasodilation in response to progressive decreases in hematocrit. Isovolemic hemodilution was produced in open-chest, anesthetized swine via concurrent removal of 500 ml of arterial blood and the addition of 500 ml of 37 °C saline or synthetic plas...
journal_title：Basic research in cardiology
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journal_title：Basic research in cardiology
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doi：10.1007/978-3-662-30769-4_9
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908177
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907422
更新日期：1986-01-01 00:00:00
abstract：:Disregarding the influence of thickness on elevated strength of isolated preparations inevitably leads to erroneous tension-frequency relations, especially in the range of high frequencies. Thus, much of the confusion in interpreting the atypical negative staircase phenomenon of the rat heart is due to this. In view o...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11289-2_25
更新日期：1987-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788873
更新日期：1993-11-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/BF02650357
更新日期：1989-01-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01908180
更新日期：1985-07-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01906463
更新日期：1983-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF01907211
更新日期：1983-11-01 00:00:00
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journal_title：Basic research in cardiology
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doi：10.1007/s00395-012-0282-4
更新日期：2012-09-01 00:00:00
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journal_title：Basic research in cardiology
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更新日期：2009-11-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02190551
更新日期：1991-03-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s00395-007-0666-z
更新日期：2007-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02023597
更新日期：1977-07-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The clinical use of positive inotropic agents has been associated with increased mortality, with proarrhythmia speculated to be a contributing factor. This study compares the arrhythmogenic potentials of six positive inotropic agents representing different mechanistic classes: the beta-adrenergic agonist dobutamine, t...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950050181
更新日期：2000-06-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF00788284
更新日期：1994-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-012-0306-0
更新日期：2012-11-01 00:00:00
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journal_title：Basic research in cardiology
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doi：10.1007/s00395-012-0307-z
更新日期：2012-11-01 00:00:00
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更新日期：2019-09-09 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
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更新日期：2016-07-01 00:00:00
abstract：:Epidemiological studies have repeatedly demonstrated a beneficial effect of moderate alcohol consumption on the incidence of coronary heart disease, myocardial infarction and overall mortality. The latter increases with excessive alcohol consumption. Although most epidemiological studies demonstrate a beneficial effec...
journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
doi：10.1007/s003950170062
更新日期：2001-04-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/BF02650875
更新日期：1989-07-01 00:00:00
abstract：:Toxic peroxides result when oxygen radicals react with various peroxidic precursors in tissue or blood. A colorimetric method based on reactions of malondialdehyde (MDA), a key intermediate in the formation of peroxides, has been described in fresh tissues. The present report adapts this assay to measure MDA levels in...
journal_title：Basic research in cardiology
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doi：10.1007/BF01910480
更新日期：1984-09-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s00395-012-0303-3
更新日期：2012-11-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章,评审
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更新日期：2005-11-01 00:00:00
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journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/s003950200013
更新日期：2002-05-01 00:00:00
abstract：:Reversibly injured myocardium after short periods of ischemia is characterized by a prolonged depression of contractile function which can, however, be enhanced by inotropic interventions. Thus, a lack of inotropic stimulation due to ischemic damage of cardiac sympathetic nerves has been suggested as a mechanism under...
journal_title：Basic research in cardiology
pub_type： 杂志文章
doi：10.1007/978-3-662-11038-6_22
更新日期：1990-01-01 00:00:00
